Article
Multidisciplinary Sciences
Wojciech Zylka, Krystyna Tecza, Krzysztof Szemela, Piotr Prach, Marta Zylka, Dorota Jakubczyk, Maciej Bladzinski, Agnieszka Gala-Bladzinska, Pawel Jakubczyk
Summary: The aim of this study was to propose a method for predicting changes in uric acid concentrations in chronically hemodialyzed patients using optical measurement of specific wavelengths in the dialysate. Blood samples were taken every 30 minutes from the arterial line to measure uric acid levels, while optical measurements were made on dialysate from the dialyzer. Uric acid concentration can be accurately measured using both direct blood measurement or dialyzer outflow, and the method can assess the adequacy of hemodialysis.
SCIENTIFIC REPORTS
(2023)
Article
Urology & Nephrology
Kiichiro Fujisaki, Nobuhiko Joki, Shigeru Tanaka, Eiichiro Kanda, Takayuki Hamano, Ikuto Masakane, Kazuhiko Tsuruya
Summary: Analysis of data from a national registry of Japanese patients with end-stage kidney disease showed that lower pre-HD SNa concentration and higher Delta SNa are associated with a greater risk of mortality in patients undergoing hemodialysis. Each 1-mEq/1 reduction in pre-HD SNa concentration was linked to an increased risk of all-cause mortality, while a larger Delta SNa was also associated with higher mortality. The combination of low pre-HD SNa concentration and large Delta SNa was especially correlated with higher mortality.
KIDNEY INTERNATIONAL REPORTS
(2021)
Article
Urology & Nephrology
Zhoucang Zhang, Liren Zheng, Yujing Pan, Mei Wang
Summary: This study aimed to evaluate the association between chronic pre-dialysis hyponatremia and clinical outcomes in maintenance hemodialysis (MHD) patients. The study found that time-averaged hyponatremia was independently associated with increased risks of all-cause mortality or new major adverse cardiovascular events (MACE) in MHD patients. Baseline serum sodium level was not a predictor of clinical outcomes.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2022)
Article
Medicine, General & Internal
Simon Krenn, Michael Schmiedecker, Daniel Schneditz, Sebastian Hoedlmoser, Christopher C. Mayer, Siegfried Wassertheurer, Haris Omic, Eva Schernhammer, Peter Wabel, Manfred Hecking
Summary: This study utilizes the changes in relative blood volume monitored by ultrasound to calculate the absolute blood volume in hemodialysis patients. The study assesses the clinical feasibility, standardizes the data read-out, determines optimal time-points for ABV calculation, and evaluates ABV variation.
FRONTIERS IN MEDICINE
(2022)
Article
Urology & Nephrology
Jule Pinter, Brendan Smyth, Stefano Stuard, Meg Jardine, Christoph Wanner, Patrick Rossignol, David C. Wheeler, Mark R. Marshall, Bernard Canaud, Bernd Genser
Summary: Excess mortality in hemodialysis patients is associated with abnormal fluid status and plasma sodium concentrations. The choice of dialysate sodium affects sodium removal and tonicity adjustment. Lower dialysate sodium may increase sodium removal but comes with certain risks, while higher dialysate sodium can preserve blood volume and hemodynamic stability.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Transplantation
Finnian R. Mc Causland, Katherine Scovner Ravi, Katherine A. Curtis, Zoe A. Kibbelaar, Samuel A. P. Short, Anika T. Singh, Simon Correa, Sushrut S. Waikar
Summary: This study found no significant difference in systolic blood pressure decline or risk of intra-dialytic hypotension between hospitalized hemodialysis patients receiving higher or lower dialysate sodium concentrations. Adjusted analyses suggested a lower risk of intra-dialytic hypotension with higher dialysate sodium concentration, warranting further larger, multi-center studies to confirm these findings.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Multidisciplinary Sciences
Naoki Suzuki, Yasumasa Hitomi, Hiroya Takata, Shinji Ushiya, Masahiro Yamada, Yusuke Sakai, Takahiro Konishi, Yuuki Takeda, Yuuki Sumino, Masaya Mizo, Yoshihiro Tsuji, Masato Nishimura, Tetsuya Hashimoto, Hiroyuki Kobayashi
Summary: The study found that low salt intake in hemodialysis patients was associated with high all-cause mortality, but no association was observed between corrected salt intake and the cumulative incidence of cardiovascular events.
