Article
Urology & Nephrology
Muhammad G. Arnous, Jennifer Arroyo, Andrea G. Cogal, Franca Anglani, Hee Gyung Kang, David Sas, Peter C. Harris, John C. Lieske
Summary: This study retrospectively analyzed the clinical and genetic factors of 162 DD1 patients and found that truncating variants associated with the CLCN5 gene were closely related to kidney stone formation and progression of chronic kidney disease in DD1 patients, while nontruncating variants were not associated with microproteinuria and nephrocalcinosis. As for kidney failure, only truncating variants were associated with it. The severity of the disease in patients may be related to the degree of residual ClC-5 function.
KIDNEY INTERNATIONAL REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Pengpeng Duan, Jin Tan, Yuyang Miao, Qiang Zhang
Summary: The study suggests that PINK1/Parkin-mediated mitophagy plays a crucial role in maintaining tubular cell survival during albumin overload by clearing damaged mitochondria and preserving mitochondrial function. This pathway could be a potential therapeutic target for proteinuria in tubular epithelial cells.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2022)
Article
Biochemistry & Molecular Biology
Xingzhao Ji, Xiaoli Yang, Xia Gu, Lingju Chu, Shengnan Sun, Jian Sun, Peng Song, Qian Mu, Ying Wang, Xiaoming Sun, Dun Su, Tong Su, Shaoshuai Hou, Yao Lu, Chen Ma, Mingqiang Liu, Tianyi Zhang, Weiying Zhang, Yi Liu, Qiang Wan
Summary: Diabetic kidney disease (DKD) is the leading cause of chronic kidney disease and mortality in diabetic patients. This study reveals that mitochondrial ribosomal protein L12 (MRPL12) plays a crucial role in DKD by affecting mitochondrial function. Cullin3 (CUL3), an E3 ubiquitin ligase, has been identified to mediate the ubiquitination of MRPL12, leading to mitochondrial biosynthesis dysfunction. The findings suggest a potential therapeutic strategy for DKD by targeting the CUL3-MRPL12 pathway.
Article
Plant Sciences
Katarine F. Silva, Diogo B. Peruchetti, Gabriela M. Sirtoli, Christina M. Takiya, Ana Acacia S. Pinheiro, Jose Henrique Leal-Cardoso, Celso Caruso-Neves
Summary: The study found that high doses of Croton zehntneri essential oil may induce tubule-interstitial injury in mouse kidneys, possibly mediated by protein overload in the proximal tubule.
Article
Health Care Sciences & Services
Maxime Ilzkovitz, Elikyah Esther Kayembe, Caroline Geers, Agnieszka Pozdzik
Summary: This study reported a rare case of kidney stone disease in an Indian woman with a strong association with Sjogren syndrome, highlighting the importance of autoimmune screening in the diagnosis of such conditions.
Review
Endocrinology & Metabolism
Safaa H. Hammoud, Ibrahim AlZaim, Yusra Al-Dhaheri, Ali H. Eid, Ahmed F. El-Yazbi
Summary: Healthy adipose tissue is crucial for human wellbeing, contributing to energy balance and internal organ insulation, and playing a role in synthesizing and secreting adipokines affecting glucose and lipid balance. Inflammation induced by obesity in adipose tissue is linked to insulin resistance, metabolic syndrome, type 2 diabetes, as well as cardiovascular diseases, while alterations in perirenal adipose tissue have implications for renal and cardiovascular function. This suggests potential avenues for future pharmacological therapies targeting adipose tissue immunometabolism in the treatment of chronic kidney disease and cardiovascular disorders.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Endocrinology & Metabolism
Suyan Duan, Fang Lu, Dandan Song, Chengning Zhang, Bo Zhang, Changying Xing, Yanggang Yuan
Summary: Studies have shown that morphological and functional changes in renal tubules play a significant role in diabetic kidney disease, with novel tubular biomarkers showing clinical importance. However, transitioning to personalized diagnosis and therapy still presents challenges.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Medicine, Research & Experimental
Tales Lyra de Oliveira, Gisele Silverio Lincevicius, Caroline Gusson Shimoura, Alex Yuri Simoes-Sato, Michelle Louvaes Garcia, Cassia T. Bergamaschi, Ruy R. Campos
Summary: The study found that bilateral renal denervation (BRD) significantly improved glycemia, renal function, and sympathetic nerve activity in streptozotocin-diabetic rats. Renal nerves may play an important role in the treatment of diabetic patients.
