期刊
NEUROBIOLOGY OF AGING
卷 34, 期 4, 页码 -出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2012.08.015
关键词
Alzheimer's disease; Genome-wide association studies; PICALM gene; Chinese population; European ancestry
资金
- National Nature Science Foundation of China [31171219, 81271213]
- US-China Biomedical Collaborative Research Program (NSFC) [812111108]
- Tianjin Science and Technology Support Program [10ZCZDSY06400, 10ZCKFSY05500]
- One Hundred Person Project of the Chinese Academy of Sciences [KSCX2-YW-BR-3]
Recently, the association between PICALM rs3851179 polymorphism and Alzheimer's disease (AD) was investigated in the Chinese population by 3 independent studies. However, both allele and genotype tests failed to reveal any association. The association was identified only in the APOE epsilon 4-negative subgroup. We think that the failure to replicate the association may be because of the relatively small sample size. In this research, we reinvestigated the association using all the samples from these 3 studies (n = 2486, and 1202 cases and 1284 control subjects). We failed to replicate this association between the rs3851179 polymorphism and AD in all samples and the APOE epsilon 4-negative subgroup. Our results indicate that rs3851179 may not be an AD susceptibility locus in the Chinese population and the APOE epsilon 4-negative subgroup. (C) 2013 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据