Article
Medicine, General & Internal
Li-Min Hu, Hsin- Tsai, Chao-Wei Lee, Hui-Ming Chen, Wei-Chen Lee, Huang-Ping Yu
Summary: This study found that preoperative serum uric acid level is associated with early allograft dysfunction (EAD), with lower uric acid levels being linked to higher incidence and risk of EAD. This provides a new predictor for evaluating EAD and may have a protective effect against EAD development.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Vassilis L. Tzounakas, Alkmini T. Anastasiadi, Vasiliki-Zoi Arvaniti, Veronica Lelli, Giuseppina Fanelli, Efthymios C. Paronis, Anastasia C. Apostolidou, Evangelos G. Balafas, Nikolaos G. Kostomitsopoulos, Effie G. Papageorgiou, Issidora S. Papassideri, Konstantinos Stamoulis, Anastasios G. Kriebardis, Sara Rinalducci, Marianna H. Antonelou
Summary: Redox imbalance and oxidative stress can cause degradation of red blood cells (RBC) during their storage at blood banks. This study investigated the effect of uric acid (UA) and/or ascorbic acid (AA) supplementation on the storability of RBC units. The addition of antioxidants maintained the quality parameters of stored RBCs and protected them against oxidative damage. The metabolic rewiring in the treated RBCs differed depending on the antioxidant used. The treated RBCs showed improved resistance to oxidative triggers in vitro and retained normal circulation levels in mice.
Article
Clinical Neurology
Yiting Kong, Chuan Liu, Chenyu Zhang, Wo Wang, Yalan Li, Haitang Qiu, Gaomao Wang, Daqi Li, Xiaorong Chen, Zhen Lv, Dongdong Zhou, Liyang Wan, Ming Ai, Jianmei Chen, Liuyi Ran, Li Kuang
Summary: This study found a relationship between serum uric acid levels and suicide attempts in adolescents and young adults with major depressive disorder. Uric acid may serve as a biological risk marker for suicide attempts, particularly in female patients with major depressive disorder.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2022)
Article
Immunology
Ya Dong, Fei Han, Yue Su, Bei Sun, Wei Zhao, Congqing Pan
Summary: Cigarette smoke exposure is the major cause of chronic obstructive pulmonary disease (COPD) and cigarette smoke extract (CSE) induces the increase of reactive oxygen species (ROS), mitochondrial dynamics disorder, and apoptosis. High uric acid (HUA) aggravates the effects of CSE by decreasing the expression of antioxidant enzyme-peroxiredoxin-2 (PRDX2). Overexpression of PRDX2 inhibits the effects of HUA, while knockdown of PRDX2 promotes the effects of HUA on cellular ROS levels, mitochondrial dynamics disorder, and apoptosis in MLE-12 cells.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Neurosciences
Qiaolifan Aerqin, Sha-Sha Jia, Xue-Ning Shen, Quan Li, Ke-Liang Chen, Ya-Nan Ou, Yu-Yuan Huang, Qiang Dong, Shu-Fen Chen, Jin-Tai Yu
Summary: This study found that decreased levels of serum UA were correlated with Alzheimer's disease, Parkinson's disease, progressive supranuclear palsy, frontotemporal dementia, and dementia with Lewy bodies. Additionally, serum UA levels were positively correlated with cognitive levels in all patients.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Multidisciplinary Sciences
Ryota Sato, Keitaro Akita, Takenori Ikoma, Keisuke Iguchi, Takayo Murase, Takashi Nakamura, Seigo Akari, Satoshi Mogi, Yoshihisa Naruse, Hayato Ohtani, Yuichiro Maekawa
Summary: This study compared the changes in plasma XOR (pXOR) activity in patients undergoing percutaneous coronary intervention (PCI) and coronary angiography (CAG). The study found that there was a significant decrease in pXOR activity after PCI, with a correlation between in-hospital adverse events and the percentage reduction in pXOR activity. No significant changes were observed in pXOR activity in patients undergoing CAG.
Article
Nutrition & Dietetics
Corrado Pelaia, Daniele Pastori, Giuseppe Armentaro, Sofia Miceli, Velia Cassano, Keti Barbara, Giulia Pelaia, Maria Perticone, Raffaele Maio, Pasquale Pignatelli, Francesco Violi, Francesco Perticone, Giorgio Sesti, Angela Sciacqua
Summary: This study demonstrates a significant decline in renal function over time in COPD patients, with uric acid (UA) and diabetes identified as the two strongest predictors.
