Article
Clinical Neurology
Ian M. Walker, Katheryn A. Cousins, Andrew Siderowf, John E. Duda, James F. Morley, Nabila Dahodwala, Thomas Tropea, Sanjeev Vaishnavi, David A. Wolk, Alice S. Chen-Plotkin, Leslie M. Shaw, Edward B. Lee, John Q. Trojanowski, Murray Grossman, Daniel Weintraub, David J. Irwin
Summary: This study conducted a retrospective analysis on the non-tremor features of Lewy body dementias (LBD) and found evidence suggesting that Alzheimer's disease (AD) co-pathology may contribute to postural instability and gait dysfunction (PIGD) motor signs in LBD patients.
PARKINSONISM & RELATED DISORDERS
(2022)
Article
Toxicology
Ema Paulovicova, Lucia Paulovicova, Monika Polakova, Miroslav Panik, Sona Jantova
Summary: The study investigated the immunomodulation, cytotoxicity, and anti-cancer activity of selected amphiphilic non-ionic (thio)alkyl alpha-D-mannosides with aglycone of C6-C12 in various cancer cell lines in vitro. Toxicological studies revealed structure-dependent immunobiological effectiveness based on tight interactions with relevant cells. The results demonstrated diverse immunomodulation of macrophage cell-line RAW264.7 proliferation and cytokine production following exposure to (thio)alkyl alpha-D-mannosides.
TOXICOLOGY IN VITRO
(2021)
Article
Biochemistry & Molecular Biology
Ninghua Wu, Wu Liu, Jiawen Wang, Yanqi Han, Yu Ye, Xiufen Liu, Yuandong Yu, Qingjie Chen, Yongfen Bao, Chao Liu
Summary: The study demonstrates that berberine can protect the brain from HGHI-induced IR, improve IR by increasing glucose application in neurons, regulate related proteins, inhibit the production of A beta 42, and extend neuronal axon.
Article
Dermatology
M. A. McAleer, I. Jakasa, N. Stefanovic, W. H. I. McLean, S. Kezic, A. D. Irvine
Summary: This study investigated the effects of topical corticosteroid treatment on infants with atopic dermatitis by measuring skin and blood biomarkers. The therapy significantly improved disease severity, although most immune markers did not reach healthy control levels. The results suggest that correcting systemic immune dysregulation through topical therapy may have long-term beneficial effects.
BRITISH JOURNAL OF DERMATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yu Na Song, Jae-Won Lee, Hyung Won Ryu, Jae Kyoung Lee, Eun Sol Oh, Doo-Young Kim, Hyunju Ro, Dahye Yoon, Ji-Yoon Park, Sung-Tae Hong, Mun-Ock Kim, Su Ui Lee, Dae Young Lee
Summary: Black ginseng extract (BGE) has preventive effects on respiratory inflammatory diseases such as asthma by inhibiting cytokine production and the activation of protein kinase C theta (PKC?) and its downstream signaling molecules.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biology
Fang Huang, Trang T. T. Nguyen, Ignacia Echeverria, Rakesh Ramachandran, Daniele C. Cary, Hana Paculova, Andrej Sali, Arthur Weiss, Boris Matija Peterlin, Koh Fujinaga
Summary: Research has found that in quiescent and terminally differentiated cells, CycT1 not bound to CDK9 is rapidly degraded. Additionally, PKC-mediated phosphorylation of CycT1 increases productive CycT1:CDK9 interactions in human cells. Conversely, dephosphorylation of CycT1 by PP1 reverses this process.
Article
Medicine, General & Internal
Jennifer A. Fulcher, Fan Li, Nicole H. Tobin, Sara Zabih, Julie Elliott, Jesse L. Clark, Richard D'Aquila, Brian Mustanski, Michele D. Kipke, Steven Shoptaw, Pamina M. Gorbach, Grace M. Aldrovandi
Summary: Few changes in the gut microbiome were found during acute HIV infection, but significant differences were observed when comparing pre-HIV infection visits to matched at-risk controls. In addition, individuals who acquired HIV had elevated inflammatory cytokines and bioactive lipids prior to HIV acquisition.
