Review
Medicine, Research & Experimental
Santiago Alonso Tobar Leitao, Douglas Dos Santos Soares, Nelson Carvas Junior, Rafael Zimmer, Nataniel Floriano Ludwig, Michael Andrades
Summary: The study found that different anesthetics have varying effects on the biological outcomes of laboratory animals before euthanasia. However, the data did not conclusively support the use of one specific anesthetic over others, or the omission of anesthesia during euthanasia.
Article
Anesthesiology
Vincent C. Hsieh, Julie Niezgoda, Margaret M. Sedensky, Charles L. Hoppel, Philip G. Morgan
Summary: The study showed that patients with complex I dysfunction are hypersensitive to sevoflurane compared to normal patients, with less hypersensitivity in patients presenting with other mitochondrial defects or without a mitochondrial diagnosis. The hypersensitivity is most significant during induction, with smaller differences during the maintenance of anesthesia.
ANESTHESIA AND ANALGESIA
(2021)
Review
Anesthesiology
Shane Varughese, Raza Ahmed
Summary: Inhaled anesthetics such as N2O and sevoflurane are potent greenhouse gases and ozone-depleting agents, posing risks to personnel through occupational exposure. Specific measures to reduce occupational exposure and environmental impact, such as efficient ventilation systems and regular monitoring of waste gas concentrations, should be implemented to mitigate these risks.
ANESTHESIA AND ANALGESIA
(2021)
Article
Biochemistry & Molecular Biology
Luke A. A. Borchardt, Amanda R. R. Scharenbrock, Zachariah P. G. Olufs, David A. A. Wassarman, Misha Perouansky
Summary: The mitochondrial electron transport chain (mETC) contains molecular targets of volatile general anesthetics (VGAs), which can cause anesthetic complications in carriers of mutations. Fruit flies with mutations in Complex I of mETC replicate characteristics of Leigh syndrome (LS) and are used as models. The flies are hypersensitive to volatile anesthetic ethers and develop anesthetic-induced neurotoxicity (AiN) after exposure to isoflurane. The study investigated the effects of the anesthetic halothane and other mutations in Complex I and Complexes II-V of mETC on AiN. The results showed that halothane toxicity and predisposition to AiN are not limited to ether anesthetics or mutations in core subunits of Complex I.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Philipp Daume, Johannes Weis, Hagen Bomberg, Martin Bellgardt, Thomas Volk, Heinrich V. Groesdonk, Andreas Meiser
Summary: This study demonstrates that the use of desflurane with the Mirus (TM) system significantly shortens washout times and leads to faster awakening in critically ill patients after sedation.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Medicine, General & Internal
Khaled Ahmed Yassen, Matthieu Jabaudon, Hussah Abdullah Alsultan, Haya Almousa, Dur Shahwar, Fatimah Yousef Alhejji, Zainab Yaseen Aljaziri
Summary: Based on a review of literature published between 2005 and 2023, inhaled sedation has been found to reduce extubation and weaning time for mechanically ventilated patients in the ICU, as well as decrease opioid and muscle relaxant consumption. It also has potential cardio-protective, anti-inflammatory, and bronchodilator properties, but careful monitoring and management are required to prevent potential risks.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Anesthesiology
Moritz Kretzschmar, James E. Baumgardner, Alf Kozian, Thomas Hachenberg, Thomas Schilling, Goran Hedenstierna, Anders Larsson
Summary: The study demonstrates that the ventilation/perfusion ratio (V-A/Q) of normal lungs significantly influences the kinetics of inhaled anesthetics.
Article
Anesthesiology
James E. Baumgardner, Moritz Kretzschmar, Alf Kozian, Thomas Hachenberg, Thomas Schilling, Anders Larsson, Goran Hedenstierna
Summary: The study assessed the impact of lung V-A/Q ratio on the elimination kinetics of desflurane and sevoflurane, finding that the V-A/Q ratio influences tissue washout speed throughout the entire elimination process.
Article
Veterinary Sciences
M. McMillan
Summary: The audit of carbon footprint in a single centre revealed that significant reductions in oxygen and inhaled anaesthetic agent consumption, as well as greenhouse gas emissions and financial expenditure, can be achieved by adapting practices. Different breathing systems and flow rates based on animal weight were suggested to reduce oxygen and anaesthetic agent usage, indicating a potential reduction of up to 97% in anaesthetics. By implementing these changes, the carbon footprint of inhaled anaesthetic agents could be reduced by 63%.
JOURNAL OF SMALL ANIMAL PRACTICE
(2021)
Article
Medicine, General & Internal
Brendan Gill, Jason L. L. Bartock, Emily Damuth, Nitin Puri, Adam Green
Summary: Volatile anesthetics, particularly isoflurane, have been shown to be effective in treating refractory status asthmaticus (SA). In this case report, we describe the use of systemic isoflurane delivered via the extracorporeal membrane oxygenation (ECMO) circuit to treat severe refractory SA in a patient on VV ECMO. This novel approach allowed for successful management of the patient's bronchospasm and ultimately led to decannulation from VV ECMO and extubation.
