期刊
NEUROBIOLOGY OF AGING
卷 30, 期 11, 页码 1890-1891出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2008.01.006
关键词
Alzheimer's disease; Genetics; DAPK 1; ABCA2; Chromosome 9
资金
- National Institute on Aging [AG13672, AG05133]
Recently genetic variation in the DAPK1 and ABCA2 genes has been reported to be associated with late- and early-onset Alzheimer's disease (AD), respectively. We examined the most significant two single-nucleotide polymorphisms (SNPs) in DAPK1 in a large case-control cohort of late-onset subjects and matched controls and one of the most significant SNPs in ABCA2 in a small set of early-onset subjects as well. We did not detect associations with AD for any variation. (C) 2008 Elsevier Inc. All fights reserved.
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