Article
Clinical Neurology
R. Sky Jones, Manus J. Donahue, L. Taylor Davis, Sumit Pruthi, Spencer L. Waddle, Chelsea Custer, Niral J. Patel, Michael R. DeBaun, Adetola A. Kassim, Mark Rodeghier, Lori C. Jordan
Summary: This study evaluated the reduction of gray matter volume (GMV) and white matter volume (WMV) in children and young adults with sickle cell disease (SCD) using high-resolution MRI. The results showed an association between anemia, low arterial oxygen content, and decreased GMV and WMV. Increased gray matter cerebral blood flow and infarct burden were also associated with reduced volume in subcortical structures. This highlights the potential of brain volume as a biomarker of brain injury in SCD.
FRONTIERS IN NEUROLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Matthew Kiely, Curtis Triebswetter, Zhaoyuan Gong, John P. Laporte, Mary E. FaulknerBs, Mohammad A. B. S. Akhonda, Maryam H. Alsameen, Richard G. Spencer, Mustapha Bouhrara
Summary: This study aimed to assess the association between blood flow and cerebral microstructural integrity and found that global brain perfusion may impact cerebral tissue microstructure.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2023)
Article
Multidisciplinary Sciences
Patricia Clement, Marco Castellaro, Thomas W. Okell, David L. Thomas, Pieter Vandemaele, Sara Elgayar, Aaron Oliver-Taylor, Thomas Kirk, Joseph G. Woods, Sjoerd B. Vos, Joost P. A. Kuijer, Eric Achten, Matthias J. P. van Osch, John A. Detre, Hanzhang Lu, David C. Alsop, Michael A. Chappell, Luis Hernandez-Garcia, Jan Petr, Henk J. M. M. Mutsaerts
Summary: ASL-BIDS is a standardized method for ASL data storage that can improve the reproducibility and data sharing of ASL research.
Article
Radiology, Nuclear Medicine & Medical Imaging
Denise Visser, Sander C. J. Verfaillie, Iris Bosch, Iman Brouwer, Hayel Tuncel, Emma M. Coomans, Roos M. Rikken, Sophie E. Mastenbroek, Sandeep S. V. Golla, Frederik Barkhof, Elsmarieke van de Giessen, Bart N. M. van Berckel, Wiesje M. van der Flier, Rik Ossenkoppele
Summary: The purpose of this study was to investigate the association between Tau pathology, atrophy, and cerebral blood flow (CBF) in Alzheimer's disease (AD). The results showed that increased Tau load was associated with cortical thinning, but not with decreased relative CBF. Baseline Tau PET load was a stronger predictor of cortical thinning than changes in Tau PET signal over time.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Jarith L. Ebenau, Denise Visser, Sander C. J. Verfaillie, Tessa Timmers, Mardou S. S. A. van Leeuwenstijn, Mara ten Kate, Albert D. Windhorst, Frederik Barkhof, Philip Scheltens, Niels D. Prins, Ronald Boellaard, Wiesje M. van der Flier, Bart N. M. van Berckel
Summary: This study investigated the associations between cerebral blood flow (CBF), amyloid burden, and cognition in cognitively normal individuals with subjective cognitive decline (SCD). The results suggest that amyloid accumulation and decrease in rCBF are two parallel disease processes without a fixed order, and both provide unique predictive information for cognitive decline, with each process enhancing the other longitudinally.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2023)
Review
Neurosciences
Genevieve Hayes, Joana Pinto, Sierra N. Sparks, Congxiyu Wang, Sana Suri, Daniel P. Bulte
Summary: Vascular smooth muscle cells (VSMCs) play a vital role in the regulation of cerebrovascular dynamics and may be a sensitive biomarker for neurodegenerative pathologies. They exhibit remarkable plasticity and their dysfunction may contribute to the process of neurodegeneration. External risk factors can also impact vascular function through changes in VSMC morphology. Cerebrovascular reactivity (CVR) is a promising technique for identifying changes in cerebral smooth muscle state.
