Article
Endocrinology & Metabolism
John T. Giblin, Seong-Wook Park, John Jiang, Kivilcim Kilic, Sreekanth Kura, Jianbo Tang, David A. Boas, Ichun A. Chen
Summary: Two photon microscopy and OCT are commonly used methods for measuring red blood cell flow speeds in microvessels. However, they have limitations in capturing the volumetric complexity of cerebral microvasculature and providing fluorescent specificity. In this study, we developed a custom two photon system with an axicon based Bessel beam and a novel scan pattern to overcome these limitations and track RBC flow speeds in capillaries.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Editorial Material
Multidisciplinary Sciences
Kassandra Kisler, Angeliki Maria Nikolakopoulou, Berislav V. Zlokovic
Summary: Microglia play a crucial role in regulating capillary vascular tone and blood flow, with a recently identified signaling mechanism attracting and maintaining them at the capillary wall.
NATURE COMMUNICATIONS
(2021)
Article
Cardiac & Cardiovascular Systems
Adam Nyul-Toth, Stefano Tarantini, Jordan DelFavero, Feng Yan, Priya Balasubramanian, Andriy Yabluchanskiy, Chetan Ahire, Tamas Kiss, Tamas Csipo, Agnes Lipecz, Attila E. Farkas, Imola Wilhelm, Istvan A. Krizbai, Qinggong Tang, Anna Csiszar, Zoltan Ungvari
Summary: Age-related blood-brain barrier disruption and cerebromicrovascular rarefaction play important roles in the pathogenesis of vascular cognitive impairment and dementia (VCID) and Alzheimer's disease (AD). Recent advances in geroscience research have provided new interventions for preventing these diseases. Sensitive and easy-to-adapt imaging methods are urgently needed for longitudinal assessment of changes in BBB permeability and brain capillarization in aged mice.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Biology
Paul Shin, Qi Pian, Hidehiro Ishikawa, Gen Hamanaka, Emiri T. Mandeville, Shuzhen Guo, Buyin Fu, Mohammed Alfadhel, Srinivasa Rao Allu, Ikbal Sencan-Egilmez, Baoqiang Li, Chongzhao Ran, Sergei A. Vinogradov, Cenk Ayata, Eng Lo, Ken Arai, Anna Devor, Sava Sakadzic, Daniel Henrion
Summary: Aging is a risk factor for cognitive impairment. Aerobic exercise benefits brain function and may promote cognitive health in older adults. This study found that aerobic exercise can improve cerebral microcirculation and cognitive function in aging individuals.
Article
Physics, Multidisciplinary
Zaiyi Shen, Franck Plouraboue, Juho S. Lintuvuori, Hengdi Zhang, Mehdi Abbasi, Chaouqi Misbah
Summary: Numerical simulations are conducted to study the transport of deformable particles in a honeycomb network. It is found that the deformability of particles strongly affects their distribution in the network. Soft particles display a diffusion-like transport with short-term memory, while stiff particles show biased distribution and long-term memory effects. The transition from anomalous superdiffusion to classical diffusion occurs when the concentration of particles increases, leading to enhanced particle-particle interactions and shorter memory effects.
PHYSICAL REVIEW LETTERS
(2023)
Article
Endocrinology & Metabolism
Meher R. Juttukonda, Kimberly A. Stephens, Yi-Fen Yen, Casey M. Howard, Jonathan R. Polimeni, Bruce R. Rosen, David H. Salat
Summary: White matter lesions (WML) are associated with cognitive decline, and this study found that venous hyperintense signal (VHS) may be a marker of impaired oxygen extraction in aging older adults.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Article
Neurosciences
Cara D. Nielson, Andy Y. Shih
Summary: This article describes a method to study pericyte function in the living mouse brain. By optically ablating individual pericytes, the researchers can examine their roles in the local capillary network and remaining cells.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Cardiac & Cardiovascular Systems
Kenji J. Maeda, Daniel M. McClung, Kurt C. Showmaker, Junie P. Warrington, Michael J. Ryan, Michael R. Garrett, Jennifer M. Sasser
Summary: Preeclampsia is characterized by hypertension and proteinuria in late pregnancy, with potential neurological symptoms like headaches and vision problems. Using animal models is essential to understanding the pathogenesis of this condition.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Article
Multidisciplinary Sciences
Beth Eyre, Kira Shaw, Paul Sharp, Luke Boorman, Llywelyn Lee, Osman Shabir, Jason Berwick, Clare Howarth
Summary: Investigating the effects of locomotion during awake imaging on sensory-evoked haemodynamic responses, this study found that the amount and timing of locomotion significantly impact the responses. Monitoring locomotion is necessary to ensure accurate conclusions in comparisons between control and disease groups.
