Article
Urology & Nephrology
Pierre Delanaye, Emmanuelle Vidal-Petiot, Thomas Stehle, Laurence Dubourg, Francois Gaillard, Gunnar Sterner, Christine A. White, Sandrine Lemoine, Vincent Audard, Dominique Prie, Etienne Cavalier, Marie Courbebaisse, Hans Pottel, Martin Flamant
Summary: This study evaluated the performance of different equations in correcting the early disappearance curve in the GFR range >90 ml/min per 1.73 m(2). The results showed that the BM and JBM equations had the best overall performance, especially with the lowest accuracy in the hyperfiltration range.
KIDNEY INTERNATIONAL REPORTS
(2021)
Article
Gastroenterology & Hepatology
Carlos Gonzalez-Alayon, Esteban Porrini, Sergio Luis-Lima, Natalia Negrin-Mena, Miguel Moreno, Dalia Morales-Arraez, Federico Gonzalez-Rinne, Laura Diaz-Martin, Flavio Gaspari, Alejandra Gonzalez-Delgado, Carmen Ferrer-Moure, Alberto Ortiz-Arduan, Manuel Hernandez-Guerra
Summary: In patients with cirrhosis, formulas for estimating renal function, whether specific to this population or classic equations, have not been proven to be reliable. The study found poor agreement between estimated and measured glomerular filtration rate in cirrhotic patients, indicating caution should be exercised when using eGFR in this population.
LIVER INTERNATIONAL
(2022)
Article
Urology & Nephrology
Christine A. White, Ayub Akbari, Celine Allen, Andrew G. Day, Patrick A. Norman, David Holland, Michael A. Adams, Greg A. Knoll
Summary: This study compared plasma iohexol and Tc-99m-DTPA GFR with varying sampling strategies to urinary inulin GFR and identified protocols with the greatest accuracy based on clinical characteristics. Delayed sampling in plasma iohexol protocols showed highest accuracy in low GFRs, while early sampling showed highest accuracy in high GFRs. Customization of GFR protocols based on anticipated GFR levels is crucial for accuracy.
KIDNEY INTERNATIONAL
(2021)
Article
Medicine, General & Internal
Zhicheng Jin, Rongrong Huang, Paul Christensen, Roger L. Bertholf, Xin Yi
Summary: This study aimed to establish a convenient laboratory test to evaluate the plasma clearance of iohexol in living kidney donors. Iohexol was measured using liquid chromatography-tandem mass spectrometry (LC-MS/MS), and automated data integration and result calculation were achieved using a custom Python script and a laboratory informatics system (LIS) vendor's direct media interface for automated result reporting.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medical Laboratory Technology
Laurence Dubourg, Sandrine Lemoine, Brune Joannard, Laurence Chardon, Vandrea de Souza, Pierre Cochat, Jean Iwaz, Muriel Rabilloud, Luciano Selistre
Summary: The studied formulas showed equivalent precision and accuracy in calculating plasma iohexol clearance, with Ng-Schwartz-Munoz formula demonstrating improved accuracy at higher levels of in-GFR.
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
(2021)
Article
Medical Laboratory Technology
Ke Gong, Yingshu Zou, Haifeng Zhu, Xu Peng, Dongfang Qin, Bixuan Sun, Xuejing Wang
Summary: The metabolic curves of iohexol at the standard dose and contrast-level dose were found to be substantially identical. This suggests that the standard dose can be used for measuring GFR, and blood collection at 2 hours and 4 hours after injection is optimal.
CLINICA CHIMICA ACTA
(2022)
Article
Pharmacology & Pharmacy
Sarah Baklouti, Didier Concordet, Vitaliano Borromeo, Paola Pocar, Paola Scarpa, Petra Cagnardi
Summary: This study aimed to develop a population pharmacokinetic model to estimate iohexol plasma clearance in dogs and determine the best sampling times for accurate estimation of clearance in different situations. The two-compartment model showed creatinine and kidney status as covariates affecting clearance variability. Different optimal sampling times were identified based on health status and creatinine levels, providing a method that could potentially be applied to other population pharmacokinetic models for precise estimation of GFR.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Urology & Nephrology
Pierre Delanaye, Etienne Cavalier, Hans Pottel, Thomas Stehle
Summary: Glomerular filtration rate (GFR) is estimated using equations based on serum biomarker concentration and demographic data. The 2009 creatinine-based CKD-EPI equation (CKD-EPI2009) was widely used until 2021 when it was recalibrated. However, both CKD-EPI2009 and the recalibrated version overestimate GFR in adults aged 18-30 years, with a particularly significant overestimation at age 18. Alternative equations like EKFC and EKFCCC provide better performance in diverse populations, with EKFCCC being a sex-free and race-free equation.
