Article
Medicine, Research & Experimental
Constantine J. Georgiou, Zhongli Cai, Noor Alsaden, Hyungjun Cho, Minou Behboudi, Mitchell A. Winnik, James T. Rutka, Raymond M. Reilly
Summary: In this study, convection-enhanced delivery (CED) of 23 +/- 3 nm gold nanoparticles (AuNPs) labeled with the beta-particle-emitting radionuclide 177Lu (177Lu-AuNPs) was found to be highly effective for treating orthotopic U251-Luc human glioblastoma multiforme (GBM) tumors in NRG mice. The cytotoxicity of 177Lu-AuNPs on U251-Luc cells was confirmed through in vitro experiments, while in vivo studies showed that the tumors treated with 177Lu-AuNPs exhibited growth arrest and improved long-term survival compared to control mice. Overall, this study highlights the potential of CED using 177Lu-AuNPs as a promising treatment for GBM patients. Rating: 8/10
MOLECULAR PHARMACEUTICS
(2023)
Article
Instruments & Instrumentation
Hongyu Chen, Guanghui Hu, Defang Ouyang
Summary: This study simulated the drug concentration in brain tumors after drug release from Gliadel wafers using numerical methods. The numerical results demonstrated the reliability of the method, with finite element method showing steady state pressure in normal tissue and finite difference method displaying changes in drug concentration at six different time points.
DRUG DELIVERY AND TRANSLATIONAL RESEARCH
(2022)
Review
Oncology
Randy S. D'Amico, Manish K. Aghi, Michael A. Vogelbaum, Jeffrey N. Bruce
Summary: Convection-enhanced delivery (CED) is a method of targeted, local drug delivery to the central nervous system that shows promise for treating glioblastoma (GBM), although the long-term efficacy of the agents studied remains difficult to assess at present.
JOURNAL OF NEURO-ONCOLOGY
(2021)
Article
Nanoscience & Nanotechnology
Jamie M. Gleason, Sarah H. Klass, Paul Huang, Tomoko Ozawa, Raquel A. Santos, Miko M. Fogarty, David R. Raleigh, Mitchel S. Berger, Matthew B. Francis
Summary: Lipid and micelle-based nanocarriers have been studied for delivering anticancer drugs to improve their accumulation and uptake in tumor tissue. In this study, a protein-based micelle nanocarrier called IDP-2Yx2A was developed to encapsulate a highly potent but water-insoluble cancer drug, SN38, for delivery into glioblastoma multiforme (GBM) tumors. The results showed promising in vivo efficacy with slowed tumor growth and increased median survival times.
ACS APPLIED BIO MATERIALS
(2022)
Article
Materials Science, Multidisciplinary
Linda Waldherr, Maria Seitanidou, Marie Jakesova, Verena Handl, Sophie Honeder, Marta Nowakowska, Tamara Tomin, Meysam Karami Rad, Tony Schmidt, Joachim Distl, Ruth Birner-Gruenberger, Gord Campe, Ute Schafer, Magnus Berggren, Beate Rinner, Martin Asslaber, Nassim Ghaffari-Tabrizi-Wizsy, Silke Patz, Daniel T. Simon, Rainer Schindl
Summary: The study confirms Gem's significantly greater potency in killing GBM cells compared to temozolomide, and demonstrates the potential of the electronically-driven organic ion pump GemIP for targeted delivery to GBM cells.
ADVANCED MATERIALS TECHNOLOGIES
(2021)
Review
Oncology
Satya Siva Kishan Yalamarty, Nina Filipczak, Xiang Li, Md Abdus Subhan, Farzana Parveen, Janaina Artem Ataide, Bharat Ashok Rajmalani, Vladimir P. Torchilin
Summary: Glioblastoma multiforme (GBM) is a highly aggressive form of brain cancer that is difficult to treat due to its resistance to traditional cancer treatments. The unique biology of GBM cells and the blood-brain barrier contribute to this resistance. However, there are several treatment options available, including surgery, chemoradiotherapy, adjuvant chemotherapy, immunotherapy, targeted therapies, and tumor-treating fields. Ongoing clinical trials aim to improve outcomes for GBM patients.
Article
Chemistry, Multidisciplinary
Jiantang Liang, Lei Li, Hailong Tian, Zhihan Wang, Guowen Liu, Xirui Duan, Meiwen Guo, Jiaqi Liu, Wei Zhang, Edouard C. Nice, Canhua Huang, Weifeng He, Haiyuan Zhang, Qifu Li
Summary: Developing therapies that can effectively target glioblastoma by crossing the blood-brain barrier (BBB) and induce ferroptosis is crucial for improving treatment outcomes. In this study, a versatile biomimetic nanoplatform, L-D-I/NPs, was designed for selective targeting of glioblastoma by binding to low-density lipoprotein receptor-related protein-1 (LRP1) and crossing the BBB, thus inducing ferroptosis in glioblastoma cells. L-D-I/NPs have demonstrated the ability to effectively suppress tumor progression and prolong survival in a mouse glioblastoma model, offering a promising approach for ferroptosis-based therapies.
