期刊
NEUROBIOLOGY OF AGING
卷 31, 期 6, 页码 1069-1071出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2009.06.008
关键词
Parkinson's disease; GIGYF2; French population; Mutation frequency; Variants
Meeus et al. (2009) reported no pathogenic mutations in a comprehensive genetic analysis of the entire GRB10-interacting GYF protein-2 gene (GIGYF2) in a Belgian series of both familial and sporadic patients with Parkinson's disease (PD). Although we initially proposed that GIGYF2 corresponds to the PARK11 locus, in familial PD, we found no causative variations in a follow-up study in which GIGYF2 was screened in an independent series of 185 patients with autosomal dominant PD, mostly of French origin. Together, these results do not support a major role of GIGYF2 in PD. (C) 2009 Elsevier Inc. All rights reserved.
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