Article
Chemistry, Medicinal
Dong Sub Kim, Hyo-Jung Lee, Deok Yong Sim, Ji Eon Park, Youngsang Park, Bonglee Kim, Bumsang Shim, Sung-Hoon Kim
Summary: The present study investigated the hepatoprotective potential of PKC#963 by inhibiting inflammatory molecules and enhancing antioxidant enzymes against acute and chronic liver injury induced by alcohol or carbon tetrachloride (CCl4).
PHYTOTHERAPY RESEARCH
(2023)
Article
Immunology
Patricia Garcia-Fernandez, Klemens Hoefflin, Antonia Rausch, Katharina Strommer, Astrid Neumann, Nadine Cebulla, Ann-Kristin Reinhold, Heike Rittner, Nurcan Ueceyler, Claudia Sommer
Summary: In patients with peripheral neuropathies (PNP), the presence of neuropathic pain is independent of the etiology and is found in 50% of the cases. The pathophysiology of pain in PNP is poorly understood, but inflammation has been implicated in neurodegeneration, regeneration, and pain. A comprehensive analysis of inflammatory markers in blood and cerebrospinal fluid (CSF) of PNP patients and controls revealed no major differences in systemic inflammation, but specific cytokines or lipids showed variations. The study highlights the importance of CSF analysis in patients with peripheral neuropathies.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Rafael Luis Luporini, Henrique Pott-Junior, Maria Carolina B. Di Medeiros Leal, Alex Castro, Antonio Gilberto Ferreira, Marcia Regina Cominetti, Fernanda de Freitas Anibal
Summary: The study found that serum phenylalanine levels are positively correlated with disease severity in COVID-19 patients, independent of inflammatory cytokines. Patients with mild disease have lower serum phenylalanine levels in the early stages of the disease.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Anne Riemann, Mandy Rauschner, Sarah Reime, Oliver Thews
Summary: Many tumors exhibit extracellular acidosis and altered microRNA expression, which affects gene expression and tumor behavior. This study aimed to investigate the role of pH-sensitive microRNAs in mediating these changes. The results showed that pH-dependent microRNAs play a minor role in modulating gene expression. However, specific microRNAs (Mir183, Mir203, Mir215) were found to affect individual genes (Ccl2, Txnip, Ypel3) in an acidotic environment, but these effects were cell line-specific. Furthermore, the regulation of microRNA expression in acidosis was found to be influenced by MAPK, PKC, ROS, and intracellular Ca2+ concentration. These findings could potentially lead to new therapeutic approaches for acidotic tumors.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Juyong Kim, Sung-Chul Hong, Eun Ha Lee, Jae Wook Lee, Seung-Hoon Yang, Jin-Chul Kim
Summary: The study on the inhibitory effect of Momordica cochinchinensis extract on melanogenesis revealed that it could reduce melanin synthesis by inhibiting tyrosinase activity and p-PKC signaling pathways. The high concentration of polyphenols and flavonoids in M. cochinchinensis might contribute to its antioxidant properties, making it a potential candidate for antimelanogenesis and functional cosmetic ingredients for skin whitening.
Article
Oncology
Mira Lanki, Hanna Seppanen, Harri Mustonen, Aino Salmiheimo, Ulf-Hakan Stenman, Marko Salmi, Sirpa Jalkanen, Caj Haglund
Summary: In this study, hs-CRP and seven cytokines were identified as potential prognostic factors for survival prediction in pancreatic ductal adenocarcinoma patients.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Review
Biochemistry & Molecular Biology
Tadej Petreski, Nejc Piko, Robert Ekart, Radovan Hojs, Sebastjan Bevc
Summary: Chronic kidney disease is a major health problem in modern society, with a continuously rising prevalence. Recent studies have identified novel markers and gained new insights into the pathogenesis of CKD. Further large-scale studies are needed to establish the role of these markers in clinical practice.
