期刊
NEUROBIOLOGY OF AGING
卷 29, 期 10, 页码 1602-1604出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.neurobiolaging.2007.03.010
关键词
Alzheimer's disease; genetics; DNMBP; chromosome 10
资金
- National Institute on Aging [AG13672, AG05133]
A recent scan of single nucleotide polymorphisms (SNPs) on chromosome 10q found significant association of six correlated SNPs with late-onset Alzheimer's disease (AD) among Japanese. We examined the SNP with the highest statistical significance (rs3740058) in a large Caucasian American case-control cohort and the remaining five SNPs in a smaller subset of cases and controls. We observed no association of statistical significance in either the total sample or the APOE*4 non-carriers for any of the SNPs. (C) 2007 Elsevier Inc. All rights reserved.
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