Article
Biochemistry & Molecular Biology
Nikol Jankovska, Tomas Olejar, Radoslav Matej
Summary: The study found that in patients with comorbid Alzheimer's disease and sporadic Creutzfeldt-Jakob disease, Aβ and PrPSc aggregates tended to be located separately, with compound plaques being relatively rare. PrPSc plaque-like structures were observed in the periphery of non-compact Aβ plaques, indicating that PrPSc aggregation may dominate in the periphery of Aβ plaques with non-compact regions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Zhongyun Chen, Min Chu, Li Liu, Jing Zhang, Yu Kong, Kexin Xie, Yue Cui, Hong Ye, Junjie Li, Lin Wang, Liyong Wu
Summary: Genetic prion diseases (gPrDs) presenting with frontotemporal dementia (FTD) are characterized by early onset, high incidence of positive family history, overlapping clinical features with prion diseases and FTD, and ancillary features closer to FTD. PRNP mutations may be a rare cause in the FTD spectrum, and PRNP genotyping should be considered in patients with these features.
ALZHEIMERS RESEARCH & THERAPY
(2022)
Article
Clinical Neurology
Vincenzo Mastrangelo, Elena Merli, Janet C. Rucker, Eric R. Eggenberger, David S. Zee, Pietro Cortelli
Summary: Fatal familial insomnia (FFI) is a rare inherited prion disease characterized by sleep, autonomic, and motor disturbances. Excessive saccadic intrusions were found to be a prominent early diagnostic clue for FFI in patients with severe insomnia. The involvement of the thalamus in FFI also suggests its role in the control of steady fixation.
ANNALS OF NEUROLOGY
(2021)
Review
Pharmacology & Pharmacy
Simone Baiardi, Angela Mammana, Sabina Capellari, Piero Parchi
Summary: Human prion diseases are rare, heterogeneous, and rapidly progressive neurodegenerative disorders characterized by misfolded prion protein aggregation and self-propagation. They occur in idiopathic, genetically determined, and acquired forms with different etiologies and phenotypic variants. This review provides an up-to-date overview of potential therapeutic targets in prion diseases, discussing the results obtained in cell and animal models and human trials, as well as the challenges associated with developing effective therapies and informative clinical trials. The most promising therapeutic strategies currently focus on targeting cellular PrP to prevent misfolded PrP formation or promote its elimination, such as passive immunization and gene therapy with antisense oligonucleotides.
EXPERT OPINION ON THERAPEUTIC TARGETS
(2023)
Article
Medicine, General & Internal
Annibale Antonioni, Emanuela Maria Raho, Andrea Gozzi, Niccolo Cotta Ramusino, Edward Cesnik, Marina Padroni, Alessandro De Vito, Maura Pugliatti, Valeria Tugnoli
Summary: The Heidenhain Variant of CJD is a rare early clinical syndrome characterized by visual disturbances, which can be easily misdiagnosed due to its varied symptoms.
Article
Clinical Neurology
Aaron Jesuthasan, Danielle Sequeira, Harpreet Hyare, Hans Odd, Peter Rudge, Tze How Mok, Akin Nihat, John Collinge, Simon Mead
Summary: This study reviewed the reporting sensitivity of MRI scans for sporadic Creutzfeldt-Jakob disease (sCJD) cases a decade later. While there has been improvement in local MRI reporting, characteristic abnormalities are still significantly under-detected on initial scans. Sensitivity is higher when the cerebral cortex and multiple regions are involved.
JOURNAL OF NEUROLOGY
(2022)
Article
Medicine, Research & Experimental
Jennifer Myskiw, Lise Lamoureux, Anne Peterson, David Knox, Gerard H. Jansen, Michael B. Coulthart, Stephanie A. Booth
Summary: Creutzfeldt-Jakob disease (CJD) is a group of transmissible neurodegenerative diseases with diverse phenotypes. We optimized and developed a capillary-based western assay to detect and characterize prion proteins from patients with CJD, which displayed outstanding sensitivity and specificity. This novel assay has the potential to enhance current detection methods and preserve valuable samples.
