Article
Medicine, General & Internal
Kai-Uwe Eckardt, Rajiv Agarwal, Ahmad Aswad, Ahmed Awad, Geoffrey A. Block, Marcelo R. Bacci, Youssef M. K. Farag, Steven Fishbane, Harold Hubert, Alan Jardine, Zeeshan Khawaja, Mark J. Koury, Bradley J. Maroni, Kunihiro Matsushita, Peter A. McCullough, Eldrin F. Lewis, Wenli Luo, Patrick S. Parfrey, Pablo Pergola, Mark J. Sarnak, Bruce Spinowitz, James Tumlin, Dennis L. Vargo, Kimberly A. Walters, Wolfgang C. Winkelmayer, Janet Wittes, Rafal Zwiech, Glenn M. Chertow
Summary: Vadadustat, an oral prolyl hydroxylase inhibitor, was found to be noninferior to darbepoetin alfa in terms of cardiovascular safety and hemoglobin concentration in anemia patients with CKD undergoing dialysis, based on two phase 3 trials.
NEW ENGLAND JOURNAL OF MEDICINE
(2021)
Article
Urology & Nephrology
Takashi Shigematsu, Fumihiko Koiwa, Yoshitaka Isaka, Masafumi Fukagawa, Keiko Hagita, Yukihisa S. Watanabe, Daisuke Honda, Tadao Akizawa
Summary: Upacicalcet, a novel injectable calcimimetic, is effective and safe for patients with secondary hyperparathyroidism receiving hemodialysis.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Urology & Nephrology
Andrew Davenport
Summary: The study reviewed the calcium balance in peritoneal dialysis patients and found that over 40% of the patients had a positive peritoneal calcium balance. The use of calcium-containing phosphate binders had a significant impact on calcium balance, and excessive prescribing may increase the risk of vascular calcification, especially for anuric patients.
JOURNAL OF NEPHROLOGY
(2023)
Article
Urology & Nephrology
Lina Zhang, Xu Ma, Yanping Zheng, Suge Tian, Jing Zhang, Lei Yan, Yue Gu, Fengmin Shao
Summary: This study aimed to investigate the effectiveness and safety of peritoneal dialysis (PD) catheter removal using the pull technique. The results of the retrospective analysis showed that this technique was effective, safe, and cost-effective.
INTERNATIONAL UROLOGY AND NEPHROLOGY
(2023)
Review
Urology & Nephrology
Poxuan Zhang, Shengmei Sang, Jinlan Huang, Sujuan Feng, Caiyun Feng, Rong Wang
Summary: This study compared the effects of sevelamer and calcium-based binders on mortality of hemodialysis patients. The results showed that after adjusting confounders, there was no significant difference in the risk of all-cause mortality between the two groups. However, further studies with larger sample sizes are needed to confirm the results due to the instability of the findings.
IRANIAN JOURNAL OF KIDNEY DISEASES
(2022)
Review
Urology & Nephrology
Qian Zeng, Yuanlong Zhong, Xiqiu Yu
Summary: This study analyzed the safety and efficacy of sevelamer compared to placebo, calcium carbonate (CC), or lanthanum carbonate (LC) in the treatment of chronic kidney disease (CKD) patients. A meta-analysis of 34 randomized controlled trials (RCTs) involving 2802 patients showed that sevelamer reduced all-cause mortality and vascular calcification score, and induced less hypercalcemia and hyperphosphatemia compared to Ca-based binders in CKD5D individuals. However, there were no significant differences in gastrointestinal adverse events (GAEs) incidence.
Article
Oncology
Qingsheng Xu, Kaiyuan Huang, Xiangqi Meng, Yuxiang Weng, Luyuan Zhang, Linghao Bu, Xiujue Zheng, Jinquan Cai, Renya Zhan, Qun Chen
Summary: The combination of anlotinib and temozolomide showed high efficacy and tolerability in treating recurrent GBM, with a good tumor response rate and disease control rate. This treatment regimen may contribute to an increase in progression-free survival and overall survival in patients with recurrent GBM.
