Article
Chemistry, Multidisciplinary
Shelby B. Smiley, Yeonhee Yun, Pranav Ayyagari, Harlan E. Shannon, Karen E. Pollok, Michael W. Vannier, Sudip K. Das, Michael C. Veronesi
Summary: This study aimed to develop a multi-drug therapy using nanotechnology to target the GBM CSC subpopulation, reduce cell viability, and potentially provide in vivo preclinical imaging. The results demonstrated that functionalized nanoparticles loaded with TMZ and idasanutlin could effectively target and kill the CSC subpopulation, offering a promising approach for future localized therapy.
PHARMACEUTICAL RESEARCH
(2021)
Review
Nutrition & Dietetics
Simone E. M. Olsthoorn, Xi Wang, Berend Tillema, Tim Vanmierlo, Stefan Kraan, Pieter J. M. Leenen, Monique T. Mulder
Summary: Brown seaweeds have been traditionally used in Asia and are believed to have multiple health benefits, particularly in impacting inflammation-related pathologies such as allergies, diabetes mellitus, and obesity. Consumption of brown seaweeds or compounds can inhibit reactive oxygen species, regulate proinflammatory signaling pathways, and modulate adaptive immune responses, potentially leading to the development of functional foods and nutraceuticals for combating various inflammation-related diseases.
Article
Medicine, General & Internal
Christine Lehner, Gabriel Spitzer, Patrick Langthaler, Dominika Jakubecova, Barbara Klein, Nadja Weissenbacher, Andrea Wagner, Renate Gehwolf, Eugen Trinka, Bernhard Iglseder, Bernhard Paulweber, Ludwig Aigner, Sebastien Couillard-Despres, Richard Weiss, Herbert Tempfer, Andreas Traweger
Summary: This study demonstrates that systemic inflammation accompanying allergic conditions negatively affects tendon structure and function. The research findings from mice and humans show that allergic reactions induce a reduction in tendon elasticity and tensile stress, as well as alterations in the tendon matrix. Furthermore, individuals with allergies are more likely to develop tendinopathy.
Article
Biochemistry & Molecular Biology
Gloria Krapez, Katarina Kouter, Ivana Jovcevska, Alja Videtic Paska
Summary: Glioblastoma is the most common and aggressive brain tumor in the central nervous system, with poor patient survival and limited treatment options. In addition to gene mutations, the malignancy of the tumor is also influenced by its communication with the surrounding environment.
Article
Gastroenterology & Hepatology
Benjamin L. Wright, Nielsen Q. Fernandez-Becker, Neeraja Kambham, Natasha Purington, Shu Cao, Dana Tupa, Wenming Zhang, Sayantani B. Sindher, Matthew A. Rank, Hirohito Kita, David A. Katzka, Kelly P. Shim, Bryan J. Bunning, Alfred D. Doyle, Elizabeth A. Jacobsen, Mindy Tsai, Scott D. Boyd, Monali Manohar, R. Sharon Chinthrajah
Summary: In this pilot study, peanut OIT-induced EE and gastrointestinal eosinophilia are usually transient and are not always associated with gastrointestinal symptoms.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Review
Immunology
Zhongwei Zhang, Peter B. Ernst, Hiroshi Kiyono, Yosuke Kurashima
Summary: Mast cells are widely distributed immune cells with diverse phenotypes and functions. They exhibit high functional heterogeneity and plasticity due to their unique maturation mechanism. Mast cells can adapt to different microenvironments and regulate allergy and inflammation under the peripheral immune education system. This review focuses on the mechanism and heterogeneity of mast cell migration to mucosal tissues, such as the gastrointestinal tract. The immunosuppressive properties of mast cells suggest a potential new approach for treating inflammatory and allergic disorders.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Plant Sciences
Lanyang Xu, Hao Duan, Yuheng Zou, Jing Wang, Huaxi Liu, Wanyu Wang, Xiao Zhu, Jiali Chen, Chuanwu Zhu, Zhixin Yin, Xiaoshan Zhao, Qirui Wang
Summary: In this study, the potential molecular mechanism and effect of the Chinese medicine Xihuang pill (XHP) on glioma stem-like cells (GSCs) were evaluated. Through analysis of the constituent of XHP and network pharmacology, it was found that XHP can induce apoptosis and inhibit self-renewal ability of GSCs. In addition, XHP can also reduce the expression of GSC markers and impede glioma growth in vivo.