Article
Biochemistry & Molecular Biology
Bilal Javed, Xinyi Zhao, Daxiang Cui, James Curtin, Furong Tian
Summary: The study synthesized Lignin-g-p (NIPAM-co-DMAEMA) gold nanogel loaded with curcumin and piperine to treat GBM, which exhibited enhanced anticancer properties, improved drug toxicity and release, and induced apoptosis through endocytic pathways. The experimental evidence suggests that the combinatorial curcumin-piperine gold nanogels have the potential to overcome the limitations of conventional chemotherapeutic treatments for glioma cells.
Article
Chemistry, Multidisciplinary
Jiaqi Liu, Yuting Sun, Xianhuang Zeng, Yang Liu, Chaozhi Liu, Ying Zhou, Yueguang Liu, Guihong Sun, Mingxiong Guo
Summary: This study developed artificial vesicles loaded with ANG-TRP-PK1 peptides for targeted therapy of brain tumors. The peptide-loaded vesicles showed better therapeutic effects and reduced side effects compared to traditional drugs in mouse models.
ADVANCED MATERIALS
(2023)
Article
Medicine, Research & Experimental
Elisa Checa-Chavarria, Eva Rivero-Buceta, Miguel Angel Sanchez Martos, Gema Martinez Navarrete, Cristina Soto-Sanchez, Pablo Botella, Eduardo Fernandez
Summary: This novel therapeutic approach using CPT-ALA shows promising results in targeting GBM cells with improved cytotoxic effects and reduced side effects on healthy tissue. In preclinical studies, CPT-ALA demonstrated significant reduction in intracranial GBM volume without notable toxicity, indicating its potential for improving the success of surgical removal and extending life expectancy by reducing tumor recurrence.
MOLECULAR PHARMACEUTICS
(2021)
Review
Chemistry, Multidisciplinary
P. Soma Yasaswi, Karishma Shetty, Khushwant S. Yadav
Summary: GBM, a life-threatening IV grade glioma brain cancer, remains a challenge to treat due to the toxic nature and fast degradation of TMZ, along with lack of targeting ability increasing chances of systemic toxicities. Nano-enabled technology improves the efficiency of TMZ and reduces toxicity to healthy tissues.
JOURNAL OF CONTROLLED RELEASE
(2021)
Article
Multidisciplinary Sciences
Yuanning Zheng, Francisco Carrillo-Perez, Marija Pizurica, Dieter Henrik Heiland, Olivier Gevaert
Summary: In this study, two deep learning models were used to predict the transcriptional subtypes and prognosis of glioblastoma (GBM) cells from histology images. The results showed consistent associations between spatial cellular organization and patient prognosis. The study also confirmed that transcriptional heterogeneity and cell-state plasticity are key factors in the development of therapeutic resistance in GBM.
NATURE COMMUNICATIONS
(2023)
Article
Pharmacology & Pharmacy
Saurabh Mittal, Sadia Shah, Harlokesh Narayan Yadav, Javed Ali, Madan Mohan Gupta, Sanjula Baboota
Summary: This study aimed to develop a novel drug formulation for the treatment of glioblastoma, targeting drug delivery to the brain through intranasal route. The optimized lipid nanoparticles showed high drug entrapment efficiency and permeation, making them effective in treating glioblastoma.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Article
Medicine, Research & Experimental
Shixue Yang, Jixing Zhao, Xiaoteng Cui, Qi Zhan, Kaikai Yi, Qixue Wang, Menglin Xiao, Yanli Tan, Biao Hong, Chuan Fang, Chunsheng Kang
Summary: The study demonstrates that targeted inhibitors can effectively disrupt energy metabolism in GBM and inhibit tumor proliferation.