SCIENTIFIC REPORTS
(2022)
Article
Biochemical Research Methods
Qi Pian, Mohammed Alfadhel, Jianbo Tang, Grace V. Lee, Baoqiang Li, Buyin Fu, Yagmur Ayata, Mohammad Abbas Yaseen, David A. Boas, Timothy W. Secomb, Sava Sakadzic
Summary: We propose a data acquisition and processing framework to co-register a large set of microvascular blood flow velocity measurements from dynamic light scattering optical coherence tomography (DLS-OCT) with the corresponding microvascular angiogram obtained using two-photon microscopy (2PM). The proposed framework may serve as a useful tool for quantitative analysis of large microvascular datasets obtained by OCT and 2PM in studies involving normal brain functioning, progression of various diseases, and numerical modeling of the oxygen advection and diffusion in the realistic microvascular networks.
JOURNAL OF BIOMEDICAL OPTICS
(2023)
Article
Endocrinology & Metabolism
Carolyn S. Kaufman, Robyn A. Honea, Joseph Pleen, Rebecca J. Lepping, Amber Watts, Jill K. Morris, Sandra A. Billinger, Jeffrey M. Burns, Eric D. Vidoni
Summary: Aerobic exercise can significantly improve hippocampal blood flow for hypertensive APOE4 carriers, with no significant effect on non-carriers. Additionally, multiple regression analysis showed an increase in hippocampal blood flow for APOE4 carriers in response to reductions in systolic blood pressure.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Editorial Material
Endocrinology & Metabolism
Connor Dufort, Yangfan Wang, Xiaoming Hu
Summary: This study characterizes the role of capillary-associated microglia (CAM) in regulating cerebral blood flow and their interaction with surrounding cells within the neurovascular unit. The findings contribute to our understanding of vascular regulation and cerebrovascular diseases.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Article
Peripheral Vascular Disease
Kiana M. Schulze, Ramona E. Weber, Andrew G. Horn, Trenton D. Colburn, Carl J. Ade, David C. Poole, Timothy Musch
Summary: The impaired skeletal muscle oxygen transport in patients with pulmonary hypertension may be related to microcirculatory hemodynamic impairments, leading to compromised oxygen delivery between blood and muscle cells.
MICROVASCULAR RESEARCH
(2022)
Article
Cell Biology
Joseph S. R. Alisch, Nikkita Khattar, Richard W. Kim, Luis E. Cortina, Abinand C. Rejimon, Wenshu Qian, Luigi Ferrucci, Susan M. Resnick, Richard G. Spencer, Mustapha Bouhrara
Summary: Cerebral blood flow varies with age in different brain regions, with white matter regions showing increased blood flow with age and women having higher blood flow than men. The study results provide a foundation for further investigation of CNS perfusion in various scenarios.
Article
Engineering, Biomedical
Fei Ye, Bei Zhang, Lige Qiu, Yunrui Zhang, Yang Zhang, Jian Zhang, Qingliang Zhao, Ligong Lu, Zhenlin Zhang
Summary: The synergy imaging modality combining capillary microscopy and laser speckle microcirculation imaging allows for dynamic visualization of thrombus events and quantification of hemodynamics information. This method demonstrated excellent thrombolysis effect in an animal model, showing potential for early detection and treatment of thrombus-related diseases in living systems.