Editorial Material
Urology & Nephrology
Tony Lopez, Debasish Banerjee
Summary: Fluid overload is a common and important complication in patients with end-stage kidney failure receiving hemodialysis, leading to adverse outcomes, necessitating the search for accurate methods for assessing fluid status.
KIDNEY INTERNATIONAL
(2021)
Article
Endocrinology & Metabolism
Mario Pazos-Guerra, Jorge Gabriel Ruiz-Sanchez, Xavier Perez-Candel, Celia Lopez-Nevado, Fernando Hernandez-Olmeda, Martin Cuesta-Hernandez, Javier Martin-Sanchez, Alfonso Luis Calle-Pascual, Isabelle de la Vega
Summary: COVID-19 patients admitted with hyponatremia are more likely to experience increased mortality. It is crucial to accurately assess volume status in hyponatremic COVID-19 patients, as isotonic saline infusion therapy in euvolemic patients can lead to elevated mortality rates.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Urology & Nephrology
Asmaa Elemshaty, Nagy Sayed-Ahmed, Abeer Mesbah, Mohammed Kamal Nassar
Summary: This study aimed to determine the impact of individualized dialysate cooling on nutritional and inflammatory parameters in chronic hemodialysis patients. The results showed that after 6 months of dialysate cooling, episodes of intradialytic hypotension significantly decreased, but there was no significant improvement in the nutritional and inflammatory markers. Therefore, further studies are needed to evaluate the effects of dialysate cooling on inflammation and nutrition in chronic hemodialysis patients.
Article
Public, Environmental & Occupational Health
Chun-Hao Chu, Wu-Chien Chien, Chiung-Chen Liu, Chi-Hsiang Chung, Ying-Chuan Chen, Feng-Chih Kuo, Hung-Hsiang Fang, Cheng-Yi Cheng, Yi-Xuan Ding, Chiung-Hsi Tien, Chien-Ming Lin
Summary: The coexistence of hypothyroidism and hyponatremia is rare, but the incidence is gradually increasing. Factors influencing mortality risk include old age, underlying catastrophic status, cardiac dysrhythmia, hospital hierarchy, and length of hospital stay.
Article
Anesthesiology
Tapio Hellman, Panu Uusalo, Mikko J. Jarvisalo
Summary: This study showed that the use of standard dialysate and citrate-calcium anticoagulation in CVVHD effectively increased plasma sodium concentration in hyponatremic critically ill AKI patients. However, nearly half of the patients experienced excessively high plasma sodium correction, and the substantial sodium load provided by the citrate anticoagulation solutions was notable.
ACTA ANAESTHESIOLOGICA SCANDINAVICA
(2021)
Article
Endocrinology & Metabolism
Ting Xiang, Ping Fu, Li Zhou
Summary: The aim of this study was to explore the prevalence of sarcopenia and its association with osteoporosis and to determine its impact on survival risk in hemodialysis patients. The study found a significant association between muscle mass and strength with bone density in hemodialysis patients, and those with osteosarcopenia had a higher mortality rate.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Physiology
Jingfang Wan, Jing Lin, Weidong Wang, Lili Fu, Weiwei Zhang, Jun Liu, Yang Xiang, Jia Chen, Yani He, Kehong Chen
Summary: This study analyzed the effect of dialysate bicarbonate levels on mortality in patients undergoing hemodialysis. The results showed a positive association between dialysate bicarbonate concentration and all-cause mortality, with a favorable concentration of 31-32 mmol/L.
KIDNEY & BLOOD PRESSURE RESEARCH
(2023)
Article
Biotechnology & Applied Microbiology
Ting-Yun Lin, Ping-Hsun Wu, Yi-Ting Lin, Szu-Chun Hung
Summary: The relationship between gut dysbiosis, inflammation, and adverse outcomes in chronic kidney disease patients is still unclear. Higher microbial diversity in hemodialysis patients is associated with a 74% lower risk of death. Nonsurvivors have lower microbial diversity and higher proinflammatory cytokine levels, with reduced abundance of certain beneficial bacteria like Succinivibrio and Anaerostipes.
