Review
Urology & Nephrology
Raymond Vanholder, Angel Argiles, Joachim Jankowski
Summary: Uraemic syndrome is a complex clinical condition associated with chronic kidney disease, characterized by retention of metabolites and peptides. The historical evolution of uraemic toxin research has led to a better understanding of the impact and strategies related to these toxins. The role and achievements of organizations like EUTox will continue to play a crucial part in future actions to address uraemic toxins.
CLINICAL KIDNEY JOURNAL
(2021)
Article
Medicine, General & Internal
Karolina Swierczynska-Mroz, Danuta Nowicka-Suszko, Mariusz G. Fleszar, Paulina Fortuna, Piotr K. Krajewski, Magdalena Krajewska, Rafal Bialynicki-Birula, Jacek C. Szepietowski
Summary: This study aimed to investigate the possible contribution of free and total Indoxyl Sulfate (IS) and p-Cresol Sulfate (PCS) to the cause of CKD-aP. The results showed no significant difference in the serum levels of free and total IS, or PCS, between patients with and without CKD-aP, and no correlation between serum IS or PCS levels and the severity of the itch.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Urology & Nephrology
Alba Santos, Nicolas Macias, Almudena Vega, Soraya Abad, Tania Linares, Ines Aragoncillo, Leonidas Cruzado, Cristina Pascual, Marian Goicoechea, Juan Manuel Lopez-Gomez
Summary: The post-dialysis aXa activity and APTT were significantly different between HF-HD and HDF as well as between HF-HD and HDx, suggesting that the dialyser may affect the anticoagulant effectiveness by causing more losses of LMWH, leading to the need for dosage adjustment according to dialysis technique.
CLINICAL KIDNEY JOURNAL
(2021)
Article
Hematology
Miquel Gomez, Elisenda Banon-Maneus, Marta Arias-Guillen, Nestor Fontsere, Jose Jesus Broseta, Raquel Ojeda, Francisco Maduell
Summary: The study demonstrated that using synthetic membranes in HDF can achieve higher removal of various molecular weight uraemic toxins, and the selection of the membrane is crucial for optimizing removal efficiency.
BLOOD PURIFICATION
(2022)
Review
Geriatrics & Gerontology
Seenivasan Boopathi, R. M. Saravana Kumar, P. Snega Priya, B. Haridevamuthu, S. P. Ramya Ranjan Nayak, Laura Chulenbayeva, Kushugulova Almagul, Jesu Arockiaraj
Summary: Ageing is associated with changes in gut microbiota composition and functions, including a reduction in gut commensals and an increase in Enterobacteriaceae. Enterobacteriaceae are linked to all-cause mortality, metabolic diseases, telomere attrition, cellular senescence, inflammasome activation, impaired mitochondrial function, and multiorgan dysfunction. Targeting Enterobacteriaceae could potentially reduce inflammaging and enhance the longevity of older individuals.
EXPERIMENTAL GERONTOLOGY
(2023)
Review
Medicine, General & Internal
Nabil Foudi, Maeva Palayer, Marie Briet, Anne-Sophie Garnier
Summary: Chronic kidney disease (CKD) poses a high cardiovascular risk due to arterial remodeling and stiffness; uremic toxins affect vascular smooth muscle cell function; low-grade inflammation may contribute to cardiovascular complications in CKD patients despite traditional risk factor management.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Transplantation
Sophie Liabeuf, Marion Pepin, Casper F. M. Franssen, Davide Viggiano, Sol Carriazo, Ron T. Gansevoort, Loreto Gesualdo, Gaye Hafez, Jolanta Malyszko, Christopher Mayer, Dorothea Nitsch, Alberto Ortiz, Vesna Pesic, Andrzej Wiecek, Ziad A. Massy
Summary: Chronic kidney disease is associated with neurological complications, including cerebrovascular disorders, movement disorders, cognitive impairment, and depression. In addition to traditional cardiovascular risk factors, non-traditional risk factors related to kidney damage, such as uremic toxins, may predispose CKD patients to neurological disorders. Uremic toxins, such as indoxyl sulfate, have been shown to have a neurotoxic effect, highlighting the need for further research and potential novel treatments for CKD patients with neurological complications.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Transplantation
Camille Andre, Gabriel Choukroun, Youssef Bennis, Said Kamel, Anne Sophie Lemaire-Hurtel, Kamel Masmoudi, Sandra Bodeau, Sophie Liabeuf
Summary: Uraemic toxins can affect the pharmacokinetics of immunosuppressants. This study found that blood concentrations of tacrolimus were associated with the accumulation of certain uraemic toxins, while blood concentrations of cyclosporine were not related to uraemic toxins.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Review
Urology & Nephrology
Sudhir K. Bowry, Peter Kotanko, Rainer Himmele, Xia Tao, Michael Anger
Summary: Informed decision-making is essential for improving dialysis therapies and patient outcomes by determining substances to be targeted for removal and strategies to be used. Current dialysis membranes allow for removal of multiple molecules of different sizes, but with limited selectivity.
CLINICAL KIDNEY JOURNAL
(2021)
Article
Hematology
Yuanyuan Shi, Huajun Tian, Yifeng Wang, Yue Shen, Qiuyu Zhu, Feng Ding
Summary: This study compared the removal of protein-bound uraemic toxins using different dialysis techniques and found that a combination of displacement and adsorption-based dialysis methods showed potential advantages in enhancing toxin removal efficiency.
BLOOD PURIFICATION
(2022)
Article
Urology & Nephrology
Mario Cozzolino, Lorenza Magagnoli, Paola Ciceri, Ferruccio Conte, Andrea Galassi
Summary: This study suggests that using the novel MCO dialyser appears to be safe and well-tolerated, without serious side effects or hypoalbuminaemia, as well as fewer infections.
CLINICAL KIDNEY JOURNAL
(2021)
Article
Food Science & Technology
Amina El Amouri, Evelien Snauwaert, Aurelie Foulon, Charlotte Vande Moortel, Maria Van Dyck, Koen Van Hoeck, Nathalie Godefroid, Griet Glorieux, Wim Van Biesen, Johan Vande Walle, Ann Raes, Sunny Eloot
Summary: Increased dietary fiber intake in pediatric CKD patients is inversely related to the serum concentrations of certain PBUTs, suggesting potential benefits of dietary fiber for this population. These findings should inform dietary recommendations for children with CKD.
Review
Food Science & Technology
Paola Ciceri, Mario Cozzolino
Summary: Treatment of chronic kidney disease focuses on clearing uremic toxins, targeting these toxins and improving dialysis techniques can reduce the risk of cardiovascular disease, and improve quality of life and outcomes.
Article
Engineering, Chemical
Jose Francisco Guerreiro, Miguel Pereira da Silva, Marta Bordonhos, Miguel Minhalma, Moises Luzia Pinto, Maria Norberta de Pinho
Summary: The research focuses on the synthesis and characterization of CA/SiO2 and CA/SiO2/MOF membranes for the removal of uremic toxins. The addition of UiO2-66(Zr) improves the hydraulic permeability of the membranes, except for the CA34/SiO2 membranes. The rejection coefficients of urea and p-cresil sulfate are below 5% within the transmembrane pressure range of 0.5-4 bar.
Review
Engineering, Environmental
Alsha Subash, Minoo Naebe, Xungai Wang, Balasubramanian Kandasubramanian
Summary: This review provides an in-depth perspective on the biosorption of various toxins by biopolymers and the possible interaction between the adsorbent and adsorbate.
JOURNAL OF HAZARDOUS MATERIALS
(2023)