CLINICAL CANCER RESEARCH
(2023)
Article
Medicine, General & Internal
Elodia Nataly Diaz-De la Cruz, Jose Ignacio Cerrillos-Gutierrez, Andres Garcia-Sanchez, Carlos Gerardo Prado-Nevarez, Jorge Andrade-Sierra, Basilio Jalomo-Martinez, Adriana Banda-Lopez, Enrique Rojas-Campos, Alejandra Guillermina Miranda-Diaz
Summary: This study found that managing hyperphosphatemia with sevelamer hydrochloride in patients with end-stage renal disease led to significant increases in antioxidant enzyme activity, reduction in inflammation levels, and regulation of oxidative stress state.
FRONTIERS IN MEDICINE
(2021)
Article
Hematology
Hidetoshi Kanai, Masaomi Nangaku, Reiko Nagai, Nobuhiko Okuda, Kyo Kurata, Takashi Nagakubo, Yukihiro Endo, Alexander Cobitz
Summary: This study demonstrated the efficacy and safety of daprodustat in Japanese peritoneal dialysis patients with anemia, with mean hemoglobin levels reaching and remaining within the target range over 52 weeks. Adverse events were generally well tolerated, with the most common being nasopharyngitis, catheter-site infection, peritonitis, diarrhea, and nausea. No deaths were reported.
THERAPEUTIC APHERESIS AND DIALYSIS
(2021)
Article
Immunology
Georg Beilhack, Rossella Monteforte, Florian Frommlet, Martina Gaggl, Robert Strassl, Andreas Vychytil
Summary: The study demonstrated that peritoneal dialysis patients had a high seroconversion rate of 97.4% after receiving the mRNA-1273 vaccine, showing significantly increased antibody titers. The most common adverse events were injection site pain and fatigue, with overall good tolerability of the vaccine.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Urology & Nephrology
Ricardo Neto, Joao Frazao
Summary: Calcium carbonate reduced urinary phosphate excretion and prevented the rise in phosphorus and iPTH serum levels, but was associated with increased vascular calcification. Calcium-based phosphate binders may not be a safe option for patients with CKD.
CLINICAL KIDNEY JOURNAL
(2021)
Article
Nutrition & Dietetics
Fabricio Moreira Reis, Maryanne Zilli Canedo da Silva, Nayrana Soares do Carmo Reis, Fabiana Lourenco Costa, Caroline Ferreira da Silva Mazeto Pupo da Silveira, Pasqual Barretti, Luis Cuadrado Martin, Silmeia Garcia Zanati Bazan
Summary: This study aimed to investigate the association between phase angle and coronary artery calcium score in patients on peritoneal dialysis. The results showed a significant association between the two variables. Phase angle may serve as a risk marker for coronary artery disease in this population.
FRONTIERS IN NUTRITION
(2022)
Article
Urology & Nephrology
Miho Murashima, Naohiko Fujii, Shunsuke Goto, Takeshi Hasegawa, Masanori Abe, Norio Hanafusa, Masafumi Fukagawa, Takayuki Hamano
Summary: This study aimed to evaluate the associations between calcium, phosphate, and intact parathyroid hormone (iPTH) levels and outcomes in peritoneal dialysis (PD) patients. The results showed that higher levels of calcium and phosphate were associated with higher mortality, while lower levels of calcium and phosphate were associated with faster decline in urine output and lower incidence of transition to hemodialysis.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Urology & Nephrology
Jose Portoles-Perez, Beatriz Dura-Gurpide, Jose Luis Merino-Rivas, Leyre Martin-Rodriguez, Covadonga Hevia-Ojanguren, Victor Burguera-Vion, Claudia Yuste-Lozano, Luisa Sanchez-Garcia, Jose Ramon Rodriguez-Palomares, Vicente Paraiso
Summary: The study aimed to evaluate the efficacy and safety of intravenous ferric carboxymaltose (FCM) in patients undergoing peritoneal dialysis (PD). The findings showed that FCM treatment was effective, safe, and easy to administer during routine clinical visits for PD patients.
