Article
Behavioral Sciences
Niklas Lonnemann, Martin Korte, Shirin Hosseini
Summary: Alzheimer's disease is a neurodegenerative disease with no successful treatment. In addition to its features, neuroinflammatory processes, genetic factors, and lifestyle also play important roles. Training in a water maze has shown positive effects on memory formation in AD mice.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Geriatrics & Gerontology
Feng-lei Chao, Yi Zhang, Lei Zhang, Lin Jiang, Chun-ni Zhou, Jing Tang, Xin Liang, Jin-hua Fan, Xiao-yun Dou, Yong Tang
Summary: FLX delays memory decline and promotes oligodendrocyte maturation in the hippocampus of APP/PS1 mice, potentially inhibiting the development of oligodendrocyte abnormalities in Alzheimer's disease.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Article
Endocrinology & Metabolism
Leigang Song, Huan Chen, Dan Qiao, Bohan Zhang, Fangzhen Guo, Yizhou Zhang, Chang Wang, Sha Li, Huixian Cui
Summary: Androgens regulate learning and memory in mice through ZIP9, which is mediated by the ERK1/2-eIF4E pathway. This study provides new experimental evidence for the improvement of learning and memory in Alzheimer's disease through androgen supplementation.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Clinical Neurology
Ni-Ya Wang, Jin-Nan Li, Wei-Lin Liu, Qi Huang, Wen-Xing Li, Ya-Hong Tan, Fang Liu, Zi-Hua Song, Meng-Yue Wang, Ning Xie, Rong-Rong Mao, Ping Gan, Yu-Qiang Ding, Zhi Zhang, Bao-Ci Shan, Li-Dian Chen, Qi-Xin Zhou, Lin Xu
Summary: Brain capillaries play a crucial role in the pathophysiology of Alzheimer's disease, with reductions in density and diameter of hippocampal capillaries being associated with early A beta plaque deposition and spatial memory deficit. Counteracting ET1-mediated vasoconstriction can prevent these issues from occurring.
Article
Neurosciences
Lili Chen, Qin Qin, Panchuan Huang, Fangli Cao, Maojia Yin, Yachen Xie, Wuchao Wang
Summary: Chronic neuropathic pain may lead to cognitive impairment in elderly patients, possibly due to the inhibitory effect of CCL2/CCR2 signaling on hippocampal neurogenesis.
BRAIN RESEARCH BULLETIN
(2023)
Article
Neurosciences
Niek Brosens, Dimitris Samouil, Sabine Stolker, Efthymia Vasilina Katsika, Sascha Weggen, Paul J. Lucassen, Harm J. Krugers
Summary: Early life stress (ELS) increases synaptic strength and decreases the number of a specific type of interneurons in young AD mice, leading to reduced cognitive flexibility. These findings provide novel insights into the etiology of Alzheimer's disease and how ELS can increase susceptibility to AD.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Review
Neurosciences
Tian Li, Qiang Su, Zhina Zhang, Yanli Zhang, Mingxuan Yang, Zhuoran Wang, Junhong Guo, Zhaojun Wang, Meina Wu, Hongyan Cai, Jinshun Qi
Summary: This study reveals a significant role of Ube2c over-expression and autophagy decline in the pathogenesis of AD, suggesting that regulation of Ube2c and autophagy may provide important clues and potential targets for novel therapeutics of AD.
PROGRESS IN NEUROBIOLOGY
(2022)
Article
Medicine, Research & Experimental
Xuerui Wang, Zequn Yin, Peichang Cao, Shihong Zheng, Yuanli Chen, Maoyun Yu, Chenzhong Liao, Zhongyuan Zhang, Yajun Duan, Jihong Han, Shuang Zhang, Xiaoxiao Yang
Summary: Alzheimer's disease (AD) is the most common neurodegenerative disease in aging population. The traditional Chinese medicine NaoXinTong Capsule (NXT) has been shown to improve spatial memory impairment and cognitive decline in AD mice by reducing p-Tau levels and A beta accumulation in the brain. This neuroprotective effect is achieved by inhibiting inflammatory cytokines and mediators, thereby suggesting the potential application of NXT for AD treatment.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Neurosciences
Hao Yang, Lin Jiang, Yi Zhang, Xin Liang, Jing Tang, Qi He, Yan-Min Luo, Chun-Ni Zhou, Lin Zhu, Shan-Shan Zhang, Kai Xiao, Pei-Lin Zhu, Jin Wang, Yue Li, Feng-Lei Chao, Yong Tang
Summary: This study aims to assess the effect of anti-LINGO-1 antibody treatment on cognition and hippocampal oligodendrocytes in an AD transgenic animal model. The results showed that anti-LINGO-1 antibody alleviated spatial learning and memory deficits, decreased A beta deposition, and promoted oligodendrocyte differentiation and maturation in the hippocampus.
