Article
Chemistry, Multidisciplinary
Wei Zhou, Fei Wang, Aimin Li, Silei Bai, Xinxin Feng, Qing He
Summary: A superphane-based carcerand with 18 anion binding sites and a fully enclosed interior space was designed and synthesized. The carcerand was capable of imprisoning H2PO4- anion and highly toxic arsenate anion, resulting in non-toxic arsenate carceplex in HEK293T cell line.
CELL REPORTS PHYSICAL SCIENCE
(2023)
Article
Oncology
Yu Zheng, Yuan-Fei Mao, Hui-Jin Zhao, Li Chen, Li-Ning Wang, Yun-Xiang Zhang, Jiong Hu, Jun-Min Li, Xiao-Yang Li, Hong-Ming Zhu
Summary: This study investigated the arsenic metabolism in APL patients who completed ATO treatment and found a decreased arsenic methylation capacity after treatment. The increased proportion of iAs(III) in urine was associated with chronic liver toxicity, highlighting the importance of monitoring urine PMI and considering SNPs of the AS3MT gene in determining ATO dosage.
EXPERIMENTAL HEMATOLOGY & ONCOLOGY
(2021)
Article
Biology
Yanan Jiang, Jianing Li, Yujie Liu, Xiuyun Shen, Junyi Li, Fengnan Zhi, Juan Xu, Xia Li, Tingting Shao, Yingqi Xu
Summary: ATOdb is a comprehensive database that collects experimentally supported data related to ATO and provides integrated analysis tools. It includes detailed information about ATO, its targets, conditions, and combined drugs. ATOdb also offers data visualization and analysis results, accessible through an easy-to-use web interface.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Article
Toxicology
Sixun Guo, Xinyu Wang, Chunlu Gao, Zhiqiang Wu, Hongzhu Chen, Liwang Lin, Meihua Guo, Yanhui Gao, Xin Hai
Summary: Arsenic trioxide has been successfully used in the treatment of acute promyelocytic leukemia, and this study established a method to determine arsenic species in red blood cells, finding that the concentration of DMA is highest in plasma while MMA is the most predominant methylated arsenic in RBCs. High affinity of MMA with human Hb contributes to the accumulation of arsenic in RBCs of APL patients.
TOXICOLOGY LETTERS
(2021)
Article
Pharmacology & Pharmacy
Hiroshi Yamauchi, Ayako Takata
Summary: The study investigated 61 patients with acute arsenic poisoning and found that adults had higher arsenic intake and more severe symptom progression, while children demonstrated better methylation capacity during acute arsenic poisoning, leading to relatively milder symptom progression.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2021)
Review
Biotechnology & Applied Microbiology
Jiang Sun, Mengying Cheng, Tingxian Ye, Bin Li, Yinghui Wei, Hangsheng Zheng, Hongyue Zheng, Meiqi Zhou, Ji-Gang Piao, Fanzhu Li
Summary: Hepatocellular carcinoma is a major threat to human health and economic development. Arsenic trioxide has shown effectiveness in treating this cancer, but its optimal concentration and bioavailability in tumor tissue need to be addressed. Nanotechnology-based delivery systems have been developed to overcome these challenges and improve the efficacy of arsenic trioxide.
Article
Materials Science, Multidisciplinary
Xuepeng Li, Dachun Liu, Juan Wang, Jun Chang, Ziyang Wang
Summary: Arsenic-iron precipitate was treated using a carbon thermal magnetization reduction method to recover arsenic and iron. Arsenic was recovered as As2O3 and iron was recovered as Fe3O4 by roasting the precipitate mixed with coke powder at a low temperature. The recovery of arsenic and iron in the form of Fe3O4 and As2O3 with a purity of 99.91 wt.% was achieved under specific conditions. The reaction mechanism involved the decomposition and reduction of FeAsO4, resulting in the generation of Fe3O4 and volatilization of As2O3.
Article
Chemistry, Multidisciplinary
Qinglong Yan, Rui Sun, Zhifen Cui, Jichao Zhang, Yu Zhag, Qi Zhang, Shitai Zhu, Lihua Wang, Qian Li, Min Lu, Zhu, Chunhai Fan
Summary: Nanodiamonds (NDs) demonstrate a potent multiple organ-specific anti-metastatic mechanism in arsenic trioxide (ATO)-based therapy for liver cancer, effectively inhibiting ATO-associated metastasis in the liver, spleen, and intestines. This study reveals a potential strategy for inhibiting multiple-organ cancer metastasis through nanoparticle-mediated modulation of autophagy.
