Editorial Material
Urology & Nephrology
Sho Hasegawa, Masaomi Nangaku
Summary: This study suggests that SGLT2 inhibitors, such as dapagliflozin, may reduce the risk of abrupt declines in kidney function in patients with chronic kidney disease.
KIDNEY INTERNATIONAL
(2022)
Article
Urology & Nephrology
James A. Diao, Gloria J. Wu, Jason K. Wang, Isaac S. Kohane, Herman A. Taylor, Hocine Tighiouart, Andrew S. Levey, Lesley A. Inker, Neil R. Powe, Arjun K. Manrai
Summary: The newly recommended 2021 CKD-EPI creatinine-based eGFR equation may result in substantial changes to recommended care for US patients of all racial and ethnic groups.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Urology & Nephrology
Gregory L. Hundemer, Christine A. White, Patrick A. Norman, Greg A. Knoll, Navdeep Tangri, Manish M. Sood, Swapnil Hiremath, Kevin D. Burns, Christopher McCudden, Ayub Akbari
Summary: This study validated the 2021 race-free CKD-EPI eGFR equations among kidney transplant recipients, finding that they performed similarly to previous equations that included race correction terms. There was no significant difference in performance between the 2021 CKD-EPI eGFRcr and eGFRcr-cys equations in the kidney transplant population.
AMERICAN JOURNAL OF KIDNEY DISEASES
(2022)
Article
Medicine, General & Internal
Ping Liu, Rob R. Quinn, Ngan N. Lam, Huda Al-Wahsh, Manish M. Sood, Navdeep Tangri, Marcello Tonelli, Pietro Ravani
Summary: This study found that with advancing age, CKD regression and death were more likely than CKD progression or kidney failure. These findings have important implications for patient care and for assessing the potential effect of population aging on the burden of CKD.
Article
Immunology
Sergio Luis Lima, Domingo Marrero Miranda, Ana Gonzalez Rinne, Natalia Negrin Mena, Lourdes Perez Tamajon, Aurelio Rodriguez, Alejandra Alvarez Gonzalez, Alejandra Gonzalez Delgado, Carmen Ferrer Moure, Federico Gonzalez Rinne, Laura Diaz Martin, Ana Elena Rodriguez Rodriguez, Laura Gomez Diaz, Veronica Garcia Cabrera, Alejandro Jimenez Sosa, Armando Torres, Alberto Ortiz, Flavio Gaspari, Esteban Porrini
Summary: This study finds that estimated glomerular filtration rate (eGFR) is not reliable in reflecting real glomerular filtration rate (GFR) changes in renal transplant patients. The formulas used in estimating eGFR do not accurately reflect actual GFR decline, making them unreliable for clinical practice and trials.
Article
Urology & Nephrology
Kristen L. King, Miko Yu, S. Ali Husain, Rachel E. Patzer, Vanessa Sandra, Peter P. Reese, Jesse D. Schold, Sumit Mohan
Summary: The use of race coefficients in eGFR equations may contribute to racial disparities in preemptive kidney transplantation. Black patients were consistently less likely to be listed preemptively and were listed at lower eGFR values. Removing the race coefficient did not eliminate the racial disparity, suggesting the need for additional efforts to achieve equity in preemptive transplantation.
KIDNEY INTERNATIONAL REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Malgorzata Kielar, Paulina Dumnicka, Ewa Ignacak, Alina Bedkowska-Prokop, Agnieszka Gala-Bladzinska, Barbara Maziarz, Piotr Ceranowicz, Beata Kusnierz-Cabala
Summary: The study evaluated serum sCD93 levels in long-term kidney transplant recipients and found an inverse association between sCD93 and renal function, suggesting its potential use in early recognition of graft dysfunction.
Article
Urology & Nephrology
Andrea G. Kattah, Sam Albadri, Mariam P. Alexander, Byron Smith, Santosh Parashuram, Marin L. Mai, Hasan A. Khamash, Fernando G. Cosio, Vesna D. Garovic
Summary: Pregnancy post-transplant in women with advanced kidney disease was associated with a higher rate of eGFR decline, but did not significantly increase the risk of graft failure or reduction in eGFR by 50%. Post-pregnancy biopsy findings suggested an increase in vascular injury as a potential mechanism for the eGFR decline.
