Article
Spectroscopy
Xiao Meng, Mengping Zhang, Lingfei Liu, Jie Du, Nianlu Li, Wei Zou, Cuijuan Wang, Wenwen Chen, Haiyan Wei, Ranran Liu, Qiang Jia, Hua Shao, Yongchao Lai
Summary: This study presents a rapid and reliable method for qualitative and quantitative detection of aristolochic acid in Chinese herbal preparations using the SERS technique. The proposed method offers the advantages of easy operation, time-saving, high sensitivity, and molecular specificity.
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
(2023)
Review
Pharmacology & Pharmacy
Mingming Zhao, Yi Yu, Rumeng Wang, Meiying Chang, Sijia Ma, Hua Qu, Yu Zhang
Summary: Through reviewing publications in peer-reviewed English-language journals, it is found that Chinese herbal medicines (CHMs) have anti-inflammatory, antioxidative, anti-apoptotic, autophagy-mediated, and antifibrotic effects in the treatment of chronic kidney disease (CKD). Some studies suggest that CHMs as an adjuvant therapy may benefit CKD patients. However, issues such as unknown active ingredients, low quality and small sample sizes in clinical trials limit the development and safety of CHMs. Further research and well-conducted randomized controlled trials (RCTs) are urgently needed to evaluate the efficacy and safety of CHMs in CKD treatment.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Letian Yang, Bo Wang, Liang Ma, Ping Fu
Summary: Hyperuricemia is a common disorder that can lead to kidney disease. Traditional Chinese medicine has been proven effective in reducing uric acid levels and protecting kidney function, making it a widely used treatment for chronic kidney disease.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Pharmacology & Pharmacy
Yan-Zhuan Xiao, Zhi-Zhong Ye, Yuan-Tong Liang, Xin-Peng Chen, Yu-Hsun Wang, Qiang Xu, James Cheng-Chung Wei
Summary: This study using data from the National Health Insurance Research database in Taiwan found that Chinese herbal medicine therapy does not significantly increase the risk of chronic kidney disease in gout patients.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Minghai Shao, Chaoyang Ye, George Bayliss, Shougang Zhuang
Summary: The clinical and experimental study of Chinese herbal medicines on chronic kidney disease has made progress over the past 40 years, with five traditional Chinese herbs showing evidence of clinical efficacy and well-studied mechanisms.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Food Science & Technology
Khai Gene Leong, Elyce Ozols, John Kanellis, Frank Y. Ma, David J. Nikolic-Paterson
Summary: The study found that Cyclophilin D (CypD) facilitates aristolochic acid-induced acute kidney injury, but does not contribute to the transition from acute kidney injury to chronic kidney disease during ongoing exposure to aristolochic acid.
Article
Integrative & Complementary Medicine
Li Pei Ang, Pit Wei Ng, Yen Loong Lean, Vijay Kotra, Nurolaini Kifli, Hui Poh Goh, Kah Seng Lee, Md. Moklesur R. Sarker, Yaser Mohammed Al-Worafi, Long Chiau Ming
Summary: Herbal products are widely used globally for their perceived health benefits, but one commonly used ingredient, Aristolochic acids (AA), has been linked to kidney failure and urinary tract cancer. International agencies have classified AA as a carcinogen with sufficient evidence of its cancer-causing effects in humans. Despite evidence of widespread exposure to AA in multiple countries and regions, awareness and attention to the toxicity and adverse events associated with AA remains insufficient.