Article
Immunology
Yasir Dilshad Siddiqui, Xuguang Nie, Sheng Wang, Yasaman Abbasi, Lauren Park, Xiaoxuan Fan, Vivek Thumbigere-Math, Man-Kyo Chung
Summary: Periodontitis, affecting over 40% of adult Americans, is a common oral disease. Recent studies suggest that pain-sensing nerves, or nociceptors, magnify host response and regulate bone loss in periodontitis. Neuropeptides like calcitonin gene-related peptide (CGRP) or substance P (SP) are found in nociceptors projected to the periodontium, but their specific roles in periodontitis need further investigation.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Harriet D. Gliddon, Myrsini Kaforou, Mary Alikian, Dominic Habgood-Coote, Chenxi Zhou, Tolu Oni, Suzanne T. Anderson, Andrew J. Brent, Amelia C. Crampin, Brian Eley, Robert Heyderman, Florian Kern, Paul R. Langford, Tom H. M. Ottenhoff, Martin L. Hibberd, Neil French, Victoria J. Wright, Hazel M. Dockrell, Lachlan J. Coin, Robert J. Wilkinson, Michael Levin
Summary: The study identified four-transcript and three-transcript signatures that can distinguish tuberculosis patients from those with other diseases or latent tuberculosis infection, offering strong quantitative support for their use as diagnostic biomarkers for tuberculosis.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Laura Ferri, Paola Ajdinaj, Marianna Gabriella Rispoli, Claudia Carrarini, Filomena Barbone, Damiano D'Ardes, Margherita Capasso, Antonio Di Muzio, Francesco Cipollone, Marco Onofrj, Laura Bonanni
Summary: While some studies suggest a potential impact of diabetes mellitus on the occurrence of ALS, the correlation between DM and ALS remains unclear. Data indicates a protective role of DM in ALS occurrence in elderly individuals, but an opposite effect in younger subjects.
Review
Infectious Diseases
Idesbald Boone, Bettina Rosner, Raskit Lachmann, Michele Luca D'Errico, Luigi Iannetti, Yves Van der Stede, Frank Boelaert, Steen Ethelberg, Tim Eckmanns, Klaus Stark, Sebastian Haller, Hendrik Wilking
Summary: The study found that the main pathogens associated with Healthcare-associated foodborne outbreaks (HA-FBO) include Salmonella, norovirus, and Listeria monocytogenes. Reasons for such outbreaks mainly involve vulnerable patients consuming high-risk foods and carriers of pathogens among food handlers. To prevent HA-FBO, it is important to avoid providing high-risk foods to vulnerable populations, strengthen outbreak surveillance, and promote interdisciplinary collaboration and information exchange between healthcare facilities, food safety, and public health authorities.
Article
Infectious Diseases
Lesley Larkin, Maria Pardos de la Gandara, Ann Hoban, Caisey Pulford, Nathalie Jourdan-Da Silva, Henriette de Valk, Lynda Browning, Gerhard Falkenhorst, Sandra Simon, Raskit Lachmann, Rikard Dryselius, Nadja Karamehmedovic, Stefan Borjesson, Dieter van Cauteren, Valeska Laisnez, Wesley Mattheus, Roan Pijnacker, Maaike van den Beld, Joel Mossong, Catherine Ragimbeau, Anne Vergison, Lin Thorstensen Brandal, Heidi Lange, Patricia Garvey, Charlotte Salgaard Nielsen, Silvia Herrera Leon, Carmen Varela, Marie Chattaway, Francois-Xavier Weill, Derek Brown, Paul McKeown
Summary: An extensive outbreak of multidrug-resistant monophasic Salmonella Typhimurium infection has occurred in multiple countries, with 150 reported cases, mainly affecting young children. The outbreak has been linked to chocolate products produced by a large multinational company. Extensive recalls and withdrawals of the affected products have been conducted. With Easter approaching and the vulnerability of the affected population, prompt and effective real-time sharing of microbiological and epidemiological information is crucial in effectively managing this serious food-borne incident.
