Article
Physiology
Ramon Paniagua, Elvia Garcia-Lopez, Marcela Avila-Diaz, Maria-de-Jesus Ventura, Oscar Orihuela, Maria-del-Carmen Prado-Uribe, Juan-Manuel Gallardo-Montoya, Bengt Lindholm
Summary: During peritoneal dialysis treatment with icodextrin solutions, females show higher levels of icodextrin metabolites in serum, which may lead to an increase in blood volume and blood pressure.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
Dmitry M. Davydov, Andrey Boev, Stas Gorbunov
Summary: This study compared various BIA models in predicting body compartments associated with hydration. Volumetric-based BIA measures obtained in parallel were found to be the best approach in predicting whole-body components, while serially-obtained BIA measures were the best fitting in predicting segmental compartments. Further validation on humans is needed for practical implementation.
SCIENTIFIC REPORTS
(2021)
Article
Nutrition & Dietetics
Sebastian Mussnig, Michael Schmiedecker, Maximilian Waller, Janosch Niknam, Christopher Paschen, Daniel Schneditz, Manfred Hecking, Simon Krenn
Summary: This study aimed to compare the differences between two versions (3.2.5 and 3.3.3) of the Body Composition Monitor (BCM) in measuring body impedance, fat and lean tissue mass, fluid compartments, and overhydration. The results showed significant differences between the two versions of the BCM in terms of overhydration, with the newer version 3.3.3 tending to measure less overhydration. Therefore, it is important to check the version of the BCM device and use devices of the same version for each patient to ensure better within-patient consistency.
Article
Radiology, Nuclear Medicine & Medical Imaging
Carolina Dona, Christian Nitsche, Oliver Anegg, Thomas Poschner, Matthias Koschutnik, Franz Duca, Stefan Aschauer, Varius Dannenberg, Matthias Schneider, Robert Schoenbauer, Dietrich Beitzke, Christian Loewe, Christian Hengstenberg, Julia Mascherbauer, Andreas Kammerlander
Summary: The study investigated the association between systemic fluid status and T-1-mapping by cardiac magnetic resonance. The results showed that T-1 times and MR-ECV were significantly associated with the degree of overhydration measured by bioimpedance analysis, independent of other factors such as age, sex, body mass index, and hematocrit.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2022)
Article
Medicine, General & Internal
Fabiana Lourenco Costa, Nayrana Soares do Carmo Reis, Fabricio Moreira Reis, Rogerio Carvalho de Oliveira, Silmeia Garcia Zanati Bazan, Maryanne Zilli Canedo da Silva, Luis Cuadrado Martin, Pasqual Barretti
Summary: This study evaluated the superiority of multifrequency bioimpedance spectroscopy (BIS) over control based on clinical assessment plus single-frequency bioimpedance (SF-BIA) in fluid control and intermediate cardiovascular outcomes in peritoneal dialysis (PD) patients. The results showed that BIS was more effective in fluid control and had positive effects on cardiovascular parameters compared to the control group.
FRONTIERS IN MEDICINE
(2022)
Article
Multidisciplinary Sciences
Seok Hui Kang, Jun Chul Kim, Ran-hui Cha, Miyeun Han, Won Suk An, Su Hyun Kim, Jun Young Do
Summary: This study aimed to evaluate the association between volume status and sarcopenia in non-dialysis chronic kidney disease (ND-CKD) patients. The results showed an inverse correlation between the edema index and muscle mass, strength, and physical performance. However, the association was not strong due to the limitations of the small sample size.
SCIENTIFIC REPORTS
(2022)
Review
Urology & Nephrology
Kaibi Yang, Shujun Pan, Nan Yang, Juan Wu, Yueming Liu, Qiang He
Summary: Using bioelectrical impedance technology for fluid management in dialysis patients can improve prognosis, but it cannot eliminate all-cause mortality risks.
Article
Urology & Nephrology
Yanna Dou, Yanan Gong, Afang Li, Peipei Wang, Dongyan Song, Yuyang Wang, Dong Liu, Genyang Cheng, Zhanzheng Zhao
Summary: Comparing fluid status between multifrequency bioimpedance spectroscopy (MF-BIS) and the isotope dilution method is feasible in Chinese HD and PD patients.
