Review
Endocrinology & Metabolism
Kaoru Sato, Ken-ichi Takayama, Satoshi Inoue
Summary: Estrogens play an important role in the female reproductive system and also regulate physiological processes associated with learning and memory in the brain. They have neuroprotective effects in the pathogenesis of Alzheimer's disease (AD), which has a higher incidence in older and postmenopausal women. Estrogens bind to estrogen receptors (ERs) and activate transcriptional machineries, and also stimulate signal transduction through membrane ERs (mERs). Estrogen-related receptors (ERRs), which lack estrogen-binding capabilities, are expressed in the human brain and implicated in AD pathogenesis.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Virology
Jiaxin Xie, Yibo Ding, Xiaopan Li, Rui Pu, Wenbin Liu, Peng Li, Jianhua Yin
Summary: Estrogen receptor alpha (ESR1) is involved in the pathological process of Hepatitis B virus (HBV) infection and may play a role in gender differences. This study investigated the correlation between ESR1 polymorphisms and the susceptibility to HBV persistence and clinical outcomes. The results suggest that combinations of ESR1 polymorphisms may be useful for predicting HBV persistence.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Food Science & Technology
Chuan Qin, Shaoqin Hu, Shuangxi Zhang, Daina Zhao, Yongyao Wang, Hua Li, Yunhua Peng, Le Shi, Xiaohong Xu, Changhe Wang, Jiankang Liu, Ying Cheng, Jiangang Long
Summary: The study found that HT-ac significantly improved cognitive function in AD mice by ameliorating neuronal apoptosis and decreasing inflammatory cytokine levels in water maze tests.
MOLECULAR NUTRITION & FOOD RESEARCH
(2021)
Article
Multidisciplinary Sciences
Anne Mette G. Jensen, Yu Kitago, Elnaz Fazeli, Christian B. Vaegter, Scott A. Small, Gregory A. Petsko, Olav M. Andersen
Summary: SORL1 gene, encoding SORLA protein, is the fourth gene associated with Alzheimer's disease (AD) and linked to both early- and late-onset forms of the disease. SORLA interacts with retromer, regulating the recycling of endosomal cargo. This study provides a structural model for how SORLA folds and fits into retromer-positive endosomal tubules, showing its dimerization and enhancing retromer-dependent recycling of APP.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Cardiac & Cardiovascular Systems
Farzaneh Foroughinia, Pooyan Dehghani, Mehdi Dianatpour, Arghavan Amiri, Iman Jamhiri, Parisa Ghasemiyeh
Summary: This study aimed to evaluate the association of two ER2 gene polymorphisms, rs4986938 (AluI) and rs1256049 (RsaI), with the severity of CAD. The results showed a significant relationship between rs4986938 polymorphism of ER2 and the severity of CAD in men, suggesting a potential role of genetic variation in CAD severity.
BMC CARDIOVASCULAR DISORDERS
(2021)
Article
Public, Environmental & Occupational Health
Longjian Liu, Kathleen M. Hayden, Nathalie S. May, Bernhard Haring, Zuolu Liu, Victor W. Henderson, Jiu-Chiuan Chen, Edward J. Gracely, Sylvia Wassertheil-Smoller, Stephen R. Rapp
Summary: This study found significant associations between hypertension, elevated SBP, and PP levels with the risk of mild cognitive impairment and cognitive loss, suggesting that intensive control of hypertension, SBP, and PP can preserve cognitive health in older women.
LANCET GLOBAL HEALTH
(2022)
Article
Clinical Neurology
Anna Dittrich, Nicholas J. J. Ashton, Henrik Zetterberg, Kaj Blennow, Anna Zettergren, Joel Simren, Tobias Skillback, Sara Shams, Alejandra Machado, Eric Westman, Michael Scholl, Ingmar Skoog, Silke Kern
Summary: This study investigates the relationship between chronic kidney disease (CKD) and neurodegenerative diseases. It shows that CKD patients have higher levels of plasma neurofilament light (P-NfL) compared to individuals with normal kidney function. Therefore, P-NfL may serve as a potential biomarker linking CKD to neurodegenerative diseases.
