期刊
NEPHROLOGY DIALYSIS TRANSPLANTATION
卷 26, 期 7, 页码 2407-2412出版社
OXFORD UNIV PRESS
DOI: 10.1093/ndt/gfr224
关键词
AA amyloid; hepatitis B; mass spectrometry; proteomics; SAA variant
We report a 13-year-old Indian boy with nephrotic syndrome caused by renal AA amyloidosis. Workup of the AA amyloidosis revealed chronic hepatitis B. Laser microdissection of the Congo-red-positive glomeruli and vessels followed by liquid chromatography and tandem mass spectrometry confirmed the presence of serum amyloid A (SAA) protein and ruled out hereditary and familial amyloidosis. Furthermore, mass spectrometry also detected a variant of SAA protein (SAA W71R).
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