Article
Chemistry, Medicinal
Judith A. Carrall, Wilford Lie, Jacob M. Lambert, Hugh H. Harris, Barry Lai, Carolyn T. Dillon
Summary: This research aims to design and develop tumor-homing peptide complexes of arsenic to strategically target specific cancers, with the goal of achieving dose reduction and decreased side effects. Studies show that the most stable complex exhibits 1000 times greater toxicity towards leukemia cells than human blood cells, indicating potential for in vivo studies.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Medicine, Research & Experimental
Xiuyun Shen, Fengnan Zhi, Chunpeng Shi, Jincheng Xu, Yuqiu Chao, Juan Xu, Yunlong Bai, Yanan Jiang, Baofeng Yang
Summary: The lncRNA Kcnq1ot1/miR-34a-5p/Sirt1 pathway is involved in ATO-induced cardiotoxicity. Propranolol can attenuate ATO-induced cardiotoxicity at least partially through the lncRNA Kcnq1ot1/miR-34a-5p/Sirt1 pathway.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Mengzhen Yu, Yanwen Zhang, Meirong Fang, Shah Jehan, Wenhu Zhou
Summary: This article reviews the medical applications of arsenic trioxide (ATO) and discusses the potential of ATO nanotechnology in the treatment of solid tumors. Nanotechnology can enhance the bioavailability and targeting capabilities of ATO, thereby improving the effectiveness of cancer treatment.
Article
Environmental Sciences
Lixuan Tang, Juan Lan, Xuanxuan Jiang, Riming Huang, Qiling Pang, Shaofeng Wu, Fang Wan, Gaolong Zhong, Zhaoxin Tang, Lianmei Hu
Summary: This study found that curcumin can counteract the immunosuppressive effect of arsenic on ducks, demonstrating anti-inflammatory and autophagy-restoring properties.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Medicine, Research & Experimental
Jian Lv, Mengliang Wu, Chunrong Pang, Rui Duan, Hong Zhang, Shuo Tian, Haixia Yang, Xin Hai
Summary: Torsemide increased the plasma concentrations of arsenic metabolites in APL patients treated with ATO by inhibiting the transporter MRP4 in a dose-dependent manner. This effect was also observed in rats treated with both ATO and torsemide. Torsemide reduced the excretion of arsenic in urine and increased its concentration in the kidneys of rats.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Biochemistry & Molecular Biology
Iman M. Ahmad, Alicia J. Dafferner, Ramia J. Salloom, Maher Y. Abdalla
Summary: This study explored new strategies that could lead to the development of less toxic and more effective therapies against PDAC by combining increased cellular stress and targeting autophagy.
Article
Engineering, Environmental
Jullieta E. Lum, Valerie A. Schoepfer, Heather E. Jamieson, Joyce M. McBeth, Anezka Borcinova Radkova, Mary P. Walls, Matthew B. J. Lindsay
Summary: Historical mining and mineral processing at Giant Mine in Yellowknife, Canada, has left a legacy of arsenic and antimony contamination. The stored arsenic trioxide roaster waste (ATRW) was found to primarily consist of arsenolite, but also showed minor associations with iron oxides. The presence of different forms of arsenic and antimony has implications for the environmental behavior and remediation of ATRW. Overall, this study provides important insights into the phase associations and environmental fate of ATRW solids.
JOURNAL OF HAZARDOUS MATERIALS
(2023)
Article
Oncology
Meghan Phelan, Susan S. Hayashi, Kara Sauerburger, Jennifer Henry, Ningying Wu, Robert J. Hayashi
Summary: This study aimed to estimate the frequency of hearing screening failures in pediatric cancer survivors at low risk for hearing loss and evaluate the feasibility of administering screenings in this population. The results showed that 23% of the eligible patients failed the hearing screen, with no significant correlation to screening failure in demographic or treatment-related variables. Broader use of hearing screening should be considered based on the findings.