JOURNAL OF HERBAL MEDICINE
(2021)
Review
Pharmacology & Pharmacy
Qing Li, Changying Xing, Yanggang Yuan
Summary: Chronic kidney disease is a global public health issue, and patients often seek traditional Chinese medicine as an alternative treatment option. Mitochondrial dysfunction plays a crucial role in CKD, and herbal medicine can alleviate renal injury by restoring mitochondrial function.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Shingo Urate, Hiromichi Wakui, Kengo Azushima, Takahiro Yamaji, Toru Suzuki, Eriko Abe, Shohei Tanaka, Shinya Taguchi, Shunichiro Tsukamoto, Sho Kinguchi, Kazushi Uneda, Tomohiko Kanaoka, Yoshitoshi Atobe, Kengo Funakoshi, Akio Yamashita, Kouichi Tamura
Summary: The study on the induction of renal aging by aristolochic acid demonstrates that kidneys show aging phenotypes, increased cellular senescence, proximal tubular mitochondrial abnormalities, decreased antiaging gene Klotho, leading to renal fibrosis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Xiao-Yuan Liu, Xu-Bin Zhang, Ya-Feng Zhao, Kai Qu, Xiao-Yong Yu
Summary: This paper reviews the mechanisms of renal interstitial fibrosis and recent studies on the disease intervention with Chinese herbal medicine. The results show that Chinese herbal medicine can improve renal interstitial fibrosis, and its effects on specific pathological mechanisms have been explored.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Pharmacology & Pharmacy
Jiayi Tian, Yuqi Huang, Tong Wu, Hsien-Da Huang, Kam Ming Ko, Bao Ting Zhu, Jihang Chen
Summary: This review explores the potential benefits of Chinese Yang/Qi-invigorating tonic botanical drugs/herbal formulations in managing CKD and its complications, as well as investigates the involvement of mitochondrial-associated signaling pathways. The systematic search highlights the effects of these herbal formulations on CKD and related alterations in mitochondrial function and signaling pathways. Future investigation into the biochemical basis of these effects may offer new insights for developing drugs to prevent and treat CKD.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Pharmacology & Pharmacy
Dan-Qian Chen, Jun Wu, Ping Li
Summary: Diabetic kidney disease (DKD) is a major complication of diabetes, and Chinese herbal medicine plays a significant role in improving DKD through regulating multiple pathways related to metabolism, oxidative stress, inflammation, and mitochondrial dysfunction.
FRONTIERS IN PHARMACOLOGY
(2022)
Editorial Material
Oncology
Felicia Chung, Jiri Zavadil
Summary: This study revealed a strong association between the incidence of hepatic angiosarcoma and chronic kidney disease, particularly in end-stage renal disease. It also identified enrichment in the mutational signature of aristolochic acid exposure, which is the first reported observation of this mutational signature in human sarcomas.
JOURNAL OF PATHOLOGY
(2023)
Article
Pharmacology & Pharmacy
Hsuan-Shu Shen, Chung-Yi Hsu, Hei-Tung Yip, I-Hsin Lin
Summary: This study investigated the risk of ischemic stroke (IS) among patients with chronic kidney disease (CKD) using Chinese herbal medicine (CHM) as add-on therapy. It found that the risk of IS was significantly reduced in the CHM group, especially for patients taking CHM for over 180 days.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Physiology
Wenguang Feng, Wei-Zhong Ying, Xingsheng Li, Lisa M. Curtis, Paul W. Sanders
Summary: The absence of STAT1 gene protected mice from kidney injury in the aristolochic acid nephropathy model, suggesting a crucial role of STAT1 in the progression of CKD.
AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY
(2021)
Article
Health Care Sciences & Services
Tso-Jung Yen, Ta-Chien Chan, Yang-Chih Fu, Jing-Shiang Hwang
Summary: By integrating demographic and socioeconomic features, this study examines the impact of social networks on quality of life. Findings suggest that both functional and structural aspects of social networks play important but different roles in shaping people's quality of life.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2022)
Article
Psychology, Developmental
Szu-Ying Chen, Jing-Shiang Hwang, Chang-Chuan Chan, Chang-Fu Wu, Charlene Wu, Ta-Chen Su
Summary: This study examined the impact of long-term exposure to urban air pollutants on subclinical atherosclerosis in young individuals. The results showed associations between PM2.5 and NOX and carotid intima-media thickness, with variations based on age, sex, and health status.
JOURNAL OF ADOLESCENT HEALTH
(2022)
Article
Environmental Sciences
Tsung-Ming Tsao, Jing-Shiang Hwang, Sung-Tsun Lin, Charlene Wu, Ming-Jer Tsai, Ta-Chen Su
Summary: This study investigates the effects of walking in forests and urban parks on cardiovascular functions (CVFs). The results show that walking in a forest park significantly lowers blood pressure, heart rate, cardiac output, and improves vascular compliance compared to walking in an urban park. This study provides evidence of the potential beneficial effects of walking exercise in forest parks on CVFs.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Environmental Sciences
Ching-chun Huang, Shih-chun Pan, Wei-shan Chin, Yu-cheng Chen, Chih-da Wu, Chin-yu Hsu, Pinpin Lin, Pau-chung Chen, Yue Leon Guo
Summary: This study aimed to evaluate the association between exposure to petrochemical facilities and emissions and the risk of ADHD development in children. The results indicated that residents of townships near petrochemical plants, highly affected by petrochemical-containing prevailing winds, and with high benzene concentrations had an increased risk of ADHD development. This study provides clear evidence that living near petrochemical plants increases the risk of ADHD in children.