CLINICAL KIDNEY JOURNAL
(2021)
Article
Oncology
Kaylyn R. Collette, Zin W. Myint, Saurabh V. Parasramka, Carleton S. Ellis
Summary: The clinical management of metastatic urothelial carcinoma has been significantly improved with the emergence of monoclonal antibodies and antibody-drug conjugates. This case report presents a patient on peritoneal dialysis who showed an impressive response to Enfortumab vedotin without significant toxicity.
FRONTIERS IN ONCOLOGY
(2022)
Editorial Material
Transplantation
Alberto Ortiz, Francesco Mattace-Raso, Maria Jose Soler, Denis Fouque
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Transplantation
Jilske A. Huijben, Anneke Kramer, Julia Kerschbaum, Johan de Meester, Frederic Collart, Olga Lucia Rodriguez Arevalo, Jaakko Helve, Mathilde Lassalle, Runolfur Palsson, Marc ten Dam, Anna Casula, Shona Methven, Alberto Ortiz, Pietro Manuel Ferraro, Marten Segelmark, Pablo Ucio Mingo, Mustafa Arici, Anna Varberg Reisaeter, Maria Stendahl, Vianda S. Stel, Kitty J. Jager
Summary: This study describes the trends in incidence, prevalence, and survival of patients on kidney replacement therapy (KRT) for end-stage kidney disease (ESKD) in Europe from 2008 to 2017. The incidence of KRT remained stable initially but increased slightly in recent years, primarily driven by an increase in older male patients. Diabetes mellitus was found to be a leading cause of kidney failure. The prevalence of KRT increased over the study period, and patient survival on KRT improved.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Editorial Material
Transplantation
Alberto Ortiz, Christoph Wanner, Ron Gansevoort
Summary: The European Society of Cardiology 2021 guideline on cardiovascular disease prevention has significant implications for CV risk screening and kidney health. The guideline proposes specific strategies for individuals with established CVD, diabetes, hypercholesterolemia, or CKD. This includes the assessment of albuminuria as an entry-level step in CVD risk assessment, which could change current clinical practice. Further research is needed to determine the optimal method for CV risk assessment, including CKD assessment in the general population.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Editorial Material
Transplantation
Ron T. Gansevoort, Hans-Joachim Anders, Mario Cozzolino, Danilo Fliser, Denis Fouque, Alberto Ortiz, Maria Jose Soler, Christoph Wanner
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Review
Medicine, Research & Experimental
Raul Fernandez-Prado, Priscila Villalvazo, Alejandro Avello, Marina Gonzalez-de-Rivera, Michelle Aguirre, Carlos G. Carrasco-Munoz, Beatriz Fernandez-Fernandez, Catalina Martin-Cleary, Sol Carriazo, Maria Dolores Sanchez-Nino, Maria Vanessa Perez-Gomez, Alberto Ortiz
Summary: Metabolic acidosis is common in CKD and has various negative effects. SZC, a potassium binder, has been shown to increase serum bicarbonate and decrease serum urea, potentially providing benefits in CKD management. The mechanism of action appears to involve SZC binding to ammonium ions in the gut, preventing their absorption and promoting the excretion of H+ ions.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Transplantation
Rianne Boenink, Anneke Kramer, Rosalie E. Tuinhout, Emilie Savoye, Anders Asberg, Alma Idrizi, Julia Kerschbaum, Ieva Ziedina, Edita Ziginskiene, Emanuel Farrugia, Liliana Garneata, Elena Zakharova, Samira Bell, Miha Arnol, Marten Segelmark, Kyriakos Ioannou, Kristine Hommel, Mai Rosenberg-Ots, Evgueniy Vazelov, Jaakko Helve, Sandor Mihaly, Runolfur Palsson, Maurizio Nordio, Nikola Gjorgjievski, Aiko P. J. de Vries, Nurhan Seyahi, Winnie A. Magadi, Halima Resic, Aleh Kalachyk, Axel O. Rahmel, Ana A. Galvao, Radomir Naumovic, Torbjörn Lundgren, Mustafa Arici, Johan M. de Meester, Alberto Ortiz, Kitty J. Jager, Vianda S. Stel
