Article
Biochemistry & Molecular Biology
Sevigean Ali, Mihaela Botnarciuc, Lavinia Carmen Daba, Sorina Ispas, Alina Mihaela Stanigut, Camelia Pana, Marian-Catalin Burcila, Liliana-Ana Tuta
Summary: There is limited research on decreased platelet count in chronic kidney disease (CKD), but platelet functions are altered in the uremic environment, leading to an increased risk of bleeding. This study monitored 104 CKD patients with thrombocytopenia who received platelet transfusion and evaluated their prognosis. The results showed that in patients with multiple comorbidities, 4.83% still experienced severe uncontrolled hemorrhages.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Yuji Oe, Nobuyuki Takahashi
Summary: Coagulation abnormalities are common in chronic kidney disease (CKD). Tissue factor plays a key role in promoting coagulation and inflammation, exacerbating renal injury.
Review
Food Science & Technology
Mara Lauriola, Ricard Farre, Pieter Evenepoel, Saskia Adriana Overbeek, Bjorn Meijers
Summary: Patients with CKD have a higher cardiovascular risk than the general population due to the accumulation of uremic toxins. Protein-bound uremic toxins originate from various sources and are difficult to remove with conventional therapies. Diet plays an important role in uremic toxicity, with most toxins derived from the gut. This review summarizes the sources of uremic toxins in foods and discusses their metabolism and potential dietary strategies for reducing their plasma levels.
Review
Food Science & Technology
Mateo Ondrussek-Sekac, Diana Navas-Carrillo, Esteban Orenes-Pinero
Summary: In chronic kidney disease, dysbiosis of intestinal microbiota can lead to uremic toxicity, inflammation and disease progression. Modulating gut microbiota through dietary changes and using probiotics, prebiotics, and low protein diets can offer therapeutic interventions to improve this imbalance and manage chronic kidney disease effectively.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2021)
Article
Cell Biology
Jung Sun Park, Dong-Hyun Kim, Hoon-In Choi, Chang Seong Kim, Eun Hui Bae, Seong Kwon Ma, Soo Wan Kim
Summary: This study investigated the effects of uremic toxins on ferroptosis in the kidney, finding that protein-bound uremic toxins can induce ferroptosis and result in cell death.
CELL DEATH & DISEASE
(2023)
Article
Nutrition & Dietetics
Zarina Ebrahim, Sebastian Proost, Raul Yhossef Tito, Jeroen Raes, Griet Glorieux, Mohammed Rafique Moosa, Renee Blaauw
Summary: There is growing evidence that gut dysbiosis contributes to the progression of chronic kidney disease. This study found that ss-glucan prebiotic has a positive effect on kidney function, uremic toxins, and the gut microbiome in CKD participants.
Article
Biotechnology & Applied Microbiology
Gerrit A. Stuivenberg, John A. Chmiel, Polycronis P. Akouris, Jessica White, Hannah Wilcox, Shannon Seney, Jeremy P. Burton, Gregor Reid
Summary: Chronic kidney disease (CKD) is a significant problem in developing countries, particularly in sub-Saharan Africa, where its prevalence is high and associated with cardiovascular issues. Uremic toxins, such as p-cresol and p-cresyl sulfate, play a role in CKD. This study found that adding specific bifidobacterial strains to probiotic yogurt produced in Tanzanian communities can potentially reduce uremic toxins and provide additional health benefits.
FERMENTATION-BASEL
(2023)
Review
Biochemistry & Molecular Biology
Kuo-Chin Hung, Wei-Cheng Yao, Yi-Lien Liu, Hung-Jen Yang, Min-Tser Liao, Keong Chong, Ching-Hsiu Peng, Kuo-Cheng Lu
Summary: Patients with chronic kidney disease (CKD) often have a high accumulation of protein-bound uremic toxins (PBUTs), such as indoxyl sulfate (IS) and p-cresyl sulfate (pCS). The buildup of PBUTs inhibits bone and muscle function, worsens muscle wasting, and contributes to low bone turnover disorders. Understanding the underlying mechanisms of bone and muscle loss in CKD can aid in developing new therapies for musculoskeletal diseases.