ENVIRONMENTAL RESEARCH
(2022)
Article
Environmental Sciences
Fu-Jun Chen, Ming-Chien Yin, Pei-Yun Chen, Min-Hua Lin, Yi-Hao Peng, Wen-Chao Ho, Pau-Chung Chen, Chung Y. Hsu
Summary: Statin therapy can reduce cardiovascular risk in patients with transient ischemic attack (TIA), and it is associated with lower risk of incident diabetes mellitus.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Public, Environmental & Occupational Health
Che-Wei Liao, Chih-Fu Wei, Mei-Huei Chen, Wu-Shiun Hsieh, Ching-Chun Lin, Pau-Chung Chen
Summary: Maternal shift work during pregnancy is associated with childhood overweight and insulin resistance.
FRONTIERS IN PUBLIC HEALTH
(2022)
Article
Environmental Sciences
Shih-Feng Chen, Yu-Hui Chien, Pau-Chung Chen
Summary: Long-term exposure to PM2.5 exceeding a threshold was found to be associated with increased risk of mortality among dialysis patients.
ENVIRONMENTAL POLLUTION
(2023)
Article
Construction & Building Technology
Po -Kai Chang, Hsiang-Hao Chuang, Ta-Chih Hsiao, Hsiao-Chi Chuang, Pau -Chung Chen
Summary: This study investigates the characteristics and transmission of pollutants in hospital operation rooms (ORs) through on-site measurements and numerical simulations. The results show that gaseous pollutants have lower air exchange rates (AERs) compared to particulate pollutants, and the AER of total volatile organic compounds (TVOC) is higher than that of carbon dioxide (CO2). The emission factors (EF) of surgical smoke particles vary depending on the surgical procedure. Coarse particles are primarily influenced by drag forces, resulting in lower AER values. Additionally, smaller particles exhibit lower AER values, potentially due to stronger Brownian motion. The combination of measurement and simulation analysis allows for the evaluation of lung deposited surface area (LDSA) concentrations, providing accurate exposure concentrations for health risk assessments.
BUILDING AND ENVIRONMENT
(2023)
Article
Environmental Sciences
Tsung-Ming Tsao, Jing-Shiang Hwang, Chung-Yen Chen, Sung-Tsun Lin, Ming-Jer Tsai, Ta-Chen Su
Summary: This study aims to investigate the effects of seasonal variations on cardiovascular functions. The results show that in winter, there is an increase in blood pressure and vascular resistance, as well as a decrease in heart rate and cardiac output. Temperature, relative humidity, and PM2.5 air pollution are identified as major factors contributing to these seasonal changes.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Environmental Sciences
Mu-Jean Chen, Yue Leon Guo, Pinpin Lin, Hung-Che Chiang, Pau-Chung Chen, Yu-Cheng Chen
Summary: The currently used air quality index (AQI) is criticized for its inability to capture the additive effects of air pollution on health risks and reflect non-threshold concentration-response relationships. In this study, we propose the air quality health index (AQHI) based on daily air pollution-mortality associations and compare its validity in predicting daily mortality and morbidity risks with the existing AQI.
ENVIRONMENTAL RESEARCH
(2023)
Meeting Abstract
Public, Environmental & Occupational Health
Min-Han Tsai, Chung-Yen Chen, Ping-Hui Chen, Rodger Tsai, Hsiao-Yu Yang, Chen Pau-Chung
SAFETY AND HEALTH AT WORK
(2022)
Meeting Abstract
Public, Environmental & Occupational Health
Rodger Tsai, Chung-Yen Chen, Min-Han Tsai, Ping-Hui Chen, Hsiao-Yu Yang, Chen Pau-Chung
SAFETY AND HEALTH AT WORK
(2022)
Meeting Abstract
Public, Environmental & Occupational Health
Chung-Yen Chen, Ping-Hui Chen, Min-Han Tsai, Rodger Tsai, Hsiao-Yu Yang, Chen Pau-Chung
SAFETY AND HEALTH AT WORK
(2022)
Meeting Abstract
Public, Environmental & Occupational Health
Ping Hui Chen, Pau Chung Chen
SAFETY AND HEALTH AT WORK
(2022)
Meeting Abstract
Public, Environmental & Occupational Health
Ping-Hui Chen, Chung-Yen Chen, Min-Han Tsai, Rodger Tsai, Hsiao-Yu Yang, Chen Pau-Chung
SAFETY AND HEALTH AT WORK
(2022)