Review
Biochemistry & Molecular Biology
Irene L. Gutierrez, Cinzia Dello Russo, Fabiana Novellino, Javier R. Caso, Borja Garcia-Bueno, Juan C. Leza, Jose L. M. Madrigal
Summary: This article summarizes the role of noradrenaline in Alzheimer's disease and suggests the use of noradrenaline-modulating drugs as a therapeutic option.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Andrew K. Evans, Erwin Defensor, Mehrdad Shamloo
Summary: This review examines the vulnerability mechanisms of locus coeruleus noradrenergic neurons, the impact of environmental and genetic factors on their risk, and potential interventions to reduce degeneration of these neurons.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biology
Dilek Mercan, Michael Thomas Heneka
Summary: This article summarizes the important contribution of Locus coeruleus degeneration to the pathogenic progression of Alzheimer's disease (AD). Degeneration of LC leads to decreased noradrenaline levels, causing increased neuroinflammation, enhanced amyloid and tau burden, as well as impairment in cognition and synaptic plasticity.
Article
Clinical Neurology
Ruihua Hou, Rebecca Beardmore, Clive Holmes, Clive Osmond, Angela Darekar
Summary: This study is the largest individually-matched case-control study to visualize the locus coeruleus degeneration in Alzheimer's disease patients, revealing significant LC degeneration which holds promise for stratifying patients for treatment targeting noradrenergic dysfunction.
EUROPEAN NEUROPSYCHOPHARMACOLOGY
(2021)
Article
Clinical Neurology
Alessandro Galgani, Francesco Lombardo, Nicola Martini, Andrea Vergallo, Luca Bastiani, Harald Hampel, Hana Hlavata, Filippo Baldacci, Gloria Tognoni, Daniele De Marchi, Irene Ghicopulos, Sara De Cori, Francesca Biagioni, Carla Letizia Busceti, Roberto Ceravolo, Ubaldo Bonuccelli, Dante Chiappino, Gabriele Siciliano, Francesco Fornai, Nicola Pavese, Filippo Sean Giorgi
Summary: This study used LC-MRI to investigate the involvement of the pontine nucleus Locus Coeruleus (LC) in Alzheimer's disease progression and its association with prognosis and cognitive performance in amnestic Mild Cognitive Impairment. The findings suggest that reductions in LC-MRI parameters may be predictive of clinical progression in Mild Cognitive Impairment and support the role of LC degeneration in the continuum of Alzheimer's disease.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Claire O'Callaghan, Frank H. Hezemans, Rong Ye, Catarina Rua, P. Simon Jones, Alexander G. Murley, Negin Holland, Ralf Regenthal, Kamen A. Tsvetanov, Noham Wolpe, Roger A. Barker, Caroline H. Williams-Gray, Trevor W. Robbins, Luca Passamonti, James B. Rowe
Summary: Cognitive decline is common in Parkinson's disease and often unresponsive to dopaminergic therapy. Targeting the locus coeruleus-noradrenaline system may improve response inhibition deficits, with atomoxetine showing potential in some patients. Predicting treatment response and patient selection for atomoxetine therapy based on locus coeruleus integrity is crucial for optimizing therapeutic outcomes.
Article
Behavioral Sciences
F. Krohn, E. Lancini, M. Ludwig, M. Leiman, G. Guruprasath, L. Haag, J. Panczyszyn, E. Duezel, D. Haemmerer, M. Betts
Summary: The locus coeruleus (LC), a small structure in the brainstem, is the main source of noradrenaline (NA) in the brain. It modulates cognition, autonomic functions, and the brain's immune response. Degeneration of the LC may contribute to the pathogenesis of Alzheimer's and Parkinson's disease. Understanding early LC degeneration could provide insights into the mechanisms of these neurodegenerative diseases.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Geriatrics & Gerontology
Roy W. E. van Hooren, Frans R. J. Verhey, Inez H. G. B. Ramakers, Willemijn J. Jansen, Heidi I. L. Jacobs
Summary: The study found that higher levels of noradrenaline metabolite (MHPG) were associated with lower cortical thickness and hippocampal volume, possibly under low A beta 42 and high phosphorylated tau levels. These associations remained significant even after adding APOE-E4 or cognitive status as covariates. The results suggest that MHPG and AD pathology together contribute to neurodegeneration, possibly before significant amyloidosis, highlighting the potential importance of the noradrenergic system in early detection of AD-related processes.
