Article
Pharmacology & Pharmacy
Miaomiao Lu, Hang Li, Wenlin Liu, Xuemei Zhang, Lili Li, Hongli Zhou
Summary: Curcumin has shown promising effects in attenuating renal interstitial fibrosis in UUO rats by inhibiting NLRP3 inflammasome activation, improving mitochondrial function, and promoting autophagy. Its mechanism of action also involves inhibiting the PI3K/AKT/mTOR pathway.
BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
(2021)
Article
Pharmacology & Pharmacy
Wenjuan Sun, Chang Hyun Byon, Dong Hyun Kim, Hoon In Choi, Jung Sun Park, Soo Yeon Joo, In Jin Kim, Inae Jung, Eun Hui Bae, Seong Kwon Ma, Soo Wan Kim
Summary: The study demonstrated that MA could alleviate renal fibrosis by regulating the expression of various proteins and interfering with the TGF-beta/Smad and MyD88 signaling pathways.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Multidisciplinary Sciences
Shang Guo Piao, Jun Ding, Xue Jing Lin, Qi Yan Nan, Mei Ying Xuan, Yu Ji Jiang, Hai Lan Zheng, Ji Zhe Jin, Can Li
Summary: This study found that RIP1-RIP3-mediated necroptosis is involved in the development of renal fibrosis via the Wnt3 alpha/beta-catenin/GSK-3 beta signaling pathway. RIP inhibitors and ICG-001 can inhibit renal fibrosis and improve cell viability in both a rat model and in vitro cell experiments.
Article
Biochemistry & Molecular Biology
Jun Wang, Zhichao Wang, Fan Xia, Qiong Duan, Xiaoping Peng
Summary: Renal interstitial fibrosis is a common pathological process in chronic kidney diseases, and obstructive kidney disease is a frequent cause of renal fibrosis. In this study, atorvastatin was found to decrease YAP and fibrosis-related gene expression, suggesting its potential as a preventive agent for fibrosis associated with obstructive kidney disease.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Chih-Hsing Hung, Hua-Yu Hsu, Hsin-Ying Clair Chiou, Mei-Lan Tsai, Huey-Ling You, Yu-Chih Lin, Wei-Ting Liao, Yi-Ching Lin
Summary: Arsenic can promote macrophage polarization to M2 type, resulting in the epithelial-mesenchymal transition of lung epithelial cells. This study found that arsenic induces repolarization of M1 macrophages to M2 macrophages through the autophagy/mitophagy pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Bin Li, Liang Wang, Xinwei Qi, Yumei Liu, Jiajun Li, Jie Lv, Xuan Zhou, Xuanlin Cai, Jiaoyu Shan, Xiumin Ma
Summary: In this study, the changes in NOTCH signaling pathway, as well as the fibrotic and inflammatory response of the liver after E. multilocularis infection, were analyzed using liver tissue samples from AE patients and an infected mouse model. It was found that blocking NOTCH signaling pathway exacerbates hepatic fibrosis levels and alters the polarization and origin of hepatic macrophages, suggesting the involvement of NOTCH3/DLL3 pathway in regulating macrophage polarization and fibrosis caused by AE.
Article
Biochemistry & Molecular Biology
Alexis Paulina Jimenez-Uribe, Belen Bellido, Omar Emiliano Aparicio-Trejo, Edilia Tapia, Laura Gabriela Sanchez-Lozada, Jose Antonio Hernandez-Santos, Francisca Fernandez-Valverde, Estefani Yaquelin Hernandez-Cruz, Marisol Orozco-Ibarra, Jose Pedraza-Chaverri
Summary: This study evaluated the time course of mitochondrial mass and bioenergetics alterations induced by a unilateral ureteral obstruction (UUO), a widely used model to study kidney fibrosis induction and progression mechanisms. The results showed a marked reduction in mitochondrial oxidative phosphorylation (OXPHOS) and mitochondrial mass during days 7 to 28 of obstruction, suggesting a key role of mitochondrial biogenesis and mitophagy induction in the impairment of OXPHOS capacity during fibrotic progression.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Article
Immunology
Xiaofei Li, Jing Zhao, Said Movahedi Naini, Gianmarco Sabiu, Stefan G. Tullius, Su Ryon Shin, Jonathan S. Bromberg, Paolo Fiorina, George C. Tsokos, Reza Abdi, Vivek Kasinath
Summary: The study revealed that after unilateral ureteral obstruction in the kidney, fibroblastic reticular cells (FRCs) in the kidney-draining lymph node also become fibrogenic, contributing to fibrosis that closely mirrors changes in the kidney. Additionally, immune cell populations in the affected lymph node were significantly higher compared to the unaffected contralateral kidney-draining lymph node. This suggests a possible mechanism for fibrosis involving the TGF beta/TGF beta R signaling pathway, and future studies are needed to delve deeper into this connection between FRCs and lymph node fibrosis.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Danyu You, Mengjie Weng, Xiaoting Wu, Kun Nie, Jiong Cui, Yi Chen, Liyan Yang, Jianxin Wan
Summary: This study aimed to elucidate the roles of C3aR and the NLRP3 inflammasome in unilateral ureteral obstruction (UUO)-induced renal interstitial fibrosis. The findings showed that C3aR deficiency improved renal function and attenuated renal fibrosis and NLRP3 inflammasome activation in UUO mice. Inhibition of the NLRP3 inflammasome also resulted in attenuated renal function and fibrosis in UUO mice.
