Article
Transplantation
Alexandra Chiorean, Nicole Lyn, Shaum Kabadi, Margot Blanchon, Paul Hayat, Paul Loustalot, Manish Maski, Martin Montmerle, Elvira Ponce
Summary: Clustering male patients with FD based on kidney function decline, organ involvement, and phenotype using real-world data provides a reference to determine the optimal time for FD-specific treatment and aid in management decisions by healthcare professionals.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Medicine, General & Internal
Giorgi Beridze, Davide L. Vetrano, Alessandra Marengoni, Lu Dai, Juan-Jesus Carrero, Amaia Calderon-Larranaga
Summary: This study compared the application of five commonly used creatinine-based estimated glomerular filtration rate (eGFR) equations in older adults and found that these equations are not interchangeable when assessing kidney function. The Berlin Initiative Study (BIS) equation performed the best in predicting mortality risk. These discrepancies should be taken into consideration by clinicians when monitoring kidney function in the elderly.
Review
Cardiac & Cardiovascular Systems
Muhammad Shahzeb Khan, George L. Bakris, Izza Shahid, Matthew R. Weir, Javed Butler
Summary: Cardiovascular trials lack statistical power to evaluate outcomes of advanced chronic kidney disease (CKD), and there is a need for alternative markers to assess the impact of interventions on kidney function at an earlier stage.
Article
Urology & Nephrology
Israel Khanimov, Boris Zingerman, Asher Korzetz, Mona Boaz, Mordechai Shimonov, Julio Wainstein, Eyal Leibovitz
Summary: This study revealed that reduced estimated glomerular filtration rate (eGFR) is associated with an increased risk of hypoglycaemia among non-critically-ill patients hospitalized in internal medicine departments. Glucose monitoring is suggested for all inpatients with chronic kidney disease, regardless of diabetes mellitus status.
Article
Geriatrics & Gerontology
Lili Yue, Li Fan, Xin Du
Summary: As a result of an aging population, the prevalence and mortality of chronic kidney disease continue to rise, especially in China. This study found that young females in the Chinese population have a higher average eGFR, while the GFR decreases by approximately 0.8 mL/min per year. The lower limit of eGFR was found to be <60 mL/min/1.73 m(2) or 45 mL/min/1.73 m(2) at the age of 40 or 65 years and older, respectively.
Article
Multidisciplinary Sciences
Thomas Waas, Andreas Schulz, Johannes Lotz, Heidi Rossmann, Norbert Pfeiffer, Manfred E. Beutel, Irene Schmidtmann, Thomas Muenzel, Philipp S. Wild, Karl J. Lackner
Summary: As individuals age, the glomerular filtration rate (GFR) decreases gradually, with factors such as systolic blood pressure having the most significant impact on the rate of decline. Diastolic blood pressure, serum uric acid, and serum albumin levels are associated with a slower decline in GFR over time.
SCIENTIFIC REPORTS
(2021)
Article
Urology & Nephrology
Hans Pottel, Etienne Cavalier, Jonas Bjork, Ulf Nyman, Anders Grubb, Natalie Ebert, Elke Schaeffner, Bjorn O. Eriksen, Toralf Melsom, Edmund J. Lamb, Christophe Mariat, Laurence Dubourg, Magnus Hansson, Karin Littmann, Per-Ola Sundin, Anna Akesson, Anders Larsson, Andrew Rule, Pierre Delanaye
Summary: Differences in serum creatinine and estimated glomerular filtration rate were evaluated in cohorts matched for age, sex, body mass index, and measured glomerular filtration rate. Significant discrepancies were observed in creatinine concentrations and performance of equations between different cohorts, highlighting the importance of standardization of serum creatinine measurement.
