Article
Neurosciences
Pingping Xia, Murat Marjan, Zhuoyi Liu, Wanqing Zhou, Qian Zhang, Chen Cheng, Minxi Zhao, Yuanyuan Tao, Zhihua Wang, Zhi Ye
Summary: Individuals who suffer from post-CA brain injury often face higher mortality and severe functional disability. Neuroinflammation plays a critical role in cerebral ischemia-reperfusion injury (CIRI) following cardiac arrest. This study found that Chrysophanol, a compound found in Rhubarb, has strong anti-inflammatory properties and can protect against CIRI-induced pyroptotic cell death. The findings suggest that Chrysophanol postconditioning inhibits NLRP3-related pyroptosis in a TRAF6-dependent manner, providing a potential therapeutic target for post-CA brain injury.
EXPERIMENTAL NEUROLOGY
(2022)
Review
Cell Biology
Kitti Thiankhaw, Nipon Chattipakorn, Siripron C. Chattipakorn
Summary: MCAO and cerebral I/R injury can lead to microvascular injury, blood-brain barrier dysfunction, inflammation, oxidative stress, and neuronal death, resulting in brain infarction. HBOT has shown positive effects on neurological outcomes after these injuries, but conflicting data exists on its impact on functional recovery. Studies have been conducted to evaluate the potential benefits of HBOT, both in vivo and clinically, in the context of stroke outcomes.
JOURNAL OF CELLULAR PHYSIOLOGY
(2021)
Review
Medicine, Research & Experimental
Yushi Wu, Haiqiong Liu, Xianbao Wang
Summary: Acute myocardial infarction requires timely reperfusion to reduce myocardial damage, but reperfusion may lead to myocardial ischemia/reperfusion injury. Pharmacological postconditioning is an effective and flexible strategy to reduce myocardial injury by administering medication before or during early reperfusion.
Article
Cell Biology
Zijun Zhao, Yishuai Li, Fei Chi, Li Ma, Yanan Li, Zhiyong Hou, Qiujun Wang
Summary: In this study, we investigated the protective effect of sevoflurane postconditioning against cerebral ischemia reperfusion (I/R) injury and its potential mechanism. The results showed that sevoflurane postconditioning ameliorated neurological deficits induced by cerebral I/R and suppressed neuroinflammatory responses by inhibiting the TLR4/MyD88/TRAF6 signaling pathway.
Article
Neurosciences
Xiaokun Geng, Qingzhu Wang, Hangil Lee, Christian Huber, Melissa Wills, Kenneth Elkin, Fengwu Li, Xunming Ji, Yuchuan Ding
Summary: This study compared the rehabilitative properties of physical exercise and remote ischemic postconditioning (RIPostC) after stroke and found that both methods significantly reduced infarct volumes and neurological deficits, outperforming the stroke group in neurobehavioral function tests. All treatment groups showed significant increases in mRNA and protein expression levels of target molecules related to neurogenesis, synaptogenesis, and angiogenesis.
MOLECULAR NEUROBIOLOGY
(2021)
Article
Immunology
Yun Wang, Zhe Chen, Jing Luo, Jing Zhang, A-ming Sang, Zhen-shun Cheng, Xin-yi Li
Summary: This study demonstrates that salidroside postconditioning attenuates ferroptosis-mediated lung ischemia-reperfusion injury by activating the Nrf2/SLC7A11 signaling axis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Cell Biology
Vyacheslav V. Ryabov, Evgenii V. Vyshlov, Leonid N. Maslov, Alexandr V. Mukhomedzyanov, Natalia V. Naryzhnaya, Alla A. Boshchenko, Aleksandra E. Gombozhapova, Julia O. Samoylova
Summary: Acute myocardial infarction (AMI) is the leading cause of death globally, necessitating the development of new and more effective approaches for treatment. Remote postconditioning (RPost) has shown promise in reducing infarct size, improving heart function, preventing apoptosis, and stimulating autophagy in animal models. Various mechanisms, including endogenous opioids, adenosine, kinases, and NO-synthase, may be involved in RPost. However, the efficacy of RPost in clinical practice remains inconclusive, with inconsistent results reported.
Article
Pharmacology & Pharmacy
Lingling Jiang, Tao Zhang, Yang Zhang, Dexin Yu, Ye Zhang
Summary: This study demonstrates that dexmedetomidine postconditioning (DPOC) can alleviate renal ischemic/reperfusion injury in patients undergoing laparoscopic partial nephrectomy (LPN), at least on a short-term basis.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Toxicology
Ning Lyu, Xiaoyun Li
Summary: This study reveals that sevoflurane can protect against cerebral ischemia-reperfusion injury by inhibiting the SP1/ACSL4 axis, reducing neurological deficits and cerebral infarction. These findings provide a new perspective on the treatment of cerebral ischemia-reperfusion injury and suggest a potential therapeutic approach for various cerebral diseases.