NEUROBIOLOGY OF AGING
(2021)
Review
Clinical Neurology
Alessandro Galgani, Francesco Lombardo, Daniele Della Latta, Nicola Martini, Ubaldo Bonuccelli, Francesco Fornai, Filippo Sean Giorgi
Summary: LC-MRI studies have shown that LC signal is minimally affected during normal aging, but significantly reduced in patients with neurodegenerative diseases, making it a potential early biomarker.
CURRENT NEUROLOGY AND NEUROSCIENCE REPORTS
(2021)
Article
Immunology
Song Cao, Daniel W. Fisher, Guadalupe Rodriguez, Tian Yu, Hongxin Dong
Summary: The study found that in APP/PS1 mice, there was increased expression of inflammatory cytokines and microglial activation in the cortex, hippocampus, and spinal cord. Additionally, there was more evident loss of LC-NE neurons and fibers, as well as reduced NET expression, in the APP/PS1 mice compared to wild-type mice.
JOURNAL OF NEUROINFLAMMATION
(2021)
Review
Clinical Neurology
Negin Holland, Trevor W. Robbins, James B. Rowe
Summary: This review highlights the important role of noradrenergic projections from the locus coeruleus in regulating cognition and behavior, as well as their loss in neurodegenerative diseases. Advances in human imaging and computational methods for quantifying the locus coeruleus and potential new noradrenergic treatment strategies are also discussed.
Article
Neurosciences
Yasufumi Sakakibara, Yu Hirota, Kyoko Ibaraki, Kimi Takei, Sachie Chikamatsu, Yoko Tsubokawa, Takashi Saito, Takaomi C. Saido, Michiko Sekiya, Koichi M. Iijima
Summary: In aged App(NL-G-F/NL-G-F) knock-in mice, cortical A beta pathology induced significant reduction in the density of noradrenergic axons from the locus coeruleus, without neuron loss or tau pathology, suggesting a mechanism of noradrenergic neurodegeneration in Alzheimer's disease. Further investigation is needed to uncover the underlying mechanisms and develop effective therapeutics to halt AD progression.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Review
Medicine, Research & Experimental
Tapan Behl, Ishnoor Kaur, Aayush Sehgal, Sukhbir Singh, Hafiz A. Makeen, Mohammed Albratty, Hassan A. Alhazmi, Saurabh Bhatia, Simona Bungau
Summary: This review examines the pathogenesis of Alzheimer's Disease (AD) and its relationship with the locus coeruleus-noradrenaline system. The findings suggest that dysregulation of the locus coeruleus-noradrenaline system may be involved in the development of AD.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Clinical Neurology
Christopher F. Madelung, David Meder, Soren A. Fuglsang, Marta M. Marques, Vincent O. Boer, Kristoffer H. Madsen, Esben T. Petersen, Anne-Mette Hejl, Annemette Lokkegaard, Hartwig R. Siebner
Summary: This study used neuromelanin sensitive magnetic resonance imaging (MRI) to examine the structural disintegration of the locus coeruleus (LC) and its association with nonmotor dysfunction in patients with Parkinson's disease (PD). The findings showed that PD patients had reduced structural integrity in the right LC, specifically in the mid-caudal region. The disintegration of the LC was linked to specific nonmotor symptoms, such as orthostatic dysregulation and apathy. Additionally, the severity of nonmotor symptoms was associated with the overall structural disintegration of the LC.
MOVEMENT DISORDERS
(2022)
Article
Clinical Neurology
Benjamin Huynh, Yuhong Fu, Deniz Kirik, James M. Shine, Glenda M. Halliday
Summary: The study compared cell loss in different brain regions of Parkinson's disease patients and found that the loss of noradrenergic A6 locus coeruleus neurons did not strictly follow a caudal to rostral trajectory in the same cases. Pathological onset in the noradrenergic A6 locus coeruleus may relate to symptom onset in people with reduced dopamine-producing A9 substantia nigra neurons.
