Article
Medicine, General & Internal
Magda Wisniewska, Natalia Serwin, Violetta Dziedziejko, Malgorzata Marchelek-Mysliwiec, Barbara Dolegowska, Leszek Domanski, Kazimierz Ciechanowski, Krzysztof Safranow, Andrzej Pawlik
Summary: Levels of renalase in serum and urine were significantly elevated in haemodialysis CKD patients, while levels in erythrocytes were lower. Plasma concentrations of dopamine, adrenaline, and noradrenaline were also decreased in CKD patients. These changes may be related to compensatory production in extrarenal organs and altered degradation by plasma renalase.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Transplantation
Ping-Hsun Wu, Rie Io Glerup, My Hanna Sofia Svensson, Niclas Eriksson, Jeppe Hagstrup Christensen, Torbjorn Linde, Osten Ljunggren, Bengt Fellstrom
Summary: This study investigated the association between bone-associated protein biomarkers and inflammatory cytokines with cardiovascular outcomes. The study found that bone-associated proteins were associated with mortality and cardiovascular events, but this association was attenuated after adjusting for inflammatory proteins. Only osteoprotegerin (OPG) remained associated with cardiovascular events. OPG also improved the prediction of cardiovascular events.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Urology & Nephrology
Madeleine Elder, Avalon Moonen, Sjorjina Crowther, Jasna Aleksova, Jacqueline Center, Grahame J. Elder
Summary: This study assessed the influence of sarcopenia on mortality in elderly haemodialysis patients. The results showed that sarcopenia is highly prevalent in this population but is not an independent predictor of mortality. Instead, a lower mean arterial pressure and higher total comorbidity score better predicted mortality.
Article
Multidisciplinary Sciences
Hiroshi Kimura, Kenichi Tanaka, Hirotaka Saito, Tsuyoshi Iwasaki, Sakumi Kazama, Michio Shimabukuro, Koichi Asahi, Tsuyoshi Watanabe, Junichiro James Kazama
Summary: This study reveals that the red blood cell distribution width-albumin ratio (RAR) is associated with adverse renal outcomes in patients with chronic kidney disease (CKD), making it a convenient and useful prognostic marker for assessing renal prognosis.
SCIENTIFIC REPORTS
(2023)
Article
Cardiac & Cardiovascular Systems
Paul M. Ridker, Katherine R. Tuttle, Vlado Perkovic, Peter Libby, Jean G. MacFadyen
Summary: This study found that residual inflammatory risk plays a significant role in determining the risk of recurrent major adverse cardiovascular events among post-myocardial infarction patients already treated with statins, especially in those with impaired kidney function.
EUROPEAN HEART JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Ian R. Barrows, Matt Devalaraja, Rahul Kakkar, Jing Chen, Jayanta Gupta, Sylvia E. Rosas, Santosh Saraf, Jiang He, Alan Go, Dominic S. Raj, Richard L. Amdur
Summary: Differences in death rate and cardiovascular disease between Black and White patients with chronic kidney disease can be explained by sociocultural factors, comorbidities, genetics, and inflammation. Plasma IL-6 and TMPRSS6 genotype are also determinants of CVD and mortality.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2022)
Article
Pharmacology & Pharmacy
Priyal Patel, Sandip Patel, Piyush Chudasama, Shailesh Soni, Manan Raval
Summary: The present investigation explored the potential treatment option of roflumilast as a PDE4 inhibitor for chronic kidney disease. The results demonstrated that roflumilast significantly reduced serum creatinine, urea, uric acid levels, increased serum calcium, and regulated protein expression of inflammatory markers. Moreover, roflumilast noticeably improved the structure and functioning of glomeruli, tubules, and cells. Therefore, roflumilast has the potential to ameliorate renal injury.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Transplantation
Emily K. Yeung, Kevan R. Polkinghorne, Peter G. Kerr
Summary: This study demonstrates that compared with facility hemodialysis, home hemodialysis patients have a significantly lower risk of death, with comparable rates of transplantation, graft survival, and biochemical control at 6 months post-transplant.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Article
Nutrition & Dietetics
M. Kyla Shea, Kathryn Barger, Sarah L. Booth, Jifan Wang, Harold Feldman, Raymond R. Townsend, Jing Chen, John Flack, Jiang He, Bernard G. Jaar, Mayank Kansal, Sylvia E. Rosas, Daniel E. Weiner
Summary: The study found that individuals with better vitamin K status in chronic kidney disease have a lower risk of all-cause mortality, but there is no significant difference in the risk of atherosclerotic cardiovascular disease events.
