Article
Urology & Nephrology
Bojan Vujkovac, Irena Srebotnik Kirbis, Tajda Keber, Andreja Cokan Vujkovac, Martin Tretjak, Sandra Rados Krnel
Summary: This study found that podocyturia is an early clinical feature in the development of kidney disease in patients with Fabry disease, and its occurrence is discontinuous and highly variable.
CLINICAL KIDNEY JOURNAL
(2022)
Article
Medicine, General & Internal
Takahiro Kanai, Takane Ito, Jun Aoyagi, Takanori Yamagata
Summary: This study reminds us of the existence of membranous nephropathy without vacuolated podocytes in Fabry disease during treatment.
Article
Medical Laboratory Technology
Guillaume Resimont, Laura Vranken, Hans Pottel, Francois Jouret, Jean-Marie Krzesinski, Etienne Cavalier, Pierre Delanaye
Summary: This study investigated the performance of two equations for estimating ACR from PCR in our population. The results showed good concordance between mACR and eACR, regardless of the equation or analyser used.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2022)
Review
Urology & Nephrology
Tyrone G. Harrison, Marcello Tonelli
Summary: The measurement of proteinuria is crucial for diagnosing and monitoring kidney disease, but there is still controversy and uncertainty surrounding the optimal measurement method. International guidelines recommend the use of urinary albumin-to-creatinine ratio, but this method is not universally available and can be costly. Additionally, the accuracy of different measurement methods may vary depending on the magnitude of albuminuria, sex, and clinical contexts.
KIDNEY INTERNATIONAL
(2023)
Review
Urology & Nephrology
Zeynepgul Kalay, Ozgun E. Sahin, Sidar Copur, Senem Danaci, Alberto Ortiz, Kevin Yau, David Z. Cherney, Mehmet Kanbay
Summary: SGLT-2 inhibitors may have a beneficial role in non-diabetic kidney patients with proteinuria. Lowering proteinuria may help to improve kidney disease patients' outcome by slowing kidney disease progression and decreasing the risk of new cardiovascular events.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Supabhorn Yimthiang, David A. Vesey, Phisit Pouyfung, Tanaporn Khamphaya, Glenda C. Gobe, Soisungwan Satarug
Summary: Chronic cadmium exposure can cause kidney damage, leading to a decline in glomerular filtration rate (GFR) and tubular proteinuria. Diabetic kidney disease (DKD) is characterized by albuminuria and declining GFR, and exposure to cadmium can worsen the progression of kidney disease in diabetics. A study involving 88 diabetics and 88 controls found that even low levels of cadmium exposure were associated with tubular dysfunction and increased risk of albuminuria, especially in individuals with a higher body burden of cadmium, hypertension, and reduced eGFR.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Nutrition & Dietetics
Massimo Cirillo, Pierpaolo Cavallo, Enrico Zulli, Rachele Villa, Rosangela Veneziano, Simona Costanzo, Sara Magnacca, Augusto Di Castelnuovo, Licia Iacoviello
Summary: The study found independent positive associations of an index of sodium intake with proteinuria and albuminuria in the population.
Review
Cardiac & Cardiovascular Systems
Christine E. Kurschat
Summary: Fabry disease is a rare X-linked lysosomal storage disorder characterized by accumulation of storage material in organs such as the heart, kidney, nervous system, and cornea, leading to cardiac issues and declining kidney function. Clinical presentation depends on mutations in the GLA gene, with early signs including albuminuria and later progression to end-stage renal disease.
CARDIOVASCULAR DIAGNOSIS AND THERAPY
(2021)
Review
Medicine, General & Internal
Peter Rossing, Murray Epstein
Summary: Chronic kidney disease affects approximately 10% of the global population, with diabetes being a leading cause. Early screening and timely intervention are crucial in avoiding the progression of chronic kidney disease to a severe stage, but there is still significant room for improvement in current screening efforts.
AMERICAN JOURNAL OF MEDICINE
(2022)
Article
Biochemical Research Methods
Francesca Torrini, Simona Scarano, Pasquale Palladino, Maria Minunni
Summary: A polydopamine-based colorimetric assay for determining urinary albumin concentration showed great reproducibility in human urine and outperformed some standard methods available on the market, especially the Bradford assay, in terms of analytical performances for early screening and assessment of kidney damage.
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
(2021)
Article
Urology & Nephrology
Huda Al-Wahsh, Ngan N. Lam, Robert R. Quinn, Paul E. Ronksley, Manish M. Sood, Brenda Hemmelgarn, Navdeep Tangri, Thomas Ferguson, Marcello Tonelli, Pietro Ravani, Ping Liu
Summary: This study compared the performance of calculated ACR and measured ACR in predicting kidney failure and death without kidney failure in patients with chronic kidney disease. The results suggest that calculated ACR, particularly PCR-calculated ACR, may have better predictive performance than dipstick-calculated ACR.
KIDNEY INTERNATIONAL
(2022)
Article
Urology & Nephrology
Rebecca I. Spain, Nicole K. Andeen, Pamela C. Gibson, Mary H. Samuels, Cynthia D. Morris, Andrew J. Solomon, Richard Solomon, Carin Waslo, Rupali S. Avasare
Summary: Lipoic acid, a popular antioxidant and insulin-mimetic supplement, was found to cause high-grade proteinuria in multiple sclerosis patients in a clinical trial. This led to the discovery of NELL1-associated membranous nephropathy cases related to lipoic acid supplementation, which improved with discontinuation of the supplement and supportive therapy.
KIDNEY INTERNATIONAL
(2021)
Article
Cardiac & Cardiovascular Systems
Joao Pedro Ferreira, Faiez Zannad, Javed Butler, Gerasimos Filippatos, Stuart J. Pocock, Martina Brueckmann, Dominik Steubl, Elke Schueler, Stefan D. Anker, Milton Packer
Summary: Empagliflozin is associated with reduced risk of HF hospitalizations or cardiovascular death, regardless of baseline albuminuria levels. It also reduces the progression of macroalbuminuria and promotes its reversal.
Article
Transplantation
Akiko Nagata, Makoto Nasu, Yusuke Kaida, Yosuke Nakayama, Yuka Kurokawa, Nao Nakamura, Ryo Shibata, Takuma Hazama, Takahiro Tsukimura, Tadayasu Togawa, Seiji Saito, Hitoshi Sakuraba, Kei Fukami
Summary: This study aimed to investigate the prevalence of FD and related factors in CKD patients, showing a significantly higher prevalence of FD in male patients with CKD Stages 1-5. Additionally, identified GLA gene mutations were found to be one of the causes of FD, and serum alpha-Gal A activity was found to be correlated with age and estimated glomerular filtration rate.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Medicine, General & Internal
Thi Thuy Uyen Nguyen, Hyeongwan Kim, Yoon Jung Chae, Jong Hwan Jung, Won Kim
Summary: This study indicates that serum VEGF-D may be an important biomarker in patients with diabetic CKD, associated with renal dysfunction and proteinuria.