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Endocrinology & Metabolism
Rachel Heutz, Jurgen Claassen, Sanne Feiner, Aaron Davies, Dewakar Gurung, Ronney B. Panerai, Rianne de Heus, Lucy C. Beishon
Summary: Dynamic cerebral autoregulation (dCA) is a key mechanism that regulates cerebral blood flow in response to transient changes in blood pressure. The literature remains conflicted on whether dCA is altered in Alzheimer's disease (AD) and mild cognitive impairment (MCI). A qualitative synthesis of eight studies suggests no significant difference in dCA parameters for spontaneous fluctuations between AD, MCI, and healthy controls. Limited data on induced fluctuations indicate preserved or possibly better autoregulatory functioning in AD and MCI compared to controls. Further research is needed to investigate dCA in dementia with induced fluctuations controlling for changes in end-tidal carbon dioxide.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Endocrinology & Metabolism
Fiona Heeman, Denise Visser, Maqsood Yaqub, Sander Verfaillie, Tessa Timmers, Yolande A. L. Pijnenburg, Wiesje M. van der Flier, Bart N. M. van Berckel, Ronald Boellaard, Adriaan A. Lammertsma, Sandeep S. Golla
Summary: Alzheimer's disease is characterized by reduced cerebral blood flow. This study compared the precision of different methods for measuring cerebral blood flow and found that relative blood flow methods had better repeatability than absolute blood flow methods. The high precision of relative blood flow may be due to a compensatory effect of the extraction fraction.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Review
Medicine, General & Internal
Anders Wahlin, Anders Eklund, Jan Malm
Summary: 4D flow MRI is a valuable technique for studying cerebrovascular diseases, providing crucial information about cerebral arterial venous blood flow and hemodynamic biomarkers indicative of cerebrovascular health. It allows for the investigation of different flow patterns and estimation of brain-wide disturbances in blood flow, which is important for prevention and intervention of cerebrovascular diseases.
JOURNAL OF INTERNAL MEDICINE
(2022)
Article
Neurosciences
Candice E. Van Skike, Stacy A. Hussong, Stephen F. Hernandez, Andy Q. Banh, Nicholas DeRosa, Veronica Galvan
Summary: The study reveals that in an Alzheimer's disease model, mTOR drives impairments in neurovascular coupling (NVC) through inhibition of neuronal nitric oxide synthase (nNOS) and non-NOS-dependent components. However, attenuation of mTOR activity effectively restores NVC function and can even enhance it above normal responses. This suggests that targeting mTOR may be a potential treatment for Alzheimer's disease and other neurological diseases associated with aging.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Clinical Neurology
Min Wang, Junyan Lv, Xiaoshan Huang, Thomas Wisniewski, Wei Zhang
Summary: Epidemiological studies suggest a link between vascular disease risk factors and Alzheimer's disease. A study on 3 x Tg mice found that a high-fat diet exacerbated memory deficits, led to blood hypercoagulation, platelet activation, formation of fibrillar Aβ aggregates, obstructed cerebral blood vessels, and induced neuroinflammation, tau hyperphosphorylation, and neuron loss. Disaggregating platelet micro-clots reduced Aβ aggregates and improved vascular permeability.
ALZHEIMERS RESEARCH & THERAPY
(2021)
Article
Endocrinology & Metabolism
Khazar Ahmadi, Joana B. Pereira, David Berron, Jacob Vogel, Silvia Ingala, Olof T. Strandberg, Shorena Janelidze, Frederik Barkhof, Josef Pfeuffer, Linda Knutsson, Danielle van Westen, Sebastian Palmqvist, Henk J. M. M. Mutsaerts, Oskar Hansson
Summary: This study investigated the role of decreased cerebral blood flow in Alzheimer's disease and found that tau tangles and neurodegeneration are more closely connected with GM-CBF changes than A beta pathology.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Endocrinology & Metabolism
Fiona Heeman, Maqsood Yaqub, Isadora Lopes Alves, Kerstin Heurling, Santiago Bullich, Juan D. Gispert, Ronald Boellaard, Adriaan A. Lammertsma
Summary: This study evaluated the effects of global and regional cerebral blood flow changes on amyloid quantification using PET imaging. RLogan method was found to be the preferable choice for accurate quantification of amyloid load in [F-18]flutemetamol and [F-18]florbetaben studies.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2021)
Article
Endocrinology & Metabolism
Alicen A. Whitaker, Saniya Waghmare, Robert N. Montgomery, Stacey E. Aaron, Sarah M. Eickmeyer, Eric D. Vidoni, Sandra A. Billinger
Summary: Individuals post-stroke had lower middle cerebral artery blood velocity during high-intensity interval training compared to their peers, and this difference persisted 30 minutes after training. Arterial stiffness may contribute to the lower cerebrovascular responsiveness post-stroke.
