Article
Transplantation
Francesco Trepiccione, Steven B. Walsh, Gema Ariceta, Olivia Boyer, Francesco Emma, Roberta Camilla, Pietro Manuel Ferraro, Dieter Haffner, Martin Konrad, Elena Levtchenko, Sergio Camilo Lopez-Garcia, Fernando Santos, Stella Stabouli, Maria Szczepanska, Velibor Tasic, Rezan Topaloglu, Rosa Vargas-Poussou, Tanja Wlodkowski, Detlef Bockenhauer
Summary: Distal renal tubular acidosis (dRTA) is a rare metabolic disorder characterized by impaired acid excretion leading to complications such as bone disease and growth failure. Adequate metabolic control with alkali supplementation is crucial, but there are challenges with treatment adherence among patients.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Review
Cell Biology
Min Chen, Xiangchen Gu
Summary: Endocytosis plays a crucial role in kidney diseases, particularly in renal fibrosis, and is affected by other diseases and factors.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Review
Medicine, Research & Experimental
Biff F. Palmer, Ellie Kelepouris, Deborah J. Clegg
Summary: Renal tubular acidosis (RTA) is a condition where the kidneys are unable to maintain normal acid-base balance due to defects in acid excretion or bicarbonate reabsorption. The three major forms of RTA are distal, proximal, and hyperkalemic, with a rare type 3 that combines features of both distal and proximal RTA. Accurate diagnosis is crucial for optimal patient management, with different treatment options available based on the specific type of RTA diagnosed.
ADVANCES IN THERAPY
(2021)
Article
Biochemistry & Molecular Biology
Yan Liu, Wenchao Sheng, Shaowei Hou, Mengzhu Hou, Ying Zhang, Xuetao Wang, Shuyue Zhang, Feiyu Zhou, Chunquan Cai, Wenhong Wang
Summary: This study reports a pRTA patient with the Arg166Trp variant and UPiD (4) pat, and analyzes the function of the Arg166Trp variant.
BIOCHEMICAL GENETICS
(2023)
Review
Chemistry, Medicinal
Hao Li, Wenni Dai, Zhiwen Liu, Liyu He
Summary: Diabetic kidney disease is a major cause of end-stage kidney disease worldwide, and new drug delivery strategies and targeted therapies are urgently needed.
Article
Genetics & Heredity
Tejashree Anil More, Prabhakar S. Kedar
Summary: The study found that in the Indian population, the A858D missense mutation in the SLC4A1 gene is the most common cause of dRTA coupled with HS. HRM analysis can be used as a rapid screening method for common SLC4A1 mutations that cause AR dRTA in the Indian population.
Article
Immunology
Yang Chen, Hui-Yi Li, Jian-Shu Liu, Dao-long Jiang, Hao-nan Zheng, Xue-Song Dong
Summary: In this study, a diquat-induced human kidney-2 cells (HK-2 cells) apoptosis model was established and differentially expressed miRNAs and signaling pathways involved in diquat poisoning were identified through gene sequencing and bioinformatics analysis. The findings contribute to understanding the mechanisms of diquat poisoning and provide new targets for gene therapy of related diseases.
JOURNAL OF INFLAMMATION RESEARCH
(2023)
Article
Medicine, General & Internal
Vidya Baleguli, Riaz Mahmood, Martin Herrera, Erine Raybon-Rojas
Summary: Type 4 renal tubular acidosis is a metabolic acidosis characterized by hyperchloremia and hyperkalemia due to reduced aldosterone levels and/or resistance, which can be caused by various medications such as ACE inhibitors/ARBs, potassium-sparing diuretics, and heparin. This case specifically discusses RTA caused by heparin use in COVID-19 patients for thromboembolic disease prevention.