JOURNAL OF COMPARATIVE NEUROLOGY
(2022)
Article
Biochemical Research Methods
Na Ying, Hanqi Luo, Baixia Li, Kaiyan Gong, Fei Liang, Hongchang Gao, Tao Huang, Hong Zheng
Summary: Exercise, including high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT), can improve behavioral and cognitive impairments in Alzheimer's disease (AD) mice. Metabolomics analysis reveals significant changes in energy metabolism, neurotransmitter metabolism, and membrane metabolism in multiple brain regions after both types of exercises. HIIT also alters astrocyte-neuron metabolism in the hippocampus and hypothalamus of AD mice. These findings suggest that exercise can modulate brain metabolism in a region- and exercise-specific manner, potentially providing a novel approach for the prevention and treatment of AD.
JOURNAL OF PROTEOME RESEARCH
(2023)
Article
Multidisciplinary Sciences
Adam M. Brickman, Lok-Kin Yeung, Daniel M. Alschuler, Javier I. Ottaviani, Gunter G. C. Kuhnle, Richard P. Sloan, Heike Luttmann-Gibson, Trisha Copeland, Hagen Schroeter, Howard D. Sesso, JoAnn E. Manson, Melanie Wall, Scott A. Small
Summary: Dietary flavanols, found in certain fruits and vegetables, have been associated with cognitive aging. In a large-scale study, habitual flavanol consumption and diet quality were positively correlated with hippocampal-dependent memory. Although the intervention did not improve memory in all participants after 1 year, it restored memory in those with lower diet quality or lower habitual flavanol consumption.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Immunology
Xiaolei Wu, Qi Shen, Haocai Chang, Junyu Li, Da Xing
Summary: This study demonstrated that photobiomodulation therapy (PBMT) effectively promotes adult hippocampal neurogenesis (AHN) and reverses cognitive deficits in AD mouse models by upregulating expression of interferon-gamma (IFN-γ) and interleukin-10 (IL-10) in non-parenchymal CD4(+) T cells through the JAK2/STAT4/STAT5 signaling pathway.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Geriatrics & Gerontology
Jeremy Ebersole, Gregory Rose, Tore Eid, Kevin Behar, Peter Patrylo
Summary: The age-related decrease in hippocampal metabolism is correlated with cognitive decline. However, the resting state neural metabolism and GLU-GLN cycling may be preserved during aging. Enhanced astroglial metabolism observed in aged cognitively-unimpaired rats may serve as a compensatory change to maintain hippocampus-dependent cognitive function.
NEUROBIOLOGY OF AGING
(2021)
Article
Pharmacology & Pharmacy
Qiqi Xin, Weili Shi, Yan Wang, Rong Yuan, Yu Miao, Keji Chen, Weihong Cong
Summary: The study demonstrates that Pantao Pill (PTP) significantly improves cognitive impairment by regulating autophagy, apoptosis, and oxidative stress.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Neurosciences
Raquel Sanchez-Varo, Elisabeth Sanchez-Mejias, Juan Jose Fernandez-Valenzuela, Vanessa De Castro, Marina Mejias-Ortega, Angela Gomez-Arboledas, Sebastian Jimenez, Maria Virtudes Sanchez-Mico, Laura Trujillo-Estrada, Ines Moreno-Gonzalez, David Baglietto-Vargas, Marisa Vizuete, Jose Carlos Davila, Javier Vitorica, Antonia Gutierrez
Summary: Alzheimer's disease is a devastating neurodegenerative disorder characterized by initial memory impairments that progress to dementia. Synaptic dysfunction and loss have been established as the pathological features that best correlate with the typical early cognitive decline in this disease.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Rodrigo Morales, Javiera Bravo-Alegria, Ines Moreno-Gonzalez, Claudia Duran-Aniotz, Nazaret Gamez, George Edwards, Claudio Soto
Summary: This study demonstrates that administration of Aβ seeds through various peripheral routes can accelerate the accumulation of Aβ in the brains of AD mouse models. Oral administration of brain extracts had no impact on brain pathology. The peripheral administration of Aβ seeds led to the generation of a large proportion of aggregates in blood vessels, suggesting a role of vascular transport in AD-related pathological changes.