KIDNEY INTERNATIONAL REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Naila Rabbani, Antonysunil Adaikalakoteswari, James R. R. Larkin, Sianna Panagiotopoulos, Richard J. J. MacIsaac, Dennis K. K. Yue, Gregory R. R. Fulcher, Matthew A. A. Roberts, Merlin A. Thomas, Elif Ekinci, Paul J. J. Thornalley
Summary: Accumulation of advanced glycation endproducts (AGEs) is associated with decline in renal function, particularly in diabetic patients. This study evaluated levels of AGEs in subjects with and without diabetes, with normal renal function and stages 2-4 chronic kidney disease (CKD), and identified a specific AGE, methylglyoxal-derived hydroimidazolone (MG-H1) free adduct, as the most responsive to CKD status and diabetes. The concentration of MG-H1 free adduct in serum was strongly related to CKD stage and increased in diabetes. This suggests that serum MG-H1 free adduct may serve as a potential AGE risk marker for diabetic and non-diabetic CKD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Urology & Nephrology
Diego Aguilar Palacios, Brigid Wilson, Mustafa Ascha, Rebecca A. Campbell, Sunah Song, Molly E. DeWitt-Foy, Steven C. Campbell, Robert Abouassaly
Summary: The study developed and validated a simplified equation to predict new baseline glomerular filtration rate in patients with renal cell carcinoma undergoing radical nephrectomy or partial nephrectomy. The equation demonstrated high correlation and accuracy in both internal and external validation cohorts, accurately predicting postoperative glomerular filtration rate above a certain threshold.
JOURNAL OF UROLOGY
(2021)
Review
Physiology
Sophie E. Claudel, Malini Gandhi, Ankit B. Patel, Ashish Verma
Summary: Accurate evaluation of GFR is crucial in Oncology due to its impact on drug eligibility and dosing. However, there are no clear guidelines on the optimal method for determining kidney function in cancer patients. The commonly used GFR estimating equations may be less applicable in Oncology due to physiological changes in cancer patients. Despite limitations, the CKD-EPICr formula is recommended in clinical Oncology, along with other considerations such as the CamGFRv2 equation and cystatin c-based equations.
Article
Peripheral Vascular Disease
Lingyan Fei, Minze Xu, Honghong Wang, Cheng Zhong, Shan Jiang, Falk-Bach Lichtenberger, Cem Erdogan, Han Wang, Julia S. Bonk, En Yin Lai, Pontus B. Persson, Richard Kovacs, Zhihua Zheng, Andreas Patzak, Pratik H. Khedkar
Summary: Acute hyperglycemia is a risk factor for acute kidney injury, and our study suggests that hyperglycemia-induced hyperosmolarity facilitates vasodilation through Piezo1-mediated eNOS activation. Our findings indicate that inhibiting Piezo1 and CaMKII can prevent the vasodilation induced by hyperglycemia and hyperosmotic mannitol solution.
Article
Cardiac & Cardiovascular Systems
Faiez Zannad, Joao Pedro Ferreira, Stuart J. Pocock, Cordula Zeller, Stefan D. Anker, Javed Butler, Gerasimos Filippatos, Sibylle Jenny Hauske, Martina Brueckmann, Egon Pfarr, Janet Schnee, Christoph Wanner, Milton Packer
Summary: In the EMPEROR-Reduced trial, empagliflozin treatment had beneficial effects on key efficacy outcomes and slowed the rate of kidney function decline in patients with and without chronic kidney disease, regardless of the severity of kidney impairment at baseline.
Article
Chemistry, Physical
Lokendra Singh, Abdulkarem H. M. Almawgani, Yesudasu Vasimalla, Roshan Kumar, Turki Alsuwian
Summary: Surface plasmon resonance (SPR) technology is a versatile tool for sensing, with advantages such as real-time, label-free, and high sensitivity. It has been widely used in healthcare, environmental management, and food-borne diseases. This study presents a highly sensitive gold nanoparticle SPR sensor based on an angular interrogation method for enzymatic detection of urea samples. The sensor's biocompatibility is enhanced by functionalizing it with layers of molybdenum disulfide (MoS2) and cerium oxide (CeO2). The maximum sensitivities achieved are 186.50 °/RIU, 217.50 °/RIU, and 275 °/RIU for samples without biocompatible layer, Au/MoS2/urease, and Au/CeO2/urease combinations, respectively.
Article
Medicine, General & Internal
Meghann Pasternak, Ping Liu, Robert Quinn, Meghan Elliott, Tyrone Gorden Harrison, Brenda Hemmelgarn, Ngan Lam, Paul Ronksley, Marcello Tonelli, Pietro Ravani
Summary: This study aims to assess the 5-year probability of CKD regression in patients with newly diagnosed CKD, taking into account the competing risks of CKD progression and death, and investigate the association between albuminuria level and CKD regression.