Article
Clinical Neurology
Marina Ritchie, Daniel L. Gillen, Joshua D. Grill
Summary: The study found that longer duration trials are associated with lower completion rates, especially in AD and MCI trials, where the dropout rates in the treatment arms were higher than in the placebo arms.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Clinical Neurology
Szu-Ying Lin, Po-Chen Lin, Yi-Cheng Lin, Yi-Jung Lee, Chen-Yu Wang, Shih-Wei Peng, Pei-Ning Wang
Summary: This study compared the prognosis and clinical course between early MCI (EMCI) and late MCI (LMCI). The results showed that during the follow-up period, more EMCI patients showed a reversion to normal cognitive status, while LMCI patients still had a risk of cognitive decline. The conversion rates to dementia were higher in the EMCI and LMCI groups compared to normal subjects, with LMCI patients showing a faster decline in cognitive function.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Brandon Henley, Maureen Okafor, Ambar Kulshreshtha, Antoine Trammell, Ihab Hajjar
Summary: This study investigated the effects of modulating the renin-angiotensin system on cerebral microvascular reactivity in individuals with mild cognitive impairment. The results showed that candesartan improved microvascular function compared to placebo and lisinopril in patients with mild cognitive impairment.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Article
Clinical Neurology
Viswanath Devanarayan, Yuanqing Ye, Arnaud Charil, Erica Andreozzi, Pallavi Sachdev, Daniel A. Llano, Lu Tian, Liang Zhu, Harald Hampel, Lynn Kramer, Shobha Dhadda, Michael Irizarry
Summary: This study developed a prediction model for forecasting the clinical progression trajectories in early Alzheimer's disease (AD), using clinical features and brain magnetic resonance imaging (MRI) measures as inputs. The validated model demonstrated the ability to predict 2-year cognitive decline in two validation cohorts, with improved accuracy when MRI features were included.
ALZHEIMERS & DEMENTIA
(2023)
Article
Medicine, General & Internal
Hong-Chun Wei, Bing Li, Kok Pin Ng, Qing-Xi Fu, Sheng-Jie Dong, Mao-Wen Ba, Min Kong
Summary: This study compared clinical and biomarker features between A+T+MCI individuals progressing to pMCI and those remaining stable sMCI, identifying CSF and cognitive measures at baseline predictive of dementia progression within 2 years. Subset differences in biomarkers, cognitive assessment, and MRI imaging were observed, with CSF t-tau levels and cognitive scores serving as potential risk factors for dementia progression in A+T+MCI individuals.
CHINESE MEDICAL JOURNAL
(2021)
Article
Clinical Neurology
Annalise Rahman-Filipiak, Corey Bolton, Joshua D. Grill, Ayda Rostamzadeh, Nathaniel Chin, Judith Heidebrink, Sarah Getz, Nicole R. Fowler, Allyson Rosen, Jennifer Lingler, Ellen Wijsman, Lindsay Clark
Summary: The development of biomarkers for Alzheimer's disease (AD) has allowed researchers to improve sample homogeneity and test candidate treatments earlier in the disease. However, it is unknown to what extent standardized methods for disclosing biomarker testing results to research participants are implemented in trials.
ALZHEIMERS & DEMENTIA
(2023)
Article
Neurosciences
Catarina Bernardes, Marisa Lima, Diana Duro, Anuschka Silva-Spinola, Joao Duraes, Miguel Tabuas-Pereira, Ines Baldeiras, Sandra Freitas, Isabel Santana
Summary: This study confirms the role of cerebrospinal fluid Alzheimer's disease biomarkers in predicting conversion from mild cognitive impairment to dementia and suggests the utility of Montreal Cognitive Assessment in predicting conversion in highly educated subjects, supporting its use in the evaluation of MCI patients.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Clinical Neurology
Wayne Silverman, Sharon J. Krinsky-McHale, Warren B. Zigman, Nicole Schupf
Summary: Adults with Down syndrome do not show declines over a 3-year period before the age of 46, but declines are observed at older ages, along with an increase in prodromal AD and dementia incidence. It is expected that significant decline in a 2- to 3-year period for a placebo group in clinical prevention trials will only occur if the group is limited to adults over the age of 45.
