Article
Biochemistry & Molecular Biology
Erasmia Sampani, Dimitra-Vasilia Daikidou, George Lioulios, Aliki Xochelli, Zoi Mitsoglou, Vasiliki Nikolaidou, Chrysostomos Dimitriadis, Asimina Fylaktou, Aikaterini Papagianni, Maria Stangou
Summary: Diabetes mellitus affects the immune profile of ESRD patients even at the predialysis stage, with more prominent changes observed after hemodialysis commencement.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ling Lin, Qiuxia Xie, Mei Zheng, Xuhui Zhou, Ilona A. Dekkers, Qian Tao, Hildo J. Lamb
Summary: In ESRD patients on peritoneal dialysis with preserved LVEF, higher myocardial mass, higher native T1 and T2 values, decreased LV strain, and increased RVGCS were observed compared with healthy controls. Increased myocardial T1 and T2 values were found in ESRD patients even in the absence of systolic or diastolic dysfunction detected by routine echocardiography.
EUROPEAN RADIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Mahmoud M. Zakaria, Safaa A. Derbala, Ayman E. Salem, Amgad E. EL-Agroudy, Fatma M. El-Tantawy
Summary: The study found that ESRD patients have a significantly lower number of T-cell subsets compared to CKD patients, which is related to a higher degree of apoptosis in these cells.
MOLECULAR BIOLOGY REPORTS
(2021)
Article
Transplantation
Joonas Rautavaara, Tuomas Kerola, Kati Kaartinen, Mari Vilpakka, Atte Aitkoski, Olli Anttonen, Jani Ahvonen, Juhani Koistinen, Kati Vaaraniemi, Marja Miettinen, Antti Ylitalo, Kaisa Laine, Seppo Ojanen, Tuomo Nieminen
Summary: The study found that a significant number of patients with end-stage renal disease (ESRD) experienced bradycardia or asystole episodes, but these arrhythmias were not detected by baseline or ambulatory ECG recordings.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Transplantation
Robert Provenzano, Evgeny Shutov, Liubov Eremeeva, Svitlana Korneyeva, Lona Poole, Gopal Saha, Charles Bradley, Meraf Eyassu, Anatole Besarab, Robert Leong, Cameron S. Liu, Thomas B. Neff, Lynda Szczech, Kin-Hung P. Yu
Summary: This study demonstrated the efficacy and safety of roxadustat in treating chronic kidney disease-related anemia. Roxadustat was shown to be as effective as epoetin alfa in correcting and maintaining hemoglobin levels, with comparable rates of adverse events.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Rahaf AlSadi, Landon C. Aziz, Michael Bohan, Shaheen Dewji, Othmane Bouhali, Mehdi Djekidel
Summary: The study retrospectively reports on RAI treatment in thyroid cancer patients with ESRD undergoing dialysis, highlighting the challenges posed by delayed biological clearance of RAI. Adjusted dose activity and balancing scheduling between RAI therapy and dialysis are recommended to ensure closer radiation exposure in ESRD patients. Pooling data from multiple centers is suggested to establish consensus and substantiated recommendations for RAI treatment in ESRD patients.