Article
Urology & Nephrology
Johanna E. Emmens, Martin H. de Borst, Eva M. Boorsma, Kevin Damman, Gerjan Navis, Dirk J. van Veldhuisen, Kenneth Dickstein, Stefan D. Anker, Chim C. Lang, Gerasimos Filippatos, Marco Metra, Nilesh J. Samani, Piotr Ponikowski, Leong L. Ng, Adriaan A. Voors, Jozine M. ter Maaten
Summary: By studying 2085 patients with heart failure, we found that proximal tubular function is frequently reduced in these patients, and this reduction is associated with an increased risk of plasma NGAL doubling and worse clinical outcomes, independent of glomerular function. In addition, inhibition of SGLT2 by empagliflozin and improvement of TmP/GFR may have a positive effect in patients with heart failure.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Chengcheng Liu, Shuyao Li, Shuang Ji, Jiayang Zhang, Feng Zheng, Youfei Guan, Guangrui Yang, Lihong Chen
Summary: Recent studies have shown that the core clock gene Bmal1 plays a significant role in renal physiological functions. This study found that deletion of Bmal1 in the proximal tubule exacerbated chronic kidney disease (CKD) and renal fibrosis. Mechanistically, Bmal1 regulates fatty acid oxidation and glutathione metabolism, and activates the transcription of CBS to stimulate glutathione biosynthesis. These findings provide a potential target for treating CKD.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Cell Biology
Yu Zhang, Ping Wen, Jing Luo, Hao Ding, Hongdi Cao, Weichun He, Ke Zen, Yang Zhou, Junwei Yang, Lei Jiang
Summary: Proximal tubular epithelial cells (TECs) require high energy and rely on mitochondrial oxidative phosphorylation as their main energy source. However, in renal fibrosis, this process is disrupted. Sirtuin 3 (SIRT3), a mitochondrial protein, regulates mitochondrial metabolic function through deacetylation. Decreased SIRT3 expression in TECs during early renal fibrosis leads to increased acetylation in mitochondria, contributing to the development of severe renal fibrosis.Activation of SIRT3 can prevent renal fibrosis by reducing acetylation levels in mitochondrial proteins.
CELL DEATH & DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Luqun Liang, Chunxin Wo, Yao Yuan, Hongjuan Cao, Wanlin Tan, Xingcheng Zhou, Dan Wang, Rongyu Chen, Mingjun Shi, Fan Zhang, Ying Xiao, Lingling Liu, Yuxia Zhou, Tian Zhang, Yuanyuan Wang, Bing Guo
Summary: In this study, the researchers found that miR-124-3p plays a crucial role in DKD progression by regulating renal mitochondrial function. They discovered that miR-124-3p down-regulated FOXQ1, which in turn suppressed Sirt4 expression and led to mitochondrial dysfunction, promoting the development of DKD.
Article
Physiology
Thomas Verissimo, Delal Dalga, Gregoire Arnoux, Imene Sakhi, Anna Faivre, Hannah Auwerx, Soline Bourgeois, Deborah Paolucci, Quentin Gex, Joseph M. Rutkowski, David Legouis, Carsten A. Wagner, Andrew M. Hall, Sophie de Seigneux
Summary: Phosphoenolpyruvate carboxykinase 1 (PCK1) plays an important role in maintaining normal tubular physiology, lactate, and glucose homeostasis in the kidney. It regulates acid-base balance and ammoniagenesis. Downregulation of PCK1 during renal injury impairs renal function, making it a potential therapeutic target in renal disease.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2023)
Article
Oncology
Yuma Shibutani, Shinya Suzuki, Atsunobu Sagara, Tomohiro Enokida, Susumu Okano, Takao Fujisawa, Fumiaki Sato, Tetsuro Yumoto, Motohiko Sano, Toshikatsu Kawasaki, Makoto Tahara
Summary: This retrospective study evaluated the association between lenvatinib-induced proteinuria and renal function in patients with thyroid cancer. The results showed that the degree of proteinuria was not associated with renal function. Therefore, treatment with lenvatinib should be continued with attention to renal function, regardless of the degree of proteinuria.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Viktoriia Sofronova, Rina Iwata, Takuya Moriya, Kiunniai Loskutova, Elizaveta Gurinova, Mairanush Chernova, Anastasia Timofeeva, Anna Shvedova, Filipp Vasilev, Saina Novgorodova, Seigo Terawaki, Takahito Moriwaki, Aitalina Sukhomyasova, Nadezhda Maksimova, Takanobu Otomo