Article
Medicine, Research & Experimental
Stine Julie Tingskov, Michael Schou Jensen, Casper-Emil Tingskov Pedersen, Isabela Bastos Binotti Abreu de Araujo, Henricus A. M. Mutsaers, Rikke Norregaard
Summary: The study found that the selective estrogen receptor modulator tamoxifen has a mitigating effect on renal fibrosis in female, male, and ovariectomized female rats, as well as demonstrating an anti-fibrotic effect in human kidney slices. Gender differences may play a role in drug treatment response.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Plant Sciences
Yue Liu, Jingyi Wu, Shuo Liang, Jiawei Xu, Minggang Wei, Zhenfang Du, Sheng Qiang
Summary: This study aimed to explore the specific effects of GBXZD on renal interstitial fibrosis (RIF) through the regulation of M1 macrophages. GBXZD has been widely used in clinical practice for RIF treatment, but its specific mechanism of action in RIF is unknown and requires further study.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Biochemistry & Molecular Biology
Ryoka Uchiyama, Eriko Toyoda, Miki Maehara, Shiho Wasai, Haruka Omura, Masahiko Watanabe, Masato Sato
Summary: PRP purified using commercial kits can affect macrophage polarization, with APS having a higher concentration of M1 and M2 macrophage related factors. When PRP supernatants were added to monocyte-derived macrophages and M1 polarized macrophages, it was observed that PRPs suppressed M1 macrophage polarization and promoted M2 macrophage polarization.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Nutrition & Dietetics
Xiaogang Li, Ruixuan Li, Nana You, Xiexiong Zhao, Jiaying Li, Weihong Jiang
Summary: The study found that butyric acid improves rat myocardial fibrosis by regulating the polarization of macrophages and promoting recovery of mitochondrial function. In addition, butyric acid inhibits the activity of rat myocardial fibroblasts, protects mitochondria, and improves symptoms.
FRONTIERS IN NUTRITION
(2022)
Article
Immunology
Xiangnan Hao, Junjun Luan, Congcong Jiao, Cong Ma, Zixuan Feng, Lingzi Zhu, Yixiao Zhang, Jingqi Fu, Enyin Lai, Beiru Zhang, Yanqiu Wang, Jeffrey B. Kopp, Jingbo Pi, Hua Zhou
Summary: Renal interstitial fibrosis (RIF) is a common pathological feature in chronic kidney injury, and there is currently no effective therapy for it. This study showed that locked nuclear acid (LNA)-anti-miR-150 can alleviate RIF in folic acid-induced RIF mice by regulating the SOCS1/JAK1/STAT1 pathway and reducing pro-inflammatory M1 and M2 macrophage polarization.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
John D. Imig, Md Abdul Hye Khan, Anna Stavniichuk, Wojciech K. Jankiewicz, Samaneh Goorani, Michael M. Yeboah, Ashraf El-Meanawy
Summary: The incidence of ureter obstruction is increasing and recovery from this kidney injury can lead to long-term consequences such as an increased risk for salt-sensitive hypertension. A study using a RUUO model found that mice with unilateral ureteral obstruction had elevated blood pressure and decreased sodium excretion, along with renal tubular injury, inflammation, decreased vascular density, and renal fibrosis. These findings highlight the importance of addressing ureter obstruction and its potential impact on sodium excretion and hypertension.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Immunology
Dan Inoue, Takashi Oda, Sachiko Iwama, Takahiro Uchida, Tadasu Kojima, Tomohiro Tomiyasu, Noriko Yoshikawa, Muneharu Yamada, Masaaki Okihara, Isao Akashi, Yu Kihara, Osamu Konno, Makoto Iwase, Hitoshi Iwamoto
Summary: This case study highlights a rare occurrence of pure red cell aplasia (PRCA) caused by parvovirus B19 infection transmitted through a kidney allograft. The patient initially responded well to intravenous immunoglobulin therapy, but experienced relapse of severe anemia after several months, ultimately requiring multiple courses of IVIG and adjustments to immunosuppressive drugs for long-term remission. This suggests that donor-transmitted PVB19 infection should be considered in kidney transplant recipients presenting with refractory anemia in the early post-operative period.