LABORATORY INVESTIGATION
(2023)
Article
Biochemistry & Molecular Biology
Gianluigi Zanusso, Elisa Colaizzo, Anna Poleggi, Carlo Masullo, Raffaello Romeo, Sergio Ferrari, Matilde Bongianni, Michele Fiorini, Dorina Tiple, Luana Vaianella, Marco Sbriccoli, Flavia Porreca, Michele Equestre, Maurizio Pocchiari, Franco Cardone, Anna Ladogana
Summary: This study reports a case of a gCJD patient with the rare V180I-129V haplotype, showing an unusually long disease duration and a characteristic pathological PrP glycotype. The family members carrying the mutation did not exhibit any symptoms. Neuropathological examination revealed a lesion pattern similar to Japanese V180I cases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Nicolas Bizat, Valeria Parrales, Sofian Laoues, Sebastien Normant, Etienne Levavasseur, Julian Roussel, Nicolas Privat, Alexianne Gougerot, Philippe Ravassard, Patrice Beaudry, Jean-Philippe Brandel, Jean-Louis Laplanche, Stephane Haik
Summary: Human prion diseases are fatal neurodegenerative disorders with no effective treatments currently available. By expressing a specific mutated human prion protein in a nematode model organism, researchers have identified potential compounds that could target the pathological effects of the disease. This model provides a breakthrough in prion therapeutic research and offers a new tool for studying the detrimental effects of misfolded prion protein in a well-characterized neuronal system.
Review
Clinical Neurology
Brian S. Appleby, Shashirekha Shetty, Mohamed Elkasaby
Summary: This article reviews the genetic aspects of human prion disease, including the impact of genetic variations on the disease and the related epidemiology, clinicopathologic phenotype, diagnostics, clinical management, and potential treatment approaches.
FRONTIERS IN NEUROLOGY
(2022)
Review
Microbiology
Diane L. Ritchie, Alexander H. Peden, Marcelo A. Barria
Summary: Twenty-five years after variant Creutzfeldt-Jakob disease (vCJD) was first described in the UK, extensive experimental evidence confirms vCJD as a zoonotic disease caused by dietary exposure to the BSE agent. Despite low numbers of vCJD cases, concerns persist over the emergence of new cases in other genetic cohorts and the presence of asymptomatic individuals carrying vCJD infectivity in the population.
Article
Virology
Nicholas Brennecke, Ignazio Cali, Tze How Mok, Helen Speedy, Laszlo L. P. Hosszu, Christiane Stehmann, Laura Cracco, Gianfranco Puoti, Thomas W. Prior, Mark L. Cohen, Steven J. Collins, Simon Mead, Brian S. Appleby
Summary: Genetic prion disease accounts for 10-15% of prion diseases, with smaller repeat insertions having unclear pathogenicity. This study focused on the 2-octapeptide repeat genetic variant, finding it to be a low-risk variant with very low penetrance. Therefore, predictive genetic testing for asymptomatic blood relatives may not be justified.
Review
Clinical Neurology
Johnny Tam, John Centola, Hatice Kurudzhu, Neil Watson, Janet MacKenzie, Margaret Leitch, Terri Hughes, Alison Green, David Summers, Marcelo Barria, Colin Smith, Suvankar Pal
Summary: This study characterized the clinical features of young individuals with sporadic Creutzfeldt-Jakob disease (sCJD) using data from UK national CJD surveillance. The findings showed that young-onset sCJD is more likely to present with neuropsychiatric symptoms and headache, longer disease duration, and lower sensitivity of RT-QuIC. These results provide guidance for evaluating younger individuals with rapidly progressive cognitive and neuropsychiatric decline and emphasize the importance of additional vigilance for atypical features.