CLINICAL NUCLEAR MEDICINE
(2021)
Article
Immunology
Lauren Van Zeebroeck, Rebeca Arroyo Hornero, Beatriz F. Corte-Real, Ibrahim Hamad, Torsten B. Meissner, Markus Kleinewietfeld
Summary: Tregs are crucial for maintaining immune homeostasis and have potential therapeutic value in various diseases. While current genome editing protocols for Tregs are limited, our rapid and effective method may advance possibilities for Treg-based cellular therapies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Georgios Lioulios, Asimina Fylaktou, Aliki Xochelli, Erasmia Sampani, Ioannis Tsouchnikas, Panagiotis Giamalis, Dimitra-Vasilia Daikidou, Vasiliki Nikolaidou, Aikaterini Papagianni, Ioannis Theodorou, Maria Stangou
Summary: End stage renal disease (ESRD) has detrimental effects on the immune system, leading to quantitative alterations of lymphocyte subpopulations. Using principal component analysis (PCA) and uniform manifold approximation and projection (UMAP), we found that ESRD patients have a more senescent immune phenotype, and dialysis prescription may play a role in determining the immunological groups within the patient cohort.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Lina A. Dahabiyeh, Refat M. Nimer, Khalid M. Sumaily, Mohamad S. Alabdaljabar, Minnie Jacob, Essa M. Sabi, Maged H. Hussein, Anas Abdel Rahman
Summary: Chronic kidney disease (CKD) is a severe public health problem that can lead to end-stage renal disease (ESRD) requiring dialysis or transplantation. This study identified altered metabolites and biochemical reactions between ESRD and CKD, offering potential new biomarkers for monitoring CKD progression. Inhibition of the kynurenine pathway may be a promising target for delaying CKD progression, and metabolites with high discriminative ability could complement current markers to better indicate kidney damage status.
SCIENTIFIC REPORTS
(2023)
Article
Immunology
Kathryn A. Knoop, Keely G. McDonald, Chyi-Song Hsieh, Phillip Tarr, Rodney D. Newberry
Summary: Atopic disorders are on the rise in Western societies, characterized by immune responses to environmental triggers. Early life exposure to diet and microbes shapes the intestinal Treg population significantly. Tregs developed early in life play a crucial role in restraining systemic inflammatory responses into adulthood.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Beatriz F. F. Corte-Real, Rebeca Arroyo Hornero, Aleksandra Dyczko, Ibrahim Hamad, Markus Kleinewietfeld
Summary: CSF2RB (CD131) may serve as a potential biomarker for autoimmune diseases in Tregs, with its overexpression potentially being linked to disease development.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Christina Seitz, Anne-Laure Joly, Fang Fang, Katie Frith, Paul Gray, John Andersson
Summary: The transcription factor FOXP3 is crucial for the development and function of CD4(+)FOXP3(+) regulatory T (Treg) cells. Alterations in the expression of FOXP3 isoforms are associated with inflammatory disease progression. This study investigates the effects of a specific FOXP3 mutation on Treg cell subsets. The findings suggest that the full-length FOXP3 isoform is important for maintaining Treg cell lineage stability but not essential for Treg cell activation.
CLINICAL IMMUNOLOGY
(2022)
Review
Immunology
Yiran Qiu, Shouyu Ke, Jieqiong Chen, Zhizhen Qin, Wenle Zhang, Yaqin Yuan, Dehua Meng, Gang Zhao, Kejin Wu, Bin Li, Dan Li
Summary: This review summarizes the latest findings on the dynamic connections and reciprocal regulations of non-lymphoid Treg cell subsets in the immune escape of tumour cells in solid tumors, providing new insights for the development of next-generation engineered T cell-based immune treatments for solid tumors.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Biaolong Deng, Weiqi Zhang, Yicheng Zhu, Yangyang Li, Dan Li, Bin Li
Summary: Regulatory T (Treg) cells play a critical role in maintaining immune homeostasis and their dysfunction in aged patients may contribute to age-related diseases. Immune therapies targeting Treg cells show promising results in treating cancers and autoimmune diseases. Understanding Treg cell function better may help in developing new immune therapies against aging.
Article
Medicine, General & Internal
Yong-Qin Zeng, Zuo-An Qin, Zi-Wei Guo, Bo Li, Hai-Yan Yu, Rui-Xue Chen, Ying-Qian Tang, Ke-Jin Hu, Cheng-Jing Guan, Rui Yan
Summary: This study investigated the association between serum albumin concentration and the risk of cardiac arrest in critically ill patients with end-stage renal disease. It found that within an albumin range of 3.26-5.6 g/dL, each 1 g/dL increase in serum levels is associated with a 68% decrease of the risk of cardiac arrest.