CLINICAL KIDNEY JOURNAL
(2023)
Article
Urology & Nephrology
Anne-Laure Faucon, Martin Flamant, Pierre Delanaye, Oriane Lambert, Marie Essig, Marie-Noelle Peraldi, Nahid Tabibzadeh, Jean-Philippe Haymann, Benedicte Stengel, Guillaume Geri, Emmanuelle Vidal-Petiot
Summary: This study analyzed the performances of existing equations for estimating extracellular fluid volume (ECFV) and developed a new equation. The new equation, incorporating body weight, height, sex, and age, demonstrated better precision and accuracy than other equations, making it suitable for clinical practice.
KIDNEY INTERNATIONAL REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Tarak Srivastava, Robert E. Garola, Jianping Zhou, Varun C. Boinpelly, Lakshmi Priya, Mohammed Farhan Ali, Mohammad H. Rezaiekhaligh, Daniel P. Heruth, Jan Novak, Uri S. Alon, Trupti Joshi, Yuexu Jiang, Ellen T. McCarthy, Virginia J. Savin, Mark L. Johnson, Ram Sharma, Mukut Sharma
Summary: Increased fluid-flow shear stress can contribute to the progression of chronic kidney disease. Modulating the expression of EP2 and EP4 receptors, as well as their signaling pathways, may provide a novel approach to mitigate kidney injury.
Article
Cardiac & Cardiovascular Systems
Athiththan Yogeswaran, Manuel J. Richter, Faeq Husain-Syed, Zvonimir Rako, Natascha Sommer, Friedrich Grimminger, Werner Seeger, Hossein Ardeschir Ghofrani, Henning Gall, Khodr Tello
Summary: In patients with idiopathic pulmonary arterial hypertension or chronic thromboembolic pulmonary hypertension, estimated plasma volume status is associated with central venous congestion and prognosis. Patients with high estimated plasma volume status and without edema have a poorer transplant-free survival rate, which may represent an under-recognized subgroup.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Transplantation
Laurence Derain Dubourg, Manon Aurelle, Laurence Chardon, Sacha Flammier, Sandrine Lemoine, Justine Bacchetta
Summary: This study retrospectively analyzed the TmP/GFR values of 2051 subjects with normal GFR, phosphate, and calcium levels, ranging from children under 19 years old to adults. Results showed a gradual decrease in plasma phosphate and TmP/GFR during puberty in both genders, with levels stabilizing after the age of 19 until 55, slightly lower in men than in women.
NEPHROLOGY DIALYSIS TRANSPLANTATION
(2022)
Article
Public, Environmental & Occupational Health
June Fabian, Robert Kalyesubula, Joseph Mkandawire, Christian Holm Hansen, Dorothea Nitsch, Eustasius Musenge, Wisdom P. Nakanga, Josephine E. Prynn, Gavin Dreyer, Tracy Snyman, Billy Ssebunnya, Michele Ramsay, Liam Smeeth, Stephen Tollman, Saraladevi Naicker, Amelia Crampin, Robert Newton, Jaya A. George, Laurie Tomlinson
Summary: The burden of kidney disease in African countries is unclear. Existing equations for estimating kidney function have limited validation in the region. This study aimed to determine the most accurate way to measure kidney function and estimate the prevalence of impaired kidney function in African populations.
LANCET GLOBAL HEALTH
(2022)
Article
Cell Biology
Tarak Srivastava, Daniel P. Heruth, R. Scott Duncan, Mohammad H. Rezaiekhaligh, Robert E. Garola, Lakshmi Priya, Jianping Zhou, Varun C. Boinpelly, Jan Novak, Mohammed Farhan Ali, Trupti Joshi, Uri S. Alon, Yuexu Jiang, Ellen T. McCarthy, Virginia J. Savin, Ram Sharma, Mark L. Johnson, Mukut Sharma
Summary: The study confirmed the activation of beta-catenin signaling in podocytes in unilaterally nephrectomized TOPGAL mice, and found that FFSS treatment leads to nuclear translocation of beta-catenin in mouse podocytes. Additionally, publicly available data from UNX mice supported beta-catenin signaling as a key regulator.
Article
Pediatrics
Evelyn Dhont, Tatjana Van der Heggen, Evelien Snauwaert, Jef Willems, Siska Croubels, Joris Delanghe, Jan J. De Waele, Roos Colman, Johan Vande Walle, Peter De Paepe, Pieter A. De Cock
Summary: The study aimed to identify predictors of ARC and describe its time-course in critically ill children. Major surgery other than cardiac surgery and eGFR were found as independent predictors of ARC.
PEDIATRIC NEPHROLOGY
(2023)