JOURNAL OF NEUROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Hideyuki Hara, Junji Chida, Agriani Dini Pasiana, Keiji Uchiyama, Yutaka Kikuchi, Tomoko Naito, Yuichi Takahashi, Junji Yamamura, Hisashi Kuromatsu, Suehiro Sakaguchi
Summary: Prions, infectious agents causing prion diseases like Creutzfeldt-Jakob disease, can be transmitted through medical instruments used for preclinical CJD patients. Investigating sterilization methods, ozone gas and vaporized hydrogen peroxide were found to reduce prion infectivity on stainless steel wires. Combining ozone gas with vaporized hydrogen peroxide showed more potent sterilization effects against prions on the wires compared to using either agent alone.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Andrea Mastrangelo, Angela Mammana, Simone Baiardi, Dorina Tiple, Elisa Colaizzo, Marcello Rossi, Luana Vaianella, Barbara Polischi, Michele Equestre, Anna Poleggi, Sabina Capellari, Anna Ladogana, Piero Parchi
Summary: The introduction of the Real-Time Quaking-Induced Conversion assay has led to a revision of the diagnostic criteria for sporadic Creutzfeldt-Jakob disease. This study compares the diagnostic value of the old and amended criteria and explores different combinations of clinical variables and biomarker results. The results show that CSF RT-QuIC is highly sensitive and specific for diagnosing CJD, and the Q-CM criteria provide a high diagnostic value.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Clinical Neurology
Katrina Moore, Rhian Convery, Martina Bocchetta, Mollie Neason, David M. Cash, Caroline Greaves, Lucy L. Russell, Mica T. M. Clarke, Georgia Peakman, John van Swieten, Lize Jiskoot, Fermin Moreno, Myriam Barandiaran, Raquel Sanchez-Valle, Barbara Borroni, Robert Laforce, Marie-Claire Dore, Mario Masellis, Maria Carmela Tartaglia, Caroline Graff, Daniela Galimberti, James B. Rowe, Elizabeth Finger, Matthis Synofzik, Hans-Otto Karnath, Rik Vandenberghe, Alexandre de Mendonca, Carolina Maruta, Fabrizio Tagliavini, Isabel Santana, Simon Ducharme, Chris Butler, Alex Gerhard, Johannes Levin, Adrian Danek, Markus Otto, Jason D. Warren, Jonathan D. Rohrer, Martin N. Rossor, Nick C. Fox, Ione O. C. Woollacott, Rachelle Shafei, Carolin Heller, Rita Guerreiro, Jose Bras, David L. Thomas, Jennifer Nicholas, Simon Mead, Lieke Meeter, Jessica Panman, Janne Papma, Rick van Minkelen, Yolande Pijnenburg, Begona Indakoetxea, Alazne Gabilondo, Mikel Tainta, Maria de Arriba, Ana Gorostidi, Miren Zulaica, Jorge Villanua, Zigor Diaz, Sergi Borrego-Ecija, Jaume Olives, Albert Llado, Mircea Balasa, Anna Antonell, Nuria Bargallo, Enrico Premi, Maura Cosseddu, Stefano Gazzina, Alessandro Padovani, Roberto Gasparotti, Silvana Archetti, Sandra Black, Sara Mitchell, Ekaterina Rogaeva, Morris Freedman, Ron Keren, David Tang-Wa, Linn Oijerstedt, Christin Andersson, Vesna Jelic, Hakan Thonberg, Andrea Arighi, Chiara Fenoglio, Elio Scarpini, Giorgio Fumagalli, Thomas Cope, Carolyn Timberlake, Timothy Rittman, Christen Shoesmith, Robart Bartha, Rosa Rademakers, Carlo Wilke, Benjamin Bender, Rose Bruffaerts, Philip Van Damme, Mathieu Vandenbulcke, Catarina B. Ferreira, Gabriel Miltenberger, Ana Verdelho, Sonia Afonso, Ricardo Taipa, Paola Caroppo, Giuseppe Di Fede, Giorgio Giaccone, Sara Prioni, Veronica Redaelli, Giacomina Rossi, Pietro Tiraboschi, Diana Duro, Maria Rosario Almeida, Miguel Castelo-Branco, Maria Joao Leitao, Miguel Tabuas-Pereira, Beatriz Santiago, Serge Gauthier, Pedro Rosa-Neto, Michele Veldsman, Toby Flanagan, Catharina Prix, Tobias Hoegen, Elisabeth Wlasich, Sandra Loosli, Sonja Schonecker, Elisa Semler, Sarah Anderl-Straub
Summary: This study investigates semantic cognition in patients with genetic frontotemporal dementia (FTD). The study finds that symptomatic patients scored lower than controls on semantic knowledge, while only late-stage MAPT and C9orf72 mutation carriers scored lower than controls in the presymptomatic groups. Furthermore, the study shows a correlation between mCCT score and brain volume in different regions in different mutation groups.