PEDIATRIC BLOOD & CANCER
(2022)
Article
Oncology
David T. Teachey, Meenakshi Devidas, Brent L. Wood, Zhiguo Chen, Robert J. Hayashi, Michelle L. Hermiston, Robert D. Annett, J. Hunter Archer, Barbara L. Asselin, Keith J. August, Steve Y. Cho, Kimberly P. Dunsmore, Brian T. Fisher, Jason L. Freedman, Paul J. Galardy, Paul Harker-Murray, Terzah M. Horton, Alok Jaju, Allison Lam, Yoav H. Messinger, Rodney R. Miles, Maki Okada, Samir Patel, Eric S. Schafer, Tal Schechter, Neelam Singh, Amii C. Steele, Maria Luisa Sulis, Sarah L. Vargas, Stuart S. Winter, Charlotte Wood, Patrick Zweidler-McKay, Catherine M. Bollard, Mignon L. Loh, Stephen P. Hunger, Elizabeth A. Raetz
Summary: The study indicates that the use of proteasome inhibitor bortezomib can significantly improve event-free survival and overall survival in patients with T-LL. Additionally, intensification of systemic therapy allows for a reduction in the proportion of T-ALL patients requiring prophylactic cranial radiation without increasing the risk of relapse.
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Meeting Abstract
Hematology
Robert J. Hayashi, Michelle L. Hermiston, David T. Teachey, Meenakshi Devidas, Brent L. Wood, Zhiguo Chen, Robert D. Annett, Barbara L. Asselin, Keith J. August, Steve Y. Cho, Kimberly P. Dunsmore, Jason L. Freedman, Paul J. Galardy, Paul Harker-Murray, Terzah M. Horton, Alok Jaju, Allison Lam, Yoav H. Messinger, Rodney R. Miles, Maki Okada, Samir Patel, Eric S. Schafer, Tal Schechter-Finkelstein, Kristin A. Shimano, Neelam Singh, Amii C. Steele, Maria Luisa Sulis, Sarah L. Vargas, Stuart S. Winter, Charlotte Wood, Patrick A. Zweidler-McKay, Mignon L. Loh, Stephen P. Hunger, Elizabeth A. Raetz, Catherine M. Bollard, Carl Allen
Meeting Abstract
Hematology
Lauren K. Meyer, Ritu P. Roy, Petri Polonen, Abdelrahman Elsayed, Benjamin J. Huang, Shunsuke Kimura, Cristina Delgado-Martin, Tiffaney L. Vincent, Theresa Ryan, Brent L. Wood, Zhiguo Chen, Yu Liu, Jinghui Zhang, Terzah M. Horton, Mignon L. Loh, Meenakshi Devidas, Elizabeth A. Raetz, Robert J. Hayashi, Stuart S. Winter, Kimberly P. Dunsmore, Stephen P. Hunger, Stanley B. Pounds, Michelle L. Hermiston, Jun J. Yang, Charles G. Mullighan, David T. Teachey, Adam B. Olshen
Article
Oncology
Daniel N. Willis, Mary Claire McGlynn, Patrick J. Reich, Robert J. Hayashi
Summary: This study evaluated the risk of bloodstream infections (BSI) and death in pediatric oncology patients, finding that BSI is a significant cause of mortality in this population. Younger age, specific diagnoses, ethnicity, and history of hematopoietic stem cell transplant (HSCT) were identified as risk factors for BSI. The mortality rate for patients with BSI was 6.5%. Patients with febrile neutropenia had a lower mortality rate compared to those without. These findings highlight the importance of BSI prevention to reduce the risk of death in pediatric oncology patients.
FRONTIERS IN ONCOLOGY
(2023)
Article
Cell Biology
Mualla Ozcan, Zhen Guo, Carla Valenzuela Ripoll, Ahmed Diab, Antonino Picataggi, David Rawnsley, Aynaz Lotfinaghsh, Carmen Bergom, Jeff Szymanski, Daniel Hwang, Aarti Asnani, Mikhail Kosiborod, Jie Zheng, Robert J. Hayashi, Pamela K. Woodard, Attila Kovacs, Kenneth B. Margulies, Joel Schilling, Babak Razani, Abhinav Diwan, Ali Javaheri
Summary: Fasting strategies are being investigated in patients on chemotherapy. Alternate-day fasting was found to aggravate doxorubicin cardiotoxicity and increase mortality and impaired cardiac function in mice. The study also showed that TFEB and GDF15 pathways contribute to doxorubicin-induced heart failure.
Editorial Material
Oncology
Paul Graham Fisher
JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Ophthalmology
Margaret Reynolds, Jacob Wise, Tiffany Wu, Sara Malone, Amer Al Badawi, Allison King, Mae Gordon, Gregg Lueder, Robert Hayashi
Summary: This study aimed to describe contrast sensitivity and saccades in children treated for retinoblastoma. The results showed decreased contrast sensitivity and impaired saccades were universally observed in this cohort of RB survivors. Therefore, comprehensive visual evaluation should be considered for all RB survivors to provide optimal rehabilitative services for these patients.