Article
Urology & Nephrology
Anusha S. Shankar, Zhaoyu Du, Hector Tejeda Mora, Thierry P. P. van den Bosch, Sander S. Korevaar, Ingrid M. Van den Berg-Garrelds, Eric Bindels, Carmen Lopez-Iglesias, Marian C. Clahsen-van Groningen, Joost Gribnau, Carla C. Baan, A. H. Jan Danser, Ewout J. Hoorn, Martin J. Hoogduijn
Summary: This study used human induced pluripotent stem cell-derived kidney organoids as a model to investigate the role of renin and the renin-angiotensin system in the kidney, demonstrating the expression of renin in kidney organoids and providing insights into their endocrine potential.
KIDNEY INTERNATIONAL
(2021)
Article
Immunology
Stine Lohmann, Marco Eijken, Ulla Moldrup, Bjarne K. Moller, James Hunter, Cyril Moers, Henri Leuvenink, Rutger J. Ploeg, Marian C. Clahsen-van Groningen, Martin Hoogduijn, Carla C. Baan, Anna Krarup Keller, Bente Jespersen
Summary: The study demonstrated that intraarterial MSC infusion to transplant kidneys is a safe and effective method to deliver MSCs to the graft, but no positive effects of this cell treatment were detected within the 14-day observation period.
Article
Surgery
Stine Lohmann, Merel B. F. Pool, Kaithlyn M. Rozenberg, Anna K. Keller, Cyril Moers, Ulla Moldrup, Bjarne K. Moller, Stina J. M. Lignell, Soren Krag, Jesus M. Sierra-Parraga, Maria L. Lo Faro, James Hunter, Martin J. Hoogduijn, Carla C. Baan, Henri G. D. Leuvenink, Rutger J. Ploeg, Marco Eijken, Bente Jespersen
Summary: This study aimed to evaluate the safety and feasibility of using MSC treatment during NMP in a porcine autotransplantation model, and found that infusing MSCs during ex vivo NMP of porcine kidneys was safe and feasible. However, no beneficial effects of ex vivo MSC therapy could be demonstrated during the short posttransplant follow-up period of 14 days.
AMERICAN JOURNAL OF TRANSPLANTATION
(2021)
Review
Transplantation
Karin Boer, Dennis A. Hesselink, Carla C. Baan
Summary: DNA methylation is important for gene transcription and cellular function, with potential clinical utility for monitoring transplant rejection. However, research on DNA methylation in relation to allograft rejection is scarce, making it challenging to determine its clinical value. Further research is needed to investigate the potential of DNA methylation in early recognition and successful treatment of allograft rejection.
CURRENT OPINION IN ORGAN TRANSPLANTATION
(2021)
Editorial Material
Immunology
Jeremy R. Chapman, Carla C. Baan, J. Bromberg, Jean E. Emond, Edward K. Geissler, B. Kaplan, Stefan G. Tullius
Article
Oncology
Jeroen G. H. P. Verhoeven, Carla C. Baan, Annemiek M. A. Peeters, Marian C. Clahsen-van Groningen, Daan Nieboer, Marielle Herzog, Marc Eccleston, Dennis A. Hesselink, Karin Boer
Summary: In this pilot study, total circulating cell-free nucleosomes (H3) concentrations are increased during acute kidney transplant rejection. The high negative predictive value suggests that when a patient experiences loss of renal transplant function and total CCFN (H3) is not increased, causes other than acute rejection should be considered. Clinical implementation of total CCFN (H3) measurement may help avoid unnecessary and potentially harmful kidney transplant biopsies.
