期刊
NEUROBIOLOGY OF AGING
卷 33, 期 6, 页码 1023-1033出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2010.09.021
关键词
Alzheimer's disease; Early onset; White matter; Atrophy; VBM
资金
- Ex Art [56533F/B 1]
- PS-Neuro Ex [56/05/11]
- Millennium Fitness e Solidarieta fund
We investigated patterns of white matter (WM) loss in 18 early onset (EO) and 24 late onset (LO) Alzheimer's disease (AD) patients compared with 42 healthy controls (HC), and explored relationships of WM atrophy and apolipoprotein E (ApoE) genotype. Subjects underwent magnetic resonance imaging (MRI). Patterns of WM were assessed using voxel-based morphometry. Compared with healthy controls, LOAD patients had a selective parahippocampal WM loss, while EOAD patients experienced a more widespread pattern of posterior WM atrophy. The distinct regional distribution of WM atrophy reflected the topography of gray matter (GM) loss. ApoE epsilon 4 status was associated with a greater parahippocampal WM loss in both AD groups. The greater WM atrophy in EOAD than LOAD fits with the evidence that EOAD is a more aggressive form of the disease. The ApoE epsilon 4 effect on WM damage in AD is restricted to specific WM regions and does not seem to be related to age of onset. (C) 2012 Elsevier Inc. All rights reserved.
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