Summary: This study aimed to analyze the trends in kidney transplantation rates in European countries. The results showed an overall increase in kidney transplantation rates from 2010 to 2018, including both deceased donor and living donor transplants, with substantial variations among different countries.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Editorial Material
Transplantation
Giovanni Gambaro, Lazaros Tzelves, Andreas Skolarikos, Mehmet Kanbay, Alberto Ortiz, Mario Cozzolino
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Article
Transplantation
Borja Quiroga, Maria Jose Soler, Alberto Ortiz, Carlos Jesus Jarava Mantecon, Virginia Olinda Gomes Perez, Antoni Bordils, Jose Lacueva, Antonio Jose Marin Franco, Pablo Delgado Conde, Patricia Munoz Ramos, Carmen Calderon Gonzalez, Juan Manuel Cazorla Lopez, Jinny Sanchez-Rodriguez, Ana Sanchez Horrillo, Tania Raquel Monzon Vazquez, Alba Leyva, Jose Rojas, Ron T. Gansevoort, Patricia de Sequera
Summary: This study evaluated the humoral response and effectiveness of the fourth dose of COVID-19 vaccines in chronic kidney disease (CKD) patients. The fourth dose increased antibody levels in CKD patients undergoing hemodialysis and non-dialysis CKD patients, and seroconverted previously negative patients. However, CKD patients with lower pre-booster antibody titres or kidney transplant recipients derived the least benefit in terms of antibody levels.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2023)
Review
Food Science & Technology
Mara Lauriola, Ricard Farre, Pieter Evenepoel, Saskia Adriana Overbeek, Bjorn Meijers
Summary: Patients with CKD have a higher cardiovascular risk than the general population due to the accumulation of uremic toxins. Protein-bound uremic toxins originate from various sources and are difficult to remove with conventional therapies. Diet plays an important role in uremic toxicity, with most toxins derived from the gut. This review summarizes the sources of uremic toxins in foods and discusses their metabolism and potential dietary strategies for reducing their plasma levels.
Review
Urology & Nephrology
Marlies Noordzij, Bjorn Meijers, Ron T. Gansevoort, Adrian Covic, Raphael Duivenvoorden, Luuk B. Hilbrands, Marc H. Hemmelder, Kitty J. Jager, Geir Mjoen, Ionut Nistor, Ekaterina Parshina, Giuseppina Pessolano, Serhan Tuglular, Priya Vart, Luca Zanoli, Casper F. M. Franssen, ERACODA collaborators
Summary: This study analyzed the infection prevention and control strategies implemented by dialysis centers in Europe during the first wave of the COVID-19 pandemic. The results showed that most centers implemented measures such as fever screening, hand disinfection, and mask-wearing to prevent the spread of the virus. There were variations between centers and national guidelines in terms of recommended distances between dialysis chairs and isolation practices.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Urology & Nephrology
Victor Martinez, Monica Furlano, Laia Sans, Lissett Pulido, Rebeca Garcia, Maria Vanessa Perez-Gomez, Jinny Sanchez-Rodriguez, Miquel Blasco, Cristina Castro-Alonso, Gema Fernandez-Fresnedo, Nicolas Roberto Robles, Maria Pau Valenzuela, Javier Naranjo, Nadia Martin, Melissa Pilco, Irene Agraz-Pamplona, Juan David Gonzalez-Rodriguez, Nayara Panizo, Gloria Fraga, Loreto Fernandez, Maria Teresa Lopez, Cecilia Dall'Anese, Alberto Ortiz, Roser Torra, Luis Marcas, Asuncion Rius, Patricia Tomas, Leonor Garcia, Enrique Luna, Maria Adoracion Martin, Pablo Inigo, Judith Martins, Fernanda Ramos, Rosa Garcia, Laura del Rio Garcia, Maria del Carmen Merino, M. Jose Fernandez-Reyes, Leire Madariaga, Cristina Canal, Ana Maria Martinez, Rocio Echarri, Hanane Bouarich, Antonio Cabezas
Summary: This study analyzed the clinical characteristics of autosomal dominant polycystic kidney disease (ADPKD) in young adults and found that they have a higher morbidity rate. This highlights the importance of comprehensive assessment for young individuals at risk of ADPKD, in order to enable early diagnosis and treatment of hypertension.