ALZHEIMERS & DEMENTIA
(2022)
Article
Clinical Neurology
Farooq Kamal, Cassandra Morrison, Josefina Maranzano, Yashar Zeighami, Mahsa Dadar
Summary: This study aimed to investigate the association between the change in white matter hyperintensities (WMH) burden and conversion to dementia in individuals with mild cognitive impairment (MCI) who are either amyloid-positive (A & beta;+) or amyloid-negative (A & beta;-). The results showed that individuals with A & beta;+ had the highest increase in WMH burden and steepest accumulation over time compared to individuals with A & beta;-.
Article
Medicine, General & Internal
Camilla Elefante, Giulio Emilio Brancati, Zahinoor Ismail, Sara Ricciardulli, Maria Francesca Beatino, Vittoria Lepri, Antonella Fama, Elisabetta Ferrari, Linda Giampietri, Filippo Baldacci, Roberto Ceravolo, Icro Maremmani, Lorenzo Lattanzi, Giulio Perugi
Summary: This study aimed to investigate the prevalence and differentiating features of Mild Behavioral Impairment (MBI) with respect to major neurocognitive disorders (MNDs) and primary psychiatric disorders (PPDs). The results showed that patients with MBI had higher scores of psychopathology, specifically in terms of negative symptoms, compared to patients with PPDs. Additionally, MBI patients frequently reported higher severity of apathy and motor retardation.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Matthew Velazquez, Yugyung Lee
Summary: The study successfully utilized a balanced random forest model to predict the conversion of MCI patients to AD with high accuracy (93.6%), providing a valuable tool for early diagnosis and candidate selection in clinical trials.
Article
Neurosciences
Sarah M. Goldberg, Yanji Zhao, Yu Cheng, Andrea M. Weinstein, Swathi Gujral, Sarah B. Berman, Robert A. Sweet, Meryl A. Butters, Oscar L. Lopez, Beth E. Snitz
Summary: This study contributes to the understanding of early clinical signs and symptoms of Alzheimer's disease and related dementias by examining subjective reports and objective neuropsychological test performance. The study found that both isolated low test scores group and subjective cognitive decline group showed faster cognitive decline risk compared to normal controls, with differences in age, racial identity, and education level.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Review
Geriatrics & Gerontology
Felix Bermejo-Pareja, Israel Contador, Teodoro del Ser, Javier Olazaran, Sara Llamas-Velasco, Saturio Vega, Julian Benito-Leon
Summary: MCI is the most commonly mentioned predementia entity, recognized as a harbinger of dementia caused by various etiologies, mainly MCI due to Alzheimer's disease. The operational definition of MCI has shortcomings, as does the recent miNCD construct. Current data suggest that miNCD is a stricter predementia condition with lower prevalence than MCI, less sensitivity to cognitive decline, and possibly a higher conversion rate to dementia.
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY
(2021)
Article
Clinical Neurology
Benjamin M. Hampstead, Anthony Y. Stringer, Alexandru D. Iordan, Robert Ploutz-Snyder, K. Sathian
Summary: Cognitive training is a potential technique for treating cognitive impairment caused by neurological injury and disease. Different training methods have different mechanisms of action and engage distinct brain regions. Mnemonic strategy training (MST) showed superior effects in the short term and increased activation and functional connectivity in multiple brain regions.
ALZHEIMERS & DEMENTIA
(2023)
Review
Chemistry, Medicinal
Svetlana I. Gavrilova, Anton Alvarez
Summary: Alzheimer's disease is a common neurocognitive disorder and a global health issue, with a growing prevalence worldwide. Developing a disease-modifying therapy has become a priority, and using a combination therapy with multiple drugs or targeting multiple pathways seems to be the most promising strategy for effective treatment and prevention.
MEDICINAL RESEARCH REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Alexander Neumann, Fahri Kucukali, Isabelle Bos, Stephanie J. B. Vos, Sebastiaan Engelborghs, Tim De Pooter, Geert Joris, Peter De Rijk, Ellen De Roeck, Magda Tsolaki, Frans Verhey, Pablo Martinez-Lage, Mikel Tainta, Giovanni Frisoni, Oliver Blin, Jill Richardson, Regis Bordet, Philip Scheltens, Julius Popp, Gwendoline Peyratout, Peter Johannsen, Lutz Froelich, Rik Vandenberghe, Yvonne Freund-Levi, Johannes Streffer, Simon Lovestone, Cristina Legido-Quigley, Mara ten Kate, Frederik Barkhof, Mojca Strazisar, Henrik Zetterberg, Lars Bertram, Pieter Jelle Visser, Christine van Broeckhoven, Kristel Sleegers
Summary: In this study, rare variants in certain genes were found to be associated with Alzheimer's disease biomarkers. Four genes were associated with neuronal injury and inflammation, potentially increasing the risk of dementia by altering cytoskeleton structure and immune activity disinhibition. Two genes were associated with synaptic functioning, but had no consequential effect on AD development.