Article
Oncology
Smita Bhatia, Alberto S. Pappo, Melissa Acquazzino, Wendy A. Allen-Rhoades, Marie Barnett, Scott C. Borinstein, Robert Casey, Sun Choo, Rashmi Chugh, Shira Dinner, Ralph Ermoian, Douglas Fair, Noah Federman, Jeanelle Folbrecht, Shipra Gandhi, Julie Germann, Robert Goldsby, Robert Hayashi, Alex Y. Huang, Mary S. Huang, Linda A. Jacobs, Cathy Lee-Miller, Michael P. Link, John A. Livingston, Maryam Lustberg, Marcio Malogolowkin, Kevin C. Oeffinger, Christine A. Pratilas, Damon Reed, Jodi Skiles, Margaret von Mehren, Nicholas Yeager, Sarah Montgomery, Lisa Hang
Summary: This article discusses considerations for the comprehensive care of adolescent and young adult (AYA) patients with cancer, based on the NCCN Guidelines for AYA Oncology. AYA patients have unique needs in terms of treatment, fertility counseling, psychosocial and behavioral issues, and supportive care services compared to older adults with cancer.
JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK
(2023)
Article
Oncology
Ema Mosleh, Stacy Snyder, Ningying Wu, Daniel N. Willis, Robert J. Hayashi, Rema Malone
Summary: This study aims to identify modifiable risk factors associated with prolonged clearance of high dose methotrexate in pediatric, adolescent, and young adult oncology patients. The research found that leukemia diagnosis, decreased urine output, and increasing age were associated with delayed clearance of methotrexate. Additionally, higher methotrexate levels, renal toxicity, specific intravenous medications, and the use of leucovorin were also related to longer clearance time and length of stay.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Mary Claire Mcglynn, Kassidy Brady, Jessica M. Healey, Vikas R. Dharnidharka, A. Marion Ybarra, Janis Stoll, Stuart Sweet, Robert J. Hayashi
Summary: Survivors of PTLD experience late effects (LE), including late mortality, regardless of chemotherapy exposure. Chemotherapy does not affect survival rate, but is associated with higher incidence of blood and lymphatic toxicity as well as cardiac toxicity, and lower incidence of infections.
PEDIATRIC BLOOD & CANCER
(2023)
Article
Oncology
Carmen L. Wilson, Kari L. Bjornard, Robyn E. Partin, Nina S. Kadan-Lottick, Paul C. Nathan, Kevin C. Oeffinger, Robert J. Hayashi, Geehong Hyun, Gregory T. Armstrong, Wendy M. Leisenring, Rebecca M. Howell, Yutaka Yasui, Stephanie B. Dixon, Matthew J. Ehrhardt, Leslie L. Robison, Kirsten K. Ness
Summary: This study investigated the impact of therapy changes for childhood ALL and NHL on the prevalence of physical performance limitations and participation restrictions among survivors. The findings suggest that despite changes in therapy, poor physical function remained consistent between the 1970s and 1990s.
JOURNAL OF CANCER SURVIVORSHIP
(2023)
Meeting Abstract
Oncology
Debra L. Friedman, Emma Schremp, Tatsuki Koyama, Lili Sun, Lori Ann Kehler, Anthony Daniels, Robert J. Hayashi, Amish C. Shah, Helen Dimaras, Rajaram Nagarajan, Mary Lou Schmidt, Murali M. Chintagumpala, Cynthia E. Herzog, Sandra Luna-Fineman, Claire Elyse Fraley, Joanna Weinstein, Thomas Arthur Olson, Bruce Crooks, Cindy L. Schwartz, Joseph Philip Neglia
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Meeting Abstract
Oncology
Debra L. Friedman, Emma Schremp, Tatsuki Koyama, Lili Sun, Lori Ann Kehler, Anthony Daniels, Amish C. Shah, Helen Dimaras, Rajaram Nagarajan, Robert J. Hayashi, Mary Lou Schmidt, Murali M. Chintagumpala, Cynthia E. Herzog, Sandra Luna-Fineman, Claire Elyse Fraley, Joanna Weinstein, Thomas Arthur Olson, Bruce Crooks, Cindy L. Schwartz, Joseph Philip Neglia
JOURNAL OF CLINICAL ONCOLOGY
(2022)
Meeting Abstract
Medicine, General & Internal
S. Khan, J. Jakubiak, M. Guan, R. Hayashi, A. King, D. Wilfley
IRISH JOURNAL OF MEDICAL SCIENCE
(2022)