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM
(2023)
Article
Geriatrics & Gerontology
Lidia Glodzik, Henry Rusinek, Tracy Butler, Yi Li, Pippa Storey, Elizabeth Sweeney, Ricardo S. Osorio, Adrienne Biskaduros, Emily Tanzi, Patrick Harvey, Christopher Woldstad, Thomas Maloney, Mony J. de Leon
Summary: Obesity is associated with hippocampal hemodynamic impairment, suggesting that targeting obesity is an important prevention strategy.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Neurosciences
Weixiong Jiang, Han Zhang, Ling-Li Zeng, Hui Shen, Jian Qin, Kim-Han Thung, Pew-Thian Yap, Huasheng Liu, Dewen Hu, Wei Wang, Dinggang Shen
Summary: This study utilized low-frequency fluctuations of dynamic functional connectivity to identify potential system-level neural correlates with ASB. The results show that individual ASB scores are associated with dynamic functional connectivity, particularly with inter-network connections, and that impaired behavior in ASB subjects is related to decreased FC dynamics in certain cognitive and sensorimotor networks.
HUMAN BRAIN MAPPING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Zixuan Lin, Dengrong Jiang, Dapeng Liu, Yang Li, Jinsoo Uh, Xirui Hou, Jay J. Pillai, Qin Qin, Yulin Ge, Hanzhang Lu
Summary: The new method can measure BBB permeability to water within 5 minutes with an intrasession, intersession, and inter-vendor test-retest reproducibility of 6% to 9%. This method may provide a useful marker of BBB breakdown in clinical studies.
MAGNETIC RESONANCE IN MEDICINE
(2021)
Article
Oncology
Jinsoo Uh, Chuang Wang, Sahaja Acharya, Matthew J. Krasin, Chia-ho Hua
Summary: The study aimed to train a deep neural network for correcting abdominal and pelvic CBCT images of children and young adults, taking into account diverse patient size, anatomic extent, and scan parameters. The network model trained with the combined dataset outperformed abdomen and pelvis models in correcting CBCT images, confirming the efficacy of combining data and standardizing body size.
RADIOTHERAPY AND ONCOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Chuang Wang, Jinsoo Uh, Tushar Patni, Thomas Merchant, Yimei Li, Chia-ho Hua, Sahaja Acharya
Summary: This study aimed to generate synthetic relative proton stopping power (sRPSP) images from magnetic resonance imaging (MRI) for proton planning and develop an online quality assurance (QA) tool for accurate integration into clinical practice. Results showed that sRPSP images generated from single T1W or T2W sequences outperformed those from multi-MRI sequences in terms of error, with preprocessing further reducing errors.
Article
Oncology
Vadim P. Moskvin, Fakhriddin Pirlepesov, Yue Yan, Ozgur Ates, William J. Myers, Jinsoo Uh, Li Zhao, Nadav Shapira, Yoad Yagil, Thomas E. Merchant, Chia-ho Hua
Editorial Material
Critical Care Medicine
James J. Gugger, Ramon Diaz-Arrastia
NEUROCRITICAL CARE
(2022)
Article
Oncology
J. Uh, J. A. Jordan, A. S. Pappo, M. J. Krasin, C. Hua
Summary: The purpose of this study is to characterize the changes in tumor volume in children with parameningeal rhabdomyosarcoma receiving upfront proton therapy with concurrent chemotherapy. The findings suggest that there is a significant reduction in tumor volume within three weeks after simulation, indicating a need for on-treatment imaging at this time point.
Article
Clinical Neurology
Jens Witsch, David Roh, Stephanie Oh, Costantino Iadecola, Ramon Diaz-Arrastia, Scott E. Kasner, Stephan A. Mayer, Santosh B. Murthy
Summary: Neutrophil-mediated inflammation exacerbates intracerebral hemorrhage (ICH) outcomes. This study aimed to investigate the association between serum levels of sICAM-1 and poor outcomes after ICH. After adjustment, sICAM-1 was found to be associated with mortality, poor outcome, and hematoma expansion.