NPJ BIOFILMS AND MICROBIOMES
(2021)
Article
Engineering, Biomedical
Simon Correa, Xavier E. Guerra-Torres, Katherine Scovner Ravi, Suraj S. Mothi, Sushrut S. Waikar, Finnian R. Mc Causland
Summary: Intradialytic hypotension (IDH) is a common complication of hemodialysis (HD) that is associated with increased risk of cardiovascular (CV) events and mortality. This study found that the risk of IDH increases with later days of the dialytic week, and CV events are more common following the longer interdialytic interval.
Article
Surgery
Karola S. Jering, Martina M. McGrath, Finnian R. Mc Causland, Brian Claggett, Jonathan W. Cunningham, Scott D. Solomon
Summary: Solid-organ transplant recipients hospitalized with COVID-19 have higher odds of complications and in-hospital mortality compared to admissions for other causes, including non-COVID-19 pneumonia. The odds of in-hospital death are 2.5 times higher for SOT recipients with COVID-19 compared to those with non-COVID-19 pneumonia, regardless of the time of hospitalization.
CLINICAL TRANSPLANTATION
(2022)
Article
Urology & Nephrology
Katherine Scovner Ravi, Patrick B. Reeves, Simon Correa, Joao Sergio Neves, Sushrut S. Waikar, Suraj S. Mothi, Finnian R. Mc Causland
Summary: The study found that higher pre-HD serum phosphate levels are independently associated with an increased risk of hypotension during hemodialysis sessions, indicating the need for further research to investigate the mechanisms behind this association.
HEMODIALYSIS INTERNATIONAL
(2022)
Article
Endocrinology & Metabolism
Jing Liu, Maria Clarissa Tio, Ashish Verma, Insa M. Schmidt, Titilayo O. Ilori, Felix Knauf, Finnian R. Mc Causland, Sushrut S. Waikar
Summary: This study aimed to investigate predictors of urinary calcium excretion and its association with adverse clinical outcomes in chronic kidney disease (CKD). The results showed that estimated glomerular filtration rate (eGFR) was positively correlated with 24-hour urinary calcium excretion. The determinants of urinary calcium excretion differed between sexes and levels of CKD. Lower urinary calcium excretion was associated with higher risks of adverse outcomes, but these associations were greatly attenuated or nullified after adjustment for baseline eGFR.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Article
Cardiac & Cardiovascular Systems
Alexander Peikert, Muthiah Vaduganathan, Finnian Mc Causland, Brian L. Claggett, Safia Chatur, Milton Packer, Marc A. Pfeffer, Faiez Zannad, Martin P. Lefkowitz, Burkert Pieske, Hans-Dirk Duengen, John J. V. McMurray, Scott D. Solomon
Summary: The study found that sacubitril/valsartan similarly attenuates the decline of eGFR and reduces clinically relevant kidney events among patients with HFpEF with and without diabetes, compared to renin-angiotensin system inhibitors alone.
EUROPEAN JOURNAL OF HEART FAILURE
(2022)
Article
Cardiac & Cardiovascular Systems
Finnian R. Mc Causland, Martin P. Lefkowitz, Brian Claggett, Milton Packer, Michele Senni, Mauro Gori, Pardeep S. Jhund, Martina M. McGrath, Jean L. Rouleau, Victor Shi, Karl Swedberg, Muthiah Vaduganathan, Faiez Zannad, Marc A. Pfeffer, Michael Zile, John J. McMurray, Scott D. Solomon
Summary: In patients with heart failure, sacubitril/valsartan reduces the risk of adverse renal outcomes and slows the decline in eGFR, regardless of baseline renal function.
EUROPEAN JOURNAL OF HEART FAILURE
(2022)
Article
Peripheral Vascular Disease
Anika T. Singh, Sushrut S. Waikar, Finnian R. Mc Causland
Summary: Intradialytic hypertension in hemodialysis patients is associated with increased mortality risk, but there is no consensus on its definition. This study found that any increase in systolic blood pressure from prehemodialysis to posthemodialysis was associated with the highest adjusted risk of mortality, compared to other threshold-based definitions.
