Article
Neurosciences
Xiaocao Liu, Qingze Zeng, Xiao Luo, Kaicheng Li, Xiaopei Xu, Luwei Hong, Jixuan Li, Xiaojun Guan, Xiaojun Xu, Peiyu Huang, Min-Ming Zhang
Summary: This study investigated the effect of the APOE epsilon 2 allele on basal forebrain cholinergic system functional connectivity in cognitively normal and mild cognitive impairment patients. The results showed an interaction effect between APOE epsilon 2 genotype and functional connectivity, and the functional connectivity was associated with cognitive performance. Therefore, the APOE epsilon 2 genotype may have a protective role in mild cognitive impairment.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Neurosciences
Jung-Min Pyun, Young Ho Park, Keon-Joo Lee, SangYun Kim, Andrew J. Saykin, Kwangsik Nho
Summary: The study found that polygenic risk scores (PRS) could predict the risk of MCI patients progressing to dementia, with a stronger association in APOE epsilon 4 non-carriers.
TRANSLATIONAL NEURODEGENERATION
(2021)
Article
Clinical Neurology
Bin Jiao, Rihui Li, Hui Zhou, Kunqiang Qing, Hui Liu, Hefu Pan, Yanqin Lei, Wenjin Fu, Xiaoan Wang, Xuewen Xiao, Xixi Liu, Qijie Yang, Xinxin Liao, Yafang Zhou, Liangjuan Fang, Yanbin Dong, Yuanhao Yang, Haiyan Jiang, Sha Huang, Lu Shen
Summary: This study aimed to identify effective EEG biomarkers for distinguishing early-stage AD patients and monitoring disease progression. The results showed that EEG biomarkers can be used for the diagnosis and evaluation of MCI and AD.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Neurosciences
Ioanna Katzourou, Ganna Leonenko, Dobril Ivanov, Alun Meggy, Rachel Marshall, Rebecca Sims, Julie Williams, Peter Holmans, Valentina Escott-Price
Summary: This study aimed to explore the genetic architecture of cognitive decline in AD patients, and found no significant association between APOE ε2 or ε4 alleles and the rate of cognitive decline. Further exploration is needed to uncover possible genetic variants that affect the rate of decline in patients with AD.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Clinical Neurology
Emrah Duezel, Gabriel Ziegler, David Berron, Anne Maass, Hartmut Schuetze, Arturo Cardenas-Blanco, Wenzel Glanz, Coraline Metzger, Laura Dobisch, Martin Reuter, Annika Spottke, Frederic Brosseron, Klaus Fliessbach, Michael T. Heneka, Christoph Laske, Oliver Peters, Josef Priller, Eike Jakob Spruth, Alfredo Ramirez, Oliver Speck, Anja Schneider, Stefan Teipel, Ingo Kilimann, Wiltfang Jens, Bjoern-Hendrik Schott, Lukas Preis, Daria Gref, Franziska Maier, Matthias H. Munk, Nina Roy, Tomasso Ballarini, Renat Yakupov, John Dylan Haynes, Peter Dechent, Klaus Scheffler, Michael Wagner, Frank Jessen
Summary: This study investigated whether the impact of tau-pathology on memory performance and hippocampal/medial temporal memory function depends on the presence of amyloid pathology. The results showed a linear relationship between amyloid pathology, tau pathology, hippocampal dysfunction, and memory impairment.
Article
Biochemistry & Molecular Biology
Wenjing Li, Yinhua Zhou, Zhaofan Luo, Rixin Tang, Yuxuan Sun, Qiangsheng He, Bin Xia, Kuiqing Lu, Qinghua Hou, Jinqiu Yuan
Summary: This study aims to construct a lipid score system to predict the risk of progression from mild cognitive impairment (MCI) to Alzheimer's disease (AD). The results showed that the lipid score system based on serum lipidomics can accurately predict the progression risk from MCI to AD.
Article
Clinical Neurology
Benjamin M. Hampstead, Anthony Y. Stringer, Alexandru D. Iordan, Robert Ploutz-Snyder, K. Sathian
Summary: Cognitive training is a potential technique for treating cognitive impairment caused by neurological injury and disease. Different training methods have different mechanisms of action and engage distinct brain regions. Mnemonic strategy training (MST) showed superior effects in the short term and increased activation and functional connectivity in multiple brain regions.
