期刊
NEUROBIOLOGY OF AGING
卷 31, 期 1, 页码 114-117出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2008.03.008
关键词
Pitx3; Ptx3; Dopamine; Substantia nigra; Dopaminergic neurons; PD; Neuronal development
资金
- Swedish Brain Power Initiative
- Swedish Research Council
- Swedish Parkinson foundation
- Swedish Brain foundation
- Ahlen's foundation
- Bergvall's foundation
- Hedberg's foundation
- Hallsten's foundation
- Lundberg's foundation
- Royal Society of Arts and Sciences in Goteborg and Karolinska Institutet funds
PITX3 is a transcription factor of importance for the differentiation and survival of midbrain dopaminergic neurons, the gene of which is disrupted in a putative mouse model for Parkinson's disease (PD). The A-allele of a HapMap, tagging SNP (rs4919621) that was genotyped in a population of 361 PD patients, 69 of which had early onset, and in 333 controls, was significantly more common in PD patients with an early age of onset when compared either to controls (p = 0.002) or to PD patients with late onset (p = 0.001). In contrast, a previous finding suggesting a SNP (rs3758549) in the putative promoter region of the PITX3 gene to be associated with PD could not be replicated. (C) 2008 Elsevier Inc. All rights reserved.
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