Article
Multidisciplinary Sciences
Aner Mesic, Marija Rogar, Petra Hudler, Nurija Bilalovic, Izet Eminovic, Radovan Komel
Summary: The study identified an association between the AURKB rs2289590 AC genotype and AURKC rs11084490 CG genotype with reduced risk of GBM. Further research in larger and multiethnic populations is needed to confirm these findings.
SCIENTIFIC REPORTS
(2021)
Article
Health Care Sciences & Services
Ekaterina A. Vetchinkina, Dmitry S. Mikhaylenko, Ekaterina B. Kuznetsova, Tatiana A. Deryagina, Ekaterina A. Alekseeva, Irina Bure, Andrey A. Zamyatnin, Marina Nemtsova
Summary: Rheumatoid arthritis is a multifactorial disease influenced by genetic predisposition and environmental factors. Genotyping of RA patients revealed significant associations between certain alleles and genotypes with the development of RA, as well as clinical criteria and biochemical factors. Targeted NGS panel application contributes to expanded genotyping to identify risk groups among RA patients.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Samira Saghafi, Elham Chamani, Fatemeh Salmani, Reza Fadaei, Efat Shafiei, Nariman Moradi, Tahmine Tavakoli
Summary: This study aimed to investigate the expression of ANGPTL8 protein in NAFLD patients and elucidate the interaction between ANGPTL8 gene polymorphisms and lipid profiles. The rs737337 and rs2278426 genetic variations were found to be associated with the risk of NAFLD. However, further research is needed to understand the specific molecular mechanisms responsible for the upregulation of ANGPTL8 in individuals with NAFLD.
LIPIDS IN HEALTH AND DISEASE
(2023)
Review
Cell Biology
Elena Masselli, Giulia Pozzi, Cecilia Carubbi, Marco Vitale
Summary: Myeloproliferative neoplasms are hematologic malignancies with a significant heritable component that can be affected by germline variants. Host genetic factors play a role in determining the phenotypic presentation, outcome, and response to therapy of MPNs. Understanding the genetic determinants of clonal hematopoiesis can provide insights into the development of hematologic neoplasms.
Article
Neurosciences
Fuju Li, Yunyun Wang, Xiaoyan Hou, Lina Cao, Xiaoyi Zhou, Weiyan Yuan, Yi Shen, Tian Tian
Summary: This study found a causal relationship between genetic susceptibility to Parkinson's disease and the incidence of stroke (especially ischemic stroke) in the European population, but there was no causal relation between Alzheimer's disease and stroke risk.
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Nutrition & Dietetics
Ana Karina Zambrano, Santiago Cadena-Ullauri, Patricia Guevara-Ramirez, Viviana A. Ruiz-Pozo, Rafael Tamayo-Trujillo, Elius Paz-Cruz, Adriana Alexandra Ibarra-Rodriguez, Nieves Domenech
Summary: Hypertension is a major risk factor for cardiovascular diseases worldwide, and its prevalence is increasing in Latin America due to various factors including age, adoption of Westernized diets, and potential genetic predisposition. Genetic diversity in Latin America can influence disease susceptibility and treatment effectiveness. The spread of Western dietary patterns and excessive sodium consumption contribute to the rising prevalence of hypertension.
FRONTIERS IN NUTRITION
(2023)
Article
Biology
Wassan Jarrar, Sawsan Khdair, Feras A. Khudeir
Summary: The study suggests that MICA gene polymorphisms do not appear to be associated with increased susceptibility to T1D in the Jordanian population, except for a negative association with the MICA*011 allele.
Review
Hematology
Julia-Annabell Georgi, Jan Moritz Middeke, Martin Bornhaeuser, Axel Matzdorff, Karolin Trautmann-Grill
Summary: Immune thrombocytopenia (ITP) is a complex disorder caused by immunological dysregulation, including autoantibody-induced platelet destruction and abnormalities in T-cell immunity. Genetic variants play a key role in susceptibility to ITP, and efforts are being made to identify predisposing factors. However, due to the clinical heterogeneity and low incidence of ITP, performing genetic analyses with sufficient sample sizes remains challenging, highlighting the need for well-annotated biomaterials in clinical trials or registry projects. Additionally, establishing genotype-phenotype associations is crucial for proving causality between genetic alterations and ITP pathogenesis.
Article
Pediatrics
Eboni Marilia Reuter, Cezane Priscila Reuter, Joao Francisco de Castro Silveira, Ana Paula Sehn, Pamela Ferreira Todendi, Andreia Rosane de Moura Valim, Javier Brazo-Sayavera, Elza Daniel de Mello
Summary: This study aimed to explore the relationship between anthropometric measurements and genetic factors. The results showed that some schoolchildren carrying the rs9939609 polymorphism of the FTO gene had a higher likelihood of maintaining unfavorable nutritional status after three years. This suggests that genetics have a certain impact on obesity and anthropometric measurements.