FRONTIERS IN MEDICINE
(2022)
Article
Pediatrics
Hiroshi Mineshima, Hiroki Kimoto, Masaya Hitomi, Fumika Akizawa, Yui Terayama, Tsuyoshi Yoshikawa
Summary: In this study, we compared the Morris water maze (MWM) and the Biel water maze (BWM) for their ability to detect learning and memory disorder (LMD) in rats exposed to isoflurane (IFN). The results showed that MWM was superior to BWM in detecting IFN-related LMD, with a simpler procedure and clearer detection in both sexes of rats. Additionally, single IFN inhalation on postnatal day 7 was considered useful as a positive control for inducing LMD, but stronger treatment regimens were recommended for future studies.
CONGENITAL ANOMALIES
(2022)
Article
Anesthesiology
Miles Berger, Sarada S. Eleswarpu, Mary Cooter Wright, Anna M. Ray, Sarah A. Wingfield, Mitchell T. Heflin, Shahrukh Bengali, Ankeet D. Udani
Summary: Although there was no effect on mean aaMAC, these results demonstrate that this EEG-ELC intervention increased resident knowledge and raise the possibility that it may reduce hospital LOS.
ANESTHESIA AND ANALGESIA
(2022)
Review
Cell Biology
Stefanie Scheid, Ulrich Goebel, Felix Ulbrich
Summary: Cerebral injury is a major cause of long-term disability and death, and current treatment options often fail to improve survival due to the brain's limited regenerative capacity. However, the use of medical gases, noble gases, and gaseous molecules as therapeutic options may offer new perspectives for the treatment of cerebral injury.
Article
Behavioral Sciences
Henry Querfurth, Angela Slitt, Amy DiCamillo, Nathan Surles, Brenton DeBoef, Han-Kyu Lee
Summary: Diabetes, insulin resistance, and obesity are risk factors for Alzheimer's disease. In this study, the PDK-1 agonist PS48 was orally administered to transgenic mice and showed positive effects on learning and memory. PS48 was particularly effective in improving spatial memory in mice on a high fat diet.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Pediatrics
H. Lepeltier, A. Lepetit, M. Gauberti, C. Escalard, J-P Salaun, C. Benard, A. Lesage, D. Brossier, I Goyer
Summary: This study evaluated the feasibility and efficacy of using dexmedetomidine for pediatric MRI examinations. The results showed that dexmedetomidine can significantly decrease invasive ventilation without impacting image quality. However, the sedation failure rate was higher with dexmedetomidine compared to general anesthesia.
ARCHIVES DE PEDIATRIE
(2022)
Review
Anesthesiology
Koichi Yuki, Roderic G. Eckenhoff
ANESTHESIA AND ANALGESIA
(2016)
Article
Anesthesiology
Kellie A. Woll, William P. Dailey, Grace Brannigan, Roderic G. Eckenhoff
ANESTHESIA AND ANALGESIA
(2016)
Article
Anesthesiology
Monica N. Kinde, Weiming Bu, Qiang Chen, Yan Xu, Roderic G. Eckenhoff, Pei Tang
Letter
Anesthesiology
Roderic. G. Eckenhoff, Kirk J. Hogan, Lisbeth Evered
Review
Public, Environmental & Occupational Health
Christopher G. Ward, Roderic G. Eckenhoff
Article
Biochemistry & Molecular Biology
Toshiaki Okuno, Sophia Koutsogiannaki, Mai Ohba, Matthew Chamberlain, Weiming Bu, Fu-Yan Lin, Roderic G. Eckenhoff, Takehiko Yokomizo, Koichi Yuki
Article
Neurosciences
Weiming Bu, Qiansheng Liang, Lianteng Zhi, Lina Maciunas, Patrick J. Loll, Roderic G. Eckenhoff, Manuel Covarrubias
MOLECULAR NEUROBIOLOGY
(2018)
Article
Multidisciplinary Sciences
Brandon M. Bensel, Stephanie Guzik-Lendrum, Erin M. Masucci, Kellie A. Woll, Roderic G. Eckenhoff, Susan P. Gilbert
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2017)
Review
Anesthesiology
T. E. F. Abbott, A. J. Fowler, P. Pelosi, M. Gama de Abreu, A. M. Moller, J. Canet, B. Creagh-Brown, M. Mythen, T. Gin, M. M. Lalu, E. Futier, M. P. Grocott, M. J. Schultz, R. M. Pearse
BRITISH JOURNAL OF ANAESTHESIA
(2018)
Review
Anesthesiology
D. J. Buggy, J. Freeman, M. Z. Johnson, K. Leslie, B. Riedel, D. I. Sessler, A. Kurz, V. Gottumukkala, T. Short, N. Pace, P. M. Myles
BRITISH JOURNAL OF ANAESTHESIA
(2018)
Review
Anesthesiology
L. Evered, B. Silbert, D. S. Knopman, D. A. Scott, S. T. DeKosky, L. S. Rasmussen, E. S. Oh, G. Crosby, M. Berger, R. G. Eckenhoff
BRITISH JOURNAL OF ANAESTHESIA
(2018)
Letter
Anesthesiology
L. Evered, R. G. Eckenhoff
BRITISH JOURNAL OF ANAESTHESIA
(2017)
Article
Biophysics
Kellie A. Woll, Kenneth A. Skinner, Eleonora Gianti, Natarajan V. Bhanu, Benjamin A. Garcia, Vincenzo Carnevale, Roderic G. Eckenhoff, Rachelle Gaudet
BIOPHYSICAL JOURNAL
(2017)
Article
Anesthesiology
F. Mardini, J. X. Tang, J. C. Li, M. J. Arroliga, R. G. Eckenhoff, M. F. Eckenhoff
BRITISH JOURNAL OF ANAESTHESIA
(2017)