MOLECULAR PSYCHIATRY
(2022)
Review
Neurosciences
Giovanni B. Frisoni, Daniele Altomare, Dietmar Rudolf Thal, Federica Ribaldi, Rik van der Kant, Rik Ossenkoppele, Kaj Blennow, Jeffrey Cummings, Cornelia van Duijn, Peter M. Nilsson, Pierre-Yves Dietrich, Philip Scheltens, Bruno Dubois
Summary: The amyloid hypothesis has long been the leading model for the pathogenesis of Alzheimer's disease, but a probabilistic model is proposed as an alternative due to the increasing understanding of the complex biology of Alzheimer's disease. This new model suggests that genetic factors, environmental exposures, and lower-risk genes play significant roles in different types of Alzheimer's disease, leading to a better understanding of disease pathophysiology and potentially accelerating the development of prevention and treatment strategies.
NATURE REVIEWS NEUROSCIENCE
(2022)
Article
Geriatrics & Gerontology
Abi Nader Clement, Federica Ribaldi, Giovanni B. Frisoni, Valentina Garibotto, Philippe Robert, Nicholas Ayache, Marco Lorenzi
Summary: This study assessed the validity and generalization of the computational disease progression model SimulAD on a new cohort, and found that it accurately estimated disease severity and had good generalization.
NEUROBIOLOGY OF AGING
(2022)
Article
Clinical Neurology
Anton F. Gietl, Giovanni B. Frisoni
Summary: This article discusses measures to protect the perceived value of study participation and maximize the scientific value in late-phase clinical trials for Alzheimer's disease. It emphasizes the importance of communication strategies, data/sample sharing, and personalized medicine in maintaining positive relationships with trial participants and enhancing the role of clinical investigators.
ALZHEIMERS & DEMENTIA
(2022)
Article
Clinical Neurology
Daniele Altomare, Lyduine Collij, Camilla Caprioglio, Philip Scheltens, Bart N. M. van Berckel, Isadora Lopes Alves, Johannes Berkhof, Yvonne de Gier, Valentina Garibotto, Christian Moro, Lea Poitrine, Julien Delrieu, Pierre Payoux, Laure Saint-Aubert, Jose Luis Molinuevo, Oriol Grau-Rivera, Juan-Domingo Gispert, Carolina Minguillon, Karine Fauria, Marta Felez Sanchez, Andreea Radoi, Alexander Drzezga, Frank Jessen, Claus Escher, Philip Zeyen, Agneta Nordberg, Irina Savitcheva, Vesna Jelic, Zuzana Walker, Ho-Yun Lee, Lean Lee, Jean-Francois Demonet, Sonia Plaza Wuthrich, Rossella Gismondi, Gill Farrar, Frederik Barkhof, Andrew W. Stephens, Giovanni B. Frisoni
Summary: The AMYPAD Diagnostic and Patient Management Study aims to investigate the clinical utility and cost-effectiveness of amyloid-PET in Europe. Participants with subjective cognitive decline, mild cognitive impairment, or dementia were recruited in eight European memory clinics and randomized into three study arms. The baseline features of the participants were representative of a memory clinic population, ensuring the generalizability of the study results.
ALZHEIMERS & DEMENTIA
(2023)
Article
Psychology, Clinical
Graziella Orru, Barbara De Marchi, Giuseppe Sartori, Angelo Gemignani, Cristina Scarpazza, Merylin Monaro, Cristina Mazza, Paolo Roma
Summary: This proof-of-concept paper supports the use of machine learning as a viable alternative to traditional psychometric techniques in developing shorter versions of parent psychological tests. The results show that state-of-the-art machine learning item selection techniques can reduce the length of a test by 72% while capturing 92% of the original test's variance.