APPLIED NEUROPSYCHOLOGY-ADULT
(2022)
Article
Clinical Neurology
Kamen A. Tsvetanov, Stefano Gazzina, P. Simon Jones, John van Swieten, Barbara Borroni, Raquel Sanchez-Valle, Fermin Moreno, Robert Laforce, Caroline Graff, Matthis Synofzik, Daniela Galimberti, Mario Masellis, Maria Carmela Tartaglia, Elizabeth Finger, Rik Vandenberghe, Alexandre de Mendonca, Fabrizio Tagliavini, Isabel Santana, Simon Ducharme, Chris Butler, Alexander Gerhard, Adrian Danek, Johannes Levin, Markus Otto, Giovanni Frisoni, Roberta Ghidoni, Sandro Sorbi, Jonathan D. Rohrer, James B. Rowe
Summary: In presymptomatic familial frontotemporal dementia (FTD) mutation carriers, differences in brain structure and function were found, but cognitive performance did not differ significantly. Specifically, behaviorally relevant structural and functional network differences were identified. Although structure-function relationships were similar in both groups, the coupling between functional connectivity and cognition was stronger for carriers and increased with proximity to the expected onset of disease.
ALZHEIMERS & DEMENTIA
(2021)
Article
Clinical Neurology
Maura Malpetti, P. Simon Jones, Kamen A. Tsvetanov, Timothy Rittman, John C. van Swieten, Barbara Borroni, Raquel Sanchez-Valle, Fermin Moreno, Robert Laforce, Caroline Graff, Matthis Synofzik, Daniela Galimberti, Mario Masellis, Maria Carmela Tartaglia, Elizabeth Finger, Rik Vandenberghe, Alexandre de Mendonca, Fabrizio Tagliavini, Isabel Santana, Simon Ducharme, Chris R. Butler, Alexander Gerhard, Johannes Levin, Adrian Danek, Markus Otto, Giovanni B. Frisoni, Roberta Ghidoni, Sandro Sorbi, Carolin Heller, Emily G. Todd, Martina Bocchetta, David M. Cash, Rhian S. Convery, Georgia Peakman, Katrina M. Moore, Jonathan D. Rohrer, Rogier A. Kievit, James B. Rowe
Summary: The study found that apathy increases over time in presymptomatic carriers of genetic FTD, and is associated with cognitive decline and brain atrophy. Apathy may be an early marker of FTD-related changes, predicting subclinical deterioration of cognition before dementia onset.
ALZHEIMERS & DEMENTIA
(2021)
Article
Neurosciences
Lianne M. Reus, Bogdan Pasaniuc, Danielle Posthuma, Toni Boltz, Yolande A. L. Pijnenburg, Roel A. Ophoff
Summary: Using a transcriptome-wide association study approach, novel candidate genes associated with FTD were identified, with most significant associations observed in the dorsolateral prefrontal cortex. In addition to SEC22B, the 17q21.31 inversion locus also showed significant associations.
BIOLOGICAL PSYCHIATRY
(2021)
Article
Neurosciences
Emanuela Maderna, Silvia Visona, Vittorio Bolcato, Veronica Redaelli, Paola Caroppo, Lorenza Montalbetti, Giorgio Giaccone, Antonio Osculati
Summary: Nasu-Hakola disease is a rare genetic disorder associated with Alzheimer's disease lesions, and the neurofibrillary changes observed do not follow the typical hierarchical staging identified by Braak.
JOURNAL OF ALZHEIMERS DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Stefano Sorrentino, Roberto Ascari, Emanuela Maderna, Marcella Catania, Bernardino Ghetti, Fabrizio Tagliavini, Giorgio Giaccone, Giuseppe Di Fede
Summary: The research suggests that microglial cells play a key role in the heterogeneous involvement of Alzheimer's disease (AD) and the neuroinflammation is significantly relevant in the pathogenesis of AD. By measuring brain levels of inflammatory factors, AD patients can be stratified into different neuroinflammatory clusters, contributing to the understanding of the disease diversity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Michele Salemi, Samanta Mazzetti, Mara De Leonardis, Federica Giampietro, Valentina Medici, Tino Emanuele Poloni, Rossella Cannarella, Giorgio Giaccone, Gianni Pezzoli, Graziella Cappelletti, Raffaele Ferri
Summary: PARP1 localization in the brain of PD patients is altered, with decreased expression in neurons and glial cells in substantia nigra. It co-localizes with alpha-Synuclein in PD tissue, indicating its potential involvement in the pathology as a therapeutic target.