AMERICAN JOURNAL OF CLINICAL NUTRITION
(2022)
Article
Cardiac & Cardiovascular Systems
Tomohiro Onishi, Yusuke Nakano, Ken-ichi Hirano, Yasuyuki Nagasawa, Toru Niwa, Atomu Tajima, Hideki Ishii, Hiroshi Takahashi, Shinichiro Sakurai, Hirohiko Ando, Hiroaki Takashima, Tetsuya Amano
Summary: This study evaluated the impact of triglyceride deposit cardiomyovasculopathy (TGCV) on cardiovascular outcomes in haemodialysis patients with suspected coronary artery disease. Results showed that definite TGCV patients had a significantly increased risk of cardiovascular events, while probable TGCV patients also had a risk.
Article
Biochemistry & Molecular Biology
Fatimah K. Khalaf, Chrysan J. Mohammed, Prabhatchandra Dube, Jacob A. Connolly, Apurva Lad, Usman M. Ashraf, Joshua D. Breidenbach, Robin C. Su, Andrew L. Kleinhenz, Deepak Malhotra, Amira F. Gohara, Steven T. Haller, David J. Kennedy
Summary: This study found that decreased PON-1 is associated with the progression of renal inflammation and fibrosis independent of blood pressure. By knockout of the Pon1 gene in a rat model, it was discovered that the absence of PON-1 leads to increased renal fibrosis, sclerosis, and tubular injury, as well as increased recruitment of immune cells in the renal interstitium and the expression of inflammatory genes. Furthermore, the absence of PON-1 also results in a decline in renal function and increased renal oxidative stress.
Review
Biochemistry & Molecular Biology
Susana Coimbra, Susana Rocha, Maria Joao Valente, Cristina Catarino, Elsa Bronze-da-Rocha, Luis Belo, Alice Santos-Silva
Summary: Chronic kidney disease is often accompanied by multiple comorbidities and poor clinical outcomes. Malnutrition-inflammation-atherosclerosis syndrome is common in severe stages of CKD, and adiponectin and leptin may be associated with the risk of cardiovascular disease events.
Review
Biochemistry & Molecular Biology
Yi-Ling Cao, Ji-Hong Lin, Hans-Peter Hammes, Chun Zhang
Summary: This review summarizes the function and beneficial properties of common flavonoids for the treatment of CKD and renal fibrosis, including preventing renal dysfunction and improving renal function by blocking or suppressing deleterious pathways such as oxidative stress and inflammation.
Article
Urology & Nephrology
Violante Olivari, Simona Maria Di Modica, Maria Rosa Lidonnici, Mariam Aghajan, Celia Cordero-Sanchez, Emanuele Tanzi, Mariateresa Pettinato, Alessia Pagani, Francesca Tiboni, Laura Silvestri, Shuling Guo, Giuliana Ferrari, Antonella Nai
Summary: Anemia, a common complication of systemic inflammation, is influenced by cytokines, hepatic hormone, and iron metabolism. Anemia of chronic kidney disease (CKD) is a distinct form of inflammatory anemia, and traditional therapy based on increased erythropoietin (EPO) is limited. Hematopoietic and hepatic targeting of transferrin receptor 2 (Tfr2) can improve anemia by promoting erythropoiesis and increasing iron supply. Thus, combined targeting of hematopoietic and hepatic Tfr2 may be a potential therapeutic option.
