Review
Medicine, Research & Experimental
Betania M. F. Nogueira, Sonya Krishnan, Beatriz Barreto-Duarte, Mariana Araujo-Pereira, Artur T. L. Queiroz, Jerrold J. Ellner, Padmini Salgame, Thomas J. Scriba, Timothy R. Sterling, Amita Gupta, Bruno B. Andrade
Summary: Tuberculosis is a preventable and curable infectious disease, but the lack of early and accurate diagnosis leads to a high number of cases. The World Health Organization has proposed biomarker-based diagnostics using easily accessible specimens, but faced challenges in developing universal diagnostic biomarkers for specific patient populations. Additionally, there are limitations to widespread validation and utilization of published biomarkers. Proposed solutions are provided to enhance TB diagnostic biomarker validation and uptake.
EMBO MOLECULAR MEDICINE
(2022)
Review
Computer Science, Interdisciplinary Applications
Vaishali Sood, Rishi Pal Chauhan
Summary: Quantum computing is an innovative concept that combines different ideas, techniques, and methodologies from various disciplines. Through a comprehensive analysis of the literature, our study provides insights into the research progression in major domains of quantum computing, such as fiducial quantum state initialization, quantum superposition, quantum coherence, fault-tolerence, and quantum algorithms. Co-citation network analysis and burst reference analysis are used to assess the importance of the field and identify research trends for the realization of quantum computers. Our findings highlight that photons, squids, nuclear magnetic resonance, semiconductor quantum dots, cryogenic temperatures, quantum machine learning, and support vector machines are the core research areas. Additionally, a meta-literature analysis is conducted to extract evolutionary pathways for future research.
ARCHIVES OF COMPUTATIONAL METHODS IN ENGINEERING
(2023)
Article
Biochemistry & Molecular Biology
Jakub Udzik, Aleksandra Waszczyk, Iwona Wojciechowska-Koszko, Pawel Kwiatkowski, Paulina Roszkowska, Karolina Rogulska, Krzysztof Safranow, Andrzej Biskupski, Sebastian Kwiatkowski, Ewa Kwiatkowska
Summary: This study indicates that plasma IL-8, plasma TNF-alpha, and urine NGAL/Cr show significant differences in postoperative biomarker concentrations between the AKI and no-AKI groups, serving as independent predictors of CSA-AKI. CKD is identified as an independent risk factor for CSA-AKI. Plasma IL-8, TNF-alpha, and urine NGAL/Cr are independent early indicators of CSA-AKI and offer a promising alternative to creatinine measurements.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Oncology
Yanna Lei, Xiaoying Li, Qian Huang, Xiufeng Zheng, Ming Liu
Summary: Over the past decade, immune checkpoint blockade therapy has significantly improved patient survival in oncology, but the response rates remain unsatisfactory and predictive biomarkers for treatment efficacy are lacking. Further research is needed to identify more accurate biomarkers to enhance the effectiveness of immune checkpoint inhibitors therapy.
FRONTIERS IN ONCOLOGY
(2021)
Review
Medicine, General & Internal
Alfredo G. Casanova, Sandra M. Sancho-Martinez, Laura Vicente-Vicente, Patricia Ruiz Bueno, Pablo Jorge-Monjas, Eduardo Tamayo, Ana I. Morales, Francisco J. Lopez-Hernandez
Summary: The diagnosis of cardiac surgery-associated acute kidney injury (CSA-AKI) is still not optimal, and this article discusses the limitations of current diagnostic procedures and presents new strategies for enhanced diagnosis. These strategies include early pathophysiological diagnosis, patient stratification based on disease mechanisms, and biomarker-based assessment of AKI evolution and prognosis. The concept of pre-emptive diagnosis of acquired risk of AKI is also highlighted, providing opportunities for personalized prevention through diagnosis-guided patient handling.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Critical Care Medicine
Yih-Ting Chen, Heng-Chih Pan, Cheng-Kai Hsu, Chiao-Yin Sun, Chun-Yu Chen, Yi-Hung Chen, Heng-Jung Hsu, I-Wen Wu, Vin-Cent Wu, Eric Hoste
Summary: Based on the analysis of six studies involving 952 patients, this research suggests that urinary CCL14 could be an effective marker for predicting persistent AKI, with a sensitivity of 0.81 and specificity of 0.71.