Review
Biochemistry & Molecular Biology
Serena Altamura, Davide Pietropaoli, Francesca Lombardi, Rita Del Pinto, Claudio Ferri
Summary: This article explores the dynamic biological connections between oral health, gut, and renal pathology, emphasizing the importance of the oral-gut-kidney axis. It also discusses the potential role of periodontal diseases and gut microbiota as disease modifiers in CKD.
Article
Food Science & Technology
Carolla El Chamieh, Islam Amine Larabi, Solene M. Laville, Christian Jacquelinet, Christian Combe, Denis Fouque, Maurice Laville, Luc Frimat, Roberto Pecoits-Filho, Celine Lange, Benedicte Stengel, Natalia Alencar De Pinho, Jean-Claude Alvarez, Ziad A. Massy, Sophie Liabeuf
Summary: Proton-pump inhibitors (PPIs) are commonly used in patients with chronic kidney disease (CKD), and are associated with the retention of uremic toxins (UTs). In this cross-sectional study, we found that patients using PPIs had higher levels of certain UTs compared to other patients. These findings are important for understanding factors that modulate serum UT concentration in CKD patients.
Article
Immunology
Robson E. Silva, Eliziaria C. Santos, Patricia B. Justino, Margarida P. Santos, Giovane Galdino, Reggiani Goncalves, Romulo D. Novaes
Summary: The relationship between dialysis adequacy and circulating levels of inflammatory mediators was investigated, showing that low Kt/V results and creatinine accumulation may serve as potential indicators of systemic inflammatory stress.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Urology & Nephrology
Laetitia Koppe, Christophe O. Soulage
Summary: Chronic kidney disease is associated with changes in the gut microbiota, and diet plays a crucial role in managing the disease. This review discusses the latest research on the interactions between diet and gut microbiota in the context of uremia, and how this knowledge can be used to develop personalized nutrition strategies to prevent the progression of chronic kidney disease to kidney failure and its complications.
KIDNEY INTERNATIONAL
(2022)
Article
Biochemistry & Molecular Biology
Vasily A. Popkov, Anastasia A. Zharikova, Evgenia A. Demchenko, Nadezda V. Andrianova, Dmitry B. Zorov, Egor Y. Plotnikov
Summary: This study presents a novel bioinformatics approach to identify the origin of uremic retention solutes and uremic toxins, particularly those produced by gut microbiota. The research utilizes database analysis and enzymatic reaction data to determine the potential toxins synthesized by bacteria residing in the human gut. The findings reveal the link between toxin concentration in uremia and the proportion of different bacterial species that can produce the toxin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Cardiac & Cardiovascular Systems
Bert Zwaenepoel, Tine De Backer, Griet Glorieux, Francis Verbeke
Summary: This study evaluated the association between plasma protein-bound uremic toxins concentrations, echocardiographic parameters of heart failure, and incident heart failure events in chronic kidney disease patients not on dialysis. The results showed that elevated free concentrations of indoxyl sulfate, p-cresyl glucuronide, and p-cresyl sulfate were independently associated with an increased risk of heart failure events in these patients.
Review
Physiology
Willem B. van Ham, Carlijn M. Cornelissen, Toon A. B. van Veen
Summary: Chronic kidney disease and cardiovascular disease are prevalent worldwide, with a high incidence of cardiovascular events in CKD patients. The relationship between kidney function, uremic toxins, and cardiac electrophysiology in the context of cardiorenal syndrome requires further investigation to understand potential arrhythmic events and improve clinical outcomes.
Article
Biochemistry & Molecular Biology
Pei-Ju Liao, Kuang-Hung Hsu, Hung-Yi Chiou, Chien-Jen Chen, Chih-Hung Lee
Summary: The study found that residents with high exposure to inorganic arsenic, high primary methylation index (PMI; MMA/InAs) (but lower secondary methylation index (SMI)), and non-heterogeneity type of genomic markers including GSTO1, AS3MT, and MPO were more likely to develop cancer. High PMI was associated with increased cancer risk, and specific genetic types were correlated with higher cancer occurrence. The study also revealed a synergistic effect between genomic markers and methylation capacity on cancer occurrence.
