期刊
NEUROBIOLOGY OF AGING
卷 34, 期 1, 页码 -出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2012.08.001
关键词
Aging; Dopamine; Genetics; DAT; SLC6A3; DRD2; Episodic memory; Serial recall
资金
- Max Planck Society [M.FE.ABild0006]
- German Federal Ministry for Education and Research
- Swedish Research Council
- Swedish Brain Power
- Alexander von Humboldt Research Award
- German Science Foundation [DFG FOR 778]
- German Federal Ministry for Education and Research (BMBF Bernstein Fokus Neuronale Grundlagen des Lernes) [01GQ0913]
Aging compromises dopamine transporter (DAT) and receptor mechanisms in the frontostriatal circuitry. In a sample of 1288 younger and older adults, we investigated (i) whether individual differences in genotypes of the DAT gene (i. e., SLC6A3, the DAT variable number of tandem repeat 9/9, 9/10, and 10/10) and in the D2 receptor (DRD2) gene (i. e., the C957T [rs6277] CC and any T) interactively contribute to phenotype variations in episodic memory performance; and (ii) whether these genetic effects are magnified in older adults, because of considerable declines in the dopamine functions. Our results showed that carrying genotypes associated with higher levels of striatal synaptic dopamine (DAT 9/9) and higher density of extrastriatal D2 receptors (C957T CC) were associated with better backward serial recall, an episodic memory task with high encoding and retrieval demands. Critically, the gene-gene interaction effect was reliably stronger in older than in younger adults. In line with the resource modulation hypothesis, our findings suggest that aging-related decline in brain phenotypes (e. g., dopamine functions) could alter the relations between genotypes and behavioral phenotypes (e. g., episodic memory). (C) 2013 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据