CLINICAL NEUROPSYCHOLOGIST
(2023)
Review
Psychology, Multidisciplinary
Elisa Straulino, Cristina Scarpazza, Luisa Sartori
Summary: The study of emotion expression has traditionally focused on prototypical facial expressions, but recent research suggests that emotions are expressed in a more nuanced and dynamic way. Emotion expression involves not only the face, but also the body and the surrounding context. A new and comprehensive approach is needed to fully understand emotion expression.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Psychology, Multidisciplinary
Graziella Orru, Erica Ordali, Merylin Monaro, Cristina Scarpazza, Ciro Conversano, Pietro Pietrini, Angelo Gemignani, Giuseppe Sartori
Summary: This research demonstrates that individual endorsement of questions can be predicted by estimating peers' responses to the same question. The technique of reconstructing individual responses from peers' estimation has been validated and shown to have a high accuracy rate of 70-80%. It is a promising method for malingering detection in forensic settings.
FRONTIERS IN PSYCHOLOGY
(2023)
Review
Psychology, Clinical
Giorgia Cona, Martin Wiener, Francesco Allegrini, Cristina Scarpazza
Summary: Through a meta-analysis of neuroimaging studies, this study identified neural regions commonly activated in aspects of space, time, and numerosity, and examined the existence of gradient transitions between these magnitude representations in the brain. Using the activation likelihood estimation method, the study included 112 experiments for space, 114 experiments for time, and 115 experiments for numerosity, following PRISMA guidelines. The findings revealed a system of brain regions consistently recruited for all three magnitudes, including bilateral insula, the supplementary motor area (SMA), the right inferior frontal gyrus, and bilateral intraparietal sulci. Gradiental transitions were observed in all regions except the insulae, with space and numbers primarily exhibiting gradients over parietal regions (and SMA), while time and numbers mainly showed gradients over frontal regions. These results support the GradiATOM theory, indicating that spatial proximity facilitated by overlapping activations and gradients plays a crucial role in efficient interactions and integrations among magnitudes.
NEUROPSYCHOLOGY REVIEW
(2023)
Article
Behavioral Sciences
Giorgia Cona, Paola Santacesaria, Cristina Scarpazza
Summary: This study found that there is no specific region or network for representing the future, but it seems to be represented on an anterior-posterior tangibility gradient based on the level of concreteness of the simulated scenario. Additionally, future-oriented cognition is mediated by two distinct networks: the Default Network and the Salience Network.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2023)
Article
Psychology, Mathematical
A. Miolla, M. Cardaioli, C. Scarpazza
Summary: Facial expressions are powerful signals for conveying emotional states. Scientific research on emotions has been biased due to reliance on static pictures of posed facial expressions. This dataset provides a large collection of dynamic genuine and posed clips to address this bias.
BEHAVIOR RESEARCH METHODS
(2023)
Review
Clinical Neurology
Femke H. Bouwman, Giovanni B. Frisoni, Sterling C. Johnson, Xiaochun Chen, Sebastiaan Engelborghs, Takeshi Ikeuchi, Claire Paquet, Craig Ritchie, Sasha Bozeat, Frances-Catherine Quevenco, Charlotte Teunissen
Summary: Biomarker testing using cerebrospinal fluid (CSF) is recommended for accurate diagnosis of Alzheimer's disease (AD) and can improve diagnostic accuracy, provide prognostic information, and guide personalized management. CSF ratios perform better than individual markers, and CSF biomarkers should be included in the diagnostic work-up of AD and mild cognitive impairment.
ALZHEIMER'S & DEMENTIA: DIAGNOSIS, ASSESSMENT & DISEASE MONITORING
(2022)
Proceedings Paper
Computer Science, Artificial Intelligence
Francesco Fontanella, Sonia Pinelli, Claudio Babiloni, Roberta Lizio, Claudio Del Percio, Susanna Lopez, Giuseppe Noce, Franco Giubilei, Fabrizio Stocchi, Giovanni B. Frisoni, Flavio Nobili, Raffaele Ferri, Tiziana D'Alessandro, Nicole Dalia Cilia, Claudio De Stefano
Summary: Although there is currently no cure for Alzheimer's disease, predicting the cognitive decline of patients at an early stage of the disease can help alleviate its burden. This study used machine learning tools and EEG-based features to predict the cognitive decline of Alzheimer's patients, and found that at least three scores were effective in accurately predicting the decline.
