期刊
NEUROBIOLOGY OF AGING
卷 33, 期 4, 页码 -出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2011.06.015
关键词
Parkinson's disease; Parkinsonism; Histamine; HNMT; Association studies in genetics
资金
- National Parkinson Foundation
- GENEPARK [EU-LSHB-CT-2006-037544]
- Volkswagen Foundation
- Hermann and Lilly Schilling Foundation
- NGFN Plus (BMBF) [PNP-01GS08135-3]
Histamine is a central neurotransmitter degraded by histamine-N-methyltransferase (HNMT). Several abnormalities in the histaminergic system were found in patients with Parkinson's disease (PD), thus we tested the possible association of a Thr105Ile functional polymorphism in HNMT with PD. A total of 913 patients with PD and 958 controls were genotyped using a TaqMan RT-PCR Genotyping Assay (Foster City, California, USA). Lower frequency of HNMT Ile105 allele that is associated with decreased enzymatic activity was found in patients compared with controls (chi(2) = 11.65; p = 0.0006). We performed meta-analysis to confirm the association of Thr105Ile functional polymorphism with PD. Our results indicate that lower HNMT activity plays a role in the pathogenesis of PD. (C) 2012 Elsevier Inc. All rights reserved.
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