CLINICAL KIDNEY JOURNAL
(2022)
Article
Transplantation
Haruomi Nishio, Akira Ishii, Hiroyuki Yamada, Keita P. Mori, Yukiko Kato, Shoko Ohno, Takaya Handa, Sayaka Sugioka, Takuya Ishimura, Akie Ikushima, Yui Inoue, Naoto Minamino, Masashi Mukoyama, Motoko Yanagita, Hideki Yokoi
Summary: Aldosterone is an aggravating factor in diabetic kidney disease (DKD), and natriuretic peptides/guanylyl cyclase-A/cGMP signaling can ameliorate aldosterone-induced renal injury in mice. This study found that sacubitril/valsartan (SAC/VAL) treatment increased renal plasma flow (RPF) and glomerular filtration rate (GFR), and improved tubulointerstitial fibrosis in a mouse model of type 2 diabetes with aldosterone excess. These beneficial effects may be mediated through increased natriuretic peptide bioavailability.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Review
Medicine, General & Internal
Gustavo Laham, Juan Pablo Ponti, Gervasio Soler Pujol
Summary: Kidney transplantation is the preferred treatment for end-stage kidney disease, but the shortage of deceased donors has led to an increase in living donor transplants. Studies suggest that living donors may have a higher risk of developing kidney disease after donation. Proper evaluation of donors is crucial to avoid rejecting suitable donors and accepting those at higher risk. Assessing glomerular filtration rate (GFR) is an important aspect of donor evaluation, but there is ongoing debate on the methods for measuring GFR.
FRONTIERS IN MEDICINE
(2022)
Article
Medical Laboratory Technology
Junyan Shi, G. Edwin Lindo, S. Geoffrey Baird, Bessie Young, Michael Ryan, J. Ashley Jefferson, Rajnish Mehrotra, C. Patrick Mathias, N. Andrew Hoofnagle
Summary: Using the CKD-EPINoRace equation to calculate eGFR may result in a lower referral rate to nephrology, and there was no significant difference in the distribution of creatinine and eGFR between Black and non-Black patients.
CLINICA CHIMICA ACTA
(2021)
Article
Urology & Nephrology
Miriam Zacchia, Francesca Del Vecchio Blanco, Annalaura Torella, Raffaele Raucci, Giancarlo Blasio, Maria Elena Onore, Emanuela Marchese, Francesco Trepiccione, Caterina Vitagliano, Valentina Di Iorio, Perna Alessandra, Francesca Simonelli, Vincenzo Nigro, Giovambattista Capasso, Davide Viggiano
Summary: This study revealed a high prevalence of renal dysfunction in patients with Bardet-Biedl syndrome, with urine concentrating defect potentially serving as a predictor of disease progression. However, the pathophysiology of hyposthenuria may not be directly linked to specific tubule dysfunctions.
CLINICAL KIDNEY JOURNAL
(2021)
Article
Surgery
Francois Gaillard, Lola Jacquemont, Helene Lazareth, Laetitia Albano, Benoit Barrou, Nicolas Bouvier, Mathias Buchler, Dimitri Titeca-Beauport, Lionel Couzi, Michel Delahousse, Didier Ducloux, Isabelle Etienne, Luc Frimat, Cyril Garrouste, Denis Glotz, Philippe Grimbert, Marc Hazzan, Alexandre Hertig, Maryvonne Hourmant, Nassim Kamar, Yann Le Meur, Moglie Le Quintrec, Christophe Legendre, Valerie Moal, Bruno Moulin, Christiane Mousson, Claire Pouteil-Noble, Philippe Rieu, Nacera Ouali, Lionel Rostaing, Antoine Thierry, Fatouma Toure, Jonathan Chemouny, Pierre Delanaye, Marie Courbebaisse, Christophe Mariat
Summary: The study suggests that in-depth screening should be proposed to all candidates with a normal eGFR for age to increase the number of eligible kidney donors. Post-donation eGFR, absolute- and relative-eGFR variation were not significantly different between different pre-donation eGFR groups in younger donors, while older donors had higher post-donation eGFR in the group with eGFR >90 ml/min/1.73 m(2).