MOVEMENT DISORDERS
(2021)
Article
Neurosciences
Carmen Lage, Andrea Gonzalez-Suarez, Maria Puerto Alcalde-Hierro, Maria Isabel Sampedro-Gonzalez, Maria Angeles Villanueva-Eguaras, Manuel Ruben Sanchez-Crespo, Catherine Widmann, Frederic Brosseron, Ana Pozueta, Sara Lopez-Garcia, Maria Garcia-Martinez, Martha Kazimierczak, Maria Bravo-Gonzalez, Andrea Fernandez-Rodriguez, Marta Drake-Perez, Juan Irure-Ventura, Marcos Lopez-Hoyos, Eloy Rodriguez-Rodriguez, Michael T. Heneka, Pascual Sanchez-Juan
Summary: Surgery may accelerate memory decline in cognitively asymptomatic individuals with preclinical Alzheimer's disease, especially in those with abnormal levels of amyloid-beta, while the presence of amyloid-beta does not seem to impact the overall incidence of perioperative neurocognitive disorders.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Medicine, Research & Experimental
Lily Keane, Ignazio Antignano, Sean-Patrick Riechers, Raphael Zollinger, Anaelle A. Dumas, Nina Offermann, Maria E. Bernis, Jenny Russ, Frederike Graelmann, Patrick Neil McCormick, Julia Esser, Dario Tejera, Ai Nagano, Jun Wang, Claude Chelala, Yvonne Biederbick, Annett Halle, Paolo Salomoni, Michael T. Heneka, Melania Capasso
Summary: Microglia in aged individuals show increased mTOR signaling and upregulation of inflammatory mediators, resulting in stronger responses to inflammatory stimuli. Genetic ablation of mTOR signaling can reduce microglia activation and inflammation response, alleviating sickness behavior in aged mice.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Immunology
Karin Odoj, Bianca Brawek, Nithi Asavapanumas, Nima Mojtahedi, Michael T. Heneka, Olga Garaschuk
Summary: Peripheral inflammation induces transient increase in neuronal activity in the early phase, while visual processing impairment occurs in the late phase. The specific cortical hyperactivity in the frontal/motor cortex may be caused by reduced cortical inhibition, and the impairment of sensory processing during resolution phase may be due to activated microglia.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Neurosciences
Boris-Stephan Rauchmann, Ersin Ersoezlue, Sophia Stoecklein, Daniel Keeser, Frederic Brosseron, Katharina Buerger, Peter Dehent, Laura Dobisch, Birgit Ertl-Wagner, Klaus Fliessbach, John Dylan Haynes, Michael T. Heneka, Enise I. Incesoy, Daniel Janowitz, Ingo Kilimann, Christoph Laake, Coraline D. Metzger, Matthias H. Munk, Oliver Peters, Josef Priller, Alfredo Ramirez, Sandra Roeske, Nina Roy, Klaus Scheffler, Anja Schneider, Annika Spottke, Eike Jakob Spruth, Stefan Teipl, Maike Tscheuschler, Ruth Vukovich, Michael Wagner, Jens Wiltfang, Renat Yakupov, Emrah Duezel, Frank Jessen, Robert Pernczky
Summary: By analyzing the brain network properties of various AD atrophy subtypes, we identified distinct differences in functional connectivity networks accompanied by CSF biomarker and cognitive differences.
Article
Biochemistry & Molecular Biology
Tatsuya Manabe, Ildiko Racz, Stephanie Schwartz, Linda Oberle, Francesco Santarelli, Julius Emmrich, Jonas J. Neher, Michael T. Heneka
Summary: Sepsis-associated encephalopathy (SAE) involves diverse cerebral dysfunctions in response to pathogen-induced systemic inflammation. Injection of LPS from different bacterial strains in aged mice resulted in short-term neuroinflammation with subsequent normalization, showing more pronounced inflammatory responses with E. coli LPS compared to Salmonella LPS. Reduction in excitatory synaptic puncta in the hippocampus was observed at a later time point, possibly attributed to microglia-mediated elimination of C3-tagged synapses.