Article
Immunology
Raskit Lachmann, Sven Halbedel, Stefanie Lueth, Alexandra Holzer, Marlen Adler, Ariane Pietzka, Sascha Al Dahouk, Klaus Stark, Antje Flieger, Sylvia Kleta, Hendrik Wilking
Summary: Invasive listeriosis outbreaks associated with the consumption of smoked and graved salmon products were investigated in Germany. Whole-genome sequencing and patient interviews were used to identify and analyze the outbreaks. The study identified 22 independent outbreaks between 2010 and 2021, with 228 cases and 50 deaths in Germany. Cross-border outbreaks were also observed. The findings highlight the serious risk posed by L. monocytogenes-contaminated salmon products in Germany, emphasizing the need for improved hygiene measures and better awareness among susceptible individuals.
EMERGING MICROBES & INFECTIONS
(2022)
Article
Medical Laboratory Technology
Chang Chu, Anne Schoenbrunn, Saban Elitok, Florian Kern, Karsten Schnatbaum, Holger Wenschuh, Kristin Klemm, Volker von Baehr, Bernhard K. Kraemer, Berthold Hocher
Summary: Both infection with and vaccination against SARS-CoV-2 can trigger a complex B-cell and T-cell response. Reliable methods for analyzing the B-cell response are well established, but methods for measuring the T-cell response still need to be proven in clinical settings. In this study, a T-cell proliferation assay based on 3H thymidine incorporation was developed and validated. The assay uses SARS-CoV-2 derived peptide pools to stimulate T-cell responses. The novel SARS-CoV-2 lymphocyte transformation test (SARS-CoV-2 LTT) showed excellent discrimination of infected and/or vaccinated individuals versus unexposed controls, with an area under the curve (AUC) of >0.95 in ROC analysis. Furthermore, the assay can also differentiate T-cell responses resulting from vaccination against those induced by infection by using peptide pools representing not only the S protein but also the N and M proteins.
CLINICA CHIMICA ACTA
(2022)
Article
Clinical Neurology
Stefano Delli Pizzi, Raffaella Franciotti, Piero Chiacchiaretta, Antonio Ferretti, Richard A. Edden, Carlo Sestieri, Mirella Russo, Stefano L. Sensi, Marco Onofrj
Summary: This study aims to investigate the neural mechanisms of somatic symptom disorder (SSD) in Parkinson's disease (PD) patients. The results showed that patients with SSD exhibited higher gamma-aminobutyric acid (GABA) levels and connectivity in the medial prefrontal cortex (mPFC), indicating both shared and individual effects of PD and SSD on mPFC neurotransmission and connectivity patterns.
MOVEMENT DISORDERS
(2022)
Review
Psychiatry
Anna Digiovanni, Paola Ajdinaj, Mirella Russo, Stefano L. Sensi, Marco Onofrj, Astrid Thomas
Summary: Psychiatric symptoms often occur before or with neurological disorders. Symptoms of bipolar spectrum disorders (BSD) can also be seen in neurological disorders such as Parkinson's disease and behavioral variant of frontotemporal dementia. Other neurological disorders also share clinical and biological characteristics with BSD, including neuroinflammation, ion channel dysfunctions, neurotransmission imbalance, and neurodegeneration. Although the pathophysiology of BSD is unclear, large-scale network dysfunctions play a role in mood disorders and psychotic symptoms. These functional alterations can manifest years before the development of organic central nervous system diseases.
FRONTIERS IN PSYCHIATRY
(2022)
Review
Clinical Neurology
Giacomo Evangelista, Fedele Dono, Stefano Consoli, Jacopo Lanzone, Clarissa Corniello, Mirella Russo, Francesca Anzellotti, Marco Onofrj, Catello Vollono, Stefano L. Sensi
Summary: HRV analysis is a valuable method for assessing cardiovascular risk and cardioautonomic impairment in SUDEP patients. The reduction of SDNN and RMSSD is common in SUDEP cases, while there are no significant differences in time and frequency domain parameters compared to controls. However, there is a trend towards increased LF/HF ratio in SUDEP patients.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Multidisciplinary Sciences
A. C. Gomes, I. A. Baraniak, A. Lankina, Z. Moulder, P. Holenya, C. Atkinson, G. Tang, T. Mahungu, F. Kern, P. D. Griffiths, M. B. Reeves
Summary: Vaccination against CMV infection is highly prioritized, and a recombinant form of gB protein with MF59 adjuvant has shown partial protection in a clinical trial. However, neutralizing responses against known antigenic domains of gB were limited. We discovered that vaccination induces an antibody response against a region of gB called AD-6, which is detected in a majority of vaccine recipients but a minority of naturally infected individuals. The AD-6 antibody binds to gB and infected cells, preventing cell-cell spread of CMV but not directly neutralizing the virus. This finding has the potential to explain part of the protection provided by gB vaccines against CMV following transplantation.