ALZHEIMERS & DEMENTIA
(2023)
Article
Neurosciences
Dianxu Ren, Oscar L. Lopez, Jennifer H. Lingler, Yvette Conley
Summary: The study found that the APOE epsilon 2/epsilon 4 genotype is not significantly associated with the risk of Alzheimer's disease and mild cognitive impairment among African Americans.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Neurosciences
Una Smailovic, Charlotte Johansson, Thomas Koenig, Ingemar Kareholt, Caroline Graff, Vesna Jelic
Summary: The study found that carriers of the APOE ε 4 allele exhibit increased global EEG power in the beta band and decreased global synchronization in theta and beta bands. These EEG characteristics may represent a compensatory mechanism for brain function in APOE ε 4 carriers with AD. The findings suggest that decreased EEG measures of global synchronization in theta and beta bands are indicative of brain functional deficits related to the APOE ε 4 genotype in patients on a biomarker-verified AD continuum.
Article
Geriatrics & Gerontology
Michal S. Beeri, Sue E. Leugrans, Osvaldo Delbono, David A. Bennett, Aron S. Buchman
Summary: In this study, poor muscle function, rather than reduced lean muscle mass, was found to be associated with late-life cognitive impairment, including incident Alzheimer's dementia, mild cognitive impairment, and cognitive decline. Further research is needed to identify muscle structure features that may enhance the specificity of sarcopenia in identifying older adults at risk for late-life cognitive impairment.
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY
(2021)
Editorial Material
Cell Biology
Zhuang-Yao D. Wei, Ashok K. Shetty
Summary: This article discusses a recent study that suggests using a miRNA triad, consisting of miR-181a-5p, miR-146a-5p, and miR-148a-3p, for diagnosing ACI, MCI, and AD. The study explores the impact of elevated levels of this miRNA triad on neural plasticity and cognitive function in the brain and the potential of inhibiting it to improve cognitive function in MCI and AD.
Article
Neurosciences
Marina Botello-Marabotto, M. Carmen Martinez-Bisbal, Miguel Calero, Andrea Bernardos, Ana B. Pastor, Miguel Medina, Ramon Martinez-Manez
Summary: This study employed 1H NMR spectroscopy to conduct a metabolomic study in serum samples from patients with Alzheimer's disease (AD), mild cognitive impairment (MCI), and cognitively healthy controls (HC). The aim was to search for potential metabolite biomarkers. The results highlight the potential of 1H NMR metabolomics to support the diagnosis of dementia in a less invasive way, and provide a starting point for the study of potential biomarkers to identify MCI or HC subjects at risk of developing AD in the future.
NEUROBIOLOGY OF DISEASE
(2023)
Article
Multidisciplinary Sciences
Matthew Velazquez, Yugyung Lee
Summary: The study successfully utilized a balanced random forest model to predict the conversion of MCI patients to AD with high accuracy (93.6%), providing a valuable tool for early diagnosis and candidate selection in clinical trials.
Article
Neurosciences
Lingyu Zhang, Yu Fu, Ziyang Zhao, Zhaoyang Cong, Weihao Zheng, Qin Zhang, Zhijun Yao, Bin Hu
Summary: This study investigated the temporal evolution pattern of MCI and the conversion to AD using multivariate morphometry statistics as features. The atrophy of hippocampus in MCI patients showed a specific distribution pattern, with the introduction of longitudinal information significantly improving the accuracy of conversion prediction.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Clinical Neurology
Allan I. Levey, Deqiang Qiu, Liping Zhao, William T. Hu, Duc M. Duong, Lenora Higginbotham, Eric B. Dammer, Nicholas T. Seyfried, Thomas S. Wingo, Chadwick M. Hales, Malu Gamez Tansey, David S. Goldstein, Anees Abrol, Vince D. Calhoun, Felicia C. Goldstein, Ihab Hajjar, Anne M. Fagan, Doug Galasko, Steven D. Edland, John Hanfelt, James J. Lah, David Weinshenker
Summary: The study demonstrated that atomoxetine, a clinically approved noradrenaline reuptake inhibitor, improved multiple Alzheimer's disease biomarkers in individuals with mild cognitive impairment. Treatment with atomoxetine significantly reduced CSF levels of Tau and pTau, normalized CSF protein biomarker panels linked to synaptic function, brain metabolism, and glial immunity, and increased brain activity and metabolism in key temporal lobe circuits.