Article
Medical Laboratory Technology
Jennifer G. Cooper, Sophie Stukas, Mohammad Ghodsi, Nyra Ahmed, Ramon Diaz-Arrastia, Daniel T. Holmes, Cheryl L. Wellington
Summary: This study aimed to establish reference intervals (RI) for plasma protein biomarkers relevant to neurological diseases and disorders using a large Canadian population-based cohort. The study generated discrete and continuous RIs for each biomarker at different age partitions. These RIs can refine normative cut-offs and improve the precision of interpreting biomarker levels.
CLINICAL BIOCHEMISTRY
(2023)
Article
Clinical Neurology
Shawn R. Eagle, Ava M. Puccio, Lindsay D. Nelson, Michael McCrea, Joseph Giacino, Ramon Diaz-Arrastia, William Conkright, Sonia Jain, Xiaoying Sun, Geoffrey Manley, David O. Okonkwo
Summary: Obesity is associated with higher symptomatology and blood inflammatory markers in recovery following mTBI. The study found that obese patients had higher concentrations of hsCRP and IL-6 at multiple time points after injury, as well as higher RPQ scores at 6 and 12 months.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Engineering, Biomedical
Jinsoo Uh, Chuang Wang, Jacob A. Jordan, Fakhriddin Pirlepesov, Jared B. Becksfort, Ozgur Ates, Matthew J. Krasin, Chia-Ho Hua
Summary: This study developed a novel method to generate synthetic CT (sCT) from CBCT of the abdomen/pelvis with gas pockets, improving the accuracy of proton range estimation for proton therapy. The hybrid method combining CycleGAN and DIR effectively generated the geometry-weighted and intensity-weighted components of sCT, resulting in more accurate CT numbers and better similarity in gas regions compared to deformed pCT or CycleGAN-only sCT. The hybrid method also showed advantages in proton range verification and adaptive replanning.
PHYSICS IN MEDICINE AND BIOLOGY
(2023)
Article
Oncology
Ozgur Ates, Jinsoo Uh, Fakhriddin Pirlepesov, Chia-Ho Hua, Brandon Triplett, Amr Qudeimat, Akshay Sharma, Thomas E. Merchant, John T. Lucas Jr
Summary: This study addresses the challenge of respiratory motion in pediatric patients undergoing proton therapy for total lymphoid irradiation (TLI). The research concludes that 4D plan evaluation and robust optimization techniques can help address respiratory motion challenges in proton TLI treatments. Patient-specific respiratory motion evaluations are crucial to ensure adequate dosimetric coverage in proton therapy for pediatric patients.
Article
Oncology
Jared Becksfort, Jinsoo Uh, Andrew Saunders, Julia A. Byrd, Hannah M. Worrall, Matt Marker, Christian Melendez-Suchi, Yimei Li, Jenghwa Chang, Kavitha Raghavan, Thomas E. Merchant, Chia-ho Hua
Summary: This study investigates the setup uncertainty in brain tumor patients undergoing image-guided proton therapy. Daily cone-beam computed tomography (CBCT) scans were performed, and statistical approaches were used to calculate and correct manual setup errors, measure residual errors, and assess intrafractional motion. The study found that CBCT reduced the 95th percentile of setup uncertainty, and there was a larger variation in roll corrections reported by radiographs compared to CBCT. The study also showed that anesthetized patients had lower intrafractional motion. The findings provide important insights for designing safe and optimal proton treatments.
Article
Neuroimaging
Pratusha Reddy, Kurtulus Izzetoglu, Patricia A. Shewokis, Michael Sangobowale, Ramon Diaz-Arrastia
Summary: The damage to the cerebrovascular network is a common feature of traumatic brain injury (TBI). This study found significant differences in the time-frequency characteristics of fNIRS signal components between healthy controls and TBI patients, and these differences changed across phases of the injury.
NEUROIMAGE-CLINICAL
(2023)
Article
Oncology
Chuang Wang, Jinsoo Uh, Thomas E. Merchant, Chia-ho Hua, Sahaja Acharya
Summary: The novel cycle-GAN model with self-attention outperforms conventional cycle-GAN for children with brain tumors. Encouraging dosimetric results suggest that sCT generation can be used to identify patients who would benefit from adaptive replanning.
