Article
Urology & Nephrology
Si-Jia Zhou, Xiao-Xiao Wang, Wen Tang, Qing-Feng Han, Lian He, Ai-Hua Zhang
Summary: This study evaluated serum irisin levels of peritoneal dialysis (PD) patients and their relationship with vascular calcification, finding a significant association between serum irisin levels and abdominal aortic calcification in PD patients. Lower irisin levels, diabetic mellitus, higher serum ultrasensitive C reactive protein, and older age could be potential predictive factors for vascular calcification in PD patients.
Article
Biochemistry & Molecular Biology
Marcela Avila, Ma del Carmen Prado, Renata Romero, Ricardo Cordova, Ma del Carmen Rigo, Miguel Trejo, Carmen Mora, Ramon Paniagua
Summary: The purpose of this study was to compare the value of vascular calcification (VC), serum osteoprotegerin (OPG) levels, and other biochemical markers as predictors of all-cause and cardiovascular mortality in patients on peritoneal dialysis (PD). The study found that OPG was a significant predictor for all-cause and cardiovascular mortality, performing better than VC. In addition, albumin and calcium levels were associated with the risk of mortality.
Review
Hematology
Refik Olmaz, Tamer Selen, Ozkan Gungor
Summary: Cardiovascular diseases are common in patients with chronic kidney disease (CKD) and peritoneal dialysis (PD) patients, leading to higher morbidity and mortality rates and financial burdens. Vascular calcification (VC) is a risk factor for morbidity and mortality, and CKD patients face a higher risk of VC. Calcification inhibitors, which can inhibit VC-related proteins, have been discovered in dialysis patients. This review provides an overview of these inhibitors, their regulatory mechanisms, and their relation to VC development in PD patients.
THERAPEUTIC APHERESIS AND DIALYSIS
(2023)
Review
Biochemistry & Molecular Biology
Ricardo Villa-Bellosta
Summary: Cardiovascular complications due to accelerated arterial stiffening and atherosclerosis are the leading cause of morbimortality in Western society, often associated with vascular calcification. The balance between phosphate and pyrophosphate, strictly controlled by several genes, plays a key role in calcification.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Urology & Nephrology
Yuxi Wang, Quanquan Shen, Junni Wang, Shilong Xiang, Yaomin Wang, Xiaohui Zhang, Jianghua Chen, Fei Han
Summary: This study aimed to construct a nomogram model for predicting cardiac valve calcification in maintenance peritoneal dialysis (MPD) patients. The model utilized independent risk factors such as age, sex, systolic blood pressure, calcium-phosphorus product, Charlson comorbidity index, and dialysis time. The model showed high efficiency in predicting cardiac valve calcification.
Article
Medicine, General & Internal
Georges Leftheriotis, Nastassia Navasiolava, Laetitia Clotaire, Christophe Duranton, Olivier Le Saux, Said Bendahhou, Audrey Laurain, Isabelle Rubera, Ludovic Martin
Summary: PXE is a rare metabolic disorder characterized by progressive calcification in the skin, the Bruch's membrane, and the vasculature. This study found a deficit in plasma PPi levels in PXE patients, with a correlation to age and gender. However, arterial calcification showed a weak connection to PPi levels, with age being the main determinant of disease severity.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Urology & Nephrology
Jichao Guan, Shuwen Gong, Qiuli He, Xiaoling Wang, Shuijuan Shen, Xiujuan Wu, Juanping Shan, Tujian Gong, Yanru Yang, Haiying Xie
Summary: Investigated the relationship between serum suPAR and cardiovascular calcification (CVC) in peritoneal dialysis (PD) patients and found that high levels of serum suPAR are associated with CVC, especially in elderly patients.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2023)
Article
Urology & Nephrology
Ho-Kwan Sin, Ping-Nam Wong, Kin-Yee Lo, Man-Wai Lo, Shuk-Fan Chan, Kwok-Chi Lo, Yuk-Yi Wong, Lo-Yi Ho, Wing-Tung Kwok, Kai-Chun Chan, Andrew Kui-Man Wong, Siu-Ka Mak
Summary: In this study, we found that ECS is an independent predictor of MACE in PD patients, regardless of DM and pre-existing CVD.
Review
Biochemistry & Molecular Biology
Briana K. Shimada, Viola Pomozi, Janna Zoll, Sheree Kuo, Ludovic Martin, Olivier Le Saux
Summary: ABCC6 plays a crucial role in the pathogenesis of PXE and other calcification disorders by regulating ATP efflux and inhibiting calcification. Current therapies only aim to alleviate symptoms, but novel approaches have been developed through extensive research.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biology
Gustavo Leal-Alegre, Claudia Lerma, Gabriela Leal-Escobar, Bernardo Moguel-Gonzalez, Karen Belen Martinez-Vazquez, Karla Berenice Cano-Escobar
Summary: The study found associations between vascular calcification and age, protein-energy wasting syndrome, sarcopenia, and diabetes, with age being the only variable independently associated with vascular calcification.
