期刊
NEUROBIOLOGY OF AGING
卷 33, 期 7, 页码 -出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2010.11.013
关键词
Telomere; Aging; Biomarker; Cognitive; Social class; Physical; Inflammatory; LBC1936
资金
- BBSRC
- EPSRC
- ESRC
- MRC, as part of the cross-council Lifelong Health and Wellbeing Initiative [G0700704/84698]
- MRC
- MRC [G0601333] Funding Source: UKRI
- Medical Research Council [G0601333, G0700704B] Funding Source: researchfish
Telomeres are nucleo-protein complexes at the end of eukaryotic chromosomes. They shorten each time a somatic cell replicates and this shortening is modulated by the effects of oxidative stress. Previous studies have associated telomere length with a number of age-related outcomes and it is hypothesized to be a quantitative indicator of aging. We tested this hypothesis in a cohort of similar to 1000 relatively healthy 70-year-old Scots (the Lothian Birth Cohort of 1936: LBC1936) on whom we have measures of cognition, physical health and associated traits, and social class. Telomeres were significantly longer in males than females (p < 0.0001). Longer telomeres were associated, in females only, with higher general cognitive ability scores (p = 0.022) and lower C-reactive protein levels (p = 0.014). Telomere length was not associated with any of the other measured cognitive, physical, or social traits. In conclusion we find little evidence that telomere length is a significant biomarker of normal aging in important cognitive and physical domains. (C) 2012 Elsevier Inc. All rights reserved.
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