期刊
NEPHROLOGY DIALYSIS TRANSPLANTATION
卷 24, 期 12, 页码 3882-3884出版社
OXFORD UNIV PRESS
DOI: 10.1093/ndt/gfp494
关键词
FGF23-Klotho axis; hypothesis of NSF development; macrocyclical gadolinium-based contrast media; NSF; case report
So far no cases of nephrogenic systemic fibrosis (NSF) have been published on macrocyclical gadolinium-based contrast media (Gd-CM), assumed as low NSF risk CM due to their complex stability. In our haemodialysis-dependent patient, the first symptoms indicating NSF appeared about 16 months after the exposure to Gadovist, a macrocyclical Gd-CM, and 1 month after x-ray angiography with iodinated CM (Ultravist). This indicates that in addition to excretory renal failure and Gd-CM exposure, the loss of biosynthetic renal function could be essential for NSF development. A hypothesis of possible pathways involved in the development of NSF is presented.
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