Article
Behavioral Sciences
Siwei Chen, Dunzhu Mima, Haiqiang Jin, Qu Dan, Fei Wang, Juan Cai, Lin Shi, Huali Wang, Ailian Du, Ying Tang, Yongan Sun
Summary: The study aimed to investigate the correlation between NEP gene polymorphisms and Alzheimer's disease in the Chinese Tibetan population. While no significant correlation was found between most NEP gene loci and AD in Tibetans, allele C of NEP gene locus rs701109 and allele T of gene locus rs3736187 were identified as potential risk factors for male AD patients in this population.
BRAIN AND BEHAVIOR
(2021)
Article
Pharmacology & Pharmacy
Nan-Rui Shi, Qi Wang, Jie Liu, Ji-Zhou Zhang, Bin-Lu Deng, Xiu-Min Hu, Jie Yang, Xin Wang, Xiang Chen, Yan-Qin Zuo, Ting-Ting Liu, Jia-Ling Zheng, Xin Yang, Peter Illes, Yong Tang
Summary: The study explored the relationship between genetic polymorphisms of A(2A)R and CD73 and epilepsy. The results showed that the TT genotype and T allele of rs4431401 in CD73 were genetic risk factors for epilepsy, while rs2267076, rs2298383, rs4822492, and rs4822489 polymorphisms of A(2A)R were mainly associated with female epilepsy patients.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Multidisciplinary Sciences
Gihan P. Ruwanpathirana, Robert C. Williams, Colin L. Masters, Christopher C. Rowe, Leigh A. Johnston, Catherine E. Davey
Summary: The molecular mechanism of intracellular tau accumulation caused by extracellular A beta-amyloid (A beta) in Alzheimer's disease is not well understood. This study used a convolutional neural network (CNN) to analyze the association between A beta and tau, revealing new associations. The CNN accurately predicted the relationship between A beta and tau.
SCIENTIFIC REPORTS
(2022)
Article
Oncology
Meng Zhou, Jin-qi Yan, Qian-xin Chen, Yuan-zhong Yang, Yue-lin Li, Yue-xiang Ren, Zi-jin Weng, Xiao-fang Zhang, Jie-xia Guan, Lu-ying Tang, Ze-fang Ren
Summary: This study revealed a close association between the prognostic value of H3K9me3 in breast cancer and ER status and expression level. High levels of H3K9me3 were associated with a better prognosis among ER-positive tumors, particularly ER-high positive tumors.
CLINICAL EPIGENETICS
(2022)
Article
Cell Biology
Hansol Heo, Hyungsun Park, Myung Shin Lee, Jongyoon Kim, Juyeong Kim, Soon-Young Jung, Sun Kyeon Kim, Seongju Lee, Jaerak Chang
Summary: TRIM22 protein has been identified to play a novel role in autophagy regulation by mediating the association of GABARAP family proteins with PLEKHM1, thereby promoting autophagosome-lysosome fusion and facilitating autophagic clearance of protein aggregates. A TRIM22 variant associated with early-onset familial Alzheimer's disease interferes with autophagosome-lysosome fusion and autophagic clearance.
Article
Genetics & Heredity
Yu-Hao Huang, Wen-Hui Fang, Dung-Jang Tsai, Yu-Hsuan Chen, Yu-Chiao Wang, Wen Su, Chung-Cheng Kao, Kevin Yi, Chih-Chien Wang, Sui-Lung Su
Summary: This study investigated the association between ESR1 Xbal and knee OA through a case-control study, meta-analysis, and trial sequential analysis. The results showed no significant association between ESR1 Xbal and knee OA, suggesting that it is not a causal relationship and future studies may not be necessary.