JOURNAL OF NEUROCHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Itziar de Rojas, Sonia Moreno-Grau, Niccolo Tesi, Benjamin Grenier-Boley, Victor Andrade, Iris E. Jansen, Nancy L. Pedersen, Najada Stringa, Anna Zettergren, Isabel Hernandez, Laura Montrreal, Carmen Antunez, Anna Antonell, Rick M. Tankard, Joshua C. Bis, Rebecca Sims, Celine Bellenguez, Ines Quintela, Antonio Gonzalez-Perez, Miguel Calero, Emilio Franco-Macias, Juan Macias, Rafael Blesa, Laura Cervera-Carles, Manuel Menendez-Gonzalez, Ana Frank-Garcia, Jose Luis Royo, Fermin Moreno, Raquel Huerto Vilas, Miquel Baquero, Monica Diez-Fairen, Carmen Lage, Sebastian Garcia-Madrona, Pablo Garcia-Gonzalez, Emilio Alarcon-Martin, Sergi Valero, Oscar Sotolongo-Grau, Abbe Ullgren, Adam C. Naj, Afina W. Lemstra, Alba Benaque, Alba Perez-Cordon, Alberto Benussi, Alberto Rabano, Alessandro Padovani, Alessio Squassina, Alexandre de Mendonca, Alfonso Arias Pastor, Almar A. L. Kok, Alun Meggy, Ana Belen Pastor, Ana Espinosa, Anais Corma-Gomez, Angel Martin Montes, Angela Sanabria, Anita L. DeStefano, Anja Schneider, Annakaisa Haapasalo, Anne Kinhult Stahlbom, Anne Tybjaerg-Hansen, Annette M. Hartmann, Annika Spottke, Arturo Corbaton-Anchuelo, Arvid Rongve, Barbara Borroni, Beatrice Arosio, Benedetta Nacmias, Borge G. Nordestgaard, Brian W. Kunkle, Camille Charbonnier, Carla Abdelnour, Carlo Masullo, Carmen Martinez Rodriguez, Carmen Munoz-Fernandez, Carole Dufouil, Caroline Graff, Catarina B. Ferreira, Caterina Chillotti, Chandra A. Reynolds, Chiara Fenoglio, Christine Van Broeckhoven, Christopher Clark, Claudia Pisanu, Claudia L. Satizabal, Clive Holmes, Dolores Buiza-Rueda, Dag Aarsland, Dan Rujescu, Daniel Alcolea, Daniela Galimberti, David Wallon, Davide Seripa, Edna Gruenblatt, Efthimios Dardiotis, Emrah Duezel, Elio Scarpini, Elisa Conti, Elisa Rubino, Ellen Gelpi, Eloy Rodriguez-Rodriguez, Emmanuelle Duron, Eric Boerwinkle, Evelyn Ferri, Fabrizio Tagliavini, Fahri Kucukali, Florence Pasquier, Florentino Sanchez-Garcia, Francesca Mangialasche, Frank Jessen, Gael Nicolas, Geir Selbaek, Gemma Ortega, Genevieve Chene, Georgios Hadjigeorgiou, Giacomina Rossi, Gianfranco Spalletta, Giorgio Giaccone, Giulia Grande, Giuliano Binetti, Goran Papenberg, Harald Hampel, Henri Bailly, Henrik Zetterberg, Hilkka Soininen, Ida K. Karlsson, Ignacio Alvarez, Ildebrando Appollonio, Ina Giegling, Ingmar Skoog, Ingvild Saltvedt, Innocenzo Rainero, Irene Rosas Allende, Jakub Hort, Janine Diehl-Schmid, Jasper Van Dongen, Jean-Sebastien Vidal, Jenni Lehtisalo, Jens Wiltfang, Jesper Qvist Thomassen, Johannes Kornhuber, Jonathan L. Haines, Jonathan Vogelgsang, Juan A. Pineda, Juan Fortea, Julius Popp, Juergen Deckert, Katharina Buerger, Kevin Morgan, Klaus Fliessbach, Kristel Sleegers, Laura Molina-Porcel, Lena Kilander, Leonie Weinhold, Lindsay A. Farrer, Li-San Wang, Luca Kleineidam, Lucia Farotti, Lucilla Parnetti, Lucio Tremolizzo, Lucrezia Hausner, Luisa Benussi, Lutz Froelich, M. Arfan Ikram, M. Candida Deniz-Naranjo, Magda Tsolaki, Maitee Rosende-Roca, Malin Lowenmark, Marc Hulsman, Marco Spallazzi, Margaret A. Pericak-Vance, Margaret Esiri, Maria Bernal Sanchez-Arjona, Maria Carolina Dalmasso, Maria