Article
Allergy
Montserrat Fernandez-Rivas, Ismael Gomez Garcia, Alejandro Gonzalo-Fernandez, Manuel Fuentes Ferrer, Sabine Dolle-Bierke, Guadalupe Marco-Martin, Barbara K. Ballmer-Weber, Riccardo Asero, Simona Belohlavkova, Kirsten Beyer, Frederic de Blay, Michael Clausen, Mareen R. Datema, Ruta Dubakiene, Kate E. C. Grimshaw, Karin Hoffmann-Sommergruber, Jonathan O'B Hourihane, Monika Jedrzejczak-Czechowicz, Andre C. Knulst, Tanya Kralimarkova, Thuy-My Le, Nikolaos G. Papadopoulos, Todor A. Popov, Lars K. Poulsen, Ashok Purohit, Suranjith L. Seneviratne, Angela Simpson, Atanasios Sinaniotis, Mirjana Turkalji, Sonia Vazquez-Cortes, Rosialzira N. Vera-Berrios, Antonella Muraro, Margitta Worm, Graham Roberts, Ronald van Ree, Cristina Fernandez-Perez, Paul J. Turner, Elizabeth N. Clare Mills
Summary: The study team developed and validated a severity score for food allergic reactions, with ordinal and numerical formats. Through internal and external validation, the score demonstrated good discrimination, classification, and calibration in emergency situations.
Article
Cardiac & Cardiovascular Systems
Pilar Jimenez-Quevedo, Esther Bernardo, Maria Del Trigo, Shuji Otsuki, Luis Nombela-Franco, Salvatore Brugaletta, Arancha Ortega-Pozi, Raul Herrera, Pablo Salinas, Ivan Nunez-Gil, Hernan Mejia-Renteria, Fernando Alfonso, Cristina Fernandez-Perez, Antonio Fernandez-Ortiz, Carlos Macaya, Javier Escaned, Manel Sabate, Nieves Gonzalo
Summary: This study aimed to investigate the relationship between circulating progenitor cells (CPC) levels and peri-procedural vascular damage, as well as stent healing, following everolimus-eluting stent (EES) implantation. The study found that an increase in CD133+/KDR+/CD45low levels one week after EES implantation was associated with vascular injury score, and the maximum neointimal thickness at a 9-month follow up. In addition, there was an inverse relationship between the changes in CPC levels and the number of uncoated and apposed struts at the 9-month follow up and one week. These findings suggest that the extent of vessel wall injury impacts early changes in CPC levels and has an effect on mid-term vascular healing after EES implantation.
CIRCULATION JOURNAL
(2022)
Article
Ophthalmology
L. Salazar-Quinones, C. Yu-Wai-Man, A. De Antonio Ramirez, C. D. Mendez-Hernandez, A. Daas, J. Garcia-Feijoo, E. Guzman-Almagro, C. Fernandez-Perez, K. Sheng Lim
Summary: This study compares the peripapillary and optic nerve head vessel density between glaucoma patients and healthy subjects of Afro-Caribbean and European descent. The results show that healthy subjects of Afro-Caribbean descent have lower vessel density compared to those of European descent, but there are no significant differences in vessel density among glaucoma patients. The vessel density is strongly correlated with the severity of visual field damage.