Article
Urology & Nephrology
Steven Menez, Dennis G. Moledina, Amit X. Garg, Heather Thiessen-Philbrook, Eric McArthur, Yaqi Jia, Caroline Liu, Wassim Obeid, Sherry G. Mansour, Jay L. Koyner, Michael G. Shlipak, Francis P. Wilson, Steven G. Coca, Chirag R. Parikh
Summary: This study investigated the association of various blood and urinary biomarkers with the development or progression of chronic kidney disease (CKD) after cardiac surgery. Results showed that elevated levels of specific biomarkers post-operatively were independently associated with the development of CKD, providing additional value for evaluating CKD incidence and progression following cardiac surgery.
KIDNEY INTERNATIONAL
(2021)
Article
Immunology
Pragyan Acharya, Rohini Saha, Javed Ahsan Quadri, Saba Sarwar, Maroof Ahmad Khan, Hem Chandra Sati, Nidhi Gauniyal, Ahmadullah Shariff, Shekhar Swaroop, Piyush Pathak
Summary: This study aimed to discover AKI biomarkers in ACLF patients, and found that plasma metallothionein can act as a predictive biomarker of AKI in ACLF.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Pediatrics
Hui Huang, Huiting Zhou, Wenwen Wang, Xiaomei Dai, Wenjing Li, Jiao Chen, Zhenjiang Bai, Jian Pan, Xiaozhong Li, Jian Wang, Yanhong Li
Summary: Urinary CXCL10 is independently associated with AKI and sepsis and may be a potential indicator of septic AKI and PICU mortality in critically ill children. Higher levels of uCXCL10 may predict septic AKI and PICU mortality.
PEDIATRIC RESEARCH
(2022)
Review
Immunology
Yongmei Liu, Xiaomeng Li, Linlin Cheng, Haoting Zhan, Yuan Huang, Haolong Li, Yongzhe Li
Summary: This review summarizes the different types of circulating biomarkers in patients with relapsing polychondritis and their clinical correlation with the disease diagnosis and activity. It highlights the need for ideal biomarkers that are sensitive and specific for RP.
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Shuai Wang, Yanhan Dong, Anjing Gong, Huimin Kong, Jinning Gao, Xiaodan Hao, Yongmei Liu, Zibo Wang, Yuqiao Fan, Chengyu Liu, Wenhua Xu
Summary: Exosomal circRNAs have emerged as potential biomarkers in cancer diagnosis and prognosis, with the ability to influence target cells or organs by regulating tumor development and metastasis. The high stability of circRNAs in exosomes makes them promising candidates for early and minimally invasive cancer diagnosis and prognosis evaluation.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Review
Chemistry, Analytical
Mina Adampourezare, Mohammad Hasanzadeh, Behzad Nikzad
Summary: Proteomics is a crucial technology in medicine and biotechnology, particularly in disease diagnosis. This review focuses on the use of molecularly imprinted polymer (MIPs)-based biosensors in the recognition of protein biomarkers of neurodegenerative diseases. The advantages and limitations of MIPs-based biosensors are critically discussed, as well as the integration of lateral flow tests with MIPs-based biosensors and the use of smartphones in data analysis.
MICROCHEMICAL JOURNAL
(2023)
Article
Psychology, Multidisciplinary
Yuefan Xia, Yawen Hu, Chenyi Wu, Ling Yang, Man Lei
Summary: This research investigates three aspects: changes in student engagement and the factors involved; students' feelings and reactions during online learning; and students' relationships with their peers and instructors. It suggests that online learning may not achieve desired results due to factors such as lack of interaction with instructors, absence of campus socialization, and inadequate technology skills and content for online courses. However, it also reveals that online learning provides opportunities for college students to learn independently and collaborate, and encourages them to improve their technology skills, learning methods, and communication skills.
