Article
Health Care Sciences & Services
Alexandru Martis, Gabriel Gusetu, Gabriel Cismaru, Dumitru Zdrenghea, Daniel-Corneliu Leucuta, Dana Pop
Summary: The study showed that cardiac pacemaker implantation led to improved cognitive function, increased cardiac output, and decreased IL-1 beta concentration in patients with symptomatic bradycardia. There were significant correlations between cognitive function, cardiac index, and inflammatory markers.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Food Science & Technology
Brigitte M. Gonzalez M. Olmo, Menaz N. N. Bettes, James W. W. DeMarsh, Fangli Zhao, Candice Askwith, Ruth M. M. Barrientos
Summary: More Americans are consuming high-fat diets, which can accelerate and aggravate memory decline, particularly in the elderly. In a study with rats, it was found that short-term high-fat diet consumption disrupted hippocampal synaptic plasticity in aged rats, leading to memory impairments. The increase in proinflammatory cytokines, specifically interleukin-1 beta, was identified as a critical factor in the deterioration of synaptic plasticity.
NPJ SCIENCE OF FOOD
(2023)
Article
Biology
Ying Zhu, Yu Mei, Nimmi Baby, Huey Yee Teo, Zuhairah Binte Hanafi, Siti Nazihah Mohd Salleh, Sreedharan Sajikumar, Haiyan Liu
Summary: Hepatocellular carcinoma alters the gut microbiota and impairs cognitive functions by affecting synaptic tagging and capture (STC), a cellular mechanism for associative memory formation. This impairment is rescued after microbiota sterilization and induced by transplantation of microbiota from tumor-bearing mice. Mechanistic study reveals that HCC growth increases IL-1β levels in the serum and hippocampus, and depletion of IL-1β restores STC in tumor-bearing mice. These findings demonstrate the crucial role of gut microbiota in mediating tumor-induced cognitive impairment through IL-1β upregulation.
COMMUNICATIONS BIOLOGY
(2023)
Article
Geriatrics & Gerontology
Yao Pan, Xiaofang Wu, Yan Liu, Zhuo Li, Yingkai Yang, Yanan Luo
Summary: Our study investigates the impact of urbanization on cognitive function among Chinese middle-aged and older adults, as well as the potential mechanisms. The findings suggest that urban nonmigrants have better cognitive function compared to urbanized-rural and rural nonmigrants. The improvement in living conditions and income are the main drivers behind the relationship, indicating the beneficial effect of urbanization on cognitive function.
JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Dong Mei Wang, Rong Rong Zhu, Yang Tian, Kadir Uludag, Jia Jing Chen, Hui Xia Zhou, Li Wang, Thomas R. Kosten, Xiang Yang Zhang
Summary: This study explored the relationship between MnSOD activity, MnSOD Ala-9Val polymorphism and cognitive dysfunction in unmedicated first-episode schizophrenia patients. The results showed extensive cognitive impairment and higher MnSOD activity in patients compared to healthy controls. The MnSOD Ala-9Val polymorphism only affected MnSOD activity in patients, and the activity was significantly correlated with cognitive impairment in patients with Val homozygotes.
Review
Endocrinology & Metabolism
Haiyang Du, Xiaoyu Meng, Yu Yao, Jun Xu
Summary: GLP-1R agonists, a type of drug used to treat type 2 diabetes, have the potential to reduce inflammation and oxidative stress, provide neurotrophic effects, and decrease the progression of Alzheimer's disease. Further clinical trials are needed to validate their effectiveness.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Geriatrics & Gerontology
Zirong Ye, Xueru Li, Haoxiang Lang, Ya Fang
Summary: This study found that long-term exposure to PM2.5 is associated with decreased lung function and cognitive impairment. It investigated whether the effect of PM2.5 on cognitive function is mediated by lung function. The results showed that lung function partially mediates the association between long-term PM2.5 exposure and cognition. Therefore, more clean air actions should be taken to improve lung function and cognitive function in older adults.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Beom Jun Kim, Noo Ri Lee, Chung Hyeok Lee, Young Bin Lee, Sung Jay Choe, Solam Lee, Hyun Jee Hwang, Eunjung Kim, Gareth G. Lavery, Kyong-Oh Shin, Kyungho Park, Eung Ho Choi
Summary: Increased expression of 11 beta-HSD1 in aged skin leads to elevated levels of active glucocorticoids, suppressing sebaceous lipid biosynthesis and causing impaired epidermal permeability barrier.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Psychiatry
Xiaorong Wang, Guofu Zhang, Weihong Lu, Yi Zhang, Weixing Fan, Wei Tang, Chen Zhang
Summary: This study identified a novel BD risk SNP rs10932201 in Han Chinese, which may be a risk factor for cognitive dysfunction in patients with BD. The G allele of rs10932201 was associated with a higher frequency in BD patients compared to control subjects, and carriers of this allele had significantly lower levels of CREB1 expression in intralobular white matter.
