Article
Medicine, Research & Experimental
Mandy Li, Levi Nguyen, Dorota Ferens, Iresha Spizzo, Yan Wang, Kate M. Denton, Mark Del Borgo, Ketav Kulkarni, Marie -Isabel Aguilar, Chengxue Helena Qin, Chrishan S. Samuel, Tracey A. Gaspari, Robert E. Widdop
Summary: This study aimed to investigate the effects of angiotensin II type 2 receptor (AT2R) stimulation in a model of hypertension with type 1 diabetes mellitus (T1DM). The results showed that the AT2R agonist attenuated cardiac fibrosis, inflammatory markers, and superoxide levels in diabetic spontaneously hypertensive rats (SHRs). However, the AT1R blocker did not show the same protective effects.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Plant Sciences
Yan Wu, Xin Yang, Yuanyuan Ju, Fei Zhao
Summary: This study found that fraxinol has significant therapeutic effects in the treatment of acute lung injury (ALI). It works by balancing the ACE-Ang II-AT1R and ACE2-Ang (1-7)-Mas axis and inhibiting the activation of NLRP3 inflammasome.
PHARMACEUTICAL BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Moudhi Almutlaq, Fatmah A. Mansour, Jahad Alghamdi, Yassen Alhendi, Abir Abdullah Alamro, Amani Ahmed Alghamdi, Hassan S. Alamri, Fayhan Alroqi, Tlili Barhoumi
Summary: This study demonstrates that angiotensin II (Ang II) exacerbates the T-cell response to SARS-CoV-2 in recovered COVID-19 patients. The presence of Ang II increases the phosphorylation levels of proteins involved in cardiovascular diseases, inflammation, and viral infection. These findings suggest that Ang II may worsen the inflammatory response and alter the immune response to a more inflammatory profile against SARS-CoV-2 infection.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Anthony Fernandez-Castaneda, Peiwen Lu, Anna C. Geraghty, Eric Song, Myoung-Hwa Lee, Jamie Wood, Michael R. O'Dea, Selena Dutton, Kiarash Shamardani, Kamsi Nwangwu, Rebecca Mancusi, Belgin Yalcin, Kathryn R. Taylor, Lehi Acosta-Alvarez, Karen Malacon, Michael B. Keough, Lijun Ni, Pamelyn J. Woo, Daniel Contreras-Esquivel, Angus Martin Shaw Toland, Jeff R. Gehlhausen, Jon Klein, Takehiro Takahashi, Julio Silva, Benjamin Israelow, Carolina Lucas, Tianyang Mao, Mario A. Pena-Hernandez, Alexandra Tabachnikova, Robert J. Homer, Laura Tabacof, Jenna Tosto-Mancuso, Erica Breyman, Amy Kontorovich, Dayna McCarthy, Martha Quezado, Hannes Vogel, Marco M. Hefti, Daniel P. Perl, Shane Liddelow, Rebecca Folkerth, David Putrino, Avindra Nath, Akiko Iwasaki, Michelle Monje
Summary: COVID survivors may experience lingering neurological symptoms similar to cognitive impairment related to cancer therapy. Research has found that respiratory SARS-CoV-2 infection can cause white-matter-selective microglial reactivity and affect neurogenesis and CCL11 levels.
Article
Endocrinology & Metabolism
Whitney Wharton, Andrea Anderson, Kathleen M. Hayden, Owen T. Carmichael, Jeanne M. Clark, Jose A. Luchsinger, Mark Espeland, Sevil Yasar
Summary: The aim of this study was to investigate whether antihypertensive medication acting through the renin angiotensin system (RAS-AHM) could mitigate cognitive function impairment and the risk of cognitive decline compared to other antihypertensive medication in individuals with type 2 diabetes mellitus (T2DM). The results showed that RAS-AHM users had a slower decline in processing speed, executive function, verbal memory, and composite score compared to other AHM users in this cohort of adults with T2DM who were free of dementia at the beginning of the study.
DIABETES OBESITY & METABOLISM
(2022)
Review
Neurosciences
Arthur Sefiani, Cedric G. Geoffroy
Summary: Approximately 291,000 individuals in the United States are currently suffering from spinal cord injuries (SCI). These patients face long-term chronic health complications such as diabetes and depression. Medical advancements have led to a longer survival rate for SCI patients, but also expose them to novel neurological complications. Inflammation plays a significant role in modulating hippocampal neurogenesis post-SCI.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Critical Care Medicine
Bruno Garcia, Fuhong Su, Francesca Manicone, Laurence Dewachter, Raphael Favory, Amina Khaldi, Alexander Moiroux-Sahroui, Anthony Moreau, Antoine Herpain, Jean-Louis Vincent, Jacques Creteur, Fabio Silvio Taccone, Filippo Annoni
Summary: The aim of this study was to investigate the effects of Ang-(1-7) infusion on the development and severity of septic shock. The results showed that early Ang-(1-7) infusion can prevent the development of septic shock, reduce norepinephrine requirements, limit the increase of interleukin-6 levels, and prevent renal dysfunction.