MATERIALS TODAY BIO
(2022)
Article
Biology
Baoqiang Li, Tatiana Esipova, Ikbal Sencan, Kivilcim Kilic, Buyin Fu, Michele Desjardins, Mohammad Moeini, Sreekanth Kura, Mohammad A. Yaseen, Frederic Lesage, Leif Ostergaard, Anna Devor, David A. Boas, Sergei A. Vinogradov, Sava Sakadzic
Article
Endocrinology & Metabolism
Ikbal Sencan, Tatiana Esipova, Kivilcim Kilic, Baoqiang Li, Michele Desjardins, Mohammad A. Yaseen, Hui Wang, Jason E. Porter, Sreekanth Kura, Buyin Fu, Timothy W. Secomb, David A. Boas, Sergei A. Vinogradov, Anna Devor, Sava Sakadzic
Summary: This study investigates the laminar profile of stimulus-induced intravascular partial pressure of oxygen (pO2) transients in fully awake mice. The results demonstrate that stimulus-induced changes in intravascular pO2 are consistent across cortical layers and show differences in response between veins and arteries, as well as differences from the response under anesthesia.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Elie Genois, Louis Gagnon, Michele Desjardins
Summary: The study investigated the influence of BOLD signals and correction methods in VASO technique, using modeling and Monte Carlo diffusion to draw conclusions that may help optimize sequence parameters in VASO and BOLD functional MRI, leading to a wider application of these techniques in healthy and diseased brain.
MAGNETIC RESONANCE IN MEDICINE
(2021)
Review
Neurosciences
Micael Carrier, Marie-Eve Robert, Fernando Gonzalez Ibanez, Michele Desjardins, Marie-Eve Tremblay
FRONTIERS IN NEUROSCIENCE
(2020)
Review
Neurosciences
Micael Carrier, Jeremie Guilbert, Jean-Philippe Levesque, Marie-Eve Tremblay, Michele Desjardins
Summary: Schizophrenia affects over 1% of the global population with highly heterogeneous symptoms. The pathogenic mechanisms are largely unknown but may involve genetic and environmental factors. Research explores potential alterations in the developing blood vessel network that could contribute to the development of schizophrenia.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2021)
Article
Physiology
Kivilcim Kilic, Michele Desjardins, Jianbo Tang, Martin Thunemann, Smrithi Sunil, Sefik Evren Erdener, Dmitry D. Postnov, David A. Boas, Anna Devor
Summary: Chronic cranial windows allow for long-term brain imaging experiments in awake, behaving mice. Different imaging technologies have unique advantages, and combining them can provide measurements of a wide range of parameters needed for comprehensive investigation. Following the surgical techniques for installation of different cranial windows targeted for specific imaging technologies can enhance experimental success and result reproducibility.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Oncology
Hanna T. Sjoberg, Yiannis Philippou, Anette L. Magnussen, Iain D. C. Tullis, Esther Bridges, Andrea Chatrian, Joel Lefebvre, Ka Ho Tam, Emma A. Murphy, Jens Rittscher, Dina Preise, Lilach Agemy, Tamar Yechezkel, Sean C. Smart, Paul Kinchesh, Stuart Gilchrist, Danny P. Allen, David A. Scheiblin, Stephen J. Lockett, David A. Wink, Alastair D. Lamb, Ian G. Mills, Adrian Harris, Ruth J. Muschel, Boris Vojnovic, Avigdor Scherz, Freddie C. Hamdy, Richard J. Bryant
Summary: The study investigated the combination of fractionated radiotherapy (FRT) and vascular-targeted photodynamic therapy (VTP) in treating prostate cancer (PCa). Results showed that FRT induced vascular normalization changes in PCa tumors, and the sequential delivery of FRT followed by VTP significantly delayed tumor growth and improved overall survival in pre-clinical models. The findings suggest that combining FRT and VTP may be a promising multimodal approach in PCa therapy, which could inform early phase clinical trials.
BRITISH JOURNAL OF CANCER
(2021)
Article
Biochemical Research Methods
Jeremie Guilbert, Michele Desjardins
Summary: Researchers demonstrated a new method to correct motion artifacts in LSCI signals, showing that regressing out flow-independent global variations can improve the quality of blood flow imaging.
