期刊
NEUROBIOLOGY OF AGING
卷 29, 期 8, 页码 1199-1203出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2007.02.011
关键词
hippocampus; atrophy rate; scanning interval; Alzheimer's disease; MRI
资金
- Medical Research Council [G90/86, G0601846] Funding Source: Medline
- Medical Research Council [G0601846, G90/86] Funding Source: researchfish
- MRC [G90/86, G0601846] Funding Source: UKRI
We measured hippocampi on baseline-, 6- and 12-month scans in a group of AD (n = 36) and control subjects (n = 20). We found that mean annualised atrophy rates using 6-month intervals were comparable at a group level to those generated from a 12-month interval. Higher variance was seen using shorter intervals, although this was only significant in the control group. This has implications where shorter inter-scan intervals may be advantageous, such as rapid diagnosis, and tracking of disease progression including in a clinical trial. (c) 2007 Elsevier Inc. All rights reserved.
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