CLINICAL EPIGENETICS
(2021)
Review
Immunology
Daphne M. Peelen, Martin J. Hoogduijn, Dennis A. Hesselink, Carla C. Baan
Summary: Endothelial cells play a key role in acute and chronic rejection of solid organ transplants, with significant impact on organ function. Innovative 3D in vitro models have been developed to expand understanding of endothelial cell roles and potentially discover new therapeutic targets.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Medical Laboratory Technology
Suwasin Udomkarnjananun, Stephen J. Kerr, Natavudh Townamchai, Nicole M. van Besouw, Dennis A. Hesselink, Carla C. Baan
Summary: Donor-specific ELISPOT assay is a promising tool for predicting acute rejection after kidney transplantation. Positive IFN-gamma ELISPOT results are associated with higher risk of rejection and lower estimated glomerular filtration rate.
CLINICAL BIOCHEMISTRY
(2021)
Article
Multidisciplinary Sciences
Ana Merino, Martin J. Hoogduijn, Maria Molina-Molina, Elena G. Arias-Salgado, Sander S. Korevaar, Carla C. Baan, Ana Montes-Worboys
Summary: The study shows that Membrane Particles (MP) derived from mesenchymal stromal cells (MSC) have anti-fibrotic effects by targeting lung cells and reducing the expression of fibrotic proteins without cytotoxic effects. These findings suggest that MP may serve as an alternative therapeutic approach to traditional MSC administration in treating idiopathic pulmonary fibrosis.
Editorial Material
Immunology
Carla C. Baan, Karin Boer
Article
Multidisciplinary Sciences
H. Tejeda-Mora, J. G. H. P. Verhoeven, W. Verschoor, K. Boer, D. A. Hesselink, M. W. F. van den Hoogen, L. J. W. van der Laan, C. C. Baan, R. C. Minnee, M. J. Hoogduijn
Summary: This study found that after kidney transplantation, the number of endothelial cells transiently increases, but is not significantly associated with rejection, function, or other pathologies. However, in patients with rejection, there is a significant increase in endothelial cell levels, which are related to the kidney injury marker KIM-1.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Ana Merino, Marta Sablik, Sander S. Korevaar, Carmen Lopez-Iglesias, Maitane Ortiz-Virumbrales, Carla C. Baan, Eleuterio Lombardo, Martin J. Hoogduijn
Summary: This study found that membrane particles (MP) generated from mesenchymal stromal cells (MSC) can preserve the beneficial effects of MSC on endothelial cell repair processes. This suggests that MP may have potential applications for treating vascular diseases where inflammatory processes damage the endothelium.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Fabiany da Costa Goncalves, Sander S. Korevaar, Maitane Ortiz Virumbrales, Carla C. Baan, Marlies E. J. Reinders, Ana Merino, Eleuterio Lombardo, Martin J. Hoogduijn
Summary: Mesenchymal stromal cells (MSC) show promise as a therapy for inflammatory diseases, but their large size leads to entrapment in the lungs after intravenous infusion, limiting their effectiveness. Researchers have developed nanometer-sized particles from MSC membranes (membrane particles, MP) to extend the reach of MSC immunoregulatory therapy beyond the lungs. These particles exhibit immunomodulatory properties and are taken up by macrophages and human umbilical vein endothelial cells (HUVEC) in a dose, time, and temperature-dependent manner. The uptake of MP depends on specific endocytic pathways and is influenced by cell type and inflammatory conditions, with anti-inflammatory M2 macrophages showing increased uptake compared to pro-inflammatory M1 macrophages.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medical Laboratory Technology
Jianzhao Zhai, Jing Liao, Minjin Wang, Zhuochun Huang, Jing Hu, Huan Xu, Qibing Xie, Bin Ma, Carla C. Baan, Yongkang Wu
Summary: The study revealed a close relationship between AGA and autoimmune diseases, with high-titer AGA being common in patients with autoimmune diseases. Joint pain/muscle pain was the most common symptom in undiagnosed patients testing positive for AGA.
LABORATORY MEDICINE
(2022)
Letter
Medical Laboratory Technology
Jeroen G. H. P. Verhoeven, Carla C. Baan, Annemiek M. A. Peeters, Daan Nieboer, Dennis A. Hesselink, Karin Boer
CLINICAL BIOCHEMISTRY
(2021)