Article
Biochemistry & Molecular Biology
Kellie A. Woll, Wesley Peng, Qiansheng Liang, Lianteng Zhi, Jack A. Jacobs, Lina Maciunas, Natarajan Bhanu, Benjamin A. Garcia, Manuel Covarrubias, Patrick J. Loll, William P. Dailey, Roderic G. Eckenhoff
ACS CHEMICAL BIOLOGY
(2017)
Article
Geriatrics & Gerontology
Sarah N. Kraeutner, Cristina Rubino, Jennifer K. Ferris, Shie Rinat, Lauren Penko, Larissa Chiu, Brian Greeley, Christina B. Jones, Beverley C. Larssen, Lara A. Boyd
Summary: This study examined the age-related changes in brain function and baseline brain structure that support motor skill acquisition. The findings showed that older adults experienced decreases in functional connectivity during motor skill acquisition, while younger adults experienced increases. Additionally, regardless of age group, lower baseline microstructure in a frontoparietal tract was associated with slower motor skill acquisition.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Karen Nuytemans, Farid Rajabli, Melissa Jean-Francois, Jiji Thulaseedhara Kurup, Larry D. Adams, Takiyah D. Starks, Patrice L. Whitehead, Brian W. Kunkle, Allison Caban-Holt, Jonathan L. Haines, Michael L. Cuccaro, Jeffery M. Vance, Goldie S. Byrd, Gary W. Beecham, Christiane Reitz, Margaret A. Pericak-Vance
Summary: This study conducted genetic research on African American AD families and identified a significant linkage signal associated with AD, highlighting the importance of diverse population-level genetic data in understanding the genetic determinants of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Kazuya Suwabe, Ryuta Kuwamizu, Kazuki Hyodo, Toru Yoshikawa, Takeshi Otsuki, Asako Zempo-Miyaki, Michael A. Yassa, Hideaki Soya
Summary: Physical exercise has a positive impact on hippocampal memory decline with aging. Recent studies have shown that even light exercise can improve memory and this improvement is mediated by the ascending arousal system. This study aimed to investigate the effects of light-intensity exercise on hippocampal memory function in healthy older adults and found that pupil dilation during exercise played a role in the memory improvement.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Ajay Sood, Ana Werneck Capuano, Robert Smith Wilson, Lisa Laverne Barnes, Alifiya Kapasi, David Alan Bennett, Zoe Arvanitakis
Summary: The objective of this study was to explore the impact of metformin on cognition and brain pathology. The results showed that metformin users had slower decline in global cognition, episodic memory, and semantic memory compared to non-users. However, the relationship between metformin use and certain brain pathology remains uncertain.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Brian N. Lee, Junwen Wang, Molly A. Hall, Dokyoon Kim, Shana D. Stites, Li Shen
Summary: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory and functional impairments. This study analyzed participants from the Alzheimer's Disease Neuroimaging Initiative and found differential associations between cerebral spinal fluid (CSF)/neuroimaging biomarkers and cognitive/functional outcomes, as well as variations between sexes. These findings suggest that sex differences may play a role in the development of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Madeline R. Hale, Rebecca Langhough, Lianlian Du, Bruce P. Hermann, Carol A. Van Hulle, Margherita Carboni, Gwendlyn Kollmorgenj, Kristin E. Basche, Davide Bruno, Leah Sanson-Miles, Erin M. Jonaitis, Nathaniel A. Chin, Ozioma C. Okonkwo, Barbara B. Bendlin, Cynthia M. Carlsson, Henrik Zetterberg, Kaj Blennow, Tobey J. Betthauser, Sterling C. Johnson, Kimberly D. Mueller
Summary: This study demonstrates a relationship between cerebrospinal fluid biomarkers and the ability to recall proper names in the preclinical phase of Alzheimer's disease.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Thomas T. Austin, Christian L. Thomas, Ben Warren
Summary: This study investigated the effects of age on the robustness and resilience of auditory system using the desert locust. The researchers found that gene expression changes were mainly influenced by age rather than noise exposure. Both young and aged locusts were able to recover their auditory nerve function within 48 hours of noise exposure, but the recovery of transduction current magnitude was impaired in aged locusts. Key genes responsible for robustness to noise exposure in young locusts and potential candidates for compensatory mechanisms in auditory neurons of aged locusts were identified.
NEUROBIOLOGY OF AGING
(2024)