ASIAN JOURNAL OF PSYCHIATRY
(2021)
Article
Geriatrics & Gerontology
Ran Zhang, Lei Zhang, Zeng Li, Ping Zhang, Hao Song, Dong-ai Yao, Jing Cao, Jun-jian Zhang
Summary: Regular green tea consumption is associated with better cognitive function, particularly in memory and executive function, among Chinese middle-aged and elderly people. Green tea may achieve protective effects by reducing Alzheimer's disease-related pathology and improving anti-oxidative stress capacity, and higher levels of tea consumption have a stronger protective effect.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Endocrinology & Metabolism
Mohammad Nazmus Sakib, Reza Ramezan, Peter A. Hall
Summary: This study utilized large-scale population-based data to investigate the association between cognitive function and diabetes in Canadian population. The results showed that type 2 diabetes is associated with lower performance in tasks assessing executive function, reaction time, and memory. However, no significant association was found between other types of diabetes and cognitive performance.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Environmental Sciences
Hang Liu, Liqin Su, Xi Chen, Sisi Wang, Yibin Cheng, Shaobin Lin, Liang Ding, Jingyi Liu, Chen Chen, Frederick W. Unverzagt, Ann M. Hake, Yinlong Jin, Sujuan Gao
Summary: This study found that higher cadmium exposure is associated with greater cognitive decline in older Chinese adults, as evidenced by lower scores in various cognitive tests and significant association with cognitive decline over a 3-year period.
SCIENCE OF THE TOTAL ENVIRONMENT
(2021)
Article
Nutrition & Dietetics
Minhong Ren, He Li, Zhen Fu, Quanyang Li
Summary: This study found that supplementation of Lactobacillus casei LTL1361 and dietary fiber complex (DFC) can improve cognitive ability, alleviate oxidative stress and inflammation in the brain, improve gut barrier function, and increase short-chain fatty acid (SCFA) concentrations and gene expression of SCFA receptors. The protective effect was enhanced when LTL1361 and DFC were used together. These results suggest that Lactobacillus casei LTL1361 and DFC may be promising anti-aging agents.
Article
Food Science & Technology
Shanyao Pan, Shanshan Guo, Jiaru Dai, Yanrong Gu, Guoxiang Wang, Yulong Wang, Zhenghong Qin, Li Luo
Summary: Exercise and trehalose can improve learning and memory, activate autophagy, and modulate autophagy through different pathways in aged mice. However, a combination of exercise and trehalose does not exert synergistic effects.
FOOD SCIENCE AND HUMAN WELLNESS
(2022)
Article
Food Science & Technology
Huan-Huan Zhou, Guiping Wang, Lan Luo, Wei Ding, Jia-Ying Xu, Zengli Yu, Li-Qiang Qin, Zhongxiao Wan
Summary: This study found that lactoferrin had no effects on cognitive function in Alzheimer's disease mice, but may help maintain gut microbiota homeostasis.
FOOD & NUTRITION RESEARCH
(2021)
Article
Oncology
Tien-Wei Hsu, Chih-Sung Liang, Shih-Jen Tsai, Ya-Mei Bai, Tung-Ping Su, Tzeng-Ji Chen, Mu-Hong Chen
Summary: Evidence suggests that childhood and adolescent cancer survivors have an increased long-term risk of major psychiatric disorders. However, it remains unclear whether these associations vary for different types of cancers.