KIDNEY INTERNATIONAL
(2023)
Article
Oncology
Taehee Kim, Sang Hyuk Kim, Hayoung Choi, Tae Rim Shin, Hwan Il Kim, Seung Hun Jang, Ji Young Hong, Myung Goo Lee, Soojie Chung, In Gyu Hyun, Yun Su Sim
Summary: The clinical outcomes of lung cancer patients with chronic kidney disease (CKD) are controversial, and there is insufficient evidence regarding the treatment and prognosis of lung cancer in patients with CKD. This study evaluated the clinical course and prognostic factors of moderate CKD patients with lung cancer.
Review
Food Science & Technology
Regiane Stafim da Cunha, Andressa Flores Santos, Fellype Carvalho Barreto, Andrea Emilia Marques Stinghen
Article
Pharmacology & Pharmacy
PauloC Gregorio, Regiane S. da Cunha, Gilson Biagini, Bruna Bosquetti, Julia Budag, Alberto Ortiz, Maria Dolores Sanchez-Nino, Fellype C. Barreto, Andrea E. M. Stinghen
Summary: COVID-19 pandemic continues with limited antiviral agents available. Chloroquine, despite showing in vitro antiviral activity, had disappointing results in clinical trials and may harm outcomes. The adverse effects of chloroquine on endothelial cells were mitigated by agalsidase-beta treatment, suggesting a potential role of endothelial cell injury in the failure of chloroquine therapy for COVID-19.
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2021)
Review
Genetics & Heredity
Dominique P. Germain, Sergey Moiseev, Fernando Suarez-Obando, Faisal Al Ismaili, Huda Al Khawaja, Gheona Altarescu, Fellype C. Barreto, Farid Haddoum, Fatemeh Hadipour, Irina Maksimova, Mirelle Kramis, Sheela Nampoothiri, Khanh Ngoc Nguyen, Dau-Ming Niu, Juan Politei, Long-Sun Ro, Dung Vu Chi, Nan Chen, Sergey Kutsev
Summary: Family genetic testing is crucial for early diagnosis of patients with rare genetic diseases, but faces challenges in some countries due to barriers such as costs, awareness, and cultural factors.
MOLECULAR GENETICS & GENOMIC MEDICINE
(2021)
Article
Pediatrics
Mariana Munhoz da Cunha, Fellype Carvalho Barreto, Samantha Nichele, Joanna Trennepohl, Lisandro Ribeiro, Gisele Loth, Adriana Koliski, Tyane de Almeida Pinto Jardim, Adriana Mello, Ricardo Pasquini, Lucimary de Castro Sylvestre, Carmem Bonfim
Summary: Fanconi anemia (FA) is a rare disease that can lead to bone marrow failure and cancer predisposition. Hematopoietic cell transplantation (HCT) is the only potential cure for FA, but it may cause acute kidney injury (AKI) and hypertension. A study on FA patients who underwent HCT found that the incidence of AKI within 100 days was 18.7%, with 72% of patients developing hypertension, and CAKUT was associated with hypertension and kidney function.
EUROPEAN JOURNAL OF PEDIATRICS
(2022)
Article
Physiology
Paulo C. Gregorio, Gilson Biagini, Regiane S. da Cunha, Julia Budag, Ana Maria Martins, Lara Valino Rivas, Elberth M. Schiefer, Maria Dolores Sanchez-Nino, Alberto Ortiz, Andrea E. M. Stinghen, Fellype C. Barreto
Summary: Inflammation and endothelial damage play a pivotal role in Fabry disease manifestations. Traditional biomarkers of target organ injury provide no information about inflammation and endothelial damage. This study found that the serum levels of 3-nitrotyrosine, growth differentiation factor-15, and syndecan-1 were associated with cardiac and renal involvement in Fabry disease patients on enzyme replacement therapy.