BIOMEDICAL JOURNAL
(2021)
Article
Nutrition & Dietetics
I-Wen Wu, Pei-Ju Liao, Ming-Kuo Ting, Shuo-Wei Chen, Ning- Yang, Kuang-Hung Hsu
Summary: This study found that chest width, waist circumference, and thigh circumference were significantly associated with chronic kidney disease (CKD). The waist-to-thigh ratio and chest-to-thigh ratio were derived to predict the occurrence of CKD. In addition to central obesity, body limb measurements can be used as an indicator to predict CKD. Further investigation is needed on the association between thigh circumference and CKD.
JOURNAL OF RENAL NUTRITION
(2022)
Article
Medicine, General & Internal
Chin-Chan Lee, Chih-Cheng Hsu, Ming-Huang Lin, Kuan-Hsing Chen, I-Wen Wu
Summary: This study investigated the hospitalization rates of end-stage kidney disease (ESKD) patients in Taiwan and found an increasing trend over time. Infection-related hospitalization was the main cause, and hemodialysis patients had higher hospitalization rates. Further strategies are needed to reduce the hospitalization burden.
JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
(2022)
Article
Health Care Sciences & Services
Chun-Yu Chen, Kuan-Ting Liu, Shin-Ru Shih, Jung- Ye, Yih-Ting Chen, Heng-Chih Pan, Heng-Jung Hsu, Chiao-Yin Sun, Chin-Chan Lee, Chun-Ying Wu, Chi-Chun Lai, I-Wen Wu
Summary: This study found that higher cardiothoracic ratio and older age could independently predict a decline in neutralizing antibody titers in hemodialysis patients vaccinated with a single dose of ChAdOx1.
JOURNAL OF PERSONALIZED MEDICINE
(2022)
Letter
Endocrinology & Metabolism
I-Wen Wu, Tsung-Hsien Tsai, Chi-Jen Lo, Yi-Ju Chou, Chi-Hsiao Yeh, Mei-Ling Cheng, Chi-Chun Lai, Huey-Kang Sytwu, Ting-Fen Tsai
Article
Education & Educational Research
Ji-Tseng Fang, Shih-Ying Chen, Ya-Chung Tian, Chien-Hung Lee, I-Wen Wu, Chen-Yi Kao, Chung-Chih Lin, Woung-Ru Tang
Summary: This study demonstrated that online ESRD communication skills training can enhance the truth-telling confidence of healthcare personnel, though it is unclear whether this improvement is due to the content of the training or its online delivery. While face-to-face training may be unsuitable during pandemics, online training remains an indispensable tool. Future intervention studies should focus on designing interactive modules and controlling for instructional methods.
BMC MEDICAL EDUCATION
(2022)
Article
Public, Environmental & Occupational Health
Shao-Chi Chu, Po-Hsi Wang, Kuan-Ying Lu, Chia-Chun Ko, Yun-Hsuan She, Chin-Chan Lee, I-Wen Wu, Chiao-Yin Sun, Heng-Jung Hsu, Heng-Chih Pan
Summary: Obesity and metabolic syndrome are risk factors for chronic kidney disease. This study found that the combination of obesity and metabolic syndrome, known as metabolic body composition status (MBCS), is associated with rapid kidney function decline (RKFD), particularly in older adults. Metabolically unhealthy normal weight and metabolically unhealthy overweight were identified as risk factors for RKFD.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Virology
Chun-Yu Chen, Kuan-Ting Liu, Shin-Ru Shih, Jung- Ye, Yih-Ting Chen, Cheng-Kai Hsu, Heng-Chih Pan, Heng-Jung Hsu, Chiao-Yin Sun, Chin-Chan Lee, Chun-Ying Wu, Chi-Chun Lai, I-Wen Wu
Summary: This study found that neutralizing antibody levels were lower in hemodialysis patients compared to healthy controls after receiving the ChAdOx1 vaccine, and dialysis adequacy could predict seroconversion in these patients.
