期刊
NEUROBIOLOGY OF AGING
卷 33, 期 4, 页码 -出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2011.06.025
关键词
Alzheimer disease; Down syndrome; Tau; DYRK1A; GSK-3 beta; Phosphorylation
资金
- UK Medical Research Council [U117527252]
- European Union Commission
- Wellcome Trust
- UK Medical Research Council
- Fidelity Foundation
- MRC [MC_U117527252, G0601056] Funding Source: UKRI
- Medical Research Council [G0601056, MC_U117527252] Funding Source: researchfish
Down syndrome (DS) results from trisomy of human chromosome 21 (Hsa21) and is associated with an increased risk of Alzheimer's disease (AD). Here, using the unique transchromosomic Tc1 mouse model of DS we investigate the influence of trisomy of Hsa21 on the protein tau, which is hyperphosphorylated in Alzheimer's disease. We show that in old, but not young, Tc1 mice increased phosphorylation of tau occurs at a site suggested to be targeted by the Hsa21 encoded kinase, dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A (DYRK1A). We show that DYRK1A is upregulated in young and old Tc1 mice, but that young trisomic mice may be protected from accumulating aberrantly phosphorylated tau. We observe that the key tau kinase, glycogen synthase kinase3-beta (GSK-3 beta) is aberrantly phosphorylated at an inhibitory site in the aged Tc1 brain which may reduce total glycogen synthase kinase3-beta activity. It is possible that a similar mechanism may also occur in people with DS. (C) 2012 Elsevier Inc. All rights reserved.
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