Review
Biochemistry & Molecular Biology
Marianna Makowska, Beata Smolarz, Hanna Romanowicz
Summary: Glioblastoma multiforme (GBM) is a common, malignant brain tumor with a poor prognosis. Traditional treatments have limited success due to the tumor's infiltrating growth and resistance. The search for new therapies is crucial.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Clinical Neurology
Tony J. C. Wang, Minesh P. Mehta
NEUROSURGERY CLINICS OF NORTH AMERICA
(2019)
Article
Oncology
Tim J. Kruser, Walter R. Bosch, Shahed N. Badiyan, Joseph A. Bovi, Amol J. Ghia, Michelle M. Kim, Abhishek A. Solanki, Sean Sachdev, Christina Tsien, Tony J. C. Wang, Minesh P. Mehta, Kevin P. McMullen
JOURNAL OF NEURO-ONCOLOGY
(2019)
Article
Clinical Neurology
Matthew D. Hall, Yazmin Odia, Joshua E. Allen, Rohinton Tarapore, Ziad Khatib, Toba N. Niazi, Doured Daghistani, Lee Schalop, Andrew S. Chi, Wolfgang Oster, Minesh P. Mehta
JOURNAL OF NEUROSURGERY-PEDIATRICS
(2019)
Article
Oncology
Vikram Jairam, Benjamin H. Kann, Henry S. Park, Joseph A. Miccio, Jason M. Beckta, James B. Yu, Roshan S. Prabhu, Sarah J. Gao, Minesh P. Mehta, Walter J. Curran, Ranjit S. Bindra, Joseph N. Contessa, Kirtesh R. Patel
ANTICANCER RESEARCH
(2019)
Letter
Oncology
Rupesh Kotecha, Minesh P. Mehta
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2019)
Meeting Abstract
Oncology
R. Jayakrishnan, M. P. Mehta, Y. D. Tseng, C. E. Vargas, V. Gondi, H. K. Tsai, L. M. Halasz, C. J. Rossi, C. J. Wang, S. N. Badiyan, R. Kotecha
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2019)
Meeting Abstract
Oncology
E. H. Bell, M. Won, J. Fleming, A. Becker, J. McElroy, E. G. Shaw, M. P. Mehta, D. G. Brachman, S. Gertler, A. D. Murtha, C. J. Schultz, D. Johnson, N. N. Laack, G. K. Hunter, I. R. Crocker, A. Chakravarti
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2019)
Meeting Abstract
Oncology
V. Gondi, S. Pugh, P. D. Brown, J. S. Wefel, W. A. Tome, T. S. Armstrong, D. W. Bruner, J. A. Bovi, C. G. Robinson, D. Khuntia, D. R. Grosshans, A. A. Konski, D. Roberge, V. Kundapur, K. Devisetty, S. A. Shah, K. Y. Usuki, B. M. Anderson, M. P. Mehta, L. A. Kachnic
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2019)
Meeting Abstract
Oncology
C. Tsien, S. Pugh, A. P. Dicker, J. J. Raizer, M. M. Matuszak, E. Lallana, J. Huang, O. Algan, N. Taylor, L. Portelance, J. Villano, J. Hamm, K. S. Oh, A. N. Ali, M. M. Kim, S. Lindhorst, M. P. Mehta
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2019)
Review
Radiology, Nuclear Medicine & Medical Imaging
Tej Ishaan Mehta, Caleb Heiberger, Stephanie Kazi, Mark Brown, Simcha Weissman, Kelvin Hong, Minesh Mehta, Douglas Yim
JOURNAL OF VASCULAR AND INTERVENTIONAL RADIOLOGY
(2020)
Article
Oncology
D. Jay Wieczorek, Rupesh Kotecha, Matthew D. Hall, Martin C. Tom, Stephen Davis, Manmeet S. Ahluwalia, Michael W. McDermott, Minesh P. Mehta, Alonso N. Gutierrez, Ranjini Tolakanahalli
Summary: This study compared the plan quality metrics of manual forward planning (MFP) and Elekta Fast Inverse Planning (FIP) for stereotactic radiosurgery (SRS) in patients treated with Gamma Knife (R). The results showed that FIP plans demonstrated a statistically significant improvement in target coverage, conformity index, and gradient index compared to MFP plans, while there was no significant difference in beam-on time and delivery parameters between the two planning methods.
Article
Oncology
Tugce Kutuk, Ranjini Tolakanahalli, Nicole C. McAllister, Matthew D. Hall, Martin C. Tom, Muni Rubens, Haley Appel, Alonso N. Gutierrez, Yazmin Odia, Alexander Mohler, Manmeet S. Ahluwalia, Minesh P. Mehta, Rupesh Kotecha
Summary: This study evaluated dosimetric data for patients treated with PRDR IMRT for recurrent primary CNS malignancies and found that PRDR re-irradiation is a safe and feasible strategy with favorable clinical outcomes and mild toxicities.
Editorial Material
Oncology
Rupesh Kotecha, Minesh P. Mehta
Article
Oncology
Kathryn E. Mittauer, Sreenija Yarlagadda, John M. Bryant, Nema Bassiri, Tino Romaguera, Andres G. Gomez, Robert Herrera, Rupesh Kotecha, Minesh P. Mehta, Alonso N. Gutierrez, Michael Chuong
Summary: This study describes a 5-fraction ablative SMART planning approach for pancreatic cancer that is robust and stable during on-table adaption, due to gradients controlled by a GI PRV technique and the use of rings. These findings are noteworthy given that daily interfraction anatomic GI OAR differences are routine, thus necessitating on-table adaptation. This work supports feasibility towards utilizing a patient-independent, template on-table adaptive approach.
RADIOTHERAPY AND ONCOLOGY
(2023)
Review
Oncology
Sarbani Ghosh Laskar, Shwetabh Sinha, Rahul Krishnatry, Cai Grau, Minesh Mehta, Jai Prakash Agarwal
Summary: The discipline of radiation oncology is faced with challenges in terms of accessibility and affordability, particularly in low-income and low-middle-income countries. The distribution of radiation therapy machines and brachytherapy facilities is unequal, while there is also a deficit in simulators, radiation oncologists, and medical physicists. Measures to address these challenges include adopting indigenous technology, promoting public-private partnerships, relaxing custom duties, enhancing human resources training, and conducting innovative research.
JCO GLOBAL ONCOLOGY
(2022)