JOURNAL OF BIOPHOTONICS
(2022)
Article
Biochemistry & Molecular Biology
Philipp Machler, Natalie Fomin-Thunemann, Martin Thunemann, Marte Julie Saetra, Michele Desjardins, Kivilcim Kilic, Layth N. Amra, Emily A. Martin, Ichun Anderson Chen, Ikbal Sencan-Egilmez, Baoqiang Li, Payam Saisan, John X. Jiang, Qun Cheng, Kimberly L. Weldy, David A. Boas, Richard B. Buxton, Gaute T. Einevoll, Anders M. Dale, Sava Sakadzic, Anna Devor
Summary: The cellular density, composition, and wiring of the cerebral cortex vary across cortical layers. This study found that the baseline oxygen consumption rate decreases from layer I to layer IV, while tissue oxygenation increases. It suggests that the higher oxygenation and cytochrome density in layer IV may serve as oxygen reserves during neuronal activity or metabolically active brain states.
Review
Engineering, Biomedical
Philipp Machler, Thomas Broggini, Celine Mateo, Martin Thunemann, Natalie Fomin-Thunemann, Patrick R. Doran, Ikbal Sencan, Kivilcim Kilic, Michele Desjardins, Hana Uhlirova, Mohammad A. Yaseen, David A. Boas, Andreas A. Linninger, Massimo Vergassola, Xin Yu, Laura D. Lewis, Jonathan R. Polimeni, Bruce R. Rosen, Sava Sakadzic, Richard B. Buxton, Martin Lauritzen, David Kleinfeld, Anna Devor
Summary: Recent advancements in optical microscopy have opened up new opportunities for studying neurovascular and neurometabolic coupling in behaving animals. Future studies will use these tools to investigate the regulation of cerebral blood flow and metabolism in different brain states, as well as how this regulation changes with brain maturation and aging. This knowledge is crucial for interpreting hemodynamic signals observed with fMRI.
CURRENT OPINION IN BIOMEDICAL ENGINEERING
(2021)
Proceedings Paper
Engineering, Biomedical
Joel Lefebvre, Avelino Javer, Manila Dmitrieva, Jens Rittscher, Bohdan Lewkow, Edward Allgeyer, George Sirinakis, Daniel St Johnston
2020 IEEE 17TH INTERNATIONAL SYMPOSIUM ON BIOMEDICAL IMAGING (ISBI 2020)
(2020)
Proceedings Paper
Engineering, Biomedical
Kristofer delas Penas, Manila Dmitrieva, Joel Lefebvre, Helen Zenner, Edward Allgeyer, Martin Booth, Daniel St Johnston, Jens Rittscher
2020 IEEE 17TH INTERNATIONAL SYMPOSIUM ON BIOMEDICAL IMAGING (ISBI 2020)
(2020)
Proceedings Paper
Engineering, Biomedical
Manila Dmitrieva, Joel Lefebvre, Kristofer delas Penas, Helen L. Zenner, Jennifer Richens, Daniel St Johnston, Jens Rittscher
2020 IEEE 17TH INTERNATIONAL SYMPOSIUM ON BIOMEDICAL IMAGING (ISBI 2020)
(2020)
Article
Neurosciences
Michele Desjardins, Kivilcim Kilic, Martin Thunemann, Celine Mateo, Dominic Holland, Christopher G. L. Ferri, Jonathan A. Cremonesi, Baoqiang Li, Qun Cheng, Kimberly L. Weldy, Payam A. Saisan, David Kleinfeld, Takaki Komiyama, Thomas T. Liu, Robert Bussell, Eric C. Wong, Miriam Scadeng, Andrew K. Dunn, David A. Boas, Sava Sakadzic, Joseph B. Mandeville, Richard B. Buxton, Anders M. Dale, Anna Devor
BIOLOGICAL PSYCHIATRY-COGNITIVE NEUROSCIENCE AND NEUROIMAGING
(2019)
Proceedings Paper
Optics
Elie Genois, Louis Gagnon, Jeremie Guilbert, Sava Sakadzic, Anna Devor, David Boas, Michele Desjardins
CLINICAL AND TRANSLATIONAL NEUROPHOTONICS 2019
(2019)
Article
Geriatrics & Gerontology
Sarah N. Kraeutner, Cristina Rubino, Jennifer K. Ferris, Shie Rinat, Lauren Penko, Larissa Chiu, Brian Greeley, Christina B. Jones, Beverley C. Larssen, Lara A. Boyd