KIDNEY & BLOOD PRESSURE RESEARCH
(2022)
Article
Urology & Nephrology
Cassiano Augusto Braga Silva, Luis Gustavo Modelli de Andrade, Maria Helena Vaisbich, Fellype de Carvalho Barreto
Summary: The purpose of this study was to produce a consensus statement to standardize the recommendations concerning kidney involvement in Fabry disease and provide advice on diagnosis, screening, and treatment for patients. The consensus document aims to manage patient and physician expectations and make decisions based on available evidence and patient preferences.
JORNAL BRASILEIRO DE NEFROLOGIA
(2022)
Article
Urology & Nephrology
Maria Helena Vaisbich, Luis Gustavo Modelli de Andrade, Cassiano Augusto Braga Silva, Fellype de Carvalho Barreto
Summary: This study aims to create a consensus to standardize the recommendations for the diagnosis, screening, and treatment of renal involvement in pediatric patients with FD. The consensus includes investigating the pediatric family members of index cases, assessing all possible FD impairments, and emphasizing the benefits of early treatment.
JORNAL BRASILEIRO DE NEFROLOGIA
(2022)
Review
Medicine, General & Internal
Eman Nagy, Mahmoud M. Sobh, Mohamed Abdalbary, Sherouk Elnagar, Rabab Elrefaey, Shimaa Shabaka, Nehal Elshabrawy, Rasha Shemies, Mona Tawfik, Cassia Gomes S. Santos, Fellype C. Barreto, Amr El-Husseini
Summary: Renal osteodystrophy is a common complication of end-stage kidney disease, which may affect bone health, increase fracture risk, and contribute to vascular calcification. Adynamic bone is a characteristic feature, but it is unclear whether it is a pathological condition or an adaptive process.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Urology & Nephrology
Fellype Carvalho Barreto, Sergio Gardano Elias Bucharles, Vanda Jorgetti
JORNAL BRASILEIRO DE NEFROLOGIA
(2021)
Article
Urology & Nephrology
Rodrigo Bueno de Oliveira, Fellype Carvalho Barreto, Lucas Acatauassu Nunes, Melani Ribeiro Custodio
JORNAL BRASILEIRO DE NEFROLOGIA
(2021)
Article
Urology & Nephrology
Sergio Gardano Elias Bucharles, Fellype Carvalho Barreto, Rodrigo Bueno de Oliveira
JORNAL BRASILEIRO DE NEFROLOGIA
(2021)
Meeting Abstract
Transplantation
Paulo C. Gregorio, Regiane Cunha, Gilson Biagini, Bruna Bosquetti, Julia Budag, Alberto Ortiz, Maria Dolores Sanchez-Nino, Fellype Barreto, Andrea E. M. Stinghen
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Review
Urology & Nephrology
Cassiano Augusto Braga Silva, Jose A. Moura-Neto, Marlene Antonia dos Reis, Osvaldo Merege Vieira Neto, Fellype Carvalho Barreto
Summary: This narrative review provides an overview of Fabry disease (FD) nephropathy, highlighting the importance of early detection of renal disorders for timely treatment and better prognosis. The review also emphasizes the role of podocytes in the pathogenesis of this nephropathy, as well as the challenges in specific treatment of FD due to delayed diagnosis.
CANADIAN JOURNAL OF KIDNEY HEALTH AND DISEASE
(2021)
Letter
Endocrinology & Metabolism
Maria Helena Vaisbich, Juliana Caires de Oliveira Achili Ferreira, Fellype de Carvalho Barreto
JOURNAL OF THE ENDOCRINE SOCIETY
(2020)
Article
Medicine, General & Internal
Paulo C. Gregorio, Sergio Bucharles, Regiane S. da Cunha, Tarcio Braga, Ana Clara Almeida, Railson Henneberg, Andrea E. M. Stinghen, Fellype C. Barreto
Summary: Vitamin D supplementation improves hypovitaminosis D in hemodialysis patients but its effects on secondary hyperparathyroidism control are unclear. While exhibiting anti-inflammatory effects in vitro, short-term supplementation does not effectively improve the inflammatory profile of hemodialysis patients.