Summary: Mucopolysaccharidoses (MPS) and Mucopolysaccharidosis-Plus Syndrome (MPSPS) are rare lysosomal storage disorders characterized by excessive accumulation of glycosaminoglycans. While conventional MPS presents with multisystemic symptoms, MPSPS, caused by a mutation in VPS33A, also shows renal and hematopoietic abnormalities. Biochemical, histological, and physical examinations indicate hematopoietic symptoms and renal dysfunction in MPSPS patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Patryk Lipinski, Agnieszka Lugowska, Ekaterina Y. Zakharova, Piotr Socha, Anna Tylki-Szymanska
JOURNAL OF PEDIATRIC GASTROENTEROLOGY AND NUTRITION
(2018)
Review
Endocrinology & Metabolism
Marco Spada, Ralf Baron, Perry M. Elliott, Bruno Falissard, Max J. Hilz, Lorenzo Monserrat, Camilla Tondel, Anna Tylki-Szymariska, Christoph Wanner, Dominique P. Germain
MOLECULAR GENETICS AND METABOLISM
(2019)
Article
Biochemistry & Molecular Biology
Marcin Wos, Magdalena Komiazyk, Slawomir Pikula, Anna Tylki-Szymanska, Joanna Bandorowicz-Pikula
JOURNAL OF CELLULAR BIOCHEMISTRY
(2019)
Review
Endocrinology & Metabolism
Yoav Zehavi, Hanna Mandel, Ayelet Eran, Sarit Ravid, Muhammad Abu Rashid, Erwin E. W. Jansen, Mirjam M. C. Wamelink, Ann Saada, Avraham Shaag, Orly Elpeleg, Ronen Spiegel
METABOLIC BRAIN DISEASE
(2019)
Article
Endocrinology & Metabolism
Paulina Pokora, Aleksandra Jezela-Stanek, Agnieszka Rozdzynska-Swiatkowska, Elzbieta Jurkiewicz, Anna Bogdanska, Edyta Szymanska, Dariusz Rokicki, Elzbieta Ciara, Malgorzata Rydzanicz, Piotr Stawinski, Rafal Ploski, Anna Tylki-Szymanska
METABOLIC BRAIN DISEASE
(2019)
Article
Endocrinology & Metabolism
Monique Williams, Vassili Valayannopoulos, Ruqaiah Altassan, Wendy K. Chung, Annemieke C. Heijboer, Wei Teik Keng, Risto Lapatto, Patricia McClean, Margot F. Mulder, Anna Tylki-Szymanska, Marie-Jose E. Walenkamp, Majid Alfadhel, Hajar Alakeel, Gajja S. Salomons, Wafaa Eyaid, Mirjam M. C. Wamelink
JOURNAL OF INHERITED METABOLIC DISEASE
(2019)
Review
Endocrinology & Metabolism
Agnieszka Rozdzynska-Swiatkowska, Anna Tylki-Szymanska
JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM
(2019)
Article
Endocrinology & Metabolism
N. Guffon, A. Tylki-Szymanska, L. Borgwardt, A. M. Lund, M. Gil-Campos, R. Parini, J. B. Hennermann
MOLECULAR GENETICS AND METABOLISM
(2019)
Article
Genetics & Heredity
Patryk Lipinski, Ladislav Kuchar, Ekaterina Y. Zakharova, Galina V. Baydakova, Agnieszka Lugowska, Anna Tylki-Szymanska
ORPHANET JOURNAL OF RARE DISEASES
(2019)
Article
Biotechnology & Applied Microbiology
Aleksandra Jezela-Stanek, Agnieszka Rozdzynska-Swiatkowska, Anna Kulpanovich, Elzbieta Ciara, Jolanta Marucha, Anna Tylki-Szymanska
JOURNAL OF APPLIED GENETICS
(2019)
Article
Endocrinology & Metabolism
Uma Ramaswami, Daniel G. Bichet, Lorne A. Clarke, Gabriela Dostalova, Alejandro Fainboim, Andreas Fellgiebel, Cassiano M. Forcelini, Kristina An Haack, Robert J. Hopkin, Michael Mauer, Behzad Najafian, C. Ronald Scott, Suma P. Shankar, Beth L. Thurberg, Camilla Tondel, Anna Tylki-Szyrnanska, Bernard Benichou, Frits A. Wijburg
MOLECULAR GENETICS AND METABOLISM
(2019)
Article
Genetics & Heredity
Parneet Kaur, Mirjam M. C. Wamelink, Marjo S. van der Knaap, Katta Mohan Girisha, Anju Shukla
EUROPEAN JOURNAL OF MEDICAL GENETICS
(2019)
Article
Multidisciplinary Sciences
Chiara Milanese, Cintia R. Bombardieri, Sara Sepe, Sander Barnhoorn, Cesar Payan-Gomez, Donatella Caruso, Matteo Audano, Silvia Pedretti, Wilbert P. Vermeij, Renata M. C. Brandt, Akos Gyenis, Mirjam M. Wamelink, Annelieke S. de Wit, Roel C. Janssens, Rene Leen, Andre B. P. van Kuilenburg, Nico Mitro, Jan H. J. Hoeijmakers, Pier G. Mastroberardino
NATURE COMMUNICATIONS
(2019)
Article
Endocrinology & Metabolism
Ana Pop, Desiree E. C. Smith, Trevor Kirby, Dana Walters, K. Michael Gibson, Soufiane Mahmoudi, Silvy J. M. van Dooren, Warsha A. Kanhai, Matilde R. Fernandez-Ojeda, Eric J. M. Wever, Janet Koster, Hans R. Waterham, Bram Grob, Birthe Roos, Mirjam M. C. Wamelink, Justin Chen, Senthil Natesan, Gajja S. Salomons
MOLECULAR GENETICS AND METABOLISM
(2020)