CLINICAL KIDNEY JOURNAL
(2023)
Review
Urology & Nephrology
Mehmet Kanbay, Sidar Copur, Berk Mizrak, Alberto Ortiz, Maria Jose Soler
Summary: Acute kidney injury (AKI) is a common condition in hospitalized patients, with risk factors including postoperative settings, baseline chronic kidney disease (CKD), and congestive heart failure. Intravenous (IV) fluid therapy is an essential component of AKI prevention and treatment. This review discusses the timing, fluid type, amount, and infusion rate of IV fluid therapy in hospitalized patients, as well as the potential adverse effects of different crystalloid and colloid solutions, specifically in patients with AKI, CKD, or heart failure, and their impact on the risk of hospital-acquired AKI.
CLINICAL KIDNEY JOURNAL
(2023)
Review
Biochemistry & Molecular Biology
Nerea Mendez-Barbero, Jorge Oller, Ana B. Sanz, Adrian M. Ramos, Alberto Ortiz, Marta Ruiz-Ortega, Sandra Rayego-Mateos
Summary: Cardiovascular disease (CVD) often accompanies chronic kidney disease (CKD), and patients with both conditions have an increased risk of all-cause mortality ranging from 20% to 500%. Maintaining mitochondrial homeostasis appears to be a promising therapeutic strategy for the cardio-renal syndrome (CRS). This review explores the role of mitochondrial dysfunction in cardiovascular and renal diseases and how it may guide the development of novel therapeutic strategies for CRS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Flavia Trionfetti, Vanessa Marchant, Guadalupe. T. T. Gonzalez-Mateo, Edyta Kawka, Laura Marquez-Exposito, Alberto Ortiz, Manuel Lopez-Cabrera, Marta Ruiz-Ortega, Raffaele Strippoli
Summary: The global incidence of chronic kidney disease (CKD) is increasing, leading to a significant number of CKD patients developing end-stage renal disease (ESRD) and requiring kidney replacement therapies (KRT). Peritoneal dialysis (PD) is a convenient home therapy for KRT, but it can lead to damage of the peritoneal membrane (PM) due to the exposure to PD fluids containing high concentrations of glucose or other osmotic agents. This damage involves inflammation and fibrosis, which can be worsened by peritonitis episodes. In this article, we review the role of immune cells in PM damage during KRT and infections, as well as the anti-inflammatory properties of current clinical treatments for CKD patients in KRT and their potential effect on preserving PM integrity. Additionally, we discuss the implications of COVID-19 in CKD and KRT.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Maria D. Sanchez-Nino, Maria I. Ceballos, Sol Carriazo, Aranzazu Pintor-Chocano, Ana B. Sanz, Moin A. Saleem, Alberto Ortiz
Summary: The interaction between diabetes and Fabry disease may increase the severity of kidney damage by modulating the Gb3 synthesis pathway and downregulating kidney protective genes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)