MOLECULAR PSYCHIATRY
(2021)
Article
Geriatrics & Gerontology
Abbi R. Hernandez, Jessica M. Hoffman, Caesar M. Hernandez, Constanza J. Cortes, Patricia Jumbo-Lucioni, Mark G. Baxter, Karyn A. Esser, Andrew C. Liu, Lori L. McMahon, Jennifer L. Bizon, Sara N. Burke, Thomas W. Buford, Christy S. Carter
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Geriatrics & Gerontology
Eunyoung Bang, Angelika Tobery, Karienn S. Montgomery, Annette S. Fincher, David J. Earnest, David A. Murchison, William H. Griffith
Summary: The study investigated the mechanism of action of amitriptyline in aged mice and found that low concentrations of amitriptyline can reduce the frequency of inhibitory postsynaptic currents by modulating neurotransmitter release, with this effect not diminishing in aged mice.
FRONTIERS IN AGING NEUROSCIENCE
(2021)
Review
Geriatrics & Gerontology
Jessica M. Hoffman, Caesar M. Hernandez, Abbi R. Hernandez, Jennifer L. Bizon, Sara N. Burke, Christy S. Carter, Thomas W. Buford
Summary: Neurodegenerative diseases are commonly diagnosed in older individuals, but there is often a lack of collaboration between gerontologists and neuroscientists. Enhanced cooperation between the two fields could lead to more efficient research with translational potential.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Review
Geriatrics & Gerontology
Caesar M. Hernandez, Abigail R. Hernandez, Jessica M. Hoffman, Peter H. King, Lori L. McMahon, Thomas W. Buford, Christy Carter, Jennifer L. Bizon, Sara N. Burke
Summary: The article discusses the history of neuroscience research on the neurobiology of aging and introduces gerontologists to the methodological approaches used by neuroscientists. The goal is to enhance collaboration between neuroscientists and gerontologists in order to strengthen the field of cognitive aging.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Geriatrics & Gerontology
Samantha M. Smith, Sabrina Zequeira, Meena Ravi, Sarah A. Johnson, Andriena M. Hampton, Aleyna M. Ross, Wonn Pyon, Andrew P. Maurer, Jennifer L. Bizon, Sara N. Burke
Summary: This study examined cognition in aged rats using a cross-species touchscreen-based platform known as paired-associates learning (PAL) and trial-by-trial behavioral analysis approach. The results revealed age-related deficits in PAL task acquisition in male rats, which appeared to be caused by vulnerability to accumulating, proactive interference. This detailed behavioral analysis provides new insights into the etiology of age-associated cognitive deficits.
NEUROBIOLOGY OF AGING
(2022)
Article
Neurosciences
Caesar M. Hernandez, Joseph A. McQuail, Tyler W. Ten Eyck, Alexa-Rae Wheeler, Chase C. Labiste, Barry Setlow, Jennifer L. Bizon
Summary: The ability to choose between immediate and delayed gratification is crucial for well-being. This study investigates the neural mechanisms underlying age differences in intertemporal choice using a rat model. The findings suggest that GABA(B) receptors in the prelimbic cortex and basolateral amygdala contribute to these age differences, and the expression of GABA(B)R subunits differs in these brain regions among aged rats.