Article
Plant Sciences
Roland Nhouma Rebe, Jordan Tonga Lembe, Simon Desire Guedang Nyayi, Herve Herve Abaissou Ngatanko, Eglantine Keugong Wado, Germain Jean Magloire Ketcha Wanda, Derek Tantoh Ndinteh, Dieudonne Njamen, Stephane Zingue, Harquin Simplice Foyet
Summary: This study evaluated the estrogenic and neuroprotective potential of Millettia griffoniana on ovariectomized (OVX) rats. The results showed that the ethanolic extract of M. griffoniana exhibits estrogenic, anticholinesterase, and antioxidant activities, and can improve memory impairment in rats. These findings shed light on the therapeutic effects of this plant in menopausal complaints and dementia.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Clinical Neurology
Jing Qian, Rebecca A. Betensky, Bradley T. Hyman, Alberto Serrano-Pozo
Summary: The study found that compared to the APOE epsilon 3/epsilon 3 reference genotype, the APOE epsilon 2 and epsilon 4 alleles have opposite effects on the rate of cognitive decline. These effects are clinically relevant and largely independent of the differential APOE allele effects on AD and comorbid pathologies, indicating that APOE genotype contributes to the heterogeneity in the rate of clinical progression in AD.
Article
Infectious Diseases
Anais Corma-Gomez, Luis M. Real, Marta Fernandez-Fuertes, Alejandro Gonzalez-Serna, Noemi Oliver, Jesus Ortega, Pilar Rincon, Elena Rodriguez-Pineda, Marta Santos, Marta Trigo-Rodriguez, Juan Macias, Juan A. Pineda
Summary: This study aimed to assess HAV serologic and vaccination status among people who live with HIV (PLWH) and evaluate the impact of a vaccination-based strategy on HAV-negative patients in Seville, Spain. The results showed that a considerable proportion of PLWH remained susceptible to HAV infection despite the vaccine delivery program, highlighting the need for new strategies to increase HAV vaccination coverage.
ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA
(2023)
Article
Biochemistry & Molecular Biology
Marta Marquie, Fernando Garcia-Gutierrez, Adelina Orellana, Laura Montrreal, Itziar de Rojas, Pablo Garcia-Gonzalez, Raquel Puerta, Claudia Olive, Amanda Cano, Isabel Hernandez, Maitee Rosende-Roca, Liliana Vargas, Juan Pablo Tartari, Ester Esteban-De Antonio, Urszula Bojaryn, Mario Ricciardi, Diana M. Ariton, Vanesa Pytel, Montserrat Alegret, Gemma Ortega, Ana Espinosa, Alba Perez-Cordon, Angela Sanabria, Nathalia Munoz, Nuria Lleonart, Nuria Aguilera, Ainhoa Garcia-Sanchez, Emilio Alarcon-Martin, Lluis Tarraga, Agustin Ruiz, Merce Boada, Sergi Valero
Summary: This study found that the association between Alzheimer's disease biomarkers and neuropsychiatric symptoms has a significant impact on the conversion to dementia in patients with mild cognitive impairment. A total of 500 individuals with MCI were followed-up yearly, and it was found that certain AT(N) profiles and the presence of depression and apathy were associated with a higher risk of conversion. The additive combination of AT(N) profile with depression exacerbates the risk of conversion, and a synergic effect of prodromal AD profile with depressive symptoms is evidenced.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Pablo Garcia-Gonzalez, Itziar de Rojas, Sonia Moreno-Grau, Laura Montrreal, Raquel Puerta, Emilio Alarcon-Martin, Ines Quintela, Adela Orellana, Victor Andrade, Pamela V. Martino Adami, Stefanie Heilmann-Heimbach, Pilar Gomez-Garre, Maria Teresa Perinan, Ignacio Alvarez, Monica Diez-Fairen, Raul Nunez Llaves, Claudia Olive Roig, Guillermo Garcia-Ribas, Manuel Menendez-Gonzalez, Carmen Martinez, Miquel Aguilar, Mariateresa Buongiorno, Emilio Franco-Macias, Maria Eugenia Saez, Amanda Cano, Maria J. Bullido, Luis Miguel Real, Eloy Rodriguez-Rodriguez, Jose Luis Royo, Victoria Alvarez, Pau Pastor, Gerard Pinol-Ripoll, Pablo Mir, Miguel Calero Lara, Miguel Medina Padilla, Pascual Sanchez-Juan, Angel Carracedo, Sergi Valero, Isabel Hernandez, Lluis Tarraga, Alfredo Ramirez, Merce Boada, Agustin Ruiz