TRANSPLANT INFECTIOUS DISEASE
(2021)
Review
Biochemistry & Molecular Biology
Takashi Oda, Nobuyuki Yoshizawa
Summary: The epidemiology of AGN has undergone a paradigm shift, with a decrease in PSAGN cases in children and an increase in adult AGN cases, as well as cases associated with non-streptococcal infections. Children with PSAGN have an excellent prognosis but face an increased risk of CKD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Urology & Nephrology
Kazumi Komaki, Yayoi Shiotsu, Hiroya Adachi, Noriko Urata, Masayuki Hara, Mayuka Nakayama, Tetsuro Kusaba, Naoko Masuzawa, Eiichi Konishi, Takashi Oda, Keiichi Tamagaki
Summary: A 75-year-old man presented with fever, alveolar hemorrhage, and renal dysfunction. Treatment with corticosteroids improved symptoms, but relapse occurred after discontinuation, along with mononeuritis multiplex. Renal biopsy revealed crescentic glomerulonephritis with C3 deposits, suggesting systemic small vessel vasculitis.
Editorial Material
Urology & Nephrology
Joichi Usui, Soko Kawashima, Ken-Ei Sada, Yoshia Miyawaki, Daigo Nakazawa, Mitsuyo Itabashi, Shuichiro Endo, Tomomi Endo, Takashi Oda, Masaki Ohya, Kiyoki Kitagawa, Tasuku Nagasawa, Junichi Hirahashi, Keiju Hiromura, Takahisa Kawaguchi, Mamiko Takayasu, Naotake Tsuboi, Kouichi Hirayama, Eri Muso, Wako Yumura, Shinya Kaname, Kengo Furuichi, Hirokazu Okada, Ichiei Narita
CLINICAL AND EXPERIMENTAL NEPHROLOGY
(2021)
Review
Biochemistry & Molecular Biology
Takahiro Uchida, Shuhji Seki, Takashi Oda
Summary: Natural killer T (NKT) cells and NK cells have important roles in antitumor and antimicrobial functions. They are involved in various renal diseases, including acute kidney injury (AKI). NKT cells in mice are activated by specific ligands, cytokines, and bacterial components, leading to AKI. Both renal vascular endothelial cell injury (via perforin-mediated pathway) and tubular epithelial cell injury (via tumor necrosis factor-alpha/Fas ligand pathway) are independently involved in the pathogenesis of AKI. NK cells complement the functions of NKT cells in the development of infection-associated AKI. Human CD56(+) T cells, which are functional counterparts of murine NKT cells, and a subpopulation of CD56(+) NK cells damage intrinsic renal cells in vitro upon activation, possibly through mechanisms similar to those in mice. These cells are also thought to be involved in the acute exacerbation of pre-existing glomerulonephritis triggered by infection in humans, and their roles in sepsis-associated AKI are currently under investigation. In this review, we provide an overview of recent advances in the understanding of the association among infections, NKT and NK cells, and kidney injury, which is much more profound than previously considered. The important role of liver macrophages in the activation of NKT cells is also introduced.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Pathology
Nobuhiro Kanazawa, Masayuki Iyoda, Junichi Hayashi, Kazuho Honda, Takashi Oda, Hirokazu Honda
Summary: This paper presents a case of a patient who developed acute kidney injury and nephrotic syndrome following streptococcal cutaneous infection. The renal biopsy showed C3 deposition in the tubular basement membrane and the presence of nephritogenic antigens and upregulation of plasmin activity in the glomeruli, suggesting a possible role of streptococcal pyrogenic exotoxin B (SpeB) toxicity in poststreptococcal tubulointerstitial nephritis.
PATHOLOGY INTERNATIONAL
(2022)
Article
Urology & Nephrology
Muneharu Yamada, Yohei Hirai, Dan Inoue, Shuhei Komatsu, Takahiro Uchida, Tadasu Kojima, Tomohiro Tomiyasu, Noriko Yoshikawa, Takashi Oda
Summary: The study found that epimorphin can suppress the expression of fibrosis-associated markers in a peritoneal fibrosis mouse model and cultured cells.