CUREUS JOURNAL OF MEDICAL SCIENCE
(2021)
Article
Multidisciplinary Sciences
Kunihiro Nakai, Minato Umehara, Atsushi Minamida, Hiroko Yamauchi-Sawada, Yasuto Sunahara, Yayoi Matoba, Natsuko Okuno-Ozeki, Itaru Nakamura, Tomohiro Nakata, Aya Yagi-Tomita, Noriko Uehara-Watanabe, Tomoharu Ida, Noriyuki Yamashita, Michitsugu Kamezaki, Yuhei Kirita, Eiichi Konishi, Hiroaki Yasuda, Satoaki Matoba, Keiichi Tamagaki, Tetsuro Kusaba
Summary: Streptozotocin (STZ) is an anti-cancer drug used to treat neuroendocrine tumors (NETs). It enters pancreatic beta-cells or proximal tubular epithelial cells through GLUT2. This study demonstrated the cytotoxic effects of STZ on kidney cells and identified DNA damage and p53 signaling as underlying mechanisms. Inhibition of p53 and SGLT2 mitigated kidney injury caused by STZ, but the cytotoxic effects on pancreatic beta-cells were not affected. These findings suggest the potential use of SGLT2 inhibitors as preventive treatments for kidney injury in NET patients treated with STZ.
SCIENTIFIC REPORTS
(2023)
Review
Pediatrics
Fernando Santos, Helena Gil-Pena
Summary: This article reviews the clinical manifestations and complications of primary distal renal tubular acidosis. The disease is caused by a genetic defect that persists throughout life and often begins in childhood. The paper focuses on the pathogenic factors responsible for kidney failure, emphasizing the importance of maintaining optimal metabolic control of the disease and regular clinical follow-up.
PEDIATRIC NEPHROLOGY
(2023)
Article
Medicine, General & Internal
Zhiyin Pei, Meng Wu, Hanqing Yu, Guangfeng Long, Zhen Gui, Xiaonan Li, Hongbing Chen, Zhanjun Jia, Weiwei Xia
Summary: This study found that ISL, a compound found in licorice, has a protective effect and can alleviate cisplatin-induced kidney injury. ISL exerts its effect by antagonizing apoptosis, oxidative stress, and inflammation.
FRONTIERS IN MEDICINE
(2022)
Review
Physiology
Shuxian Chen, Jinxia Chen, Shangmei Li, Fengbiao Guo, Aifen Li, Han Wu, Jiaxuan Chen, Quanren Pan, Shuzhen Liao, Hua-feng Liu, Qingjun Pan
Summary: With improvements in living standards and changes in living habits, high-fat diet has become more common worldwide. Studies have shown that high-fat diet can induce lipid accumulation and structural abnormalities in proximal tubular epithelial cells, potentially leading to inflammation.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Keiko Hosohata, Denan Jin, Shinji Takai
Summary: In this study, the protective effect of Glaucocalxin A (GLA) on acute kidney injury (AKI) was investigated. GLA improved cell viability, suppressed reactive oxygen species (ROS) production, elevated superoxide dismutase activity, and prevented cell death in HK-2 human renal tubular epithelial cells exposed to hypoxia/reoxygenation (H/R). GLA also ameliorated the activation of the Akt/Nrf2/HO-1 signaling pathway. These findings suggest that GLA may serve as a promising therapeutic drug for AKI.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Chi Zhang, Zhihuang Zheng, Kexin Xu, Guozhe Cheng, Huijuan Wu, Jun Liu
Summary: This study reveals that LATS2 deficiency exacerbates maladaptive repair after acute kidney injury and contributes to the progression of kidney disease. LATS2 deficiency activates p53 and increases the level of apoptotic molecules while decreasing the level of anti-apoptotic molecules. Inhibiting p53 effectively attenuates the damage caused by LATS2 deficiency. Additionally, overexpression of LATS2 decreases the expression of p53. In conclusion, LATS2 deficiency aggravates maladaptive repair through the regulation of the MDM2-p53 axis in acute kidney injury-induced damage.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Shi-qing Chen, Bing-feng Hu, Ya-ru Yang, Yuan He, Lin Yue, Dong Guo, Ting-ni Wu, Xiao-wen Feng, Qing Li, Wei Zhang, Jia-gen Wen
Summary: This study investigated the protective effect of proton pump inhibitors (PPIs) on cisplatin-induced nephrotoxicity. It was found that rabeprazole (Rab) had a significant protective effect against cisplatin-induced kidney damage. The results also showed that Rab attenuated cisplatin-induced nephrotoxicity by inhibiting organic cation transporter 2 (OCT2)-mediated cisplatin uptake.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)