Summary: Mosaic loss of chromosome Y (mLOY) is a common somatic event associated with Alzheimer's disease (AD) and can be age-confounded in genome-wide association studies. This study used Mendelian randomisation to construct an age-independent mLOY polygenic risk score (mloy-PRS) and found that higher genetic risk for mLOY was associated with faster progression to AD in men with mild cognitive impairment. The study suggests that mLOY is involved in AD pathogenesis and shows associations with cerebrospinal fluid biomarkers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Itziar de Rojas, Laura del Barrio, Isabel Hernandez, Laura Montrreal, Pablo Garcia-Gonzalez, Marta Marquie, Sergi Valero, Amanda Cano, Adelina Orellana, Merce Boada, Santos Manes, Agustin Ruiz
Summary: Cholesterol efflux capacity (CEC), which is closely related to Alzheimer's disease and other clinical conditions, is determined by APOE genotype and plasma metabolome profile. In this study, it was found that plasma 3-hydroxybutyrate and male sex were strongly correlated with CEC. Most NMR particles associated with CEC were not correlated with APOE genotype. The study confirmed the impact of APOE genotype on plasma lipoprotein particles and omega-3 fatty acids independently of plasma cholesterol level.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Javier Villadiego, Juan Garcia-Arriaza, Reposo Ramirez-Lorca, Roberto Garcia-Swinburn, Daniel Cabello-Rivera, Alicia E. Rosales-Nieves, Maria I. Alvarez-Vergara, Fernando Cala-Fernandez, Ernesto Garcia-Roldan, Juan L. Lopez-Ogayar, Carmen Zamora, David Astorgano, Guillermo Albericio, Patricia Perez, Ana M. Munoz-Cabello, Alberto Pascual, Mariano Esteban, Jose Lopez-Barneo, Juan Jose Toledo-Aral
Summary: In this study using a transgenic mouse model, it was found that SARS-CoV-2 primarily replicates in neurons in the brain, causing neuronal loss, glial activation, and vascular damage. However, vaccination with the MVA-CoV2-S vaccine provided full protection against cerebral infection and associated damage, even after reinfection.
NATURE NEUROSCIENCE
(2023)
Correction
Clinical Neurology
Antonio Boza-Serrano, Rocio Ruiz, Raquel Sanchez-Varo, Juan Garcia-Revilla, Yiyi Yang, Itzia Jimenez-Ferrer, Agnes Paulus, Malin Wennstroem, Anna Vilalta, David Allendorf, Jose Carlos Davila, John Stegmayr, Sebastian Jimenez, Maria A. Roca-Ceballos, Victoria Navarro-Garrido, Maria Swanberg, Christine L. Hsieh, Luis M. Real, Elisabet Englund, Sara Linse, Hakon Leffler, Ulf J. Nilsson, Guy C. Brown, Antonia Gutierrez, Javier Vitorica, Jose Luis Venero, Tomas Deierborg
ACTA NEUROPATHOLOGICA
(2023)
Article
Biochemistry & Molecular Biology
Francisco Mayo, Lourdes Gonzalez-Vinceiro, Laura Hiraldo-Gonzalez, Claudia Calle-Castillejo, Sara Morales-Alvarez, Reposo Ramirez-Lorca, Miriam Echevarria
Summary: Aquaporin-4 (AQP4) is a water channel that is abundant in the central nervous system and plays a key role in maintaining water balance. While its expression and function in adults are well-established, little is known about its expression and localization during postnatal development. This study examined the expression of AQP4 mRNA and protein in the brain and spinal cord of mice at different stages of postnatal development. The results revealed changes in the expression and localization of AQP4 during early development, suggesting a potential role for AQP4 in early cell differentiation and myelination.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Infectious Diseases
Ines Suarez-Garcia, Belen Alejos, Victoria Hernando, Laura Vinuela, Mar Vera Garcia, David Rial-Crestelo, Maria Jesus Perez Elias, Helena Albendin Iglesias, Joaquim Peraire, Juan Tiraboschi, Asuncion Diaz, Santiago Moreno, Inma Jarrin
Summary: The study assessed the effectiveness and tolerability of DTG/3TC in treatment-naive and virologically suppressed treatment-experienced individuals. The results showed that 91.4% and 93.8% of treatment-naive individuals achieved viral suppression at 24 and 48 weeks, respectively, after starting DTG/3TC. Among treatment-experienced individuals, 97.4% and 95.5% maintained viral suppression at 24 and 48 weeks, respectively, after switching to DTG/3TC.