HUMAN & EXPERIMENTAL TOXICOLOGY
(2023)
Article
Neurosciences
Shumeng Li, Yiheng Li, Pengcheng Huang, Xiaocheng Mao, Kaiyan Jiang, Ran Chen, Qing Li, Lulu Wang, Zeqing Jin, Chenyi Wan, Ying Xiong, Yaqing Yu, Wenli Sheng, Daojun Hong, Jing Lin
Summary: RNF213 is found to be associated with cerebrovascular disease and systemic vasculopathy. This study reveals that removal of Rnf213 reduces brain infarct volume and improves neurological deficit score in cerebral ischemia reperfusion injury (CIRI), possibly by regulating the Akt/GSK-313/13-catenin/Bcl-2 signaling pathway to reduce neuronal apoptosis.
Article
Pharmacology & Pharmacy
Kemeng Zhao, Pengwei Wang, Xiaoguang Tang, Na Chang, Haonan Shi, Longfei Guo, Bingyi Wang, Pengfei Yang, Tiantian Zhu, Xinghua Zhao
Summary: Stroke is caused by ruptured or blocked cerebral blood vessels and subsequent disruption of brain blood circulation, resulting in rapid neurological deficits. The majority of stroke cases are ischemic strokes. Current treatments for ischemic stroke, such as t-PA thrombolytic therapy and surgical thrombectomy, can paradoxically lead to ischemia-reperfusion injury, exacerbating brain damage. Minocycline, a semi-synthetic tetracycline antibiotic, has demonstrated a wide range of neuroprotective effects independent of its antibacterial activity. In this article, we summarize the mechanisms underlying the protective effects of minocycline against cerebral ischemia-reperfusion injury, including modulation of oxidative stress, inflammatory response, excitotoxicity, programmed cell death, and blood-brain barrier injury. We also discuss the role of minocycline in alleviating stroke-related complications, providing a theoretical basis for its clinical application in cerebral ischemia-reperfusion injury.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Neurosciences
Haiyan Li, Sijie Li, Changhong Ren, Chen Gao, Ning Li, Chunxiu Wang, Lin Wang, Wenbo Zhao, Xunming Ji, Kunlin Jin
Summary: This study found that hypoxic postconditioning (HPC) helps promote neurogenesis after ischemic stroke, increasing the proliferation and migration of neural stem cells. HPC also regulates the metabolism of neural stem cells, including reducing fatty acid oxidation and increasing glycolysis.
EXPERIMENTAL NEUROLOGY
(2022)
Article
Neurosciences
Li Li, Dongyi Zhi, Ruibo Cheng, Jing Li, Chuanming Luo, Hao Li
Summary: Limb ischemic postconditioning (LPostC) can increase the protein and mRNA levels of SIRT1 and PGC-1α in cerebral ischemic tissue, improve mitochondrial function, reduce brain damage, and relieve cerebral ischemia/reperfusion injury (IRI) by decreasing the size of cerebral infarct, neuronal apoptosis, and neurological deficits. Meanwhile, LPostC can increase SOD activity and reduce MDA content in brain tissue. Treatment with EX-527, a SIRT1 inhibitor, reverses the protective effects of LPostC, indicating that LPostC may protect against cerebral IRI by up-regulating the SIRT1/PGC-1α signaling pathway.
NEUROSCIENCE LETTERS
(2021)
Review
Biochemistry & Molecular Biology
Loic Benoit, Audrey Dieu, Maxime Foguenne, Eliano Bonaccorsi-Riani
Summary: Ischemia-reperfusion injury (IRI) is an inflammatory process in organ transplantation. Sevoflurane has shown potential benefits in reducing hepatic IRI (HIRI). Experimental studies support its protective effects, but clinical studies have conflicting results. Further clinical trials are needed to determine the clinical relevance of sevoflurane as a protective factor against HIRI.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Pharmacology & Pharmacy
Tao Sun, Ping Wang, Ting Deng, Xingbao Tao, Bin Li, Ying Xu
Summary: Panax notoginseng saponins (PNS) significantly reduces neurologic deficit scores and cerebral infarct volumes in focal cerebral ischemia-reperfusion rat models, inhibits inflammatory factors release, and shows better efficacy with combination therapy. Drug dosage and administration duration significantly affect the efficacy of PNS.
FRONTIERS IN PHARMACOLOGY
(2021)