Teresa Martinez-Larrad, Marina Arcaro, Markus M. Noethen, Marta Fernandez-Fuertes, Martin Dichgans, Martin Ingelsson, Martin J. Herrmann, Martin Scherer, Martin Vyhnalek, Mary H. Kosmidis, Mary Yannakoulia, Matthias Schmid, Michael Ewers, Michael T. Heneka, Michael Wagner, Michela Scamosci, Miia Kivipelto, Mikko Hiltunen, Miren Zulaica, Montserrat Alegret, Myriam Fornage, Natalia Roberto, Natasja M. van Schoor, Nazib M. Seidu, Nerisa Banaj, Nicola J. Armstrong, Nikolaos Scarmeas, Norbert Scherbaum, Oliver Goldhardt, Oliver Hanon, Oliver Peters, Olivia Anna Skrobot, Olivier Quenez, Ondrej Lerch, Paola Bossu, Paolo Caffarra, Paolo Dionigi Rossi, Paraskevi Sakka, Per Hoffmann, Peter A. Holmans, Peter Fischer, Peter Riederer, Qiong Yang, Rachel Marshall, Rajesh N. Kalaria, Richard Mayeux, Rik Vandenberghe, Roberta Cecchetti, Roberta Ghidoni, Ruth Frikke-Schmidt, Sandro Sorbi, Sara Hagg, Sebastiaan Engelborghs, Seppo Helisalmi, Sigrid Botne Sando, Silke Kern, Silvana Archetti, Silvia Boschi, Silvia Fostinelli, Silvia Gil, Silvia Mendoza, Simon Mead, Simona Ciccone, Srdjan Djurovic, Stefanie Heilmann-Heimbach, Steffi Riedel-Heller, Teemu Kuulasmaa, Teodoro del Ser, Thibaud Lebouvier, Thomas Polak, Tiia Ngandu, Timo Grimmer, Valentina Bessi, Valentina Escott-Price, Vilmantas Giedraitis, Vincent Deramecourt, Wolfgang Maier, Xueqiu Jian, Yolande A. L. Pijnenburg, A. David Smith, C. Abdelnour, A. D. Adarmes-Gomez, C. Macleod, Iris E. Jansen, Patrick Gavin Kehoe, Guillermo Garcia-Ribas, Pascual Sanchez-Juan, Pau Pastor, Jordi Perez-Tur, Gerard Pinol-Ripoll, Adolfo Lopez de Munain, Jose Maria Garcia-Alberca, Maria J. Bullido, Victoria Alvarez, Alberto Lleo, Luis M. Real, Pablo Mir, Miguel Medina, Philip Scheltens, Henne Holstege, Marta Marquie, Maria Eugenia Saez, Angel Carracedo, Philippe Amouyel, Gerard D. Schellenberg, Julie Williams, Sudha Seshadri, Cornelia M. van Duijn, Karen A. Mather, Raquel Sanchez-Valle, Manuel Serrano-Rios, Adelina Orellana, Lluis Tarraga, Kaj Blennow, Martijn Huisman, Ole A. Andreassen, Danielle Posthuma, Jordi Clarimon, Merce Boada, Wiesje M. van der Flier, Alfredo Ramirez, Jean-Charles Lambert, Sven J. van der Lee, Agustin Ruiz
Summary: This study identified 6 new genetic variants associated with Alzheimer's disease risk through a large-scale genetic association study. It also demonstrated the efficacy of a polygenic risk score in stratifying individuals at high risk of Alzheimer's disease, providing important data support for further research and preventive treatment of the disease.
NATURE COMMUNICATIONS
(2021)
Article
Clinical Neurology
Sofia Bergstrom, Julia Remnestal, Jamil Yousef, Jennie Olofsson, Ioanna Markaki, Stephanie Carvalho, Jean-Christophe Corvol, Kim Kultima, Lena Kilander, Malin Lowenmark, Martin Ingelsson, Kaj Blennow, Henrik Zetterberg, Bengt Nellgard, Frederic Brosseron, Michael T. Heneka, Beatriz Bosch, Raquel Sanchez-Valle, Anna Manberg, Per Svenningsson, Peter Nilsson
Summary: This study identified six proteins significantly increased in the CSF of AD patients and showed strong to moderate correlations with tau levels, suggesting their potential as candidate biomarkers for AD progression.