NATURE COMMUNICATIONS
(2023)
Article
Clinical Neurology
Maria Camila Gonzalez, Diego Alejandro Tovar-Rios, Guido Alves, Ingvild Dalen, Caroline H. Williams-Gray, Marta Camacho, Lars Forsgren, David Backstrom, Rachael A. Lawson, Angus D. Macleod, Carl E. Counsell, Claire Paquet, Carlo DeLena, Fabrizia D'Antonio, Andrea Pilotto, Alessandro Padovani, Frederic Blanc, Cristian Falup-Pecurariu, Simon J. G. Lewis, Konrad Rejdak, Ewa Papuc, Jakub Hort, Zuzana Nedelska, John O'Brien, Laura Bonanni, Marta Marquie, Merce Boada, Vanesa Pytel, Carla Abdelnour, Daniel Alcolea, Katrin Beyer, Ole-Bjorn Tysnes, Dag Aarsland, Jodi Maple-Grodem
Summary: This study compares the rate of cognitive and motor decline in patients with DLB and PDD, finding that both disorders show similar rates of decline. This has implications for future clinical trial designs.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Article
Clinical Neurology
Winston Dzau, Sifat Sharmin, Francesco Patti, Guillermo Izquierdo, Sara Eichau, Alexandre Prat, Marc Girard, Pierre Duquette, Marco Onofrj, Alessandra Lugaresi, Serkan Ozakbas, Oliver Gerlach, Cavit Boz, Pierre Grammond, Murat Terzi, Maria Pia Amato, Daniele La Spitaleri, Cristina Ramo-Tello, Davide Maimone, Elisabetta Cartechini, Katherine Buzzard, Olga Skibina, Anneke van der Walt, Helmut Butzkueven, Gerardo Iuliano, Aysun Soysal, Tomas Kalincik
Summary: This study investigated the association between early progression independent of relapse activity (PIRA) and relapse-associated worsening (RAW) with the onset and disability accumulation of secondary progressive multiple sclerosis (SPMS). It found that early PIRA and RAW were associated with increased risk of SPMS, but not with the rate of disability progression during SPMS.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Immunology
Stephan Fuhrmann, Bernhard Reus, Oliver Frey, Alejandra Pera, Louis J. Picker, Florian Kern
Summary: The effect of CMV infection on non-CMV-specific T-cells is limited to a minority of individuals and is not closely related to the degree of memory subset differentiation of CMV-specific T-cells. Unknown predisposing factors might determine to what extent CMV infection affects non-CMV-specific T-cell differentiation.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Gerontology
Esra Hassan, Ben Hicks, Naji Tabet, Nicolas Farina
Summary: Reducing stigma is an important benefit of intergenerational programs aimed at dementia-related attitudes in adolescents. However, there is a lack of knowledge regarding the availability and suitability of measures to capture these attitudes, which hinders interpretation of program efficacy. This scoping review aimed to provide an overview of outcome measures used in capturing dementia-related attitudes in adolescents. Fourteen studies met the inclusion criteria, identifying 13 unique measures. Yet, there are gaps in psychometric properties and a lack of underlying theoretical frameworks.