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Clinical Neurology
Shih-Jen Tsai, Chung-Feng Kao, Tung-Ping Su, Cheng-Ta Li, Wei-Chen Lin, Chen-Jee Hong, Ya-Mei Bai, Pei-Chi Tu, Mu-Hong Chen
Summary: The aim of this study was to analyze whether specific genes related to inflammatory processes and VEGF were associated with treatment response to low-dose ketamine in patients with treatment-resistant depression. The findings revealed that specific single nucleotide polymorphisms in IL1R1 and VEGFC were related to the rapid antidepressant effect, while single nucleotide polymorphisms in PIGF and TNFRSF8 were associated with the sustained antidepressant effect. The synergic modulation of inflammatory and VEGF systems may contribute to the antidepressant effect of ketamine.
Article
Clinical Neurology
Tung-Ping Su, Cheng-Ta Li, Wei-Chen Lin, Hui-Ju Wu, Shih-Jen Tsai, Ya-Mei Bai, Wei-Chung Mao, Pei-Chi Tu, Li-Fen Chen, Wei-Chi Li, Mu-Hong Chen
Summary: This study suggests that low-dose ketamine infusion is a safe and effective treatment for patients with TRD and prominent suicidal ideation. The timing of ketamine administration, specifically the duration of the current depressive episode and the number of failed antidepressant trials, plays an important role in achieving therapeutic response.
INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY
(2023)
Article
Psychiatry
Hsin-Jung Tsai, Wei-Cheng Yang, Shih-Jen Tsai, Ching-Hua Lin, Albert C. Yang
Summary: Major depressive disorder has a significant impact on global healthcare resources. Antidepressants are commonly used as the first-line treatment, but brain stimulation therapy may be necessary for non-responders. Digital phenotyping can help predict treatment effectiveness for patients with major depressive disorder.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Psychiatry
Che-Sheng Chu, Kai-Lin Huang, Ya-Mei Bai, Tung-Ping Su, Shih-Jen Tsai, Tzeng-Ji Chen, Ju-Wei Hsu, Chih-Sung Liang, Mu-Hong Chen
Summary: We investigated the risk of suicide in patients diagnosed with sleep apnea and found that they are more likely to attempt suicide compared to those without sleep apnea.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Dentistry, Oral Surgery & Medicine
Shih-Jen Tsai, Ju-Wei Hsu, Kai-Lin Huang, Ya-Mei Bai, Tung-Ping Su, Tzeng-Ji Chen, Mu-Hong Chen
Summary: This study investigated the difference in periodontitis risk between adolescents with autism spectrum disorder (ASD) and those without ASD. The results showed that adolescents with ASD were more likely to develop periodontitis compared to those without ASD. ASD can be considered as an independent risk factor for subsequent periodontitis development.
JOURNAL OF THE AMERICAN DENTAL ASSOCIATION
(2023)
Article
Psychiatry
Jiajia Zhao, Chu-Chung Huang, Yajuan Zhang, Yuchen Liu, Shih-Jen Tsai, Ching-Po Lin, Chun-Yi Zac Lo
Summary: This study reveals the widespread connectivity abnormalities in both structural and functional brain circuits in individuals with schizophrenia. The abnormal signal transfer along the white matter pathways is found to be significantly associated with psychotic symptoms and illness duration in schizophrenia. This work supports the dysconnectivity hypothesis of schizophrenia and emphasizes the critical role of white matter networks in the pathophysiology of this disorder.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Psychiatry
Jun-Ding Zhu, Yung-Fu Wu, Shih-Jen Tsai, Ching-Po Lin, Albert C. C. Yang
Summary: Brain-age prediction models were constructed using multimodal MRI, and deviations in aging trajectories in different brain regions of participants with schizophrenia were examined. The results showed accelerated aging in most gray matter regions, especially in the frontal lobe, temporal lobe, and insula. Deviations in aging trajectories were also observed in some white matter tracts. However, no accelerated brain aging was found in functional connectivity maps. These findings provide insights into the neuropathology of schizophrenia.