Article
Multidisciplinary Sciences
Otavio Cabral-Marques, Gilad Halpert, Lena F. Schimke, Yuri Ostrinski, Aristo Vojdani, Gabriela Crispim Baiocchi, Paula Paccielli Freire, Igor Salerno Filgueiras, Israel Zyskind, Miriam T. Lattin, Florian Tran, Stefan Schreiber, Alexandre H. C. Marques, Desiree Rodrigues Placa, Dennyson Leandro M. Fonseca, Jens Y. Humrich, Antje Mueller, Lasse M. Giil, Hanna Grasshoff, Anja Schumann, Alexander Hackel, Juliane Junker, Carlotta Meyer, Hans D. Ochs, Yael Bublil Lavi, Carmen Scheibenbogen, Ralf Dechend, Igor Jurisica, Kai Schulze-Forster, Jonathan Silverberg, Howard Amital, Jason Zimmerman, Harry Heidecke, Avi Z. Rosenberg, Gabriela Riemekasten, Yehuda Shoenfeld
Summary: The abundance and network signature of autoantibodies targeting G protein-coupled receptors and RAS-related proteins are altered in COVID-19 patients, and the level of disruption marks clinical severity.
NATURE COMMUNICATIONS
(2022)
Article
Oncology
Pi-Shan Sung, Pei-Wen Chen, Chia-Jui Yen, Meng-Ru Shen, Chih-Hung Chen, Kuen-Jer Tsai, Chou-Ching K. Lin
Summary: The study revealed that memantine could potentially treat paclitaxel-induced chemotherapy-induced cognitive impairment (CICI) by enhancing neurogenesis and modulating inflammation. Different treatment strategies may lead to variations in the treatment efficacy.
Review
Pharmacology & Pharmacy
Annamaria Mascolo, Cristina Scavone, Concetta Rafaniello, Antonella De Angelis, Konrad Urbanek, Gabriella di Mauro, Donato Cappetta, Liberato Berrino, Francesco Rossi, Annalisa Capuano
Summary: The renin-angiotensin-aldosterone system (RAAS) is now recognized as a local tissue system that affects organ function and can contribute to the onset of diseases. It operates in both the heart and lungs, with classic and non-classic pathways having different effects on cardiovascular and pulmonary health.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Cell Biology
Shun He, Yuanyuan Lu, Yuetong Guo, Shijin Li, Xiao Lu, Shuai Shao, Handan Zhou, Ruiqi Wang, Jiguang Wang, Pingjin Gao, Xiaodong Li
Summary: The study revealed that KLF15 in cardiac fibroblasts negatively regulates the CXCL1/CXCR2 axis-mediated inflammatory response and subsequent cardiac remodeling in hypertension.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Peripheral Vascular Disease
Mario Zanaty, Fernando A. C. Seara, Pablo Nakagawa, Guorui Deng, Natalia M. Mathieu, Kirthikaa Balapattabi, Sadashiva S. Karnik, Justin L. Grobe, Curt D. Sigmund
Summary: The study found that intracerebroventricular administration of TRV027 can increase aversion to saline and lower blood pressure in a model of salt-sensitive hypertension. Both TRV027 and losartan increased aversion to saline, with a more pronounced effect on highly aversive saline solutions.
Article
Biochemistry & Molecular Biology
Kewarin Jinawong, Chanon Piamsiri, Nattayaporn Apaijai, Chayodom Maneechote, Hiranya Pintana, Titikorn Chunchai, Busarin Arunsak, Nipon Chattipakorn, Siriporn C. Chattipakorn
Summary: We previously reported that apoptosis plays a role in cognitive impairment in rats with myocardial infarction (MI). In this study, we investigated the effects of an apoptosis inhibitor, Z-vad, on cognitive function, brain inflammation, mitochondrial function, cell death pathways, and neurogenesis in MI rats. Our findings showed that Z-vad effectively improved cardiac function, cognitive function, and dendritic spine density in MI rats by reducing oxidative stress, mitochondrial dysfunction, and apoptosis, as well as enhancing mitophagy and neurogenesis.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Chemistry, Medicinal
Sana Khajeh Pour, Arina Ranjit, Emma L. Summerill, Ali Aghazadeh-Habashi
Summary: This study evaluated the anti-inflammatory effects of a novel and stable conjugate of Ang-(1-7) in a rat model of arthritis. The results showed that the conjugate reduced inflammation-related body weight loss and joint edema, and decreased nitric oxide levels. In addition, the conjugate modulated the components of the renin-angiotensin system and exhibited enhanced therapeutic effects.
Article
Biochemistry & Molecular Biology
Francesca Antonelli, Arianna Casciati, Montserrat Belles, Noemi Serra, Maria Victoria Linares-Vidal, Carmela Marino, Mariateresa Mancuso, Simonetta Pazzaglia
Summary: Radiation therapy is a primary treatment modality for brain tumors, but long-term neurocognitive decline significantly affects quality of life. Recent evidence suggests that modulating the Shh signaling pathway can mitigate hippocampal radiation injury and improve brain repair and functional recovery after radio-induced injury.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)