JOURNAL FRANCAIS D OPHTALMOLOGIE
(2022)
Article
Health Care Sciences & Services
Ines Lopez-Cuenca, Elena Salobrar-Garcia, Ines Gil-Salgado, Lidia Sanchez-Puebla, Lorena Elvira-Hurtado, Jose A. Fernandez-Albarral, Federico Ramirez-Torano, Ana Barabash, Jaisalmer de Frutos-Lucas, Juan J. Salazar, Jose M. Ramirez, Ana Ramirez, Rosa de Hoz
Summary: Having a family history and carrying ApoE gene are risk factors for Alzheimer's disease, while both Alzheimer's disease and age-related macular degeneration share some risk factors. However, the role of ApoE gene in these diseases is controversial. This study analyzed retinal drusen using optical coherence tomography and found no relationship between family history or ApoE gene and the presence of drusen. Subjects with drusen showed choroidal thinning, which may contribute to the formation of drusen.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Article
Clinical Neurology
Ines Lopez-Cuenca, Alberto Marcos-Dolado, Miguel Yus-Fuertes, Elena Salobrar-Garcia, Lorena Elvira-Hurtado, Jose A. Fernandez-Albarral, Juan J. Salazar, Ana Ramirez, Lidia Sanchez-Puebla, Manuel Enrique Fuentes-Ferrer, Ana Barabash, Federico Ramirez-Torano, Lidia Gil-Martinez, Juan Arrazola-Garcia, Pedro Gil, Rosa de Hoz, Jose M. Ramirez
Summary: In individuals at high genetic risk of developing sporadic AD, significant correlations were found between retinal changes and brain areas closely related to the disease.
ALZHEIMERS RESEARCH & THERAPY
(2022)
Article
Medicine, General & Internal
Ines Lopez-Cuenca, Elena Salobrar-Garcia, Lidia Sanchez-Puebla, Eva Espejel, Lucia Garcia del Arco, Pilar Rojas, Lorena Elvira-Hurtado, Jose A. Fernandez-Albarral, Federico Ramirez-Torano, Ana Barabash, Juan J. Salazar, Jose M. Ramirez, Rosa de Hoz, Ana Ramirez
Summary: By using optical coherence tomography angiography (OCTA) analysis, it was discovered that patients with a high genetic risk of developing Alzheimer's disease showed a significant increase in retinal vascular density, which may serve as one of the earliest detectable vascular changes and a promising biomarker for monitoring disease progression.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Nutrition & Dietetics
Macarena Torrego-Ellacuria, Ana Barabash, Pilar Matia-Martin, Andres Sanchez-Pernaute, Antonio J. Torres, Alfonso L. Calle-Pascual, Miguel A. Rubio-Herrera
Summary: The study examined the association between single nucleotide polymorphisms (SNPs) of the CLOCK gene and obesity, as well as long-term weight response following bariatric surgery. The findings showed that certain SNPs were significantly associated with obesity and had an impact on long-term weight loss and regain after surgery.
Article
Clinical Neurology
Ines Lopez-Cuenca, Alberto Nebreda, Alejandra Garcia-Colomo, Elena Salobrar-Garcia, Jaisalmer de Frutos-Lucas, Ricardo Bruna, Ana I. Ramirez, Federico Ramirez-Torano, Juan J. Salazar, Ana Barabash, Pedro Gil, Fernando Maestu, Jose M. Ramirez, Rosa de Hoz
Summary: The earliest pathological features of Alzheimer's disease (AD) can be observed in the brain and the eye decades before clinical symptoms appear. This study investigates the relationship between ophthalmological measures and visual-related electrophysiological activity in healthy individuals at different risks of developing AD. The results reveal novel findings, including an increase in visual acuity among high-risk subjects and a correlation between visual acuity and visual-related electrophysiological activity.
ALZHEIMERS RESEARCH & THERAPY
(2023)
Article
Oncology
Sergio Garcia-Martinez, Daniel Gonzalez-Gamo, Sofia Elena Tesolato, Ana Barabash, Sofia Cristina de la Serna, Inmaculada Dominguez-Serrano, Jana Dziakova, Daniel Rivera, Antonio Jose Torres, Pilar Iniesta
Summary: It has been found that there is a correlation between obesity and the development of colorectal cancer, but specific biomarkers linking the degree of obesity to the clinical evolution of colorectal cancer patients have not been defined. Through a study on 147 colorectal cancer patients, it was discovered that both the relative telomere length and the activity of telomerase in adipose tissues may serve as parameters of interest in the clinical evaluation of individuals with colorectal cancer.