TRANSPLANT INTERNATIONAL
(2021)
Review
Cardiac & Cardiovascular Systems
Maurizio Pieroni, James C. Moon, Eloisa Arbustini, Roberto Barriales-Villa, Antonia Camporeale, Andreja Cokan Vujkovac, Perry M. Elliott, Albert Hagege, Johanna Kuusisto, Ales Linhart, Peter Nordbeck, Iacopo Olivotto, Paivi Pietila-Effati, Mehdi Namdar
Summary: Fabry disease is a rare genetic disorder that can lead to cardiovascular complications, including left ventricular hypertrophy, myocardial fibrosis, heart failure, and arrhythmias. Early diagnosis and treatment are essential for slowing disease progression and preventing cardiac complications.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2021)
Article
Medicine, General & Internal
Maria Perticone, Raffaele Maio, Giovanni Tripepi, Domenico Abelardo, Michele Andreucci, Egidio Imbalzano, Alfredo Francesco Toscani, Angela Sciacqua, Francesco Andreozzi, Giorgio Sesti, Francesco Perticone
Summary: Chronic kidney disease is a risk factor for cardiovascular events, and smoking and chronic obstructive pulmonary disease (COPD) are risk factors for renal impairment. This study found that smoking and COPD have a competitive interaction in the decline of renal function, suggesting the need for kidney damage screening in patients with both conditions.
INTERNAL AND EMERGENCY MEDICINE
(2023)
Article
Multidisciplinary Sciences
Rouvick M. Gama, Amanda Clery, Kathryn Griffiths, Neil Heraghty, Adrien M. Peters, Kieran Palmer, Henry Kibble, Royce P. Vincent, Claire C. Sharpe, Hugh Cairns, Kate Bramham
Summary: The study compared the accuracy of eGFR equations with and without ethnicity adjustment in estimating glomerular filtration rate in people of Black ethnicity in the UK. The findings suggest that ethnicity adjustment in eGFR estimation may lead to overestimation of GFR in Black participants, while disregarding ethnicity adjustment significantly improves GFR estimates for this population.
Article
Endocrinology & Metabolism
Mendy M. Welsink-Karssies, Michel van Weeghel, Carla E. M. Hollak, Hyung L. Elfrink, Mirian C. H. Janssen, Kent Lai, Janneke G. Langendonk, Esmee Oussoren, Jos P. N. Ruiter, Eileen P. Treacy, Maaike de Vries, Sacha Ferdinandusse, Annet M. Bosch
MOLECULAR GENETICS AND METABOLISM
(2020)
Review
Endocrinology & Metabolism
Eline C. B. Eskes, Barbara Sjouke, Frederic M. Vaz, Susan M. I. Goorden, Andre B. P. van Kuilenburg, Johannes M. F. G. Aerts, Carla E. M. Hollak
MOLECULAR GENETICS AND METABOLISM
(2020)
Article
Urology & Nephrology
A. T. N. van Diepen, A. M. Coester, C. J. Janmaat, F. W. Dekker, D. G. Struijk, R. T. Krediet
KIDNEY INTERNATIONAL REPORTS
(2020)
Article
Cardiac & Cardiovascular Systems
Mohamed El Sayed, Alexander Hirsch, Matthijs Boekholdt, Laura van Dussen, Mareen Datema, Carla Hollak, Mirjam Langeveld
Summary: The study demonstrates that sex and disease phenotype significantly influence the risk and age of onset of cardiac events in patients with Fabry disease (FD), highlighting the importance of patient-specific follow-up and treatment.
Article
Economics
Sandra M. Sirrs, Marie-Francoise Arthus, Daniel G. Bichet, Cheryl Rockman-Greenberg, Kaye LeMoine, Chantal F. Morel, Robin Lachmann, Larry D. Lynd, Syed Wasim, Michael L. West, Carla Hollak
Summary: Analysis of data from the Canadian Fabry Disease Initiative showed that establishing an independent registry for ongoing postauthorization surveillance of orphan medicinal products is cost-effective and efficient, with higher data completeness. 77% of patients continued to enroll in the registry even after enrollment ceased to be a requirement for therapy, indicating patient acceptance of the structure.
Editorial Material
Medicine, General & Internal
C. E. M. Hollak
JOURNAL OF INTERNAL MEDICINE
(2021)
Article
Economics
Sibren van den Berg, Vincent van der Wel, Saco J. de Visser, Bas C. Stunnenberg, Lonneke Timmers, Martijn H. van der Ree, Pieter G. Postema, Carla E. M. Hollak
Summary: Mexiletine is a drug initially used for arrhythmias, but later repurposed for NDM patients. Recent price increases in Europe led to discussions on affordability. A cost-based pricing model was used to calculate a fair price for Mexiletine, with results showing a significant difference from the current list price.