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
(2023)
Article
Virology
Anais Corma-Gomez, Marta Fernandez-Fuertes, Laura Vinuela, Carmen Dominguez, Marta Santos, Ana Fuentes-Lopez, Almudena Rojas, Nieves Fernandez-Perez, Jessica Martin-Carmona, Esther Serrano-Conde, Luis M. Real, Joaquin Mendoza, Juan Macias, Juan A. Pineda, Federico Garcia
Summary: The aim of this study was to assess the immunogenicity of SARS-CoV-2 vaccines among people living with HIV with severe immunosuppression. The findings showed that patients with CD4 cell count <200 cells/mm(3) had reduced immune response after vaccination.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Amanda Cano, Ester Esteban-de-Antonio, Mireia Bernuz, Raquel Puerta, Pablo Garcia-Gonzalez, Itziar de Rojas, Claudia Olive, Alba Perez-Cordon, Laura Montrreal, Raul Nunez-Llaves, Oscar Sotolongo-Grau, Emilio Alarcon-Martin, Sergi Valero, Montserrat Alegret, Elvira Martin, Pamela V. Martino-Adami, Miren Ettcheto, Antonio Camins, Assumpta Vivas, Marta Gomez-Chiari, Miguel angel Tejero, Adelina Orellana, Lluis Tarraga, Marta Marquie, Alfredo Ramirez, Merce Marti, Maria Isabel Pividori, Merce Boada, Agustin Ruiz
Summary: Alzheimer's disease (AD) is commonly preceded by a prodromal phase characterized by high levels of A beta and p-tau-mediated neuronal injury and mild cognitive impairment (MCI). Differential diagnosis of MCI causes in these prodromal stages is a challenge for clinicians. Blood biomarkers, particularly plasma extracellular vesicles (pEVs), are emerging as potential tools for early AD detection.
JOURNAL OF NANOBIOTECHNOLOGY
(2023)
Article
Neurosciences
Marta Marquie, Ainhoa Garcia-Sanchez, Emilio Alarcon-Martin, Joan Martinez, Miguel Castilla-Marti, Luis Castilla-Marti, Adelina Orellana, Laura Montrreal, Itziar de Rojas, Pablo Garcia-Gonzalez, Raquel Puerta, Claudia Olive, Amanda Cano, Isabel Hernandez, Maitee Rosende-Roca, Liliana Vargas, Juan Pablo Tartari, Ester Esteban-De Antonio, Urszula Bojaryn, Mario Ricciardi, Diana M. Ariton, Vanesa Pytel, Montserrat Alegret, Gemma Ortega, Ana Espinosa, Alba Perez-Cordon, Angela Sanabria, Nathalia Munoz, Nuria Lleonart, Nuria Aguilera, Lluis Tarraga, Sergi Valero, Agustin Ruiz, Merce Boada
Summary: This study aimed to investigate the association between macular vessel density measured by optical coherence tomography angiography (OCT-A) and the AT(N) classification based on cerebrospinal fluid (CSF) biomarkers in individuals with mild cognitive impairment (MCI). The results showed that there was no association between macular vessel density measures and the AT(N) classification in MCI patients.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Alvaro Esteban-Martos, Ana Maria Brokate-Llanos, Luis Miguel Real, Sonia Melgar-Locatelli, Itziar de Rojas, Adriana Castro-Zavala, Maria Jose Bravo, Maria del Carmen Manas-Padilla, Pablo Garcia-Gonzalez, Maximiliano Ruiz-Galdon, Beatriz Pacheco-Sanchez, Rocio Polvillo, Fernando Rodriguez de Fonseca, Irene Gonzalez, Estela Castilla-Ortega, Manuel J. Munoz, Patricia Rivera, Armando Reyes-Engel, Agustin Ruiz, Jose Luis Royo
Summary: Genome-wide association studies (GWAS) are a powerful tool for identifying disease-related biochemical pathways and facilitating drug repurposing. DAGGER is a pipeline used to find approved drugs with repurposing potential by analyzing GWAS and gene expression data. Using this pipeline, we identified midostaurin as a protective drug for Alzheimer's disease and confirmed its effect in both C. elegans and 3xTg AD transgenic mice models. Our pipeline has the potential to be a useful tool for drug repurposing in complex diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Yann