Article
Clinical Neurology
Rita Perelroizen, Bar Philosof, Noga Budick-Harmelin, Tom Chernobylsky, Ariel Ron, Rotem Katzir, Dor Shimon, Adi Tessler, Orit Adir, Anat Gaoni-Yogev, Tom Meyer, Avivit Krivitsky, Nuphar Shidlovsky, Asaf Madi, Eytan Ruppin, Lior Mayo
Summary: This study reveals that depletion of reactive astrocytes can lead to regression of glioblastoma and prolonged survival. It also demonstrates that glioma cells depend on astrocyte-derived cholesterol for survival. The findings highlight the important role of astrocytes in controlling the pathogenicity of glioblastoma.
Article
Immunology
Qiang Wang, Hong Huang, Peng Chen, Xiao Xiao, Xiaolei Luo, Yanyun Wang, Siyu Long, Linbo Gao, Lin Zhang
Summary: The rs8101923 G allele is significantly associated with a higher risk of papillary thyroid carcinoma (PTC), and it is related to increased enhancer activities and gene expression.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Immunology
Boyuan Huang, Xuesong Li, Yuntao Li, Jin Zhang, Zhitao Zong, Hongbo Zhang
Summary: Glioblastoma multiforme (GBM) is the most common and aggressive malignant tumor in the central nervous system. Immunotherapy has shown promising results in the treatment of GBM, but future developments will require an integrated approach with various treatment modalities and specific targeted therapies for the tumor microenvironment.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Rosa M. M. Pascale, Diego F. F. Calvisi, Francesco Feo, Maria M. M. Simile
Summary: Liver lesions of F344 and BN rats, which represent a model for studying genetic predisposition to HCC and therapy response, cluster with human HCCB and HCCP, respectively. The proteolysis of DUSP1 and the activation of ERK, CKS1, and SKP2 play important roles in HCC progression. GNMT regulates SAM-methyl-transferase reactions and binds to gene promoters involved in HCC. MYBL2 upregulation promotes liver malignancy. Comparative genetics studies reveal clustering patterns of DNs and HCCs in rats and humans.
Article
Oncology
Zili Tang, Ivana Dokic, Maximilian Knoll, Federica Ciamarone, Christian Schwager, Carmen Klein, Gina Cebulla, Dirk C. Hoffmann, Julian Schlegel, Philipp Seidel, Christiane Rutenberg, Stephan Brons, Christel Herold-Mende, Wolfgang Wick, Juergen Debus, Dieter Lemke, Amir Abdollahi
Summary: This study reveals that invasive tumor cells in glioblastoma exhibit high radioresistance and are closely associated with patient prognosis. Transcriptome analysis identifies the gene expression profile of invasive cells and validates the involvement of key pathways. Inhibition of specific signaling pathways and the use of carbon ion therapy can enhance the sensitivity of invasive cells to radiation treatment.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS
(2022)
Article
Oncology
Katie M. Troike, Arlet M. Acanda de la Rocha, Tyler J. Alban, Matthew M. Grabowski, Balint Otvos, Gino Cioffi, Kristin A. Waite, Jill S. Barnholtz Sloan, Justin D. Lathia, Tomas R. Guilarte, Diana J. Azzam
Summary: The genetic variant of the TSPO gene may have a significant impact on the prognosis of GBM patients, with an association between the TSPO rs6971 variant and adverse outcomes observed in male GBM patients but not in females. These results suggest that the TSPO rs6971 polymorphism could serve as a significant predictor of poor prognosis in GBM patients.
