期刊
NEUROBIOLOGY OF AGING
卷 32, 期 4, 页码 754-755出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2009.04.009
关键词
Progranulin; PGRN; Frontotemporal lobar degeneration; Rs5848; TDP-43
资金
- MRC [MC_U123160651, MC_U123192748, G0701441] Funding Source: UKRI
- Medical Research Council [MC_U123160651, MC_U123192748, G0701441] Funding Source: researchfish
- Medical Research Council [MC_U123160651, G0701441, MC_U123192748] Funding Source: Medline
- Wellcome Trust [089701] Funding Source: Medline
Frontotemporal lobar degeneration (FTLD) is a highly familial neurodegenerative disease. It has been claimed that homozygosity of the SNP rs5848 located in the 3'UTR of progranulin increases risk for FTLD. We have attempted to replicate the association of rs5848 in three independent FTLD cohorts. No association of rs5848 with FTLD was observed in any individual cohort nor was any observed when the data was combined. These data argue that rs5848 is not a risk factor for FTLD. (C) 2009 Elsevier Inc. All rights reserved.
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