NEUROCHEMISTRY INTERNATIONAL
(2021)
Letter
Clinical Neurology
M. Meattini, G. Giaccone, L. D'Incerti, A. R. Giovagnoli
NEUROLOGICAL SCIENCES
(2021)
Article
Neurosciences
Samanta Mazzetti, Michela Barichella, Federica Giampietro, Angelica Giana, Alessandra M. Calogero, Alida Amadeo, Nicola Palazzi, Alessandro Comincini, Giorgio Giaccone, Manuela Bramerio, Serena Caronni, Viviana Cereda, Emanuele Cereda, Graziella Cappelletti, Chiara Rolando, Gianni Pezzoli
Summary: This study found a specific subpopulation of astrocytes in the brains of Parkinson's disease (PD) patients, which can protect neurons by sequestering alpha-Synuclein oligomers and are associated with Lewy body negative neurons. These findings suggest the potential neuroprotective role of the vitamin D pathway in neurodegenerative diseases.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Clinical Neurology
Cristina Villa, Giacomina Rossi, Ilaria Bizzozero, Sara Prioni, Chiara Boiocchi, Federica Agosta, Elisa Canu, Massimo Filippi, Giorgio Giaccone, Paola Caroppo
Summary: This study describes the clinical characteristics of a new family carrying the Q336H MAPT mutation. The proband was diagnosed with semantic variant primary progressive aphasia (svPPA), while the proband's parent was diagnosed with Alzheimer's disease (AD). The study shows that this mutation is associated with svPPA and an AD-like phenotype, and there is significant clinical variability within affected individuals. Therefore, this gene should be analyzed in patients with svPPA.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Sara Cimini, Sonia Bellini, Claudia Saraceno, Luisa Benussi, Roberta Ghidoni, Silvia Clara Giliani, Gianfranco Puoti, Laura Canafoglia, Giorgio Giaccone, Giacomina Rossi
Summary: This study found toxic 25 kDa p-TDP-43 fragments in extracellular vesicles (EVs) derived from GRN mutation carriers, but not in the WT control group. This suggests a significant role of EVs in the spread of pathological molecules in FTLD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Neurosciences
Alessandra Consonni, Martina Miglietti, Chiara Maria Giulia De Luca, Federico Angelo Cazzaniga, Arianna Ciullini, Ilaria Linda Dellarole, Giuseppe Bufano, Alessio Di Fonzo, Giorgio Giaccone, Fulvio Baggi, Fabio Moda
Summary: Parkinson's disease is associated with gastrointestinal and olfactory symptoms, and microbial agents may play a role in its development. Dysbiosis of the microbiota, both in the gut and nose, could contribute to the misfolding of alpha-synuclein, the leading cause of PD. Seed amplification assays can be used to study the gut and olfactory mucosa of PD patients and investigate the role of pathogenic bacteria in promoting alpha-synuclein misfolding and aggregation.
Article
Neuroimaging
Martina Bocchetta, Emily G. Todd, Georgia Peakman, David M. Cash, Rhian S. Convery, Lucy L. Russell, David L. Thomas, Juan Eugenio Iglesias, John C. van Swieten, Lize C. Jiskoot, Harro Seelaar, Barbara Borroni, Daniela Galimberti, Raquel Sanchez-Valle, Robert Laforce, Fermin Moreno, Matthis Synofzik, Caroline Graff, Mario Masellis, Maria Carmela Tartaglia, James B. Rowe, Rik Vandenberghe, Elizabeth Finger, Fabrizio Tagliavini, Alexandre de Mendonca, Isabel Santana, Chris R. Butler, Simon Ducharme, Alexander Gerhard, Adrian Danek, Johannes Levin, Markus Otto, Sandro Sorbi, Isabelle Le Ber, Florence Pasquier, Jonathan D. Rohrer
Summary: Studies have shown evidence of early subcortical involvement in genetic FTD, with C9orf72 expansion carriers exhibiting the earliest and most widespread changes. Investigating individual subregions, early changes can also be seen in MAPT mutation carriers within the limbic system.
NEUROIMAGE-CLINICAL
(2021)
Article
Neuroimaging
Sergi Borrego-Ecija, Roser Sala-Llonch, John van Swieten, Barbara Borroni, Fermin Moreno, Mario Masellis, Carmela Tartaglia, Caroline Graff, Daniela Galimberti, Robert Laforce, James B. Rowe, Elizabeth Finger, Rik Vandenberghe, Fabrizio Tagliavini, Alexandre de Mendonca, Isabel Santana, Matthis Synofzik, Simon Ducharme, Johannes Levin, Adrian Danek, Alex Gerhard, Markus Otto, Chris Butler, Giovanni Frisoni, Sandro Sorbi, Carolin Heller, Martina Bocchetta, David M. Cash, Rhian S. Convery, Katrina M. Moore, Jonathan D. Rohrer, Raquel Sanchez-Valle
Summary: The study found that presymptomatic GRN mutation carriers demonstrate significant age-related cortical thinning in the left superior frontal cortex, with no significant differences in whole brain cortical thickness between carriers and noncarriers.