Article
Geriatrics & Gerontology
Ines Moreno-Gonzalez, George Edwards, Rodrigo Morales, Claudia Duran-Aniotz, Gabriel Escobedo Jr, Mercedes Marquez, Marti Pumarola, Claudio Soto
Summary: Alzheimer's disease (AD) is one of the leading causes of dementia in late life, and the misfolding and aggregation of amyloid beta (A β) and tau proteins are thought to be hallmark events. Recent studies have shown that small quantities of preformed aggregates can induce protein misfolding and aggregation, similar to the transmission of prion diseases. This study investigated the presence of A β aggregates in the brains of aged cattle and their ability to promote AD pathological features. The findings demonstrate that cows can develop seeding-competent A β aggregates, similar to what is observed in AD patients.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Psychology, Clinical
Catherine E. Myers, Chintan Dave, Michael Callahan, Megan S. Chesin, John G. Keilp, Kevin D. Beck, Lisa A. Brenner, Marianne S. Goodman, Erin A. Hazlett, Alexander B. Niculescu, Lauren St Hill, Anna Kline, Barbara H. Stanley, Alejandro Interian
Summary: This study examined whether performance on a Go/No-go (GNG) task and computational modeling could enhance prediction of suicide attempts within the next 90 days among individuals at high-risk for suicide. The results showed that increased miss rate on the GNG task predicted actual suicide attempts, while increased false alarm rate predicted other suicide-related events. Computational modeling revealed that decreases in decisional efficiency to targets were specifically associated with upcoming suicide attempts. These findings suggest that GNG testing may improve prediction of near-term suicide risk.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
M. Todd Allen, Michelle M. Shields, Catherine E. Myers
Summary: The study found that Type D personality and social inhibition (SI) were positively correlated with avoidance scores on the avatar task, while negative affectivity (NA) showed a weaker correlation. Additionally, individuals with Type D personality exhibited higher avoidance scores. These findings support the significant role of avoidance in Type D personality.
Editorial Material
Behavioral Sciences
Barry Setlow, Jennifer L. Bizon
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Geriatrics & Gerontology
Karienn A. Souza, Andrew Powell, Gregg C. Allen, David J. Earnest
Summary: Preclinical quantitative models of cognitive performance are necessary for translation from basic research to clinical studies. To address the limitations of existing models in rodents, researchers developed a cognitive index based on mice's strategies in escaping the Barnes maze. The cognitive index was positively correlated with the memory portion of the task in all age groups. The study also found age-related alterations in circadian entrainment of the activity rhythm, which preceded learning and memory deficits in aged mice. The results suggest that circadian rhythm disturbances may serve as an early predictor of age-related cognitive decline.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Neurosciences
Caitlin A. Orsini, Wonn S. Pyon, Richard J. Dragone, Mojdeh Faraji, Alexa-Rae Wheeler, Marjory Pompilus, Marcelo Febo, Jennifer L. Bizon, Barry Setlow
Summary: Altered decision making at advanced ages can impact quality of life and personal independence. Rodent models have been useful in understanding age-related changes in decision making, but have focused mostly on rewards and timing, neglecting the potential risk of adverse consequences. This study used a rat model to examine age-related changes in decision making and identified potential cognitive and neurobiological mechanisms, finding that aged rats displayed greater risk aversion and changes in brain connectivity.
Article
Neurosciences
Diana P. P. Guerra, Wei Wang, Karienn A. A. Souza, Justin M. M. Moscarello
Summary: The bed nucleus of the stria terminalis (BNST) plays a role in aversive responses to uncertain threat. This study investigates the contribution of BNST to a task where subjects learn to prevent an aversive outcome. Chemogenetic inhibition of BNST reduces the avoidance response in male rats, while inactivation of the neighboring medial septum has no effect, suggesting that BNST specifically mediates avoidance behavior. Activation of BNST extends the tone-evoked shuttling period, suggesting a sex-specific role of the systems underlying proactive defensive behavior.
NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Clinical Neurology
Cigdem Ulasoglu-Yildiz, Zerrin Yildirim, Catherine E. Myers, Mark A. Gluck, Hakan Gurvit
Summary: Hunger strike can cause Korsakoff's syndrome, and most patients with hunger strike-related KS have impaired learning and transfer abilities in simple association tasks, while some also have slower learning and impairment in transfer in more complex association tasks. This pattern of task-complexity-related impairment in learning and transfer is distinct from the spared learning but impaired transfer previously observed in patients with medial temporal lobe amnesia.