JOURNAL OF INTERGENERATIONAL RELATIONSHIPS
(2023)
Meeting Abstract
Biotechnology & Applied Microbiology
M. Drosch, K. Schnatbaum, T. Knaute, J. Zerweck, M. Eckey, P. Holenya, F. Kern, H. Wenschuh, U. Reimer
HUMAN GENE THERAPY
(2022)
Article
Geriatrics & Gerontology
Sarah N. Kraeutner, Cristina Rubino, Jennifer K. Ferris, Shie Rinat, Lauren Penko, Larissa Chiu, Brian Greeley, Christina B. Jones, Beverley C. Larssen, Lara A. Boyd
Summary: This study examined the age-related changes in brain function and baseline brain structure that support motor skill acquisition. The findings showed that older adults experienced decreases in functional connectivity during motor skill acquisition, while younger adults experienced increases. Additionally, regardless of age group, lower baseline microstructure in a frontoparietal tract was associated with slower motor skill acquisition.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Karen Nuytemans, Farid Rajabli, Melissa Jean-Francois, Jiji Thulaseedhara Kurup, Larry D. Adams, Takiyah D. Starks, Patrice L. Whitehead, Brian W. Kunkle, Allison Caban-Holt, Jonathan L. Haines, Michael L. Cuccaro, Jeffery M. Vance, Goldie S. Byrd, Gary W. Beecham, Christiane Reitz, Margaret A. Pericak-Vance
Summary: This study conducted genetic research on African American AD families and identified a significant linkage signal associated with AD, highlighting the importance of diverse population-level genetic data in understanding the genetic determinants of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Kazuya Suwabe, Ryuta Kuwamizu, Kazuki Hyodo, Toru Yoshikawa, Takeshi Otsuki, Asako Zempo-Miyaki, Michael A. Yassa, Hideaki Soya
Summary: Physical exercise has a positive impact on hippocampal memory decline with aging. Recent studies have shown that even light exercise can improve memory and this improvement is mediated by the ascending arousal system. This study aimed to investigate the effects of light-intensity exercise on hippocampal memory function in healthy older adults and found that pupil dilation during exercise played a role in the memory improvement.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Ajay Sood, Ana Werneck Capuano, Robert Smith Wilson, Lisa Laverne Barnes, Alifiya Kapasi, David Alan Bennett, Zoe Arvanitakis
Summary: The objective of this study was to explore the impact of metformin on cognition and brain pathology. The results showed that metformin users had slower decline in global cognition, episodic memory, and semantic memory compared to non-users. However, the relationship between metformin use and certain brain pathology remains uncertain.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Brian N. Lee, Junwen Wang, Molly A. Hall, Dokyoon Kim, Shana D. Stites, Li Shen
Summary: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory and functional impairments. This study analyzed participants from the Alzheimer's Disease Neuroimaging Initiative and found differential associations between cerebral spinal fluid (CSF)/neuroimaging biomarkers and cognitive/functional outcomes, as well as variations between sexes. These findings suggest that sex differences may play a role in the development of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Madeline R. Hale, Rebecca Langhough, Lianlian Du, Bruce P. Hermann, Carol A. Van Hulle, Margherita Carboni, Gwendlyn Kollmorgenj, Kristin E. Basche, Davide Bruno, Leah Sanson-Miles, Erin M. Jonaitis, Nathaniel A. Chin, Ozioma C. Okonkwo, Barbara B. Bendlin, Cynthia M. Carlsson, Henrik Zetterberg, Kaj Blennow, Tobey J. Betthauser, Sterling C. Johnson, Kimberly D. Mueller
Summary: This study demonstrates a relationship between cerebrospinal fluid biomarkers and the ability to recall proper names in the preclinical phase of Alzheimer's disease.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Thomas T. Austin, Christian L. Thomas, Ben Warren
Summary: This study investigated the effects of age on the robustness and resilience of auditory system using the desert locust. The researchers found that gene expression changes were mainly influenced by age rather than noise exposure. Both young and aged locusts were able to recover their auditory nerve function within 48 hours of noise exposure, but the recovery of transduction current magnitude was impaired in aged locusts. Key genes responsible for robustness to noise exposure in young locusts and potential candidates for compensatory mechanisms in auditory neurons of aged locusts were identified.
NEUROBIOLOGY OF AGING
(2024)