NEUROIMAGE-CLINICAL
(2021)
Article
Geriatrics & Gerontology
Sarah N. Kraeutner, Cristina Rubino, Jennifer K. Ferris, Shie Rinat, Lauren Penko, Larissa Chiu, Brian Greeley, Christina B. Jones, Beverley C. Larssen, Lara A. Boyd
Summary: This study examined the age-related changes in brain function and baseline brain structure that support motor skill acquisition. The findings showed that older adults experienced decreases in functional connectivity during motor skill acquisition, while younger adults experienced increases. Additionally, regardless of age group, lower baseline microstructure in a frontoparietal tract was associated with slower motor skill acquisition.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Karen Nuytemans, Farid Rajabli, Melissa Jean-Francois, Jiji Thulaseedhara Kurup, Larry D. Adams, Takiyah D. Starks, Patrice L. Whitehead, Brian W. Kunkle, Allison Caban-Holt, Jonathan L. Haines, Michael L. Cuccaro, Jeffery M. Vance, Goldie S. Byrd, Gary W. Beecham, Christiane Reitz, Margaret A. Pericak-Vance
Summary: This study conducted genetic research on African American AD families and identified a significant linkage signal associated with AD, highlighting the importance of diverse population-level genetic data in understanding the genetic determinants of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Kazuya Suwabe, Ryuta Kuwamizu, Kazuki Hyodo, Toru Yoshikawa, Takeshi Otsuki, Asako Zempo-Miyaki, Michael A. Yassa, Hideaki Soya
Summary: Physical exercise has a positive impact on hippocampal memory decline with aging. Recent studies have shown that even light exercise can improve memory and this improvement is mediated by the ascending arousal system. This study aimed to investigate the effects of light-intensity exercise on hippocampal memory function in healthy older adults and found that pupil dilation during exercise played a role in the memory improvement.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Ajay Sood, Ana Werneck Capuano, Robert Smith Wilson, Lisa Laverne Barnes, Alifiya Kapasi, David Alan Bennett, Zoe Arvanitakis
Summary: The objective of this study was to explore the impact of metformin on cognition and brain pathology. The results showed that metformin users had slower decline in global cognition, episodic memory, and semantic memory compared to non-users. However, the relationship between metformin use and certain brain pathology remains uncertain.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Brian N. Lee, Junwen Wang, Molly A. Hall, Dokyoon Kim, Shana D. Stites, Li Shen
Summary: Alzheimer's disease (AD) is a neurodegenerative disorder characterized by memory and functional impairments. This study analyzed participants from the Alzheimer's Disease Neuroimaging Initiative and found differential associations between cerebral spinal fluid (CSF)/neuroimaging biomarkers and cognitive/functional outcomes, as well as variations between sexes. These findings suggest that sex differences may play a role in the development of AD.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Madeline R. Hale, Rebecca Langhough, Lianlian Du, Bruce P. Hermann, Carol A. Van Hulle, Margherita Carboni, Gwendlyn Kollmorgenj, Kristin E. Basche, Davide Bruno, Leah Sanson-Miles, Erin M. Jonaitis, Nathaniel A. Chin, Ozioma C. Okonkwo, Barbara B. Bendlin, Cynthia M. Carlsson, Henrik Zetterberg, Kaj Blennow, Tobey J. Betthauser, Sterling C. Johnson, Kimberly D. Mueller
Summary: This study demonstrates a relationship between cerebrospinal fluid biomarkers and the ability to recall proper names in the preclinical phase of Alzheimer's disease.
NEUROBIOLOGY OF AGING
(2024)
Article
Geriatrics & Gerontology
Thomas T. Austin, Christian L. Thomas, Ben Warren
Summary: This study investigated the effects of age on the robustness and resilience of auditory system using the desert locust. The researchers found that gene expression changes were mainly influenced by age rather than noise exposure. Both young and aged locusts were able to recover their auditory nerve function within 48 hours of noise exposure, but the recovery of transduction current magnitude was impaired in aged locusts. Key genes responsible for robustness to noise exposure in young locusts and potential candidates for compensatory mechanisms in auditory neurons of aged locusts were identified.
NEUROBIOLOGY OF AGING
(2024)