ANNALS OF CLINICAL AND TRANSLATIONAL NEUROLOGY
(2021)
Review
Anatomy & Morphology
Matthias Cavelius, Theo Brunel, Anne Didier
Summary: This article discusses the role of sensory information in brain lateralization, with a focus on the olfactory system. Studies have found that the two hemispheres of the brain process olfactory stimuli differently to achieve various sensory operations, which may be related to behavioral performance.
BRAIN STRUCTURE & FUNCTION
(2022)
Article
Neurosciences
Juan R. Perea, Marta Bolos, Raquel Cuadros, Esther Garcia, Vega Garcia-Escudero, Felix Hernandez, Roisin M. McManus, Michael T. Heneka, Jesus Avila
Summary: This study demonstrates that inhibiting p38 can attenuate the toxic effect of tau in microglia and enhance microglia-mediated tau phagocytosis.
MOLECULAR NEUROBIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Charlotte Braatz, Max P. Komes, Kishore Aravind Ravichandran, Matheus Garcia de Fragas, Angelika Griep, Stephanie Schwartz, Roisin M. McManus, Michael T. Heneka
Summary: Alzheimer's disease (AD) is characterized by the deposition of Amyloid-beta (Aβ) peptide, which leads to NLRP3 inflammasome activation and the release of interleukin-1 beta (IL-1β) and interleukin-18 (IL-18). NLRP3-directed antisense oligonucleotides (ASOs) have been found to suppress NLRP3 inflammasome activity and IL-1β release in primary murine microglia and human THP-1 cells.
JOURNAL OF NEUROCHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Deniz Karabag, Hannah Scheiblich, Angelika Griep, Francesco Santarelli, Stephanie Schwartz, Michael T. Heneka, Christina Ising
Summary: The highest risk factor for the development of tauopathies is aging. Senescent microglia have been identified in the brains of tau-transgenic mice and patients suffering from tauopathies. Exposure to tau can lead to microglial senescence, suggesting the presence of a vicious circle.
JOURNAL OF NEUROCHEMISTRY
(2023)
Review
Biochemistry & Molecular Biology
Shilauni Dadwal, Michael T. Heneka
Summary: Microglia, as the resident immune cells of the central nervous system, play critical roles in maintaining brain homeostasis, mediating cerebral immune responses, and neuroinflammation. Recent studies have shown that microglia consist of multiple subpopulations with unique properties, suggesting their specialized roles in different environments and diseases. Understanding microglial heterogeneity and their interactions with other cell types in the central nervous system offers promising therapeutic strategies for microglia-related pathologies.
Correction
Medicine, Research & Experimental
Lily Keane, Michael T. Heneka, Melania Capasso
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Clinical Neurology
Tommaso Ballarini, Debora Melo van Lent, Julia Brunner, Alina Schroeder, Steffen Wolfsgruber, Slawek Altenstein, Frederic Brosseron, Katharina Buerger, Peter Dechent, Laura Dobisch, Emrah Duezel, Birgit Ertl-Wagner, Klaus Fliessbach, Silka Dawn Freiesleben, Ingo Frommann, Wenzel Glanz, Dietmar Hauser, John Dylan Haynes, Michael T. Heneka, Daniel Janowitz, Ingo Kilimann, Christoph Laske, Franziska Maier, Coraline Danielle Metzger, Matthias Munk, Robert Perneczky, Oliver Peters, Josef Priller, Alfredo Ramirez, Boris Rauchmann, Nina Roy, Klaus Scheffler, Anja Schneider, Annika Spottke, Eike Jakob Spruth, Stefan J. Teipel, Ruth Vukovich, Jens Wiltfang, Frank Jessen, Michael Wagner
Summary: The study found a positive association between adherence to a Mediterranean-like diet and brain structure, cognitive function, and Alzheimer's disease-related biomarkers. Greater adherence to MeDi was linked to better memory, reduced AD pathology, and larger gray matter volume in the brain.