Review
Urology & Nephrology
Raymond T. Krediet
Summary: Ultrafiltration in peritoneal dialysis is crucial for maintaining optimal blood volume, but long-term treatment can lead to complex issues with ultrafiltration failure. This failure is primarily attributed to the increased perfusion of peritoneal microvessels, resulting in a decline in the osmotic gradient. The contribution of peritoneal interstitial tissue becomes more significant in long-term PD due to the development of fibrosis.
JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2021)
Review
Urology & Nephrology
Alena Parikova, Kristyna Michalickova, Anouk T. N. van Diepen, Ludek Voska, Ondrej Viklicky, Raymond T. Krediet
Summary: Several studies have shown that low glucose degradation product neutral pH dialysis solutions can mitigate and delay peritoneal alterations compared to conventional solutions, emphasizing better mesothelial preservation and reduced functional changes.
PERITONEAL DIALYSIS INTERNATIONAL
(2022)
Article
Medicine, General & Internal
Johann Morelle, Celine Marechal, Zanzhe Yu, Huguette Debaix, Tanguy Corre, Mark Lambie, Marion Verduijn, Friedo Dekker, Philippe Bovy, Pieter Evenepoel, Bert Bammens, Rafael Selgas, Maria A. Bajo, Annemieke M. Coester, Amadou Sow, Nicolas Hautem, Dirk G. Struijk, Raymond T. Krediet, Jean-Luc Balligand, Eric Goffin, Ralph Crott, Pierre Ripoche, Simon Davies, Olivier Devuyst
Summary: A common variant in AQP1 is associated with decreased ultrafiltration and an increased risk of death or technique failure among patients treated with peritoneal dialysis.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Review
Urology & Nephrology
Raymond T. Krediet, Deirisa Lopes Barreto, Anouk T. N. van Diepen
Summary: This study focused on the transport of serum proteins to peritoneal dialysate in peritoneal dialysis patients, specifically individual proteins. The researchers determined the concentrations of four individual proteins with different molecular weights in the serum and effluent of the patients. The results showed that the transport of these proteins depended on their molecular weight and diffusion coefficient. The peritoneal protein restriction coefficient (PPRC), which represents the size restriction to transport, was developed based on the relationship between the clearances of these proteins and their diffusion coefficients. Long-term follow-up of patients revealed an increase in PPRC, possibly due to venous vasculopathy of the peritoneal microcirculation.
PERITONEAL DIALYSIS INTERNATIONAL
(2022)
Review
Urology & Nephrology
Raymond T. Krediet, Alena Parikova
Summary: Long-term peritoneal dialysis can cause alterations in peritoneal function, such as high small solute transfer rates and impaired ultrafiltration, which are driven by peritoneal inflammation. A new hypothesis suggests that high glucose-induced pseudohypoxia plays a role in the development of these alterations. The high NADH-NAD1 ratio induced by glucose upregulates the expression of various profibrotic genes, leading to peritoneal fibrosis.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2022)
Review
Physiology
Raymond T. Krediet
Summary: This review summarizes the structural and functional alterations of the peritoneal dialysis membrane caused by long-term peritoneal dialysis, and discusses the pseudohypoxia hypothesis and glucose-induced conditions as explanations for these alterations. The upregulation of GLUT-1 in interstitial fibroblasts is highlighted as a key factor in ultrafiltration failure.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Urology & Nephrology
Anabela Malho Guedes, Roberto Marques, Ana Teresa Domingos, Ana Paula Silva, Idalecio Bernardo, Pedro Leao Neves, Anabela Rodrigues, Raymond T. Krediet
Summary: This study investigated the impact of fluid overload on peritoneal protein clearance in peritoneal dialysis patients. The findings revealed a significant association between fluid overload and peritoneal protein clearance, supporting the importance of hydrostatic pressure-induced convection for peritoneal protein clearance. Additionally, peritoneal small solute transport was found to be associated with peritoneal protein clearance.
Article
Physiology
Alena Parikova, Petra Hruba, Zdenek Krejcik, Viktor Stranecky, Janka Franekova, Raymond T. Krediet, Ondrej Viklicky
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2020)