Article
Biochemistry & Molecular Biology
Beata Szlachta, Anna Birkova, Tomasz Wielkoszynski, Alicja Gospodarczyk, Beata Hubkova, Maria Dydon, Jolanta Zalejska-Fiolka
Summary: This study aims to investigate the impact of reductions in various body mass components on oxidative, glycemic, and lipid parameters in obese individuals. The results demonstrate that weight loss can decrease cardiovascular risk, improve oxidative status, and reduce markers of oxidative damage. However, the effects on glycemic state vary depending on the specific body mass components. Glycemic status plays a crucial role in weight reduction.
Article
Food Science & Technology
Sabrina Geisslitz, Darina Pronin, Manjusha Neerukonda, Valentina Curella, Sibylle Neufang, Sandra Koch, Heiko Weichert, Hans Weber, Andreas Boerner, Detlef Schuppan, Katharina Anne Scherf
Summary: The prevalence of hypersensitivities towards wheat has increased and is not solely limited to celiac disease but also includes non-celiac wheat sensitivity. One possible cause for this increase is the activation of toll-like receptor 4 on immune cells by amylase/trypsin-inhibitors (ATIs), which are non-gluten proteins and wheat allergens. However, the study found no changes in the total ATI content or distribution between old and modern wheat cultivars.
NPJ SCIENCE OF FOOD
(2023)
Article
Medicine, General & Internal
Peong Gang Park, Jeesu Min, Seon Hee Lim, Ji Hyun Kim, Yo Han Ahn, Il-Soo Ha, Hee Gyung Kang
Summary: BIS is effective in evaluating fluid status in pediatric dialysis patients, with overhydration being a common issue. Clinical characteristics such as multiple antihypertensive medication use and elevated blood pressure despite medication were associated with fluid overload detected by BIS. Changes in body weight, medication, and cardiac parameters were observed in overhydrated children after modification of dialysis prescription based on BIS results, indicating the potential clinical utility of BIS in managing fluid overload.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Biology
Alexander Bertuccioli, Marco Cardinali, Piero Benelli
Summary: This study investigated the potential of using segmental BIVA analysis to predict performance status and injuries in athletes. The results suggest a correlation between higher cellularity and reduced risk of training injuries. However, there are still many uncertainties regarding the predictive potential of BIVA in terms of performance and injuries during competitions.
Article
Multidisciplinary Sciences
Joanna Stachowska-Pietka, Beata Naumnik, Ewa Suchowierska, Rafael Gomez, Jacek Waniewski, Bengt Lindholm
Summary: It was found in the study that patients on automated peritoneal dialysis with a dry day experienced lower ultrafiltration during initial exchanges, likely due to inflow of water into peritoneal tissue leading to increased hydration.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Analytical
Jesus Antonio Sanchez-Perez, John A. Berkebile, Brandi N. Nevius, Goktug C. Ozmen, Christopher J. Nichols, Venu G. Ganti, Samer A. Mabrouk, Gari D. Clifford, Rishikesan Kamaleswaran, David W. Wright, Omer T. Inan
Summary: Exacerbations of heart failure often result in frequent hospitalizations and poor outcomes. Current methods for tracking lung fluid and respiratory distress are limited in providing continuous and holistic assessment of cardiopulmonary health. This study presents a multimodal sensing system that combines various parameters to track changes in cardiopulmonary status, and demonstrates its feasibility in a clinical setting. The system is capable of detecting changes in pulmonary fluid status and capturing high-quality respiratory signals and lung sounds.
Article
Urology & Nephrology
Abdul Hamid Ismail, Theresa Gross, Georg Schlieper, Marian Walter, Frank Eitner, Juergen Floege, Steffen Leonhardt
Summary: The study found that in patients prone to intradialytic hypotension, there is a rapid drop in extracellular fluid (ECF) that exceeds the expected rate of ultrafiltration, accompanied by a significant increase in intracellular fluid (ICF), possibly due to transcellular fluid shifts. Additionally, unstable patients experienced a greater loss of ECF than predicted, indicating a pattern of fluid removal that differs significantly from hemodynamically stable patients.