TRANSLATIONAL PSYCHIATRY
(2023)
Article
Psychology, Developmental
Shih-Jen Tsai, Wen-Han Chang, Chih-Ming Cheng, Chih-Sung Liang, Ya-Mei Bai, Ju-Wei Hsu, Kai-Lin Huang, Tung-Ping Su, Tzeng-Ji Chen, Mu-Hong Chen
Summary: Evidence suggests that autistic individuals have increased risks of mortality, including natural-cause, suicide, and accident mortalities. A study conducted in Taiwan found that autistic individuals had higher likelihoods of all-cause mortality, natural-cause mortality, and suicide mortality compared with non-autistic individuals. Autistic males were more likely to die by suicide, and autistic females were more likely to die of accident compared with non-autistic individuals.
Article
Psychiatry
Mu-Hong Chen, Wei-Chen Lin, Cheng-Ta Li, Hui-Ju Wu, Ya-Mei Bai, Shih-Jen Tsai, Tung-Ping Su, Pei-Chi Tu
Summary: This study found that low-dose ketamine did not alter the levels of vascular endothelial growth factor (VEGF) and matrix metalloproteinase-9 (MMP-9) in patients with treatment-resistant depression and strong suicidal ideation. However, baseline VEGF levels were associated with the antidepressant and antisuicidal effects of a single low-dose ketamine infusion.
JOURNAL OF PSYCHIATRIC RESEARCH
(2023)
Article
Psychiatry
Che-Sheng Chu, Shu-Li Cheng, Ya-Mei Bai, Tung-Ping Su, Shih-Jen Tsai, Tzeng-Ji Chen, Fu-Chi Yang, Mu-Hong Chen, Chih-Sung Liang
Summary: Individuals with dementia who have multiple comorbidities such as fractures, urinary and pulmonary infections, upper gastrointestinal bleeding, and nasogastric intubation face a higher risk of mortality within 5 years compared to those with cancer or cardiometabolic comorbidities.
PSYCHIATRY INVESTIGATION
(2023)
Article
Psychiatry
Cheng-Ta Li, Chih-Ming Cheng, Hui-Ching Lin, Skye Hsin-Hsieh Yeh, Jia-Shyun Jeng, Hui-Ting Wu, Ya-Mei Bai, Shih-Jen Tsai, Tung-Ping Su, Paul B. Fitzgerald
Summary: This double-blind, sham-controlled study aimed to investigate the antidepressant efficacy of 2 daily prolonged intermittent theta-burst stimulation (piTBS) sessions for treating major depressive disorder (MDD) patients. The results showed that the piTBS group had significantly more responders at week 2 than the sham group, but there was no evidence to support that longer piTBS treatment duration resulted in more rapid or better antidepressant effects. Longer treatment duration did not result in stronger placebo effects.
ASIAN JOURNAL OF PSYCHIATRY
(2023)
Article
Endocrinology & Metabolism
Tien-Wei Hsu, Mu-Hong Chen, Ya-Mei Bai, Wen-Han Chang, Chih-Ming Cheng, Tung-Ping Su, Tzeng-Ji Chen, Shih-Jen Tsai, Chih-Sung Liang
Summary: This study aimed to examine the risk of T1D, MDD, ADHD, and ASD in first-degree relatives of T1D patients. The results showed that FDRs of individuals with T1D had a higher risk of T1D and MDD compared to controls. Stratified by sex and kinship, female FDRs had an increased risk of MDD, while male FDRs had an increased risk of ADHD. Furthermore, FDRs of individuals with T1D and DKA had a higher risk of MDD and ADHD.
ACTA DIABETOLOGICA
(2023)
Article
Psychiatry
Chen-Lan Shen, Shih-Jen Tsai, Ching-Po Lin, Albert C. C. Yang
Summary: This study examined the structural and functional brain abnormalities in patients with schizophrenia, and found that these abnormalities progress at different rates and in different brain areas throughout the course of the illness. Using MRI scanning, the study found that in the early stages of schizophrenia, there were only limited functional abnormalities in certain brain regions, but as the illness progressed, the abnormalities spread to wider brain areas and also involved gray matter density. In the third decade of the illness, structural connectivity abnormalities affecting almost all white matter tracts emerged.