Article
Multidisciplinary Sciences
Seishi Aihara, Shunsuke Yamada, Shumei Matsueda, Akinori Nagashima, Kumiko Torisu, Takanari Kitazono, Toshiaki Nakano
Summary: Peritoneal calcification is a prominent characteristic of the later stage of encapsulating peritoneal sclerosis in patients on long-term peritoneal dialysis. This study found that calcifying medium accelerates peritoneal cell calcification, which can be prevented by magnesium supplementation.
SCIENTIFIC REPORTS
(2023)
Article
Cell Biology
Ana Amaya-Garrido, Manon Brunet, Benedicte Buffin-Meyer, Alexis Piedrafita, Lucile Grzesiak, Ezechiel Agbegbo, Arnaud Del Bello, Ines Ferrandiz, Serban Ardeleanu, Marcelino Bermudez-Lopez, Camille Fedou, Mylene Camus, Odile Burlet-Schiltz, Jean Massines, Marie Buleon, Guylene Feuillet, Melinda Alves, Eric Neau, Audrey Casemayou, Benjamin Breuil, Jean-Sebastien Saulnier-Blache, Colette Denis, Jakob Voelkl, Griet Glorieux, Sam Hobson, Samsul Arefin, Awahan Rahman, Karolina Kublickiene, Peter Stenvinkel, Jean-Loup Bascands, Stanislas Faguer, Jose M. Valdivielso, Joost P. Schanstra, Julie Klein
Summary: Vascular calcification is a significant risk factor for cardiovascular mortality in patients with chronic kidney disease. A study found that circulating calprotectin is independently associated with calcification, cardiovascular outcomes, and mortality in CKD patients. Inhibition of calprotectin may be a promising strategy to prevent vascular calcification in these patients.
SCIENCE TRANSLATIONAL MEDICINE
(2023)
Review
Pharmacology & Pharmacy
Xinyue Pan, Caixia Pi, Xianchun Ruan, Hanhua Zheng, Demao Zhang, Xiaoheng Liu
Summary: Cardiovascular diseases have a high impact on millions of individuals each year. Vascular calcification, which involves the deposition of calcium-phosphate complexes, is closely related to various cardiovascular diseases. Sirtuins, a family of histone deacetylases, play important roles in bone homeostasis and the process of vascular calcification, offering new possibilities for the prevention and treatment of cardiovascular diseases.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Medicine, Research & Experimental
Yaxin Lian, Yue Li, Aiting Liu, Sounak Ghosh, Yuncong Shi, Hui Huang
Summary: This article provides an overview of the key role of oxidative stress in vascular calcification (VC) and discusses the challenges surrounding the use of dietary antioxidants in preventing VC.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Genetics & Heredity
Philip Duesing, Andreas Zietzer, Philip Roger Goody, Mohammed Rabiul Hosen, Christian Kurts, Georg Nickenig, Felix Jansen
Summary: CKD and CVD are interlinked, with CKD increasing the risk of cardiovascular disease mainly due to accumulation of uremic toxins, chronic inflammation, and oxidative stress. Vascular alterations, especially atherosclerosis and vascular calcification, play a significant role in the association between CKD and cardiovascular mortality.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2021)
Article
Pediatrics
Mariana Munhoz da Cunha, Fellype Carvalho Barreto, Samantha Nichele, Joanna Trennepohl, Lisandro Ribeiro, Gisele Loth, Adriana Koliski, Tyane de Almeida Pinto Jardim, Adriana Mello, Ricardo Pasquini, Lucimary de Castro Sylvestre, Carmem Bonfim
Summary: Fanconi anemia (FA) is a rare disease that can lead to bone marrow failure and cancer predisposition. Hematopoietic cell transplantation (HCT) is the only potential cure for FA, but it may cause acute kidney injury (AKI) and hypertension. A study on FA patients who underwent HCT found that the incidence of AKI within 100 days was 18.7%, with 72% of patients developing hypertension, and CAKUT was associated with hypertension and kidney function.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Article
Urology & Nephrology
Jodie L. Babitt, Michele F. Eisenga, Volker H. Haase, Abhijit Kshirsagar, Adeera Levin, Francesco Locatelli, Jolanta Malyszko, Dorine W. Swinkels, Der-Cherng Tarng, Michael Cheung, Michel Jadoul, Wolfgang C. Winkelmayer, Tilman B. Drueke
Summary: Chronic kidney disease is often associated with anemia and disordered iron homeostasis, which have significant adverse consequences. In 2012, KDIGO issued guidelines for managing anemia in chronic kidney disease, and in 2019, they convened conferences to review new evidence and controversies related to iron and anemia treatment. The first conference focused on iron-related issues like diagnostic challenges, treatment options and patient outcomes.