Le Guen, Guo Luo, Aditya Ambati, Vincent Damotte, Iris Jansen, Eric Yu, Aude Nicolas, Itziar de Rojasj, Thiago Peixoto Leal, Akinori Miyashita, Celine Bellenguez, Michelle Mulan Lian, Kayenat Parveen, Takashi Morizono, Hyeonseul Park, Benjamin Grenier-Boley, Tatsuhiko Naito, Fahri Kucukali, Seth D. Talyansky, Selina Maria Yogeshwar, Vicente Sempere, Wataru Satake, Victoria Alvarez, Beatrice Arosio, Michael E. Belloy, Luisa Benussi, Anne Boland, Barbara Borroni, Maria J. Bullido, Paolo Caffarra, Jordi Clarimon, Antonio Daniele, Daniel Darling, Stephanie Debette, Jean-Francois Deleuze, Martin Dichgans, Carole Dufouil, Emmanuel During, Emrah Duzel, Daniela Galimberti, Guillermo Garcia-Ribas, Jose Maria Garcia-Alberca, Pablo Garcia-Gonzalez, Vilmantas Giedraitis, Oliver Goldhardt, Caroline Graff, Edna Grunblatt, Olivier Hanon, Lucrezia Hausner, Stefanie Heilmann-Heimbach, Henne Holstege, Jakub Hort, Yoo Jin Jung, Deckert Jurgen, Silke Kern, Teemu Kuulasmaa, Kun Ho Lee, Ling Lin, Carlo Masullo, Patrizia Mecocci, Shima Mehrabian, Alexandre de Mendonca, Merce Boada, Pablo Mir, Susanne Moebus, Fermin Moreno, Benedetta Nacmias, Gael Nicolas, Shumpei Niida, Borge G. Nordestgaard, Goran Papenberg, Janne Papma, Lucilla Parnetti, Florence Pasquier, Pau Pastor, Oliver Peters, Yolande A. L. Pijnenburg, Gerard Pinol-Ripoll, Julius Popp, Laura Molina Porcel, Raquel Puertaj Jordi Perez-Tur, Innocenzo Rainero, Inez Ramakers, Luis M. Real, Steffi Riedel-Heller, Eloy Rodriguez-Rodriguez, Owen A. Ross, Jose Luis Royo, Dan Rujescu, Nikolaos Scarmeas, Philip Scheltens, Norbert Scherbaum, Anja Schneider, Davide Seripa, Ingmar Skoog, Vincenzo Solfrizzi, Gianfranco Spalletta, Alessio Squassina, John van Swieten, Raquel Sanchez-Valle, Eng-King Tan, Thomas Tegos, Charlotte Teunissen, Jesper Qvist Thomassen, Lucio Tremolizzo, Martin Vyhnalek, Frans Verhey, Margda Waern, Jens Wiltfang, Jing Zhangc, Henrik Zetterberg, Kaj Blennow, Zihuai He, Julie Williams, Philippe Amouyel, Frank Jessen, Patrick G. Kehoe, Ole A. Andreassen, Cornelia Van Duin, Magda Tsolaki, Pascual Sanchez-Juan, Ruth Frikke-Schmidt, Kristel Sleegers, Tatsushi Todau, Anna Zettergren, Martin Ingelsson, Yukinori Okada, Giacomina Rossi, Mikko Hiltunen, Jungsoo Gim, Kouichi Ozaki, Rebecca Sims, Jia Nee Foo, Wiesje van der Fliere, Takeshi Ikeuchi, Alfredo Ramirez, Ignacio Mata, Agustin Ruiz, Ziv Gan-Or, Jean-Charles Lambert, Michael D. Greicius, Emmanuel Mignot
Summary: We analyzed the HLA associations in individuals with Parkinson's disease and Alzheimer's disease across different ancestry groups and found that these two diseases share a common protective association at the HLA locus. Fine-mapping showed that specific subtypes of HLA-DRB1*04 were responsible for this association, with HLA-DRB1*04:04 and HLA-DRB1*04:07 showing the strongest association. This protective effect was also associated with decreased neurofibrillary tangles in the brain and reduced levels of tau protein in cerebrospinal fluid.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Geriatrics & Gerontology
Sarah N. Kraeutner, Cristina Rubino, Jennifer K. Ferris, Shie Rinat, Lauren Penko, Larissa Chiu, Brian Greeley, Christina B. Jones, Beverley C. Larssen, Lara A. Boyd
Summary: This study examined the age-related changes in brain function and baseline brain structure that support motor skill acquisition. The findings showed that older adults experienced decreases in functional connectivity during motor skill acquisition, while younger adults experienced increases. Additionally, regardless of age group, lower baseline microstructure in a frontoparietal tract was associated with slower motor skill acquisition.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Karen Nuytemans, Farid Rajabli, Melissa Jean-Francois, Jiji Thulaseedhara Kurup, Larry D. Adams, Takiyah D. Starks, Patrice L. Whitehead, Brian W. Kunkle, Allison Caban-Holt, Jonathan L. Haines, Michael L. Cuccaro, Jeffery M. Vance, Goldie S. Byrd, Gary W. Beecham, Christiane Reitz, Margaret A. Pericak-Vance