Summary: This study examined the age-related changes in brain function and baseline brain structure that support motor skill acquisition. The findings showed that older adults experienced decreases in functional connectivity during motor skill acquisition, while younger adults experienced increases. Additionally, regardless of age group, lower baseline microstructure in a frontoparietal tract was associated with slower motor skill acquisition.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Karen Nuytemans, Farid Rajabli, Melissa Jean-Francois, Jiji Thulaseedhara Kurup, Larry D. Adams, Takiyah D. Starks, Patrice L. Whitehead, Brian W. Kunkle, Allison Caban-Holt, Jonathan L. Haines, Michael L. Cuccaro, Jeffery M. Vance, Goldie S. Byrd, Gary W. Beecham, Christiane Reitz, Margaret A. Pericak-Vance
Summary: This study conducted genetic research on African American AD families and identified a significant linkage signal associated with AD, highlighting the importance of diverse population-level genetic data in understanding the genetic determinants of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Kazuya Suwabe, Ryuta Kuwamizu, Kazuki Hyodo, Toru Yoshikawa, Takeshi Otsuki, Asako Zempo-Miyaki, Michael A. Yassa, Hideaki Soya
Summary: Physical exercise has a positive impact on hippocampal memory decline with aging. Recent studies have shown that even light exercise can improve memory and this improvement is mediated by the ascending arousal system. This study aimed to investigate the effects of light-intensity exercise on hippocampal memory function in healthy older adults and found that pupil dilation during exercise played a role in the memory improvement.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Ajay Sood, Ana Werneck Capuano, Robert Smith Wilson, Lisa Laverne Barnes, Alifiya Kapasi, David Alan Bennett, Zoe Arvanitakis
Summary: The objective of this study was to explore the impact of metformin on cognition and brain pathology. The results showed that metformin users had slower decline in global cognition, episodic memory, and semantic memory compared to non-users. However, the relationship between metformin use and certain brain pathology remains uncertain.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Brian N. Lee, Junwen Wang, Molly A. Hall, Dokyoon Kim, Shana D. Stites, Li Shen
Summary: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory and functional impairments. This study analyzed participants from the Alzheimer's Disease Neuroimaging Initiative and found differential associations between cerebral spinal fluid (CSF)/neuroimaging biomarkers and cognitive/functional outcomes, as well as variations between sexes. These findings suggest that sex differences may play a role in the development of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Madeline R. Hale, Rebecca Langhough, Lianlian Du, Bruce P. Hermann, Carol A. Van Hulle, Margherita Carboni, Gwendlyn Kollmorgenj, Kristin E. Basche, Davide Bruno, Leah Sanson-Miles, Erin M. Jonaitis, Nathaniel A. Chin, Ozioma C. Okonkwo, Barbara B. Bendlin, Cynthia M. Carlsson, Henrik Zetterberg, Kaj Blennow, Tobey J. Betthauser, Sterling C. Johnson, Kimberly D. Mueller
Summary: This study demonstrates a relationship between cerebrospinal fluid biomarkers and the ability to recall proper names in the preclinical phase of Alzheimer's disease.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Thomas T. Austin, Christian L. Thomas, Ben Warren
Summary: This study investigated the effects of age on the robustness and resilience of auditory system using the desert locust. The researchers found that gene expression changes were mainly influenced by age rather than noise exposure. Both young and aged locusts were able to recover their auditory nerve function within 48 hours of noise exposure, but the recovery of transduction current magnitude was impaired in aged locusts. Key genes responsible for robustness to noise exposure in young locusts and potential candidates for compensatory mechanisms in auditory neurons of aged locusts were identified.
NEUROBIOLOGY OF AGING
(2024)