PERITONEAL DIALYSIS INTERNATIONAL
(2022)
Article
Urology & Nephrology
Dan Inoue, Takashi Oda, Sachiko Iwama, Takahiko Hoshino, Mitsuya Mukae, Takashi Sakai, Aki Kojima, Takahiro Uchida, Tadasu Kojima, Kentaro Sugisaki, Tomohiro Tomiyasu, Noriko Yoshikawa, Muneharu Yamada
Summary: This case report describes a 44-year-old male patient who developed acute nephritic syndrome, followed by hemolytic anemia and thrombocytopenia, as well as features resembling thrombotic microangiopathy. Renal biopsy revealed typical PSAGN with atypical severe tubulointerstitial lesions.
Article
Medicine, General & Internal
Marie Nagai, Takahiro Uchida, Muneharu Yamada, Shuuhei Komatsu, Kohei Ota, Mitsuya Mukae, Hitoshi Iwamoto, Hiroshi Hirano, Miho Karube, Shinya Kaname, Takashi Oda
Summary: A 57-year-old man who had received a kidney transplant developed TAFRO syndrome, which led to thrombocytopenia and ultimately death, despite treatment with high-dose steroids and other measures. Pathological analysis of kidney tissues showed similarities to his pre-transplant condition, suggesting recurrence of TAFRO syndrome.
FRONTIERS IN MEDICINE
(2021)
Article
Urology & Nephrology
Marina Asano, Takashi Oda, Masashi Mizuno
Summary: This case report describes a 17-year-old female diagnosed with C3 glomerulonephritis (C3GN) despite the absence of streptococcal infection. Immunotherapy showed some improvement in the patient's condition, but there is currently no established gold standard treatment for this disease. Accumulation of similar cases may help advance treatment strategies by clarifying the etiology and pathogenic mechanism of C3GN for future prognosis.
Article
Medicine, General & Internal
Takahiro Uchida, Takashi Oda, Dan Inoue, Shuhei Komatsu, Tadasu Kojima, Tomohiro Tomiyasu, Noriko Yoshikawa, Muneharu Yamada
Summary: Infections with neuraminidase-producing bacteria, such as Capnocytophaga, can cause acute kidney injury (AKI) due to tubulointerstitial damage caused by neuraminidase production and subsequent exposure of T-antigen on the tubular cells.
Article
Urology & Nephrology
Ayano Onishi, Aya Mizumoto, Kensuke Mitsumoto, Rinko Katsunuma, Takafumi Shingu, Takashi Oda, Takashi Uzu
Summary: A 27-year-old man presented with heavy proteinuria, hematuria, and acute kidney injury after a fever, diagnosed with infection-related glomerulonephritis with coexisting immunoglobulin A nephropathy. The deposition of nephritis-associated plasmin receptor was identified as a useful marker for worsening urinalysis findings post-bacterial infection in chronic glomerulonephritis.
Article
Surgery
Masaaki Okihara, Hironori Takeuchi, Shinichi Akiyama, Reichi Yoshinaga, Sayuri Osato, Isao Akashi, Yu Kihara, Osamu Konno, Hitoshi Iwamoto, Takashi Oda, Sachiko Tanaka, Sakae Unezaki, Toshihiko Hirano
Summary: This study found that the combination of EVL and TAC has a synergistic effect on the proliferation of mitogen-activated PBMCs within the therapeutic concentration range used in renal transplantation. However, at concentrations higher than those clinically used, these drugs antagonize each other.
ANNALS OF TRANSPLANTATION
(2021)
Article
Urology & Nephrology
Takahiro Uchida, Shuuhei Komatsu, Takashi Sakai, Aki Kojima, Sachiko Iwama, Kentaro Sugisaki, Takashi Oda
Summary: A 74-year-old Japanese woman with FGN causing nephrotic syndrome achieved complete remission with steroid therapy, suggesting that some FGN patients can benefit from this treatment approach. Reported cases of DNAJB9-positive FGN among Asians, particularly Japanese individuals, are rare.
Article
Urology & Nephrology
Asako Kageyama, Hiroko Fukushima, Joichi Usui, Atsushi Iwabuchi, Ryoko Suzuki, Kouji Masumoto, Takashi Oda, Michio Nagata, Hidetoshi Takada
Summary: This case report describes a girl with renal cell carcinoma who developed rapid renal failure due to poststreptococcal acute glomerulonephritis, but promptly recovered after nephrectomy. Elevated serum interleukin-6 level before surgery was detected and the patient's renal function returned to normal six and a half years later. Renal cell carcinoma may have played a key role in accentuating the poststreptococcal acute glomerulonephritis.