Article
Biochemistry & Molecular Biology
Pei-Ju Liao, Ming-Kuo Ting, Chang-Fu Kuo, Yu-Hao Ding, Ciao-Ming Lin, Kuang-Hung Hsu
Summary: This study investigated the familial aggregation of type 2 diabetes mellitus (T2DM) among different kinship relatives in the Taiwanese population. The results showed that individuals with first-degree relatives with T2DM had a higher risk of developing T2DM, followed by those with second-degree relatives. The risk was higher when the affected family member was the mother. There was a dose-response relationship between the number of affected family members and the risk of T2DM.
BIOMEDICAL JOURNAL
(2023)
Article
Medicine, General & Internal
Yi-Chia Su, Cheng-Yu Chien, Chung-Hsien Chaou, Kuang-Hung Hsu, Shi-Ying Gao, Chip-Jin Ng
Summary: This study aimed to determine appropriate vital sign cut points for triage designation in older patients visiting the emergency department. The newly proposed triage scale showed comparable discriminatory ability for triage in older patients compared to the existing triage scale. Revising the vital signs triage criteria for older patients could improve the identification of critical cases and triage accuracy in the emergency department.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Wei-Ching Fang, Hsing-Yu Chen, Shao-Chi Chu, Po-Hsi Wang, Chin-Chan Lee, I-Wen Wu, Chiao-Yin Sun, Heng-Jung Hsu, Chun-Yu Chen, Yung-Chang Chen, Vin-Cent Wu, Heng-Chih Pan
Summary: This study evaluated the predictive performance of biomarkers in determining the likelihood of developing rapid kidney function decline (RKFD) in a healthy population. It found that serum cystatin C level could predict the possibility of RKFD, and suggested that a low cystatin C level should be considered as a risk factor for RKFD in healthy subjects.
Article
Biochemistry & Molecular Biology
Cheng-Kai Hsu, Shih-Chi Su, Lun-Ching Chang, Kai-Jie Yang, Chin-Chan Lee, Heng-Jung Hsu, Yih-Ting Chen, Chiao-Yin Sun, I-Wen Wu
Summary: This study aimed to assess the effects of AST-120 on the gut microbiota, related functional capability, and metabolomic profiling in advanced CKD patients. The results showed that AST-120 can partially restore the gut microbiota and intervene in the metabolism of short- and medium-chain fatty acids.
Article
Medicine, General & Internal
Wei-Chun Lin, Chien-Hsiung Huang, Liang-Tien Chien, Hsiao-Jung Tseng, Chip-Jin Ng, Kuang-Hung Hsu, Chi-Chun Lin, Cheng-Yu Chien
Summary: In this study, various machine learning algorithms and association rules mining were used to identify determinants for neurological outcomes in out-of-hospital cardiac arrest (OHCA) patients and assess the impact of first-aid and basic characteristics in the EMS system. The results showed that the random forest model had better predictive ability for OHCA patients.
INTERNATIONAL JOURNAL OF GENERAL MEDICINE
(2022)
Review
Medicine, General & Internal
Chin-Chan Lee, Chia-Chun Chen, Cheng-Kai Hsu, Yih-Ting Chen, Chun-Yu Chen, Kai-Jie Yang, Ming-Jui Hung, I-Wen Wu
Summary: Diabetic kidney disease is a common primary disease of end-stage kidney disease, but there is currently no sensitive and accurate biomarker to predict it. microRNAs, which are noncoding RNAs, have been reported to play a potential role in the pathophysiology of diabetic kidney disease. Urinary microRNAs have emerged as a novel, non-invasive liquid biopsy for disease diagnosis. This review discusses the experimental and clinical evidence of urinary microRNA in the context of diabetic kidney disease and explores its future application in routine practice.
MEDICINA-LITHUANIA
(2023)
Article
Health Care Sciences & Services
Chun-Yu Chen, Shih-Chieh Shao, Yih-Ting Chen, Cheng-Kai Hsu, Heng-Jung Hsu, Chin-Chan Lee, Chiao-Yin Sun, Yung-Chan Chen, Ming-Jui Hung, I-Wen Wu
Summary: A total of 3261 confirmed COVID-19 cases were identified in 29 articles from a pool of 396,062 HD patients. The incidence of COVID-19 in these HD patients was 7.7%, with an overall mortality rate of 22.4%. Reported estimates were higher in non-Asian countries compared to Asian countries. Study quality may affect the reported incidence but not the mortality among studies.