Article
Biotechnology & Applied Microbiology
Pilar Martin-Escudero, Ana Maria Cabanas, Maria Luisa Dotor-Castilla, Mercedes Galindo-Canales, Francisco Miguel-Tobal, Cristina Fernandez-Perez, Manuel Fuentes-Ferrer, Romano Giannetti
Summary: The market for wrist-worn devices is growing rapidly, but there is a lack of research on their accuracy in different populations and activities. This study compared heart rate measurements of four popular wrist-worn devices and found that they were reasonably accurate at low activity levels, but tended to underestimate heart rate values during intense physical effort. It is essential to evaluate wrist-worn wearable technology in order to fully understand its impact on psychological and physical health, especially during high-intensity exercise.
BIOENGINEERING-BASEL
(2023)
Article
Nutrition & Dietetics
Ana M. Lorenzo-Mora, Ana M. Lopez-Sobaler, Laura M. Bermejo, Liliana G. Gonzalez-Rodriguez, Esther Cuadrado-Soto, Africa Peral-Suarez, Maria Dolores Salas-Gonzalez, Maria Luisa Delgado-Losada, Inmaculada C. Rodriguez-Rojo, Ana Barabash, Fernando Maestu-Unturbe, Aranzazu Aparicio
Summary: This study found that low mineral intake, especially low iron and manganese intake in women, is associated with worse cognitive performance as assessed by MoCA. These findings emphasize the importance of mineral intake for cognitive function.
Article
Nutrition & Dietetics
Veronica Melero, Maria Arnoriaga, Ana Barabash, Johanna Valerio, Laura del Valle, Rocio Martin O'Connor, Maria Paz de Miguel, Jose Angel Diaz, Cristina Familiar, Inmaculada Moraga, Alejandra Duran, Martin Cuesta, Maria Jose Torrejon, Mercedes Martinez-Novillo, Maria Moreno, Gisela Romera, Isabelle Runkle, Mario Pazos, Miguel A. A. Rubio, Pilar Matia-Martin, Alfonso Luis Calle-Pascual
Summary: A Mediterranean diet-based intervention in early pregnancy reduces the rate of postpartum metabolic disorders, and these effects remain significant at 3 years postpartum.
Article
Medicine, General & Internal
Macarena Torrego-Ellacuria, Ana Barabash, Pilar Matia-Martin, Andres Sanchez-Pernaute, Antonio J. Torres, Alfonso L. Calle-Pascual, Miguel A. Rubio-Herrera
Summary: The pathophysiology of body weight control involves complex interactions between hormonal, environmental, behavioral and genetic factors. This study analyzed the association between single nucleotide polymorphisms (SNPs) of 13 genes encoding gastrointestinal peptides and long-term weight response in patients undergoing bariatric surgery. Eight genetic variants were identified that were independently associated with weight response, and the highest scoring category in each risk score was significantly associated with lower weight loss and greater weight regain at the end of the follow-up.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Oncology
Sofia Elena Tesolato, Daniel Gonzalez-Gamo, Ana Barabash, Paula Claver, Sofia Cristina de la Serna, Inmaculada Dominguez-Serrano, Jana Dziakova, Carmen de Juan, Antonio Jose Torres, Pilar Iniesta
Summary: This study aims to analyze and correlate the expression levels of four miRNAs associated with cancer and obesity in colorectal cancer (CRC) patients and a control group. The results indicate the significance of hsa-miR-143-3p and hsa-miR-181a-5p in the clinical management of CRC.
Article
Biochemistry & Molecular Biology
Ines Lopez-Cuenca, Lidia Sanchez-Puebla, Elena Salobrar-Garcia, Maria Alvarez-Gutierrez, Lorena Elvira-Hurtado, Ana Barabash, Federico Ramirez-Torano, Jose A. Fernandez-Albarral, Jose A. Matamoros, Alberto Nebreda, Alejandra Garcia-Colomo, Ana I. I. Ramirez, Juan J. J. Salazar, Pedro Gil, Fernando Maestu, Jose M. Ramirez, Rosa de Hoz
Summary: This study aimed to analyze the evolution of visual changes in cognitively healthy individuals at risk for Alzheimer's disease (AD). Participants with a first-degree family history of AD (FH+) and carrying the E4+ allele for the ApoE gene (ApoE e4+) underwent retinal thickness analysis using optical coherence tomography (OCT) and visual function assessments. The results showed progressive retinal structural changes but stable functional changes in individuals at risk for AD.