FRONTIERS IN PSYCHOLOGY
(2022)
Review
Transplantation
Daniel Lazzareschi, Ravindra L. Mehta, Laura M. Dember, Juliane Bernholz, Alparslan Turan, Amit Sharma, Sachin Kheterpal, Chirag R. Parikh, Omar Ali, Ivonne H. Schulman, Abigail Ryan, Jean Feng, Noah Simon, Romain Pirracchio, Patrick Rossignol, Matthieu Legrand
Summary: Acute kidney injury is a growing epidemic that is associated with increased risk of death, chronic kidney disease, and cardiovascular events. Clinical trials in this field are challenging due to the heterogeneity of the disease. Identifying subphenotypes of acute kidney injury can help elucidate its diverse etiologies and enhance prevention and treatment strategies.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Review
Chemistry, Multidisciplinary
Catriona C. James, Bas de Bruin, Joost N. H. Reek
Summary: The importance of transition metal catalysis lies in its wide range of applications, including the synthesis of chemicals, natural products, and pharmaceuticals. However, a relatively new application is the catalysis of new-to-nature reactions inside living cells. The complex environment of living cells poses challenges to transition metal catalysts due to the potential inhibition or deactivation by various biological components. In this review, we summarize the current progress in the field of transition metal catalysis, focusing on the evaluation of catalysis efficiency under living cell and biological conditions. Catalyst poisoning is a common issue in this field, and we suggest that future research should explore physical and kinetic protection strategies to enhance the reactivity of catalysts in cells.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Editorial Material
Urology & Nephrology
Sean M. Bagshaw, Javier A. Neyra, Ashita J. Tolwani, Ron Wald
Summary: Continuous kidney replacement therapy (CKRT) is a dominant modality in critical care, offering precise and safe treatment for critically ill patients. It has improved the recovery and independence of kidney function compared to intermittent hemodialysis. CKRT allows flexibility in adjusting solute and fluid removal based on dynamic circumstances, and enables early physical therapy and rehabilitation for patients, addressing immobility concerns.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Review
Critical Care Medicine
Vincent I. Lau, Ryan Donnelly, Sehar Parvez, Jivanjot Gill, Sean M. Bagshaw, Ian M. Ball, John Basmaji, Deborah J. Cook, Kirsten M. Fiest, Robert A. Fowler, Jonathan F. Mailman, Claudio M. Martin, Bram Rochwerg, Damon C. Scales, Henry T. Stelfox, Alla Iansavichene, Eric J. Sy
Summary: This study evaluated the impact of direct discharge home (DDH) from ICUs compared to ward transfer on safety outcomes such as readmissions, emergency department visits, and mortality. Six studies were included, and three high-quality studies involving 49,376 patients were subject to meta-analysis. The findings suggest that DDH from ICUs may have no significant difference in safety outcomes compared to ward transfer, but the evidence is of low certainty.
CRITICAL CARE MEDICINE
(2023)
Correction
Critical Care Medicine
John Muscedere, Sean M. M. Bagshaw, Gordon Boyd, Stephanie Sibley, Patrick Norman, Andrew Day, Miranda Hunt, Darryl Rolfson
INTENSIVE CARE MEDICINE EXPERIMENTAL
(2023)
Article
Urology & Nephrology
Lawrence Ledoux-Hutchinson, Ron Wald, Manu L. N. G. Malbrain, Francois Martin Carrier, Sean M. Bagshaw, Rinaldo Bellomo, Neill K. J. Adhikari, Martin Gallagher, Samuel A. Silver, Josee Bouchard, Michael J. J. Connor Jr, Edward G. Clark, Jean-Maxime Cote, Javier A. Neyra, Andre Denault, William Beaubien-Souligny
Summary: This international survey aimed to evaluate current practices and knowledge gaps related to fluid removal with KRT in critically ill patients. The survey revealed variations in fluid removal targets and differences between nephrologists and intensivists in fluid management methods and adjunct assessment methods. Most physicians agreed on the need for randomized controlled trials to address knowledge gaps in fluid management strategies.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Critical Care Medicine
Federico Angriman, Fiona Muttalib, Francois Lamontagne, Neill K. J. Adhikari, LOVIT Invest
Summary: The Lessening Organ Dysfunction with Vitamin C trial showed that vitamin C has a harmful effect on 28-day death or persistent organ dysfunction. A post hoc Bayesian reanalysis confirmed that there is a high probability of harm in using vitamin C for adult patients with infection and vasopressor support.
CRITICAL CARE MEDICINE
(2023)
Article
Critical Care Medicine
Vincent I. Lau, Graham D. Mah, Xiaoming Wang, Leon Byker, Andrea Robinson, Lazar Milovanovic, Aws Alherbish, Jeffrey Odenbach, Cristian Vadeanu, David Lu, Leo Smyth, Mitchell Rohatensky, Brian Whiteside, Phillip Gregoire, Warren Luksun, Sean van Diepen, Dustin Anderson, Sanam Verma, Jocelyn Slemko, Peter Brindley, Demetrios J. Kustogiannis, Michael Jacka, Andrew Shaw, Matt Wheatley, Jonathan Windram, Dawn Opgenorth, Nadia Baig, Oleksa G. Rewa, Sean M. Bagshaw, Brian M. Buchanan
Summary: A study on COVID-19 and non-COVID ARDS patients found a higher frequency of right-to-left shunts in COVID-19 patients, which was associated with in-hospital mortality.