INTERNATIONAL JOURNAL OF PARTICLE THERAPY
(2022)
Article
Geriatrics & Gerontology
Sarah N. Kraeutner, Cristina Rubino, Jennifer K. Ferris, Shie Rinat, Lauren Penko, Larissa Chiu, Brian Greeley, Christina B. Jones, Beverley C. Larssen, Lara A. Boyd
Summary: This study examined the age-related changes in brain function and baseline brain structure that support motor skill acquisition. The findings showed that older adults experienced decreases in functional connectivity during motor skill acquisition, while younger adults experienced increases. Additionally, regardless of age group, lower baseline microstructure in a frontoparietal tract was associated with slower motor skill acquisition.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Karen Nuytemans, Farid Rajabli, Melissa Jean-Francois, Jiji Thulaseedhara Kurup, Larry D. Adams, Takiyah D. Starks, Patrice L. Whitehead, Brian W. Kunkle, Allison Caban-Holt, Jonathan L. Haines, Michael L. Cuccaro, Jeffery M. Vance, Goldie S. Byrd, Gary W. Beecham, Christiane Reitz, Margaret A. Pericak-Vance
Summary: This study conducted genetic research on African American AD families and identified a significant linkage signal associated with AD, highlighting the importance of diverse population-level genetic data in understanding the genetic determinants of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Kazuya Suwabe, Ryuta Kuwamizu, Kazuki Hyodo, Toru Yoshikawa, Takeshi Otsuki, Asako Zempo-Miyaki, Michael A. Yassa, Hideaki Soya
Summary: Physical exercise has a positive impact on hippocampal memory decline with aging. Recent studies have shown that even light exercise can improve memory and this improvement is mediated by the ascending arousal system. This study aimed to investigate the effects of light-intensity exercise on hippocampal memory function in healthy older adults and found that pupil dilation during exercise played a role in the memory improvement.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Ajay Sood, Ana Werneck Capuano, Robert Smith Wilson, Lisa Laverne Barnes, Alifiya Kapasi, David Alan Bennett, Zoe Arvanitakis
Summary: The objective of this study was to explore the impact of metformin on cognition and brain pathology. The results showed that metformin users had slower decline in global cognition, episodic memory, and semantic memory compared to non-users. However, the relationship between metformin use and certain brain pathology remains uncertain.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Brian N. Lee, Junwen Wang, Molly A. Hall, Dokyoon Kim, Shana D. Stites, Li Shen
Summary: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory and functional impairments. This study analyzed participants from the Alzheimer's Disease Neuroimaging Initiative and found differential associations between cerebral spinal fluid (CSF)/neuroimaging biomarkers and cognitive/functional outcomes, as well as variations between sexes. These findings suggest that sex differences may play a role in the development of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Madeline R. Hale, Rebecca Langhough, Lianlian Du, Bruce P. Hermann, Carol A. Van Hulle, Margherita Carboni, Gwendlyn Kollmorgenj, Kristin E. Basche, Davide Bruno, Leah Sanson-Miles, Erin M. Jonaitis, Nathaniel A. Chin, Ozioma C. Okonkwo, Barbara B. Bendlin, Cynthia M. Carlsson, Henrik Zetterberg, Kaj Blennow, Tobey J. Betthauser, Sterling C. Johnson, Kimberly D. Mueller
Summary: This study demonstrates a relationship between cerebrospinal fluid biomarkers and the ability to recall proper names in the preclinical phase of Alzheimer's disease.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Thomas T. Austin, Christian L. Thomas, Ben Warren
Summary: This study investigated the effects of age on the robustness and resilience of auditory system using the desert locust. The researchers found that gene expression changes were mainly influenced by age rather than noise exposure. Both young and aged locusts were able to recover their auditory nerve function within 48 hours of noise exposure, but the recovery of transduction current magnitude was impaired in aged locusts. Key genes responsible for robustness to noise exposure in young locusts and potential candidates for compensatory mechanisms in auditory neurons of aged locusts were identified.
NEUROBIOLOGY OF AGING
(2024)