Article
Oncology
Amin Izadpanah, Fatemeh Daneshimehr, Kurtis Willingham, Zahra Barabadi, Stephen E. Braun, Aaron Dumont, Ricardo Mostany, Bysani Chandrasekar, Eckhard U. Alt, Reza Izadpanah
Summary: TRAF3IP2 has been identified as a critical regulator of angiogenesis in glioblastoma multiforme (GBM), and targeting TRAF3IP2 could significantly reduce vascularization and inhibit the expression of growth factors, providing a potential therapeutic option for GBM.
FRONTIERS IN ONCOLOGY
(2022)
Article
Immunology
Bruno Marques Vieira, Vitoria Santorio de Sao Jose, Paulo Soares Niemeyer, Vivaldo Moura-Neto
Summary: This study aimed to evaluate the interaction between eosinophils and glioblastoma cells, the mechanism of potential killing of glioblastoma cells by eosinophils, and how allergy/asthma could improve the prognosis of glioblastoma. The study found that eosinophils can be recruited and activated by glioblastoma cells via GM-CSF signaling, leading to inhibition of glioblastoma cell metabolism, proliferation, and migration through Fas/FasL pathway and induction of cell death. Cysteinyl leukotrienes present in asthmatic serum enhance glioblastoma cell migration and proliferation, but also activate eosinophils that suppress glioblastoma cells.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Katie D. Hunter, Robert W. E. Crozier, Jessica L. Braun, Val A. Fajardo, Adam J. MacNeil
Summary: In this study, the role of SARCA in allergen-activated mast cells was characterized. Treatment with the SARCA activating compound, CDN1163, was found to attenuate early phase mast cell degranulation, reactive oxygen species (ROS) production, and secretion of IL-6, IL-13, and CCL3. These protective effects may be driven by the suppression of p38 MAPK signaling. These findings suggest that SARCA is an important regulator of the mast cell response to allergens and may have therapeutic potential in targeting allergic pathologies.
Article
Allergy
Rinkesh K. Gupta, Jacqueline Miller, Michael Croft
Summary: This study found that the TNF family cytokine TWEAK plays an important role in keratinocyte dysregulation and the pathogenesis of AD. Blocking TWEAK and IL-13 had similar therapeutic effects in treating AD. Therefore, neutralizing TWEAK could be a potential therapeutic option for treating AD.
Article
Pharmacology & Pharmacy
Caigui Xiang, Chen Fan, Qiukai Lu, Moting Liu, Huimin Lu, Chunlan Feng, Yanwei Wu, Bing Wu, Heng Li, Wei Tang
Summary: Our study demonstrated that CSF-1R expression was increased in HDM-induced experimental asthma and inhibition of CSF-1R significantly affected the disease severity of asthma by suppressing allergic mediators secretion, airway epithelium dysfunction, and inflammatory cells infiltration. Furthermore, CSF-1R inhibitor could notably restrain the polarization and expression of transcriptional factors of alternatively activated macrophages (AAMs) induced by IL-4/IL-13 and reduce the recruitment of CSF1R-dominant macrophages in both acute and chronic allergic airway inflammation models.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Gastroenterology & Hepatology
Michael Brusilovsky, Mark Rochman, Tetsuo Shoda, Michael Kotliar, Julie M. Caldwell, Lydia E. Mack, John A. Besse, Xiaoting Chen, Matthew T. Weirauch, Artem Barski, Marc E. Rothenberg
Summary: This study identifies vitamin D as a natural IL-13 antagonist that can regulate the functions of the esophageal epithelial barrier, providing a novel therapeutic approach for type 2 immunity-related diseases.
Article
Environmental Sciences
Khairul Nizam Mohd Isa, Juliana Jalaludin, Saliza Mohd Elias, Leslie Thian Lung Than, Mohammed Abdulrazzaq Jabbar, Ahmad Shakir Mohd Saudi, Dan Norback, Jamal Hisham Hashim, Zailina Hashim
Summary: The study investigated the impact of indoor air pollutants on allergy and respiratory diseases in school children, identifying specific fungi species associated with childhood asthma and their correlation with protein expression levels on eosinophils and neutrophils.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Review
Oncology
Thomas Joyce, Sarisha Jagasia, Erdal Tasci, Kevin Camphausen, Andra Valentina Krauze
Summary: CD133 is associated with prognosis, tumor microenvironment, tumor resistance, and tumor recurrence in GBM.