CRITICAL CARE MEDICINE
(2023)
Correction
Critical Care Medicine
Sean M. Bagshaw, Ary Serpa Neto, Orla Smith, Matthew Weir, Haibo Qiu, Bin Du, Amanda Y. Wang, Martin Gallagher, Rinaldo Bellomo, Ron Wald
INTENSIVE CARE MEDICINE
(2023)
Editorial Material
Critical Care Medicine
Fernando G. Zampieri, Nazir I. Lone, Sean M. Bagshaw
INTENSIVE CARE MEDICINE
(2023)
Review
Medicine, General & Internal
Fernando G. Zampieri, Sean M. Bagshaw, Matthew W. Semler
Summary: Approximately 20% to 30% of ICU patients have sepsis. Intravenous fluids in the ICU are essential for the therapy of sepsis, as they can increase cardiac output and blood pressure, maintain or increase intravascular fluid volume, and deliver medications.
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
(2023)
Article
Urology & Nephrology
Alexander Zarbock, Mitra K. Nadim, Peter Pickkers, Hernando Gomez, Samira Bell, Michael Joannidis, Kianoush Kashani, Jay L. Koyner, Neesh Pannu, Melanie Meersch, Thiago Reis, Thomas Rimmele, Sean M. Bagshaw, Rinaldo Bellomo, Vicenzo Cantaluppi, Akash Deep, Silvia De Rosa, Xose Perez-Fernandez, Faeq Husain-Syed, Sandra L. Kane-Gill, Yvelynne Kelly, Ravindra L. Mehta, Patrick T. Murray, Marlies Ostermann, John Prowle, Zaccaria Ricci, Emily J. See, Antoine Schneider, Danielle E. Soranno, Ashita Tolwani, Gianluca Villa, Claudio Ronco, Lui G. Forni
Summary: Sepsis-associated acute kidney injury (SA-AKI) is a common condition that is strongly associated with poor outcomes in critically ill patients. The exact cause of SA-AKI is still not fully understood, but dysfunction in microcirculation, cellular metabolism, and inflammatory responses are considered to be involved. Early identification of patients at risk and timely initiation of supportive measures are crucial for improving outcomes. Research on biomarkers for early diagnosis and clinical trials on potential therapeutic approaches are ongoing.
NATURE REVIEWS NEPHROLOGY
(2023)
Article
Critical Care Medicine
Paul J. Young, Abdulrahman Al-Fares, Diptesh Aryal, Yaseen M. Arabi, Muhammad Sheharyar Ashraf, Sean M. Bagshaw, Mohd Basri Mat-Nor, Abigail Beane, Giovanni Borghi, Airton L. de Oliveira Manoel, Layoni Dullawe, Fathima Fazla, Tomoko Fujii, Rashan Haniffa, Carol L. Hodgson, Anna Hunt, Cassie Lawrence, Diane Mackle, Kishore Mangal, Alistair D. Nichol, Shaanti Olatunji, Aasiyah Rashan, Sumayyah Rashan, Bruno Tomazini, Jessica Kasza
Summary: This international randomized clinical trial compares the effect of conservative vs. liberal oxygen therapy on the 90-day in-hospital mortality of ICU patients with acute brain injuries. The trial aims to enroll between 7500 and 9500 participants and will assess outcomes such as mortality, duration of survival, mechanical ventilation, and length of stay.
CRITICAL CARE AND RESUSCITATION
(2023)
Article
Urology & Nephrology
Rachel Jeong, Matthew T. James, Robert R. Quinn, Pietro Ravani, Sean M. Bagshaw, Henry T. Stelfox, Neesh Pannu, Alix Clarke, Ron Wald, Tyrone G. Harrison, Daniel J. Niven, Ngan N. Lam
Summary: This retrospective cohort study evaluated the follow-up care of critically ill patients with acute kidney injury (AKI). The results showed that many patients did not receive the recommended follow-up care, highlighting a gap in the transition of care for survivors of critical illness and AKI.
Letter
Anesthesiology
Fernando G. Zampieri, Sean M. Bagshaw
BRITISH JOURNAL OF ANAESTHESIA
(2023)
Review
Critical Care Medicine
Natalja L. Stanski, Camila E. Rodrigues, Michael Strader, Patrick T. Murray, Zoltan H. Endre, Sean M. Bagshaw
Summary: Acute kidney injury (AKI) is a complex syndrome characterized by a wide spectrum of pathobiology. Sub-phenotypes of AKI can be distinguished by shared features and can be used for prognostic enrichment and predictive enrichment. Biomarkers, both specific and non-specific, can aid in identifying pathobiological mechanisms and guide patient care in AKI.
INTENSIVE CARE MEDICINE
(2023)
Article
Urology & Nephrology
Sean M. Bagshaw