Article
Biochemistry & Molecular Biology
Masaru Matsuoka, Junko Yamaguchi, Kosaku Kinoshita
Summary: This study aimed to investigate the relationship between blood levels of uric acid (UA), xanthine dehydrogenase (XDH), and 8-hydroxy-2-deoxyguanosine (8-OHdG) in sepsis patients. The results showed that UA and XDH levels were correlated with the severity of sepsis and poor outcomes. Elevated XDH levels were associated with reduced survival rates. The findings suggest that increased oxidative stress in sepsis can be counteracted by elevated UA levels.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Pablo Muriel, Pedro Lopez-Sanchez, Erika Ramos-Tovar
Summary: Chronic diseases, particularly metabolic syndrome and non-alcoholic fatty liver disease (NAFLD), are major health challenges globally, with fructose overconsumption playing a significant role in their development. Fructose-induced inflammation, fibrosis, and oncogenic signaling pathways contribute to the progression of NAFLD, leading to serious liver complications such as NASH and ultimately liver cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Medicine, Research & Experimental
W. A. Saka, R. E. Akhigbe, A. O. Abidoye, O. S. Dare, A. O. Adekunle
Summary: The study showed that Dichlorvos induced hepatic and renal damage, accompanied by redox dyshomeostasis. L-arginine was found to reverse the damage and improve organ structure, suggesting a potential therapeutic role against Dichlorvos-induced toxicity.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Pharmacology & Pharmacy
Pengqiang Ma, Menghui Zhao, Yue Li, Guanqian Zhang, Yuxia Ma, Youlan Shi, Peihui Su, Rongxia Chen, Zhen-gang Tang, Yan Zhang, Bing Liu, Qiong Zhang, Xiang Liu, Feifeng Li
Summary: This study demonstrates that uric acid can ameliorate oxidative stress caused by myocardial ischemia by activating the Nrf2 pathway and inducing downstream antioxidant factors. This finding contributes to the understanding of the protective effects of uric acid in heart disease.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Medicine, General & Internal
Yavuz Altunkaynak, Asli Keskek, Suleyman Donmezler, Tamer Yazar, Hulya Olgun, Firuze Delen, Imren Kurt Sabitay, Musa Ozturk, Devrimsel Harika Ertem
Summary: This study aimed to explore the relationship between pain characteristics and serum uric acid (SUA) levels in patients with migraine and compare them with those of a control group. It was found that SUA levels in migraine patients during a headache-free period were higher than those in the control group, although the difference was not statistically significant. The correlation between SUA levels and headache intensity was weak in female migraine patients and moderate in male patients.
Article
Engineering, Environmental
Xinchen Lu, Yan Lin, Xinghua Qiu, Jinming Liu, Tong Zhu, Jesus A. Araujo, Junfeng Zhang, Yifang Zhu
Summary: By conducting metabolomics analysis on healthy young adults exposed to elevated PAHs after traveling to Beijing, it was found that 50 metabolites significantly changed 6-8 weeks later, with metabolites falling into oxidative homeostasis-related response or delayed enzymatic deinduction response. The study results suggested differential subacute effects of unsubstituted and alkylated PAHs, with some metabolite changes being reversible. Further research is needed to elucidate the role of metabolite changes reversibility in the adverse health effects of PAHs.
ENVIRONMENTAL SCIENCE & TECHNOLOGY
(2021)
Review
Biology
Marko Kumric, Josip A. Borovac, Tina Ticinovic Kurir, Josko Bozic
Summary: Heart failure is a major global health problem with increasing prevalence, requiring further research to improve outcomes and reduce healthcare costs. Uric acid serves as a significant prognostic factor in both acute and chronic HF, and is being explored as a potential therapeutic target in the pathogenesis of the condition.
Article
Nutrition & Dietetics
Juliana Farias de Novaes, Mariana De Santis Filgueiras, Lara Gomes Suhett, Mariane Alves Silva, Fernanda Martins de Albuquerque, Rafaela Mara Silva Fonseca, Maria do Carmo Gouveia Peluzio
Summary: The aim of this study was to evaluate the association of serum uric acid with adiposity, adipokines, and anti-and oxidative markers in Brazilian children. We compared the distributions of adiposity, adipokines, and anti-and oxidative markers by serum uric acid categories using linear regression. The results showed a positive association between serum uric acid and adiposity, adipokines, and antioxidative status.