Article
Biology
Marc Sturrock, Wenrui Hao, Judith Schwartzbaum, Grzegorz A. Rempala
JOURNAL OF THEORETICAL BIOLOGY
(2015)
Letter
Oncology
Quinn T. Ostrom, Luc Bauchet, Faith G. Davis, Isabelle Deltour, James L. Fisher, Chelsea Eastman Langer, Melike Pekmezci, Judith A. Schwartzbaum, Michelle C. Turner, Kyle M. Walsh, Margaret R. Wrensch, Jill S. Barnholtz-Sloan
Article
Oncology
Victoria Zigmont, Amy Garrett, Jin Peng, Michal Seweryn, Grzegorz A. Rempala, Randall Harris, Christopher Holloman, Thomas E. Gundersen, Anders Ahlbom, Maria Feychting, Tom Borge Johannesen, Tom Kristian Grimsrud, Judith Schwartzbaum
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL
(2015)
Article
Multidisciplinary Sciences
Judith Schwartzbaum, Michal Seweryn, Christopher Holloman, Randall Harris, Samuel K. Handelman, Grzegorz A. Rempala, Ruo-Pan Huang, Brett Burkholder, Adam Brandemihl, Henrik Kallberg, Tom Borge Johannesen, Anders Ahlbom, Maria Feychting, Tom K. Grimsrud
Article
Oncology
Brittany M. Bernardo, Robert C. Orellana, Yiska Lowenberg Weisband, Niklas Hammar, Goran Walldius, Hakan Malmstrom, Anders Ahlbom, Maria Feychting, Judith Schwartzbaum
BRITISH JOURNAL OF CANCER
(2016)
Article
Oncology
Giorgio Tettamanti, Rickard Ljung, Tiit Mathiesen, Judith Schwartzbaum, Maria Feychting
CANCER EPIDEMIOLOGY
(2016)
Article
Oncology
Giorgio Tettamanti, Rickard Ljung, Tiit Mathiesen, Judith Schwartzbaum, Maria Feychting
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2016)
Article
Multidisciplinary Sciences
Judith Schwartzbaum, Min Wang, Elisabeth Root, Maciej Pietrzak, Grzegorz A. Rempala, Ruo-Pan Huang, Tom Borge Johannesen, Tom K. Grimsrud
Review
Oncology
Kimberly J. Johnson, Jennifer Cullen, Jill S. Barnholtz-Sloan, Quinn T. Ostrom, Chelsea E. Langer, Michelle C. Turner, Roberta McKean-Cowdin, James L. Fisher, Philip J. Lupo, Sonia Partap, Judith A. Schwartzbaum, Michael E. Scheurer
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2014)
Article
Oncology
Quinn T. Ostrom, Luc Bauchet, Faith G. Davis, Isabelle Deltour, James L. Fisher, Chelsea Eastman Langer, Melike Pekmezci, Judith A. Schwartzbaum, Michelle C. Turner, Kyle M. Walsh, Margaret R. Wrensch, Jill S. Barnholtz-Sloan
Article
Oncology
Maral Adel Fahmideh, Judith Schwartzbaum, Paolo Frumento, Maria Feychting
Article
Multidisciplinary Sciences
Judith Schwartzbaum, Michael Edlinger, Victoria Zigmont, Par Stattin, Grzegorz A. Rempala, Gabriele Nagel, Niklas Hammar, Hanno Ulmer, Bernhard Foeger, Goran Walldius, Jonas Manjer, Hakan Malmstrom, Maria Feychting
SCIENTIFIC REPORTS
(2017)
Editorial Material
Oncology
Judith Schwartzbaum, Randall Harris
Article
Oncology
Randall E. Harris, Judith A. Schwartzbaum
FRONTIERS IN ONCOLOGY
(2022)
Article
Clinical Neurology
Kimberly J. Johnson, Judith Schwartzbaum, Carol Kruchko, Michael E. Scheurer, Ching C. Lau, Adelheid Woehrer, Johannes A. Hainfellner, Joseph Wiemels
CLINICAL NEUROPATHOLOGY
(2017)