Article
Geriatrics & Gerontology
Sarah N. Kraeutner, Cristina Rubino, Jennifer K. Ferris, Shie Rinat, Lauren Penko, Larissa Chiu, Brian Greeley, Christina B. Jones, Beverley C. Larssen, Lara A. Boyd
Summary: This study examined the age-related changes in brain function and baseline brain structure that support motor skill acquisition. The findings showed that older adults experienced decreases in functional connectivity during motor skill acquisition, while younger adults experienced increases. Additionally, regardless of age group, lower baseline microstructure in a frontoparietal tract was associated with slower motor skill acquisition.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Karen Nuytemans, Farid Rajabli, Melissa Jean-Francois, Jiji Thulaseedhara Kurup, Larry D. Adams, Takiyah D. Starks, Patrice L. Whitehead, Brian W. Kunkle, Allison Caban-Holt, Jonathan L. Haines, Michael L. Cuccaro, Jeffery M. Vance, Goldie S. Byrd, Gary W. Beecham, Christiane Reitz, Margaret A. Pericak-Vance
Summary: This study conducted genetic research on African American AD families and identified a significant linkage signal associated with AD, highlighting the importance of diverse population-level genetic data in understanding the genetic determinants of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Kazuya Suwabe, Ryuta Kuwamizu, Kazuki Hyodo, Toru Yoshikawa, Takeshi Otsuki, Asako Zempo-Miyaki, Michael A. Yassa, Hideaki Soya
Summary: Physical exercise has a positive impact on hippocampal memory decline with aging. Recent studies have shown that even light exercise can improve memory and this improvement is mediated by the ascending arousal system. This study aimed to investigate the effects of light-intensity exercise on hippocampal memory function in healthy older adults and found that pupil dilation during exercise played a role in the memory improvement.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Ajay Sood, Ana Werneck Capuano, Robert Smith Wilson, Lisa Laverne Barnes, Alifiya Kapasi, David Alan Bennett, Zoe Arvanitakis
Summary: The objective of this study was to explore the impact of metformin on cognition and brain pathology. The results showed that metformin users had slower decline in global cognition, episodic memory, and semantic memory compared to non-users. However, the relationship between metformin use and certain brain pathology remains uncertain.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Brian N. Lee, Junwen Wang, Molly A. Hall, Dokyoon Kim, Shana D. Stites, Li Shen
Summary: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory and functional impairments. This study analyzed participants from the Alzheimer's Disease Neuroimaging Initiative and found differential associations between cerebral spinal fluid (CSF)/neuroimaging biomarkers and cognitive/functional outcomes, as well as variations between sexes. These findings suggest that sex differences may play a role in the development of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Madeline R. Hale, Rebecca Langhough, Lianlian Du, Bruce P. Hermann, Carol A. Van Hulle, Margherita Carboni, Gwendlyn Kollmorgenj, Kristin E. Basche, Davide Bruno, Leah Sanson-Miles, Erin M. Jonaitis, Nathaniel A. Chin, Ozioma C. Okonkwo, Barbara B. Bendlin, Cynthia M. Carlsson, Henrik Zetterberg, Kaj Blennow, Tobey J. Betthauser, Sterling C. Johnson, Kimberly D. Mueller
Summary: This study demonstrates a relationship between cerebrospinal fluid biomarkers and the ability to recall proper names in the preclinical phase of Alzheimer's disease.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Thomas T. Austin, Christian L. Thomas, Ben Warren
Summary: This study investigated the effects of age on the robustness and resilience of auditory system using the desert locust. The researchers found that gene expression changes were mainly influenced by age rather than noise exposure. Both young and aged locusts were able to recover their auditory nerve function within 48 hours of noise exposure, but the recovery of transduction current magnitude was impaired in aged locusts. Key genes responsible for robustness to noise exposure in young locusts and potential candidates for compensatory mechanisms in auditory neurons of aged locusts were identified.
NEUROBIOLOGY OF AGING
(2024)