Summary: This study conducted genetic research on African American AD families and identified a significant linkage signal associated with AD, highlighting the importance of diverse population-level genetic data in understanding the genetic determinants of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Kazuya Suwabe, Ryuta Kuwamizu, Kazuki Hyodo, Toru Yoshikawa, Takeshi Otsuki, Asako Zempo-Miyaki, Michael A. Yassa, Hideaki Soya
Summary: Physical exercise has a positive impact on hippocampal memory decline with aging. Recent studies have shown that even light exercise can improve memory and this improvement is mediated by the ascending arousal system. This study aimed to investigate the effects of light-intensity exercise on hippocampal memory function in healthy older adults and found that pupil dilation during exercise played a role in the memory improvement.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Ajay Sood, Ana Werneck Capuano, Robert Smith Wilson, Lisa Laverne Barnes, Alifiya Kapasi, David Alan Bennett, Zoe Arvanitakis
Summary: The objective of this study was to explore the impact of metformin on cognition and brain pathology. The results showed that metformin users had slower decline in global cognition, episodic memory, and semantic memory compared to non-users. However, the relationship between metformin use and certain brain pathology remains uncertain.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Brian N. Lee, Junwen Wang, Molly A. Hall, Dokyoon Kim, Shana D. Stites, Li Shen
Summary: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory and functional impairments. This study analyzed participants from the Alzheimer's Disease Neuroimaging Initiative and found differential associations between cerebral spinal fluid (CSF)/neuroimaging biomarkers and cognitive/functional outcomes, as well as variations between sexes. These findings suggest that sex differences may play a role in the development of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Madeline R. Hale, Rebecca Langhough, Lianlian Du, Bruce P. Hermann, Carol A. Van Hulle, Margherita Carboni, Gwendlyn Kollmorgenj, Kristin E. Basche, Davide Bruno, Leah Sanson-Miles, Erin M. Jonaitis, Nathaniel A. Chin, Ozioma C. Okonkwo, Barbara B. Bendlin, Cynthia M. Carlsson, Henrik Zetterberg, Kaj Blennow, Tobey J. Betthauser, Sterling C. Johnson, Kimberly D. Mueller
Summary: This study demonstrates a relationship between cerebrospinal fluid biomarkers and the ability to recall proper names in the preclinical phase of Alzheimer's disease.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Thomas T. Austin, Christian L. Thomas, Ben Warren
Summary: This study investigated the effects of age on the robustness and resilience of auditory system using the desert locust. The researchers found that gene expression changes were mainly influenced by age rather than noise exposure. Both young and aged locusts were able to recover their auditory nerve function within 48 hours of noise exposure, but the recovery of transduction current magnitude was impaired in aged locusts. Key genes responsible for robustness to noise exposure in young locusts and potential candidates for compensatory mechanisms in auditory neurons of aged locusts were identified.
NEUROBIOLOGY OF AGING
(2024)