Article
Cardiac & Cardiovascular Systems
Finnian R. Mc Causland, Brian L. Claggett, Muthiah Vaduganathan, Akshay S. Desai, Pardeep Jhund, Rudolf A. de Boer, Kieran Docherty, James Fang, Adrian F. Hernandez, Silvio E. Inzucchi, Mikhail N. Kosiborod, Carolyn S. P. Lam, Felipe Martinez, Jose F. Kerr Saraiva, Martina M. McGrath, Sanjiv J. Shah, Subodh Verma, Anna Maria Langkilde, Magnus Petersson, John J. McMurray, Scott D. Solomon
Summary: Dapagliflozin has no effect on baseline kidney function in patients with heart failure and a mildly reduced or preserved ejection fraction. Dapagliflozin does not significantly reduce the frequency of kidney composite outcomes, but can slow the decline in eGFR.
Article
Medicine, General & Internal
Natalie Staplin, Richard Haynes, Kaitlin J. Mayne, Alistair J. Roddick, Brendon L. Neuen, Sibylle J. Hauske, Stefan D. Anker, Martina Brueckmann, Javed Butler, David Z. Cherney, Jennifer B. Green, Chih-Chin Liu, Finnian R. McCausland, Darren K. McGuire, John J. McMurray, Milton Packer, Vlado Perkovic, Marc S. Sabatine, Scott D. Solomon, Muthiah Vaduganathan, Christoph Wanner, Stephen D. Wiviott, Faiez Zannad, Hiddo J. L. Heerspink, Sarah Y. A. Ng, Doreen Zhu, Parminder Judge, David Preiss, Martin J. Landray, Colin Baigent, Jonathan R. Emberson, William G. Herrington, Deepak L. Bhatt, Bruce Neal, Silvio E. Inzucchi, Meg J. Jardine, Kenneth W. Mahaffey, David C. Wheeler
Summary: This study provides evidence that SGLT2 inhibitors can reduce the risk of kidney disease progression and acute kidney injury, not only in patients with type 2 diabetes at high cardiovascular risk, but also in patients with chronic kidney disease or heart failure regardless of diabetes status, primary kidney disease, or kidney function.
Article
Transplantation
Ajay K. Singh, Finnian R. Mc Causland, Brian L. Claggett, Christoph Wanner, Andrzej Wiecek, Michael B. Atkins, Kevin Carroll, Vlado Perkovic, John J. McMurray, Janet Wittes, Steven Snapinn, Allison Blackorby, Amy Meadowcroft, Tara Barker, Tara DiMino, Stephen Mallett, Alexander R. Cobitz, Scott D. Solomon
Summary: Different dosing intervals were used in the study, which resulted in different risks of cancer-related adverse events for daprodustat compared to darbepoetin in patients with CKD. However, no excess risk of cancer-related adverse events was observed in dialysis patients.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Editorial Material
Urology & Nephrology
Finnian R. Mc Causland, David M. Charytan
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Review
Peripheral Vascular Disease
Murad Alostaz, Simon Correa, Gavin S. Lundy, Sushrut S. Waikar, Finnian R. Mc Causland
Summary: Patients who undergo hemodialysis in the morning have a lower risk of intradialytic hypotension and a higher risk of intradialytic hypertension compared to those who undergo dialysis in the afternoon.
JOURNAL OF HUMAN HYPERTENSION
(2023)
Article
Urology & Nephrology
Finnian R. Mc Causland, Jesse Y. Hsu, Jonathan Himmelfarb, Talat Alp Ikizler, Dominic S. Raj, Rajnish Mehrotra, Sushrut S. Waikar, Paul L. Kimmel, Alan S. Kliger, Laura M. Dember, David M. Charytan
Summary: In a post hoc analysis, it was found that spironolactone treatment resulted in a higher frequency of bradycardia and conduction blocks in patients receiving maintenance hemodialysis. Close monitoring is necessary for these patients while awaiting definitive trial results.
Meeting Abstract
Cardiac & Cardiovascular Systems
F. McCausland, A. Singh, B. Claggett, K. Carroll, J. Wittes, J. J. V. McMurray, V. Perkovic, S. Snappin, R. Lopes, S. Solomon
EUROPEAN HEART JOURNAL
(2022)
Meeting Abstract
Cardiac & Cardiovascular Systems
Alexander Peikert, Muthiah Vaduganathan, Finnian McCausland, Brian Claggett, Safia Chatur, Milton Packer, Marc A. Pfeffer, Faiez Zannad, Martin Lefkowitz, Burkert Mathias Pieske, Hans-Dirk Dungen, John J. V. McMurray, Scott D. Solomon
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)