Article
Geriatrics & Gerontology
Francesca Mantile, Angelo Capasso, Nadia Villacampa, Maria Donnini, Giovanna L. Liguori, Gabriela Constantin, Piergiuseppe De Berardinis, Michael T. Heneka, Antonella Prisco
Summary: Immunization against Aβ is being explored for AD prevention, but current vaccines face challenges in safety and immunogenicity. While immunization with (1-11)E2 can induce antibody response, it does not protect against Aβ accumulation and neuroinflammation, highlighting the need for further research into the immune response against Aβ that could prevent accumulation.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2021)
Article
Geriatrics & Gerontology
Sarah N. Kraeutner, Cristina Rubino, Jennifer K. Ferris, Shie Rinat, Lauren Penko, Larissa Chiu, Brian Greeley, Christina B. Jones, Beverley C. Larssen, Lara A. Boyd
Summary: This study examined the age-related changes in brain function and baseline brain structure that support motor skill acquisition. The findings showed that older adults experienced decreases in functional connectivity during motor skill acquisition, while younger adults experienced increases. Additionally, regardless of age group, lower baseline microstructure in a frontoparietal tract was associated with slower motor skill acquisition.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Karen Nuytemans, Farid Rajabli, Melissa Jean-Francois, Jiji Thulaseedhara Kurup, Larry D. Adams, Takiyah D. Starks, Patrice L. Whitehead, Brian W. Kunkle, Allison Caban-Holt, Jonathan L. Haines, Michael L. Cuccaro, Jeffery M. Vance, Goldie S. Byrd, Gary W. Beecham, Christiane Reitz, Margaret A. Pericak-Vance
Summary: This study conducted genetic research on African American AD families and identified a significant linkage signal associated with AD, highlighting the importance of diverse population-level genetic data in understanding the genetic determinants of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Kazuya Suwabe, Ryuta Kuwamizu, Kazuki Hyodo, Toru Yoshikawa, Takeshi Otsuki, Asako Zempo-Miyaki, Michael A. Yassa, Hideaki Soya
Summary: Physical exercise has a positive impact on hippocampal memory decline with aging. Recent studies have shown that even light exercise can improve memory and this improvement is mediated by the ascending arousal system. This study aimed to investigate the effects of light-intensity exercise on hippocampal memory function in healthy older adults and found that pupil dilation during exercise played a role in the memory improvement.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Ajay Sood, Ana Werneck Capuano, Robert Smith Wilson, Lisa Laverne Barnes, Alifiya Kapasi, David Alan Bennett, Zoe Arvanitakis
Summary: The objective of this study was to explore the impact of metformin on cognition and brain pathology. The results showed that metformin users had slower decline in global cognition, episodic memory, and semantic memory compared to non-users. However, the relationship between metformin use and certain brain pathology remains uncertain.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Brian N. Lee, Junwen Wang, Molly A. Hall, Dokyoon Kim, Shana D. Stites, Li Shen
Summary: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory and functional impairments. This study analyzed participants from the Alzheimer's Disease Neuroimaging Initiative and found differential associations between cerebral spinal fluid (CSF)/neuroimaging biomarkers and cognitive/functional outcomes, as well as variations between sexes. These findings suggest that sex differences may play a role in the development of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Madeline R. Hale, Rebecca Langhough, Lianlian Du, Bruce P. Hermann, Carol A. Van Hulle, Margherita Carboni, Gwendlyn Kollmorgenj, Kristin E. Basche, Davide Bruno, Leah Sanson-Miles, Erin M. Jonaitis, Nathaniel A. Chin, Ozioma C. Okonkwo, Barbara B. Bendlin, Cynthia M. Carlsson, Henrik Zetterberg, Kaj Blennow, Tobey J. Betthauser, Sterling C. Johnson, Kimberly D. Mueller
Summary: This study demonstrates a relationship between cerebrospinal fluid biomarkers and the ability to recall proper names in the preclinical phase of Alzheimer's disease.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Thomas T. Austin, Christian L. Thomas, Ben Warren
Summary: This study investigated the effects of age on the robustness and resilience of auditory system using the desert locust. The researchers found that gene expression changes were mainly influenced by age rather than noise exposure. Both young and aged locusts were able to recover their auditory nerve function within 48 hours of noise exposure, but the recovery of transduction current magnitude was impaired in aged locusts. Key genes responsible for robustness to noise exposure in young locusts and potential candidates for compensatory mechanisms in auditory neurons of aged locusts were identified.
NEUROBIOLOGY OF AGING
(2024)
