期刊
NEUROBIOLOGY OF AGING
卷 33, 期 5, 页码 -出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2011.10.003
关键词
APOE; Education; Demenita; Risk factor; Epidemiology
资金
- Swedish Council for Working Life and Social Research
- American Alzheimer Foundation
- Alzheimer Foundation, Sweden
- Swedish Research Council
- Fredrik and Ingrid Thurings Foundation
- Gun and Bertil Stohnes Foundation
- Gamla Tjanarinnor Foundation
- Soderstrom-Konigska Foundation
- Handlanden Hjalmar Svenssons Forskningsfond
- Foundation for Geriatric Diseases
- Loo and Hans Osterman Foundation for Geriatric Research at Karolinska Institutet
- Centre for Health Care Science at Karolinska Institutet
- Karolinska Institutet
- Novo Nordisk Fonden [NNF11OC1014884, NNF12OC1016402] Funding Source: researchfish
A number of studies have explored the relationships of apolipoprotein F (APOE) genotype and education with dementia over the last decade. However. observations concerning the possible modifying effect of education on the APOE-dementia association are limited. The objective of this study was to test the hypothesis that education may decrease the risk of APOE epsilon 4 on dementia. Pooled data from 3 major population-based studies in Northern Europe were used in this study, with a total of 3436 participants aged 65 and older derived from the Kungsholmen project and the Gothenburg Birth Cohort studies in Sweden, and the Cardiovascular Risk Factors, Aging and Dementia (CAME) project in Finland. The main outcome measure was dementia, which was diagnosed in 219 persons according to standard criteria. APOE epsilon 4 was associated with increased risk of dementia independent of the effect of education (odds ratio [OR], 2.5; 95% confidence interval [CI], 1.9-3.4 for 1 epsilon 4 carrier and OR, 3.7; 95% CI, 1.8-7.2 for 2 epsilon 4 carriers). High education (8 years and more) was related to a lower dementia risk (OR, 0.5; 95% CI, 0.3-0.6). An interaction between education and APOE epsilon 4 was observed. Compared with those with less education and no e4, the odds of dementia among persons with low education who carried any epsilon 4 allele was 2.7 (95% CI, 1.9-3.9), and 1.2 (0.7-1.8) if they had higher education. This study suggests that genetic (APOE epsilon 4) and environmental (education) factors are not only independently but also interactively related to dementia risk and that high education may buffer the negative effect of APOE epsilon 4 on dementia occurrence. (C) 2012 Elsevier Inc. All rights reserved.
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