IMAGE ANALYSIS AND PROCESSING, ICIAP 2022, PT I
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Francesca B. Pizzini, Enrico Conti, Angelo Bianchetti, Alessandra Splendiani, Domenico Fusco, Ferdinando Caranci, Alessandro Bozzao, Francesco Landi, Nicoletta Gandolfo, Lisa Farina, Vittorio Miele, Marco Trabucchi, Giovanni B. Frisoni, Stefano Bastianello
Summary: This article presents a disease-oriented protocol for radiological image evaluation and reporting, aiming to increase diagnostic accuracy and effectiveness of interdisciplinary dialogue for radiologists.
Article
Geriatrics & Gerontology
Sarah N. Kraeutner, Cristina Rubino, Jennifer K. Ferris, Shie Rinat, Lauren Penko, Larissa Chiu, Brian Greeley, Christina B. Jones, Beverley C. Larssen, Lara A. Boyd
Summary: This study examined the age-related changes in brain function and baseline brain structure that support motor skill acquisition. The findings showed that older adults experienced decreases in functional connectivity during motor skill acquisition, while younger adults experienced increases. Additionally, regardless of age group, lower baseline microstructure in a frontoparietal tract was associated with slower motor skill acquisition.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Karen Nuytemans, Farid Rajabli, Melissa Jean-Francois, Jiji Thulaseedhara Kurup, Larry D. Adams, Takiyah D. Starks, Patrice L. Whitehead, Brian W. Kunkle, Allison Caban-Holt, Jonathan L. Haines, Michael L. Cuccaro, Jeffery M. Vance, Goldie S. Byrd, Gary W. Beecham, Christiane Reitz, Margaret A. Pericak-Vance
Summary: This study conducted genetic research on African American AD families and identified a significant linkage signal associated with AD, highlighting the importance of diverse population-level genetic data in understanding the genetic determinants of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Kazuya Suwabe, Ryuta Kuwamizu, Kazuki Hyodo, Toru Yoshikawa, Takeshi Otsuki, Asako Zempo-Miyaki, Michael A. Yassa, Hideaki Soya
Summary: Physical exercise has a positive impact on hippocampal memory decline with aging. Recent studies have shown that even light exercise can improve memory and this improvement is mediated by the ascending arousal system. This study aimed to investigate the effects of light-intensity exercise on hippocampal memory function in healthy older adults and found that pupil dilation during exercise played a role in the memory improvement.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Ajay Sood, Ana Werneck Capuano, Robert Smith Wilson, Lisa Laverne Barnes, Alifiya Kapasi, David Alan Bennett, Zoe Arvanitakis
Summary: The objective of this study was to explore the impact of metformin on cognition and brain pathology. The results showed that metformin users had slower decline in global cognition, episodic memory, and semantic memory compared to non-users. However, the relationship between metformin use and certain brain pathology remains uncertain.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Brian N. Lee, Junwen Wang, Molly A. Hall, Dokyoon Kim, Shana D. Stites, Li Shen
Summary: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory and functional impairments. This study analyzed participants from the Alzheimer's Disease Neuroimaging Initiative and found differential associations between cerebral spinal fluid (CSF)/neuroimaging biomarkers and cognitive/functional outcomes, as well as variations between sexes. These findings suggest that sex differences may play a role in the development of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Madeline R. Hale, Rebecca Langhough, Lianlian Du, Bruce P. Hermann, Carol A. Van Hulle, Margherita Carboni, Gwendlyn Kollmorgenj, Kristin E. Basche, Davide Bruno, Leah Sanson-Miles, Erin M. Jonaitis, Nathaniel A. Chin, Ozioma C. Okonkwo, Barbara B. Bendlin, Cynthia M. Carlsson, Henrik Zetterberg, Kaj Blennow, Tobey J. Betthauser, Sterling C. Johnson, Kimberly D. Mueller
Summary: This study demonstrates a relationship between cerebrospinal fluid biomarkers and the ability to recall proper names in the preclinical phase of Alzheimer's disease.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Thomas T. Austin, Christian L. Thomas, Ben Warren
Summary: This study investigated the effects of age on the robustness and resilience of auditory system using the desert locust. The researchers found that gene expression changes were mainly influenced by age rather than noise exposure. Both young and aged locusts were able to recover their auditory nerve function within 48 hours of noise exposure, but the recovery of transduction current magnitude was impaired in aged locusts. Key genes responsible for robustness to noise exposure in young locusts and potential candidates for compensatory mechanisms in auditory neurons of aged locusts were identified.
NEUROBIOLOGY OF AGING
(2024)