Article
Psychiatry
Jun-Ding Zhu, Shih-Jen Tsai, Ching-Po Lin, Yi-Ju Lee, Albert C. Yang
Summary: Brain-age prediction is a novel approach for assessing deviated brain aging trajectories in different diseases. This study aimed to investigate the presence of declined brain structures in schizophrenia using brain volume, cortical thickness, and fractional anisotropy as features. The results showed that individuals with schizophrenia had larger brain age gaps compared to healthy controls across different illness durations.
Article
Geriatrics & Gerontology
Sarah N. Kraeutner, Cristina Rubino, Jennifer K. Ferris, Shie Rinat, Lauren Penko, Larissa Chiu, Brian Greeley, Christina B. Jones, Beverley C. Larssen, Lara A. Boyd
Summary: This study examined the age-related changes in brain function and baseline brain structure that support motor skill acquisition. The findings showed that older adults experienced decreases in functional connectivity during motor skill acquisition, while younger adults experienced increases. Additionally, regardless of age group, lower baseline microstructure in a frontoparietal tract was associated with slower motor skill acquisition.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Karen Nuytemans, Farid Rajabli, Melissa Jean-Francois, Jiji Thulaseedhara Kurup, Larry D. Adams, Takiyah D. Starks, Patrice L. Whitehead, Brian W. Kunkle, Allison Caban-Holt, Jonathan L. Haines, Michael L. Cuccaro, Jeffery M. Vance, Goldie S. Byrd, Gary W. Beecham, Christiane Reitz, Margaret A. Pericak-Vance
Summary: This study conducted genetic research on African American AD families and identified a significant linkage signal associated with AD, highlighting the importance of diverse population-level genetic data in understanding the genetic determinants of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Kazuya Suwabe, Ryuta Kuwamizu, Kazuki Hyodo, Toru Yoshikawa, Takeshi Otsuki, Asako Zempo-Miyaki, Michael A. Yassa, Hideaki Soya
Summary: Physical exercise has a positive impact on hippocampal memory decline with aging. Recent studies have shown that even light exercise can improve memory and this improvement is mediated by the ascending arousal system. This study aimed to investigate the effects of light-intensity exercise on hippocampal memory function in healthy older adults and found that pupil dilation during exercise played a role in the memory improvement.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Ajay Sood, Ana Werneck Capuano, Robert Smith Wilson, Lisa Laverne Barnes, Alifiya Kapasi, David Alan Bennett, Zoe Arvanitakis
Summary: The objective of this study was to explore the impact of metformin on cognition and brain pathology. The results showed that metformin users had slower decline in global cognition, episodic memory, and semantic memory compared to non-users. However, the relationship between metformin use and certain brain pathology remains uncertain.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Brian N. Lee, Junwen Wang, Molly A. Hall, Dokyoon Kim, Shana D. Stites, Li Shen
Summary: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory and functional impairments. This study analyzed participants from the Alzheimer's Disease Neuroimaging Initiative and found differential associations between cerebral spinal fluid (CSF)/neuroimaging biomarkers and cognitive/functional outcomes, as well as variations between sexes. These findings suggest that sex differences may play a role in the development of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Madeline R. Hale, Rebecca Langhough, Lianlian Du, Bruce P. Hermann, Carol A. Van Hulle, Margherita Carboni, Gwendlyn Kollmorgenj, Kristin E. Basche, Davide Bruno, Leah Sanson-Miles, Erin M. Jonaitis, Nathaniel A. Chin, Ozioma C. Okonkwo, Barbara B. Bendlin, Cynthia M. Carlsson, Henrik Zetterberg, Kaj Blennow, Tobey J. Betthauser, Sterling C. Johnson, Kimberly D. Mueller
Summary: This study demonstrates a relationship between cerebrospinal fluid biomarkers and the ability to recall proper names in the preclinical phase of Alzheimer's disease.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Thomas T. Austin, Christian L. Thomas, Ben Warren
Summary: This study investigated the effects of age on the robustness and resilience of auditory system using the desert locust. The researchers found that gene expression changes were mainly influenced by age rather than noise exposure. Both young and aged locusts were able to recover their auditory nerve function within 48 hours of noise exposure, but the recovery of transduction current magnitude was impaired in aged locusts. Key genes responsible for robustness to noise exposure in young locusts and potential candidates for compensatory mechanisms in auditory neurons of aged locusts were identified.
NEUROBIOLOGY OF AGING
(2024)