APPLIED NEUROPSYCHOLOGY-ADULT
(2023)
Article
Geriatrics & Gerontology
Sarah N. Kraeutner, Cristina Rubino, Jennifer K. Ferris, Shie Rinat, Lauren Penko, Larissa Chiu, Brian Greeley, Christina B. Jones, Beverley C. Larssen, Lara A. Boyd
Summary: This study examined the age-related changes in brain function and baseline brain structure that support motor skill acquisition. The findings showed that older adults experienced decreases in functional connectivity during motor skill acquisition, while younger adults experienced increases. Additionally, regardless of age group, lower baseline microstructure in a frontoparietal tract was associated with slower motor skill acquisition.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Karen Nuytemans, Farid Rajabli, Melissa Jean-Francois, Jiji Thulaseedhara Kurup, Larry D. Adams, Takiyah D. Starks, Patrice L. Whitehead, Brian W. Kunkle, Allison Caban-Holt, Jonathan L. Haines, Michael L. Cuccaro, Jeffery M. Vance, Goldie S. Byrd, Gary W. Beecham, Christiane Reitz, Margaret A. Pericak-Vance
Summary: This study conducted genetic research on African American AD families and identified a significant linkage signal associated with AD, highlighting the importance of diverse population-level genetic data in understanding the genetic determinants of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Kazuya Suwabe, Ryuta Kuwamizu, Kazuki Hyodo, Toru Yoshikawa, Takeshi Otsuki, Asako Zempo-Miyaki, Michael A. Yassa, Hideaki Soya
Summary: Physical exercise has a positive impact on hippocampal memory decline with aging. Recent studies have shown that even light exercise can improve memory and this improvement is mediated by the ascending arousal system. This study aimed to investigate the effects of light-intensity exercise on hippocampal memory function in healthy older adults and found that pupil dilation during exercise played a role in the memory improvement.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Ajay Sood, Ana Werneck Capuano, Robert Smith Wilson, Lisa Laverne Barnes, Alifiya Kapasi, David Alan Bennett, Zoe Arvanitakis
Summary: The objective of this study was to explore the impact of metformin on cognition and brain pathology. The results showed that metformin users had slower decline in global cognition, episodic memory, and semantic memory compared to non-users. However, the relationship between metformin use and certain brain pathology remains uncertain.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Brian N. Lee, Junwen Wang, Molly A. Hall, Dokyoon Kim, Shana D. Stites, Li Shen
Summary: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory and functional impairments. This study analyzed participants from the Alzheimer's Disease Neuroimaging Initiative and found differential associations between cerebral spinal fluid (CSF)/neuroimaging biomarkers and cognitive/functional outcomes, as well as variations between sexes. These findings suggest that sex differences may play a role in the development of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Madeline R. Hale, Rebecca Langhough, Lianlian Du, Bruce P. Hermann, Carol A. Van Hulle, Margherita Carboni, Gwendlyn Kollmorgenj, Kristin E. Basche, Davide Bruno, Leah Sanson-Miles, Erin M. Jonaitis, Nathaniel A. Chin, Ozioma C. Okonkwo, Barbara B. Bendlin, Cynthia M. Carlsson, Henrik Zetterberg, Kaj Blennow, Tobey J. Betthauser, Sterling C. Johnson, Kimberly D. Mueller
Summary: This study demonstrates a relationship between cerebrospinal fluid biomarkers and the ability to recall proper names in the preclinical phase of Alzheimer's disease.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Thomas T. Austin, Christian L. Thomas, Ben Warren
Summary: This study investigated the effects of age on the robustness and resilience of auditory system using the desert locust. The researchers found that gene expression changes were mainly influenced by age rather than noise exposure. Both young and aged locusts were able to recover their auditory nerve function within 48 hours of noise exposure, but the recovery of transduction current magnitude was impaired in aged locusts. Key genes responsible for robustness to noise exposure in young locusts and potential candidates for compensatory mechanisms in auditory neurons of aged locusts were identified.
NEUROBIOLOGY OF AGING
(2024)