CLINICAL KIDNEY JOURNAL
(2021)
Article
Urology & Nephrology
Kerry Allen, Sarah L. Damery, Kim Sein, David W. Johnson, Simon J. Davies, Mark Lambie, Els Holvoet, Gill M. Combes
Summary: This study aimed to understand the transition experience and perceptions of patients and caregivers from peritoneal dialysis (PD) to haemodialysis (HD). The findings suggest that while each transition is unique, there are common themes such as resistance to change, importance of family support, and bodily adjustment that affect the transition. Expert support during the transition and providing information about potential treatment options could optimize the process.
PERITONEAL DIALYSIS INTERNATIONAL
(2022)
Article
Nutrition & Dietetics
Zhimin Chen, Erik Nilsson, Bengt Lindholm, Olof Heimburger, Peter Barany, Peter Stenvinkel, Abdul Rashid Qureshi, Jianghua Chen
Summary: Chronic kidney disease (CKD) is associated with metabolic and nutritional abnormalities, including resistance to insulin-like growth factor-1 (IGF-1) and reduced muscle mass and strength. Low levels of IGF-1 and hand-grip muscle strength (HGS) are independent predictors of increased mortality in CKD patients. The association of IGF-1 with survival in CKD patients depends on nutritional status.
JOURNAL OF RENAL NUTRITION
(2023)
Article
Urology & Nephrology
Mauricio Sanabria, Jasmin Vesga, Bengt Lindholm, Angela Rivera, Peter Rutherford
Summary: The use of remote patient monitoring (RPM) in automated peritoneal dialysis (APD) patients was associated with a significant increase in treatment time, but did not affect mortality rates.
INTERNATIONAL JOURNAL OF NEPHROLOGY
(2022)
Article
Urology & Nephrology
Ivan Damgov, Maria Bartosova, Iva Marinovic, Obaida Istanbuly, Meinhard Kieser, Mark Lambie, Simon J. Davies, Claus Peter Schmitt
KIDNEY INTERNATIONAL REPORTS
(2023)
Article
Urology & Nephrology
Simon J. Davies, David Coyle, Elizabeth J. Lindley, David Keane, John Belcher, Fergus J. Caskey, Indranil Dasgupta, Andrew Davenport, Ken Farrington, Sandip Mitra, Paula Ormandy, Martin Wilkie, Jamie MacDonald, Mandana Zanganeh, Lazaros Andronis, Ivonne Solis-Trapala, Julius Sim
Summary: Avoiding excessive dialysis-associated volume depletion may help preserve residual kidney function. A randomized controlled trial was conducted to examine whether knowledge of estimated normally hydrated weight could reduce the rate of loss of residual kidney function. The results showed that using a standardized clinical protocol for fluid assessment can effectively preserve residual kidney function without the need for bioimpedance measurements.
KIDNEY INTERNATIONAL
(2023)
Article
Urology & Nephrology
Johann Morelle, Mark Lambie, Carl M. Oberg, Simon Davies
Summary: A healthy peritoneal membrane is crucial for effective peritoneal dialysis treatment. Variability and dysfunction of the membrane can lead to fluid overload and complications. This review provides an overview of the structure, function, and pathophysiology of the peritoneal membrane and discusses their clinical implications for patient-centered care.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Article
Urology & Nephrology
Olof Heimburger, Jorgen Hegbrant, Giedre Martus, Martin Wilkie, Charlotte De Leon, Ola Carlsson, Ann-Cathrine Johansson
Summary: Steady concentration peritoneal dialysis (PD) performed with the Carry Life UF device resulted in higher ultrafiltration rates, more efficient use of glucose, and greater sodium removal compared with a standard continuous ambulatory PD (CAPD) dwell.
CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
(2023)
Editorial Material
Nursing
Sintra Eyre, Jenny Stenberg, Ola Wallengren, David M. Keane, Carla Avesani, Ingvar Bosaeus, Naomi Clyne, Olof Heimburger, Ainhoa Indurain, Ann-Cathrine Johansson, Bengt Lindholm, Fernando Seoane, Mia Trondsen, SWEBIS network
JOURNAL OF RENAL CARE
(2023)
Article
Urology & Nephrology
Xiejia Li, Abdul Rashid Qureshi, Mohamed E. Suliman, Olof Heimburger, Peter Barany, Peter Stenvinkel, Bengt Lindholm
Summary: This study examined the association of interleukin-6 (IL-6) and albumin levels with outcomes in chronic kidney disease (CKD) patients, using the IL-6 to albumin ratio (IAR) as a predictor of death risk in incident dialysis patients. The results showed that IAR had a higher discrimination for predicting all-cause mortality compared to IL-6 and albumin alone. Additionally, high and middle IAR tertiles were significantly associated with an increased risk of all-cause mortality.
AMERICAN JOURNAL OF NEPHROLOGY
(2023)
Review
Urology & Nephrology
Fabiola Martin-del-Campo, Carla Maria Avesani, Peter Stenvinkel, Bengt Lindholm, Alfonso M. Cueto-Manzano, Laura Cortes-Sanabria
Summary: Protein-energy wasting (PEW) is common in patients with chronic kidney disease (CKD) and is associated with increased morbidity and mortality, and lower quality of life. Gut dysbiosis plays an important role in inflammation and uremic toxin retention, contributing to the development of PEW. Understanding the interactions between gut microbiota and the host may lead to the development of new strategies to improve nutrition and clinical outcomes in CKD patients.
JOURNAL OF NEPHROLOGY
(2023)
Review
Urology & Nephrology
Carla Maria Avesani, Aline Miroski de Abreu, Heitor S. Ribeiro, Torkel B. Brismar, Peter Stenvinkel, Alice Sabatino, Bengt Lindholm
Summary: Muscle fat infiltration (MFI), also known as myosteatosis, refers to the accumulation of lipids in the skeletal muscle. MFI is usually assessed using imaging methods like CT, MRI, and ultrasound, primarily in the legs, arms, and trunk muscle groups. MFI is considered a marker of muscle quality, where higher fat deposition in the muscle leads to decreased contraction power and force production per unit of muscle mass.
JOURNAL OF NEPHROLOGY
(2023)
Article
Urology & Nephrology
Simon J. Davies
Article
Urology & Nephrology
Xiejia Li, Bengt Lindholm
Summary: Cardiovascular disease is a major complication of chronic kidney disease, even in its early stages. Accurate risk prediction models are important in identifying high-risk individuals and improving prognosis in CKD patients.
AMERICAN JOURNAL OF NEPHROLOGY
(2023)
Article
Nutrition & Dietetics
Julie Ann Kemp, Henrique Fragoso dos Santos, Hugo Emiliano de Jesus, Marta Esgalhado, Bruna Regis de Paiva, Renata Azevedo, Peter Stenvinkel, Peter Bergman, Bengt Lindholm, Marcelo Ribeiro-Alves, Denise Mafra
Summary: The study showed that amylose-resistant starch (RS) supplementation did not affect plasma trimethylamine N-Oxide (TMAO) levels in hemodialysis (HD) patients, nor did it alter the bacterial taxa associated with TMAO. No significant impact of RS on choline, betaine, anthropometric measurements, biochemical parameters, or food intake was observed in both groups.
JOURNAL OF THE AMERICAN NUTRITION ASSOCIATION
(2022)
Review
Urology & Nephrology
Erika F. Gomez-Garcia, Fabiola Martin del Campo, Laura Cortes-Sanabria, Francisco Mendoza-Carrera, Carla Maria Avesani, Peter Stenvinkel, Bengt Lindholm, Alfonso M. Cueto-Manzano
Summary: Increased muscle protein breakdown leading to muscle wasting is a prominent feature of protein-energy wasting syndrome in patients with chronic kidney disease. This review explores the role of nuclear factor erythroid 2-related factor 2 (NRF2) in maintaining muscle mass and suggests that sustained activation of NRF2 through non-pharmacological interventions could be a plausible strategy to prevent skeletal muscle disorders in aging CKD patients.
JOURNAL OF NEPHROLOGY
(2022)