KIDNEY INTERNATIONAL
(2021)
Editorial Material
Urology & Nephrology
Ziad A. Massy, Tilman B. Drueke
Summary: RNA interference is a biological process that can directly regulate gene expression and has shown great potential in treating rare diseases. Several RNA interference-based drugs have been approved for clinical use, with many others currently undergoing clinical trials. However, challenges such as site-specific delivery, specificity, and stability still need to be overcome for the widespread use of RNA interference therapeutics.
KIDNEY INTERNATIONAL
(2022)
Article
Physiology
Paulo C. Gregorio, Gilson Biagini, Regiane S. da Cunha, Julia Budag, Ana Maria Martins, Lara Valino Rivas, Elberth M. Schiefer, Maria Dolores Sanchez-Nino, Alberto Ortiz, Andrea E. M. Stinghen, Fellype C. Barreto
Summary: Inflammation and endothelial damage play a pivotal role in Fabry disease manifestations. Traditional biomarkers of target organ injury provide no information about inflammation and endothelial damage. This study found that the serum levels of 3-nitrotyrosine, growth differentiation factor-15, and syndecan-1 were associated with cardiac and renal involvement in Fabry disease patients on enzyme replacement therapy.
KIDNEY & BLOOD PRESSURE RESEARCH
(2022)
Editorial Material
Urology & Nephrology
Ziad A. Massy, Tilman B. Drueke
KIDNEY INTERNATIONAL
(2022)
Article
Cell Biology
Bessem Mornagui, Raja Rezg, Cendrine Repond, Luc Pellerin
Summary: Bisphenol S (BPS), a substitute for bisphenol A (BPA), may act as an obesogenic endocrine disruptor and affect monocarboxylate transporters and mitochondrial respiratory system in the liver, leading to the development of hepatic steatosis.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Letter
Urology & Nephrology
Fellype Carvalho Barreto, Ziad A. Massy, Tilman B. Drueke
KIDNEY INTERNATIONAL REPORTS
(2022)
Article
Urology & Nephrology
Cassiano Augusto Braga Silva, Luis Gustavo Modelli de Andrade, Maria Helena Vaisbich, Fellype de Carvalho Barreto
Summary: The purpose of this study was to produce a consensus statement to standardize the recommendations concerning kidney involvement in Fabry disease and provide advice on diagnosis, screening, and treatment for patients. The consensus document aims to manage patient and physician expectations and make decisions based on available evidence and patient preferences.
JORNAL BRASILEIRO DE NEFROLOGIA
(2022)
Article
Urology & Nephrology
Maria Helena Vaisbich, Luis Gustavo Modelli de Andrade, Cassiano Augusto Braga Silva, Fellype de Carvalho Barreto
Summary: This study aims to create a consensus to standardize the recommendations for the diagnosis, screening, and treatment of renal involvement in pediatric patients with FD. The consensus includes investigating the pediatric family members of index cases, assessing all possible FD impairments, and emphasizing the benefits of early treatment.
JORNAL BRASILEIRO DE NEFROLOGIA
(2022)
Article
Ecology
Raja Rezg, Rahime Oral, Serkan Tez, Bessem Mornagui, Giovanni Pagano, Marco Trifuoggi
Summary: This study evaluates the toxic effects of bisphenol S (BP-S) on the early life stages of Arbacia lixula sea urchins and finds that it exhibits similar toxicity to bisphenol A (BP-A). The results suggest that bisphenol compounds may have adverse effects on embryonic development within a certain concentration range.
Editorial Material
Urology & Nephrology
Amelie Bernier-Jean, Tilman B. Drueke
KIDNEY INTERNATIONAL
(2022)
Editorial Material
Urology & Nephrology
Tilman B. Drueke, Ziad A. Massy
KIDNEY INTERNATIONAL
(2023)
Editorial Material
Urology & Nephrology
Tilman B. Drueke, Ziad A. Massy
Summary: Vascular calcification associated with CKD is regulated by apoptosis and ferroptosis, according to studies by Ye et al.
KIDNEY INTERNATIONAL
(2022)
Review
Medicine, General & Internal
Eman Nagy, Mahmoud M. Sobh, Mohamed Abdalbary, Sherouk Elnagar, Rabab Elrefaey, Shimaa Shabaka, Nehal Elshabrawy, Rasha Shemies, Mona Tawfik, Cassia Gomes S. Santos, Fellype C. Barreto, Amr El-Husseini
Summary: Renal osteodystrophy is a common complication of end-stage kidney disease, which may affect bone health, increase fracture risk, and contribute to vascular calcification. Adynamic bone is a characteristic feature, but it is unclear whether it is a pathological condition or an adaptive process.
JOURNAL OF CLINICAL MEDICINE
(2022)
Editorial Material
Urology & Nephrology
Tilman B. Drueke, T. Alp Ikizler
KIDNEY INTERNATIONAL
(2023)