Editorial Material
Hematology
Chrissa Sioka, Konstantinos Sakelariou, Alexandra Papoudou-Bai, Christos Tolis, Jihand Al-Boucharali, Andreas Fotopoulos
TURKISH JOURNAL OF HEMATOLOGY
(2019)
Article
Radiology, Nuclear Medicine & Medical Imaging
Aristeidis H. Katsanos, George A. Alexiou, Andreas D. Fotopoulos, Pascal Jabbour, Athanasios P. Kyritsis, Chrissa Sioka
CLINICAL NUCLEAR MEDICINE
(2019)
Letter
Oncology
Chrissa Sioka, Georgia Karpathiou, Alexandra Papoudou-Bai, Anastasia Zikou, Elpida Tsina, Vanesa Bellou, Vasilios Ragos, Maria I. Argyropoulou, Andreas Fotopoulos, Athanasios Konstantinidis
Editorial Material
Cardiac & Cardiovascular Systems
Chrissa Sioka, Konstantinos Papadimitropoulos, Lampros Michalis, Konstantinos Pappas, Lampros Lakkas, Andreas Fotopoulos, Evangelia Dounousi
CARDIOLOGY JOURNAL
(2019)
Review
Clinical Neurology
Pavlos Texakalidis, Ahmad Sweid, Nikolaos Mouchtouris, Eric C. Peterson, Chrissa Sioka, Leonardo Rangel-Castilla, John Reavey-Cantwell, Pascal Jabbour
WORLD NEUROSURGERY
(2019)
Review
Biochemistry & Molecular Biology
Konstantinos C. Siaravas, Christos S. Katsouras, Chrissa Sioka
Summary: Radiotherapy may be used alone or in combination with chemotherapy for cancer treatment, and it has various mechanisms of radiation-induced cardiac toxicities. This systematic review summarizes the known mechanisms, dosage values, and timeline of cardiovascular toxicities after radiation therapy. The findings can be used for the assessment of cardiovascular risk factors and the development of screening programs for cancer patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, General & Internal
Vasiliki Zoi, Maria Giannakopoulou, George A. Alexiou, Penelope Bouziotis, Savvas Thalasselis, Andreas G. Tzakos, Andreas Fotopoulos, Athanassios N. Papadopoulos, Athanassios P. Kyritsis, Chrissa Sioka
Summary: Cancer theragnostics is an innovative approach that combines diagnostic imaging and radionuclide therapy for early diagnosis and targeted treatment of cancer. It uses a pair of radiopharmaceuticals, one for imaging and the other for damaging cancer cells. The advantages of this approach include simplified procedures, reduced adverse effects, and personalized patient care.
Article
Oncology
George A. Alexiou, Georgios S. Markopoulos, Evrysthenis Vartholomatos, Anna C. Goussia, Lefkothea Dova, Savvas Dimitriadis, Stefania Mantziou, Vasiliki Zoi, Anastasios Nasios, Chrissa Sioka, Athanasios P. Kyritsis, Spyridon Voulgaris, George Vartholomatos
Summary: This study investigated the role of intraoperative flow cytometry in differentiating low-grade (grade 1) from high-grade (grade 2-3) meningiomas. Intraoperative flow cytometry analysis using the 'Ioannina Protocol' was performed on 59 patients. The results showed that high-grade meningiomas had higher S-phase fraction, mitosis fraction, and tumor index, while low-grade meningiomas had lower G0/G1 phase fraction. ROC analysis identified a tumor index cutoff value of 11.4% for discriminating between low- and high-grade meningiomas.
Article
Medicine, General & Internal
Chrissa Sioka, Paraskevi Zotou, Michail Papafaklis, Aris Bechlioulis, Konstantinos Sakellariou, Aidonis Rammos, Evangelia Gkika, Lampros Lakkas, Sotiria Alexiou, Pavlos Kekiopoulos, Katerina K. Naka, Christos Katsouras
Summary: This study found that BMI was an independent predictor of myocardial ischemia, and in women, both BMI and waist circumference were significantly associated with myocardial ischemia.
MEDICINA-LITHUANIA
(2022)
Article
Medicine, General & Internal
Christina Batsi, Evangelia Gkika, Loukas Astrakas, Athanassios Papadopoulos, Ioannis Iakovou, Alexandros Dogoritis, Andreas Fotopoulos, Chrissa Sioka
Summary: This study found that low levels of vitamin D may represent a risk factor for myocardial ischemia, with patients deficient or insufficient in vitamin D more likely to have abnormal myocardial perfusion imaging results.
MEDICINA-LITHUANIA
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Andreas Fotopoulos, Chrissa Sioka, Konstantinos Papadimitropoulos, Tzihad Al Boucharali, John Kalef Ezra
NUCLEAR MEDICINE REVIEW
(2019)
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
C. Sioka, G. Georgiou, A. Karampas, P. Petrikis, A. Papadopoulos, S. Tsiouris, A. Fotopoulos
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2019)
Article
Radiology, Nuclear Medicine & Medical Imaging
Andreas Fotopoulos, Konstantinos Papadimitropoulos, Athanasios Papadopoulos, Labros Lakkas, Maria Spiliotopoulou, Tzimis-Dimitrios Kotrotsios, Konstantinos Pappas, Athanasios Notopoulos, Chrissa Sioka
NUCLEAR MEDICINE REVIEW
(2019)
Article
Clinical Neurology
Aristeidis H. Katsanos, Chrissa Sioka, Maria Chondrogiorgi, Athanasios Papadopoulos, Andreas Fotopoulos, Athanassios P. Kyritsis, Vasileios Ragos
Meeting Abstract
Radiology, Nuclear Medicine & Medical Imaging
C. Sioka, A. Papadopoulos, G. Zafeiri, M. Tsironi, O. Papanikolaou, A. Papanikolaou, A. Fotopoulos, J. Kalef Ezra
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2018)